ID   A7RT58_NEMVE            Unreviewed;       360 AA.
AC   A7RT58;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   02-SEP-2026, entry version 79.
DE   RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE            EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN   ORFNames=NEMVEDRAFT_v1g162365 {ECO:0000313|EMBL:EDO45402.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO45402.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO45402.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1. {ECO:0000256|ARBA:ARBA00004823}.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000256|ARBA:ARBA00007274}.
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DR   EMBL; DS469536; EDO45402.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7RT58; -.
DR   STRING; 45351.A7RT58; -.
DR   KEGG; nve:5517449; -.
DR   eggNOG; KOG1322; Eukaryota.
DR   HOGENOM; CLU_029499_0_0_1; -.
DR   InParanoid; A7RT58; -.
DR   OMA; GPNCWIC; -.
DR   OrthoDB; 1733332at2759; -.
DR   PhylomeDB; A7RT58; -.
DR   UniPathway; UPA00126; UER00930.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009101; P:glycoprotein biosynthetic process; IBA:GO_Central.
DR   CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR   FunFam; 2.160.10.10:FF:000018; Mannose-1-phosphate guanyltransferase beta; 1.
DR   FunFam; 3.90.550.10:FF:000013; mannose-1-phosphate guanyltransferase beta; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   Gene3D; 3.90.550.10; Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A; 1.
DR   InterPro; IPR056729; GMPPB_C.
DR   InterPro; IPR045233; GMPPB_N.
DR   InterPro; IPR050486; Mannose-1P_guanyltransferase.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR   Pfam; PF25087; GMPPB_C; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          2..233
FT                   /note="Nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF00483"
FT   DOMAIN          250..359
FT                   /note="Mannose-1-phosphate guanyltransferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF25087"
SQ   SEQUENCE   360 AA;  40048 MW;  46E4E5C745468C99 CRC64;
     MKALILVGGY GTRLRPLTLS KPKPLVEFCN KPMLLHQVEA LVQAGVKHII LAVSYRAELL
     EKEMKEQEQK LGIKITISQE KEPLGTAGPL ALAHDYLTVN NEPFFVLNSD VICDFPFREM
     VEFHKKHGKE GTIVVTKVEE PSKYGVVVYN SETGCIERFV EKPEVFVSNK INAGMYIFNP
     SILNRIEMRP TSIEKEVFPF MAKDSQLFAF DLQGFWMDVG QPKDFLTGMC MYLNSLRKKS
     PELLHEGPGI IGNVLVCPTS KIGDHCRIGP NVVIGPGVVV QDGACLSRCV VLKDATIRSH
     SWIQSSIIGW KSVVGQWVRM EGVSVLGEDV IVKDELYING GRILPHKSIG ASSPEPQIIM
//