ID   A7RTW5_NEMVE            Unreviewed;       322 AA.
AC   A7RTW5;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   28-JAN-2026, entry version 82.
DE   RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN   ORFNames=NEMVEDRAFT_v1g181888 {ECO:0000313|EMBL:EDO45157.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO45157.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO45157.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC       {ECO:0000256|ARBA:ARBA00007905}.
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DR   EMBL; DS469538; EDO45157.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7RTW5; -.
DR   FunCoup; A7RTW5; 754.
DR   STRING; 45351.A7RTW5; -.
DR   KEGG; nve:5517137; -.
DR   eggNOG; KOG1577; Eukaryota.
DR   HOGENOM; CLU_023205_0_0_1; -.
DR   InParanoid; A7RTW5; -.
DR   OMA; WRDSSHP; -.
DR   OrthoDB; 416253at2759; -.
DR   PhylomeDB; A7RTW5; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004032; F:aldose reductase (NADPH) activity; IBA:GO_Central.
DR   FunFam; 3.20.20.100:FF:000006; Aldo-keto reductase family 1 member A1; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR036812; NAD(P)_OxRdtase_dom_sf.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   DOMAIN          15..289
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        48
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         109
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            76
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   322 AA;  36714 MW;  CEC9C6C2F6913D10 CRC64;
     MATVKLNNGL EMPVLGLGTW KSKPGQVENA VKFAIKEGYR HIDCAYAYRN EKEVGDALRE
     LLGSVVERKD LFITSKLWNT KHNPKDVRSN CVDSLKDLGL DYLDLYLIHW PLSFRDGDEF
     FPKDEQGNVL YAYHDPCDTW KAMEKLVDEG LVKAIGLSNF NSKQVDDICA IARIKPVANQ
     VECHPLLNQA KLIDHHKKHN IQTIAYSPLG SLDRPWAKPD DPHVMRDPTM VALADRYSRT
     VAQICIRFQI QRGVLVIPKS VTPERIKSNF QVFDFELSAE DMATIEGLNR DWRACLPMKK
     LADGTMVPRD GEHPHYPFNI PF
//