ID   MAGBH_HUMAN             Reviewed;         336 AA.
AC   A8MXT2; A6NE98;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 3.
DT   02-SEP-2026, entry version 107.
DE   RecName: Full=Melanoma-associated antigen B17;
GN   Name=MAGEB17;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Formerly thought to be the product of a pseudogene, although
CC       could be a bona fide protein. However, scarce EST evidence confirms
CC       only the C-terminal sequence. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW98911.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC078993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471074; EAW98911.1; ALT_SEQ; Genomic_DNA.
DR   CCDS; CCDS59524.1; -.
DR   RefSeq; NP_001264236.1; NM_001277307.2.
DR   RefSeq; XP_047298311.1; XM_047442355.1.
DR   RefSeq; XP_054183550.1; XM_054327575.1.
DR   AlphaFoldDB; A8MXT2; -.
DR   SMR; A8MXT2; -.
DR   BioGRID; 570806; 1.
DR   FunCoup; A8MXT2; 27.
DR   STRING; 9606.ENSP00000382884; -.
DR   GlyGen; A8MXT2; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; A8MXT2; -.
DR   PhosphoSitePlus; A8MXT2; -.
DR   BioMuta; MAGEB17; -.
DR   MassIVE; A8MXT2; -.
DR   PaxDb; 9606-ENSP00000382884; -.
DR   PeptideAtlas; A8MXT2; -.
DR   ProteomicsDB; 2350; -.
DR   Antibodypedia; 5170; 8 antibodies from 7 providers.
DR   DNASU; 645864; -.
DR   Ensembl; ENST00000400003.1; ENSP00000382883.1; ENSG00000182798.10.
DR   Ensembl; ENST00000400004.6; ENSP00000382884.2; ENSG00000182798.10.
DR   GeneID; 645864; -.
DR   KEGG; hsa:645864; -.
DR   MANE-Select; ENST00000400004.6; ENSP00000382884.2; NM_001277307.2; NP_001264236.1.
DR   UCSC; uc031tgu.2; human.
DR   AGR; HGNC:17418; -.
DR   ClinPGx; PA134872991; -.
DR   CTD; 645864; -.
DR   GeneCards; MAGEB17; -.
DR   HGNC; HGNC:17418; MAGEB17.
DR   HPA; ENSG00000182798; Group enriched (pancreas, testis).
DR   MIM; 300763; gene.
DR   OpenTargets; ENSG00000182798; -.
DR   VEuPathDB; HostDB:ENSG00000182798; -.
DR   eggNOG; KOG4562; Eukaryota.
DR   GeneTree; ENSGT00940000166998; -.
DR   HOGENOM; CLU_039582_1_0_1; -.
DR   InParanoid; A8MXT2; -.
DR   OMA; VINKKYT; -.
DR   OrthoDB; 205198at2759; -.
DR   PAN-GO; A8MXT2; 2 GO annotations based on evolutionary models.
DR   PhylomeDB; A8MXT2; -.
DR   PathwayCommons; A8MXT2; -.
DR   BioGRID-ORCS; 645864; 15 hits in 756 CRISPR screens.
DR   GenomeRNAi; 645864; -.
DR   Pharos; A8MXT2; Tdark.
DR   PRO; PR:A8MXT2; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; A8MXT2; protein.
DR   Bgee; ENSG00000182798; Expressed in body of pancreas and 32 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-ARBA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   FunFam; 1.10.10.1200:FF:000007; Melanoma-associated antigen C2; 1.
DR   FunFam; 1.10.10.1210:FF:000001; melanoma-associated antigen D1; 1.
DR   Gene3D; 1.10.10.1200; MAGE homology domain, winged helix WH1 motif; 1.
DR   Gene3D; 1.10.10.1210; MAGE homology domain, winged helix WH2 motif; 1.
DR   InterPro; IPR037445; MAGE.
DR   InterPro; IPR021072; MAGE_N.
DR   InterPro; IPR041898; MAGE_WH1.
DR   InterPro; IPR041899; MAGE_WH2.
DR   InterPro; IPR002190; MHD_dom.
DR   PANTHER; PTHR11736:SF88; MELANOMA-ASSOCIATED ANTIGEN B17; 1.
DR   PANTHER; PTHR11736; MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   Pfam; PF12440; MAGE_N; 1.
DR   SMART; SM01373; MAGE; 1.
DR   SMART; SM01392; MAGE_N; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification; Reference proteome.
FT   CHAIN           1..336
FT                   /note="Melanoma-associated antigen B17"
FT                   /id="PRO_0000332218"
FT   DOMAIN          109..336
FT                   /note="MAGE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT   REGION          1..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..54
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..80
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..103
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   336 AA;  37578 MW;  D6CA349109F6BEE4 CRC64;
     MPRGQASKRR AREKRRQARG EDQCLGGAQA TAAEKEKLPS SSSPACQSPP QSFPNAGIPQ
     ESQRASYPSS PASAVSLTSS DEGAKGQKGE SPNSFHGPSS SESTGRDLLN TKTGELVQFL
     LNKYIRKEPI TREAMLKVIN RKYKQHFPEI LRRSTENVEV VFGLYLKEMD PSRQSYVLVG
     KLDFPNQGSL SDGGGFPLSG LLMVLLSTIF MHGNRATEEE MWECLNALGM YKGRKHFIYG
     EPQELVTKDL VREGYLEYQQ VPSSDPPRYE FLWGPRARAE TSKMKVLEFV AKLNDTVAST
     YKSRYEEALR EEEEQARARA VARDSARARA SRSFQP
//