ID   A8FHC2_BACP2            Unreviewed;       485 AA.
AC   A8FHC2;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   02-SEP-2026, entry version 90.
DE   SubName: Full=Altronate oxidoreductase {ECO:0000313|EMBL:ABV63639.1};
DE            EC=1.1.1.58 {ECO:0000313|EMBL:ABV63639.1};
GN   OrderedLocusNames=BPUM_2985 {ECO:0000313|EMBL:ABV63639.1};
OS   Bacillus pumilus (strain SAFR-032).
OC   Bacteria; Bacillati; Bacillota; Bacilli; Caryophanales; Bacillaceae;
OC   Bacillus.
OX   NCBI_TaxID=315750 {ECO:0000313|EMBL:ABV63639.1, ECO:0000313|Proteomes:UP000001355};
RN   [1] {ECO:0000313|EMBL:ABV63639.1, ECO:0000313|Proteomes:UP000001355}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032 {ECO:0000313|EMBL:ABV63639.1,
RC   ECO:0000313|Proteomes:UP000001355};
RX   PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA   Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA   Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA   Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA   Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA   Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA   Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA   Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA   Weinstock G.M.;
RT   "Paradoxical DNA repair and peroxide resistance gene conservation in
RT   Bacillus pumilus SAFR-032.";
RL   PLoS ONE 2:E928-E928(2007).
RN   [2] {ECO:0000313|EMBL:ABV63639.1, ECO:0000313|Proteomes:UP000001355}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032 {ECO:0000313|EMBL:ABV63639.1,
RC   ECO:0000313|Proteomes:UP000001355};
RX   PubMed=23812891; DOI=10.1007/s00792-013-0559-z;
RA   Tirumalai M.R., Fox G.E.;
RT   "An ICEBs1-like element may be associated with the extreme radiation and
RT   desiccation resistance of Bacillus pumilus SAFR-032 spores.";
RL   Extremophiles 17:767-774(2013).
RN   [3] {ECO:0000313|EMBL:ABV63639.1, ECO:0000313|Proteomes:UP000001355}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032 {ECO:0000313|EMBL:ABV63639.1,
RC   ECO:0000313|Proteomes:UP000001355};
RX   PubMed=23799069;
RA   Tirumalai M.R., Rastogi R., Zamani N., O'Bryant Williams E., Allen S.,
RA   Diouf F., Kwende S., Weinstock G.M., Venkateswaran K.J., Fox G.E.;
RT   "Candidate genes that may be responsible for the unusual resistances
RT   exhibited by Bacillus pumilus SAFR-032 spores.";
RL   PLoS ONE 8:E66012-E66012(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate
CC         + NADH + H(+); Xref=Rhea:RHEA:19661, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57634, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:61381; EC=1.1.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00048615};
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DR   EMBL; CP000813; ABV63639.1; -; Genomic_DNA.
DR   RefSeq; WP_012011235.1; NC_009848.4.
DR   AlphaFoldDB; A8FHC2; -.
DR   STRING; 315750.BPUM_2985; -.
DR   PaxDb; 315750-BPUM_2985; -.
DR   GeneID; 5622273; -.
DR   KEGG; bpu:BPUM_2985; -.
DR   eggNOG; COG0246; Bacteria.
DR   HOGENOM; CLU_027324_1_0_9; -.
DR   OrthoDB; 9768714at2; -.
DR   Proteomes; UP000001355; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009026; F:tagaturonate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019698; P:D-galacturonate catabolic process; IEA:TreeGrafter.
DR   GO; GO:0019592; P:mannitol catabolic process; IEA:TreeGrafter.
DR   Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR000669; Mannitol_DH.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; NF002969; PRK03643.1; 1.
DR   PANTHER; PTHR30524:SF0; ALTRONATE OXIDOREDUCTASE-RELATED; 1.
DR   PANTHER; PTHR30524; MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ABV63639.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001355}.
FT   DOMAIN          17..260
FT                   /note="Mannitol dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01232"
FT   DOMAIN          271..459
FT                   /note="Mannitol dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08125"
SQ   SEQUENCE   485 AA;  55664 MW;  604AF5C4986BE513 CRC64;
     MKRLSKSIYP VSEYPETILQ IGEGNFMRGF MNWHIQKLND CTDFKGRAVV VPPRKGSVAA
     LNEQDGLYTL CIQGYHDGQE MNERMIIQSI SRGISTYMDY DVFLQVAENP DLRFVFSNTT
     EAGLMFRKED RLEDRPQASF PGKLTAFLYH RFKSFAGDEQ KGMIILPCEL VEHNGDRLKE
     YVVDMAIEWE LPLAFITWIK EANTFCNTLV DRIVPGFSKE VAEMVQKEEG YIDELLVTAE
     YYHLFVIEAP VFVQKELPFQ KAGLNVLFVE DIAPYRISKV RILNGAHTAM VPIAYSCGIE
     TVNEAVGDED VGPFIRRMLE EEVLPGLELS RDELLLYTQS VWDRFCNPFV QHQLLDIALN
     GVSKFRTRIL PSLLDYVEQK KQLPMKLVFS LSSLIYFYRA HAEKIKDDET VLAFMKDVFE
     EVNKSNEAIA AKVLSCESLW GRNLTDIHDL VHAVADQLTF IQEEGMRAAV QRMLQHQYES
     QGEKA
//