ID   CDH_CITK8               Reviewed;         249 AA.
AC   A8AL09;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   02-SEP-2026, entry version 88.
DE   RecName: Full=CDP-diacylglycerol pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_00319};
DE            EC=3.6.1.26 {ECO:0000255|HAMAP-Rule:MF_00319};
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
DE   AltName: Full=CDP-diglyceride hydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
GN   Name=cdh {ECO:0000255|HAMAP-Rule:MF_00319};
GN   OrderedLocusNames=CKO_03081;
OS   Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=290338;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696;
RG   The Citrobacter koseri Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:60377; EC=3.6.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00319};
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00319}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000822; ABV14172.1; -; Genomic_DNA.
DR   RefSeq; WP_012133879.1; NC_009792.1.
DR   AlphaFoldDB; A8AL09; -.
DR   SMR; A8AL09; -.
DR   STRING; 290338.CKO_03081; -.
DR   GeneID; 45136883; -.
DR   KEGG; cko:CKO_03081; -.
DR   HOGENOM; CLU_077117_0_1_6; -.
DR   OrthoDB; 481399at2; -.
DR   UniPathway; UPA00609; UER00664.
DR   Proteomes; UP000008148; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.428.30; HIT family - CDH-like; 1.
DR   HAMAP; MF_00319; Cdh; 1.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase.
DR   InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR   InterPro; IPR036265; HIT-like_sf.
DR   NCBIfam; TIGR00672; cdh; 1.
DR   NCBIfam; NF003986; PRK05471.1-5; 1.
DR   NCBIfam; NF003987; PRK05471.1-6; 1.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   SUPFAM; SSF54197; HIT-like; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW   Phospholipid metabolism; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..249
FT                   /note="CDP-diacylglycerol pyrophosphatase"
FT                   /id="PRO_1000019262"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00319"
SQ   SEQUENCE   249 AA;  27971 MW;  114B0CAB4D897F5E CRC64;
     MKKTGYFLLA VVIVAAVAGI GYWKLAANPN ALRDIVLQQC VPNQLQQQNP APCAEVKPDA
     GYVVFKDRNG PLQYLLMPTY RINGTESPLL VEPYTPNFFW LAWQARSFMS QKYGKDIPDS
     AISLAINSRS GRTQNHFHIH ISCLRPDVRA QLDDNLAKVS TRWLPLPGGL RGNEYLARRV
     TESELAQRSP FMMLAEEVPD AREHMGSYAL AVVRQSDDSF VLLATQRNLL AFNLASAEEI
     QDHQCEILQ
//