ID   A8ES61_ALIB4            Unreviewed;       452 AA.
AC   A8ES61;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   28-JAN-2026, entry version 85.
DE   RecName: Full=malate dehydrogenase (quinone) {ECO:0000256|ARBA:ARBA00013026};
DE            EC=1.1.5.4 {ECO:0000256|ARBA:ARBA00013026};
DE   AltName: Full=MQO {ECO:0000256|ARBA:ARBA00031550};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000256|ARBA:ARBA00030660};
GN   Name=mqo {ECO:0000313|EMBL:ABV66785.1};
GN   OrderedLocusNames=Abu_0518 {ECO:0000313|EMBL:ABV66785.1};
OS   Aliarcobacter butzleri (strain RM4018) (Arcobacter butzleri).
OC   Bacteria; Pseudomonadati; Campylobacterota; Epsilonproteobacteria;
OC   Campylobacterales; Arcobacteraceae; Aliarcobacter.
OX   NCBI_TaxID=367737 {ECO:0000313|EMBL:ABV66785.1, ECO:0000313|Proteomes:UP000001136};
RN   [1] {ECO:0000313|EMBL:ABV66785.1, ECO:0000313|Proteomes:UP000001136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RM4018 {ECO:0000313|EMBL:ABV66785.1,
RC   ECO:0000313|Proteomes:UP000001136};
RX   PubMed=18159241; DOI=10.1371/journal.pone.0001358;
RA   Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M.,
RA   Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A.,
RA   Rogosin A., Stanker L.H., Mandrell R.E.;
RT   "The complete genome sequence and analysis of the Epsilonproteobacterium
RT   Arcobacter butzleri.";
RL   PLoS ONE 2:E1358-E1358(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001139};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005012}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000256|ARBA:ARBA00006389}.
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DR   EMBL; CP000361; ABV66785.1; -; Genomic_DNA.
DR   RefSeq; WP_012012316.1; NC_009850.1.
DR   AlphaFoldDB; A8ES61; -.
DR   STRING; 367737.Abu_0518; -.
DR   GeneID; 24304187; -.
DR   KEGG; abu:Abu_0518; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_613842_0_0_7; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000001136; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0047545; F:(S)-2-hydroxyglutarate dehydrogenase activity; IEA:TreeGrafter.
DR   GO; GO:0008924; F:L-malate dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   PANTHER; PTHR43104; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43104:SF2; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ABV66785.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001136};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
SQ   SEQUENCE   452 AA;  50944 MW;  23696795A4AC3E41 CRC64;
     MNEKHYEVVI VGGGISGAAL FFELAKYSDV NSICLLEKYE DLATLNSKGT SNSQTIHVGD
     IETNYTFEKA KITKRTAKMI EKFNLMYDLQ DKIMFKHQKM ALGVGEKEVQ FITDRYNKFK
     EIFPYLELWD KEALREKEPL LVYADKERTK DRPEPIVAMG TNDQYTTVDF GAMTKELVKA
     GQNADSSKTT DVFFNSEVEE IEQVGKKFKL TTVHGTVYTA DFVVVDAGAH SLFLAHKMGY
     GKHMGSLSMA GSFYITSGHF LNGKVYMVQN DKLPFAALHG DPDILCEGKT RFGPTALALL
     VLERYKGGKS FFQCLKTMNF DGSIMKIFWD LLKDSDIRNY VFKNFLFEVP GINKGLFVKD
     ARKIVPSLSV EDIEYAKGFG GVRPQVLNKD EKKLMLGEAS ITELDGIIFN MTPSPGATSC
     LGNAERDIKK VCQYLGKTFY EDKFLSDFTD DK
//