ID   A7SWU4_NEMVE            Unreviewed;       287 AA.
AC   A7SWU4;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   02-SEP-2026, entry version 81.
DE   RecName: Full=GMP reductase {ECO:0000256|ARBA:ARBA00015800};
DE            EC=1.7.1.7 {ECO:0000256|ARBA:ARBA00012678};
DE   AltName: Full=Guanosine 5'-monophosphate oxidoreductase {ECO:0000256|ARBA:ARBA00030699};
DE   Flags: Fragment;
GN   ORFNames=NEMVEDRAFT_v1g227565 {ECO:0000313|EMBL:EDO31825.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO31825.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO31825.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP
CC       to IMP. It functions in the conversion of nucleobase, nucleoside and
CC       nucleotide derivatives of G to A nucleotides, and in maintaining the
CC       intracellular balance of A and G nucleotides.
CC       {ECO:0000256|ARBA:ARBA00037691}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+);
CC         Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115,
CC         ChEBI:CHEBI:58349; EC=1.7.1.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00048616};
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DR   EMBL; DS469868; EDO31825.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7SWU4; -.
DR   STRING; 45351.A7SWU4; -.
DR   KEGG; nve:5502773; -.
DR   eggNOG; KOG2550; Eukaryota.
DR   HOGENOM; CLU_022552_5_3_1; -.
DR   InParanoid; A7SWU4; -.
DR   OMA; IVWRQNS; -.
DR   PhylomeDB; A7SWU4; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:1902560; C:GMP reductase complex; IEA:InterPro.
DR   GO; GO:0003920; F:GMP reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:InterPro.
DR   CDD; cd00381; IMPDH; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   HAMAP; MF_00596; GMP_reduct_type1; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR050139; GMP_reductase.
DR   InterPro; IPR005993; GMPR.
DR   InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   NCBIfam; TIGR01305; GMP_reduct_1; 1.
DR   NCBIfam; NF003470; PRK05096.1; 1.
DR   PANTHER; PTHR43170; GMP REDUCTASE; 1.
DR   PANTHER; PTHR43170:SF5; GMP REDUCTASE; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   SMART; SM01240; IMPDH; 1.
DR   SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR   PROSITE; PS00487; IMP_DH_GMP_RED; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   DOMAIN          10..280
FT                   /note="IMP dehydrogenase/GMP reductase"
FT                   /evidence="ECO:0000259|Pfam:PF00478"
FT   NON_TER         287
FT                   /evidence="ECO:0000313|EMBL:EDO31825.1"
SQ   SEQUENCE   287 AA;  31067 MW;  2D264993602471A2 CRC64;
     MPHVDHSIKL DFKDVLIRPK RSTLRSRADV DLSRHFTFRY AAKRFPDDVI PIIAANMDTI
     GTFELAQALS QHKLLTAIHK HYPIEAWAEF ASEHSDVLPY TIASAGMADK DLEKLQKILE
     LVPTVPGICL DVANGYSEHF VDFVKKVRSM FPEHIIIAGN VVTGEMVEQL ILSGADIVKV
     GIGPGSVCTT RRQTGVGYPQ ISAVLECGDA AHGLKGHIIS DGGCTCPGDV SKAFGAGADF
     VMLGGMLAGH DQSGGEIIER DGKKYKIFYG MSSNTAMRKH AGGVAEY
//