ID   A7IB53_METB6            Unreviewed;       376 AA.
AC   A7IB53;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   10-JUN-2026, entry version 77.
DE   SubName: Full=Dolichyl-phosphate beta-D-mannosyltransferase {ECO:0000313|EMBL:ABS56964.1};
DE            EC=2.4.1.83 {ECO:0000313|EMBL:ABS56964.1};
GN   OrderedLocusNames=Mboo_2450 {ECO:0000313|EMBL:ABS56964.1};
OS   Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8).
OC   Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC   Methanomicrobia; Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX   NCBI_TaxID=456442 {ECO:0000313|EMBL:ABS56964.1, ECO:0000313|Proteomes:UP000002408};
RN   [1] {ECO:0000313|Proteomes:UP000002408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21154 / JCM 14090 / 6A8
RC   {ECO:0000313|Proteomes:UP000002408};
RX   PubMed=25998264; DOI=10.1099/mic.0.000117;
RA   Braeuer S., Cadillo-Quiroz H., Kyrpides N., Woyke T., Goodwin L.,
RA   Detter C., Podell S., Yavitt J.B., Zinder S.H.;
RT   "Genome of Methanoregula boonei 6A8 reveals adaptations to oligotrophic
RT   peatland environments.";
RL   Microbiology 161:1572-1581(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC       {ECO:0000256|ARBA:ARBA00006739}.
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DR   EMBL; CP000780; ABS56964.1; -; Genomic_DNA.
DR   RefSeq; WP_012108028.1; NC_009712.1.
DR   AlphaFoldDB; A7IB53; -.
DR   STRING; 456442.Mboo_2450; -.
DR   GeneID; 5412010; -.
DR   KEGG; mbn:Mboo_2450; -.
DR   eggNOG; arCOG00894; Archaea.
DR   eggNOG; arCOG02228; Archaea.
DR   HOGENOM; CLU_039727_0_0_2; -.
DR   OrthoDB; 46222at2157; -.
DR   Proteomes; UP000002408; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004582; F:dolichyl-phosphate beta-D-mannosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035269; P:protein O-linked glycosylation via mannose; IEA:TreeGrafter.
DR   CDD; cd06442; DPM1_like; 1.
DR   Gene3D; 3.90.550.10; Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A; 1.
DR   InterPro; IPR039528; DPM1-like.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR007267; GtrA_DPMS_TM.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43398; DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1; 1.
DR   PANTHER; PTHR43398:SF1; DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1; 1.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   Pfam; PF04138; GtrA_DPMS_TM; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000313|EMBL:ABS56964.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002408};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABS56964.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        312..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        342..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          5..169
FT                   /note="Glycosyltransferase 2-like"
FT                   /evidence="ECO:0000259|Pfam:PF00535"
FT   DOMAIN          246..364
FT                   /note="GtrA/DPMS transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04138"
SQ   SEQUENCE   376 AA;  42322 MW;  F6D2F8A1DBD6065D CRC64;
     MYDLTVIIPT FKEESNIGTI IKAVDAVFLQ NRINGEILIV DDNSPDRTIE LVREMQKTLP
     YLSLAVRIED PGLSQSVVEG FRRAQSDIFL VIDADLSHPP EHIPLMLAEI RAGNDIVIGS
     RYMEGGGIKK WPLKRRIISL GATFLGRLLF PEIHDPVSGF FAVKRGVVDH APLRPRGYKI
     LLEVLGKGTW HTVKEIPFEF VDRAIGSSKL GWRTIIEYAA QVLDNARFSW NHHGSVVWQE
     WVKLFRFGIV GLTGIIVNEG LLIYLRSYAQ FALPVASIIS IELSILSNFI LNDSWTFKTG
     QHALPHWWQR LLSFQVVSLG GAAINFVILN ALALYVGVDY RVANILGIVV AFAWNFLVNR
     RVTWKKSGQV VPSQEK
//