ID   A7NNP7_ROSCS            Unreviewed;       127 AA.
AC   A7NNP7;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   05-FEB-2025, entry version 94.
DE   RecName: Full=Large-conductance mechanosensitive channel {ECO:0000256|HAMAP-Rule:MF_00115};
GN   Name=mscL {ECO:0000256|HAMAP-Rule:MF_00115};
GN   OrderedLocusNames=Rcas_3137 {ECO:0000313|EMBL:ABU59191.1};
OS   Roseiflexus castenholzii (strain DSM 13941 / HLO8).
OC   Bacteria; Bacillati; Chloroflexota; Chloroflexia; Chloroflexales;
OC   Roseiflexineae; Roseiflexaceae; Roseiflexus.
OX   NCBI_TaxID=383372 {ECO:0000313|EMBL:ABU59191.1, ECO:0000313|Proteomes:UP000000263};
RN   [1] {ECO:0000313|EMBL:ABU59191.1, ECO:0000313|Proteomes:UP000000263}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13941 / HLO8 {ECO:0000313|Proteomes:UP000000263};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P.;
RT   "Complete sequence of Roseiflexus castenholzii DSM 13941.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Channel that opens in response to stretch forces in the
CC       membrane lipid bilayer. May participate in the regulation of osmotic
CC       pressure changes within the cell. {ECO:0000256|HAMAP-Rule:MF_00115}.
CC   -!- SUBUNIT: Homopentamer. {ECO:0000256|HAMAP-Rule:MF_00115}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|HAMAP-Rule:MF_00115}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|HAMAP-Rule:MF_00115}.
CC   -!- SIMILARITY: Belongs to the MscL family. {ECO:0000256|ARBA:ARBA00007254,
CC       ECO:0000256|HAMAP-Rule:MF_00115}.
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DR   EMBL; CP000804; ABU59191.1; -; Genomic_DNA.
DR   RefSeq; WP_012121615.1; NC_009767.1.
DR   AlphaFoldDB; A7NNP7; -.
DR   STRING; 383372.Rcas_3137; -.
DR   KEGG; rca:Rcas_3137; -.
DR   eggNOG; COG1970; Bacteria.
DR   HOGENOM; CLU_095787_1_0_0; -.
DR   OrthoDB; 9810350at2; -.
DR   Proteomes; UP000000263; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1200.120; Large-conductance mechanosensitive channel, MscL, domain 1; 1.
DR   HAMAP; MF_00115; MscL; 1.
DR   InterPro; IPR019823; Mechanosensitive_channel_CS.
DR   InterPro; IPR001185; MS_channel.
DR   InterPro; IPR037673; MSC/AndL.
DR   InterPro; IPR036019; MscL_channel.
DR   NCBIfam; TIGR00220; mscL; 1.
DR   PANTHER; PTHR30266:SF2; LARGE-CONDUCTANCE MECHANOSENSITIVE CHANNEL; 1.
DR   PANTHER; PTHR30266; MECHANOSENSITIVE CHANNEL MSCL; 1.
DR   Pfam; PF01741; MscL; 1.
DR   PRINTS; PR01264; MECHCHANNEL.
DR   SUPFAM; SSF81330; Gated mechanosensitive channel; 1.
DR   PROSITE; PS01327; MSCL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW   Rule:MF_00115};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|HAMAP-
KW   Rule:MF_00115};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065, ECO:0000256|HAMAP-
KW   Rule:MF_00115};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00115};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000263};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_00115};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_00115};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_00115}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00115"
FT   TRANSMEM        55..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00115"
SQ   SEQUENCE   127 AA;  13710 MW;  7D4606E9D4FCF683 CRC64;
     MFEGFRKFVM RGNVVDLAVG VVIGTAFSAV VNSLVNDVLL AAIATLVGKP DFSGVLVFGA
     VRIGAFLTAV VNFLLIAAAV YFFVVTPVNK LNDLIRKPEP PAPPEPSTQE KLLIEIRDLL
     RQNITRS
//