ID   A7IG32_XANVE            Unreviewed;       508 AA.
AC   A7IG32;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   02-SEP-2026, entry version 74.
DE   SubName: Full=Acetyl-CoA hydrolase {ECO:0000313|EMBL:ABS66975.1};
DE            EC=3.1.2.1 {ECO:0000313|EMBL:ABS66975.1};
GN   OrderedLocusNames=Xaut_1730 {ECO:0000313|EMBL:ABS66975.1};
OS   Xanthobacter versatilis.
OC   Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC   Hyphomicrobiales; Xanthobacteraceae; Xanthobacter.
OX   NCBI_TaxID=78245 {ECO:0000313|EMBL:ABS66975.1, ECO:0000313|Proteomes:UP000002417};
RN   [1] {ECO:0000313|EMBL:ABS66975.1, ECO:0000313|Proteomes:UP000002417}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1158 / Py2 {ECO:0000313|Proteomes:UP000002417};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA   Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Tapia R., Brainard J., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P.;
RT   "Complete sequence of chromosome of Xanthobacter autotrophicus Py2.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC       {ECO:0000256|ARBA:ARBA00009632}.
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DR   EMBL; CP000781; ABS66975.1; -; Genomic_DNA.
DR   RefSeq; WP_012113753.1; NZ_JBAFVA010000008.1.
DR   AlphaFoldDB; A7IG32; -.
DR   STRING; 78245.Xaut_1730; -.
DR   KEGG; xau:Xaut_1730; -.
DR   eggNOG; COG0427; Bacteria.
DR   HOGENOM; CLU_019748_3_0_5; -.
DR   OrthoDB; 9801795at2; -.
DR   PhylomeDB; A7IG32; -.
DR   Proteomes; UP000002417; Chromosome.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IEA:InterPro.
DR   GO; GO:0003986; F:acetyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   FunFam; 3.40.1080.10:FF:000004; Acetyl-CoA hydrolase; 1.
DR   FunFam; 3.30.750.70:FF:000002; Acetyl-CoA hydrolase Ach1; 1.
DR   FunFam; 3.40.1080.20:FF:000001; Acetyl-CoA hydrolase Ach1; 1.
DR   Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR   Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR   Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR   InterPro; IPR026888; AcetylCoA_hyd_C.
DR   InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR   InterPro; IPR046433; ActCoA_hydro.
DR   InterPro; IPR003702; ActCoA_hydro_N.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR017821; Succinate_CoA_transferase.
DR   NCBIfam; TIGR03458; YgfH_subfam; 1.
DR   PANTHER; PTHR43609; ACETYL-COA HYDROLASE; 1.
DR   PANTHER; PTHR43609:SF1; ACETYL-COA HYDROLASE; 1.
DR   Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR   Pfam; PF02550; AcetylCoA_hydro; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:ABS66975.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002417}.
FT   DOMAIN          12..220
FT                   /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02550"
FT   DOMAIN          330..468
FT                   /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13336"
FT   ACT_SITE        293
FT                   /note="5-glutamyl coenzyme A thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-1"
FT   BINDING         383
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         387
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         407
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
SQ   SEQUENCE   508 AA;  54784 MW;  246D97198FBEC28C CRC64;
     MPHARIRLSS LADKIVSAEE AAAHIQDGMI VGMSGFTRAG EAKAVPMALA ARAKEAHAAG
     QPLKITLITG ASLGNDLDKQ MAEAHLLSRR IPFQSDPALR KAINAGEVMF VDQHLSETVE
     HLRTNQLGPV DVAVIEAVGI TAQGGIIPTT SVGNSATFAI LAKKVIVEIN LTQPMELEGL
     HDIYIPTRRP FREPIPVVAP ESRVGLPFIP IPAEKIAAIV ITQKLDSASN VLPPDHETAA
     IASHLMEFLK HEVKIGRLTN RLQPLQAGIG TIANAVMHGF IESPFSDLTM YSEVLQDSTF
     DLFDAGKLNF ASGSSVTLSK AKHDQVMPRI ADYKSRLILR PQEISNHPEI IRRLGLIGIN
     TALEFDIFGN VNSTHVGGTG MMNGIGGSGD FARNAYLSVF VTKSIAKGGA LSSVVPMVSH
     VDHTEHDVDI LVTEQGLADL RELAPRERAR VIIDNCVHPL YRDALDDYFA RGCARGGHTP
     HIIEEALSWH VKARETGSML PGQDLKIA
//