ID A7AWK9_BABBO Unreviewed; 589 AA. AC A7AWK9; DT 11-SEP-2007, integrated into UniProtKB/TrEMBL. DT 11-SEP-2007, sequence version 1. DT 02-SEP-2026, entry version 84. DE RecName: Full=phosphoenolpyruvate carboxykinase (ATP) {ECO:0000256|ARBA:ARBA00012363}; DE EC=4.1.1.49 {ECO:0000256|ARBA:ARBA00012363}; GN ORFNames=BBOV_I003550 {ECO:0000313|EMBL:EDO05437.1}; OS Babesia bovis. OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida; OC Babesiidae; Babesia. OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO05437.1, ECO:0000313|Proteomes:UP000002173}; RN [1] {ECO:0000313|EMBL:EDO05437.1, ECO:0000313|Proteomes:UP000002173} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO05437.1}; RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148; RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S., RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D., RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H., RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr., RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F., RA Nene V.M.; RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan RT hemoprotozoa."; RL PLoS Pathog. 3:1401-1413(2007). RN [2] {ECO:0000313|Proteomes:UP000002173} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533; RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R., RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.; RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and RT invertebrate hosts."; RL Data Brief 33:106533-106533(2020). RN [3] {ECO:0000313|Proteomes:UP000002173} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=33069745; RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R., RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.; RT "Comparative analysis of gene expression between Babesia bovis blood stages RT and kinetes allowed by improved genome annotation."; RL Int. J. Parasitol. 51:123-136(2021). CC -!- CATALYTIC ACTIVITY: CC Reaction=oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2; CC Xref=Rhea:RHEA:18617, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58702, ChEBI:CHEBI:456216; CC EC=4.1.1.49; Evidence={ECO:0000256|ARBA:ARBA00047371}; CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. CC {ECO:0000256|ARBA:ARBA00004742}. CC -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase (ATP) CC family. {ECO:0000256|ARBA:ARBA00006052}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EDO05437.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAXT01000005; EDO05437.1; -; Genomic_DNA. DR RefSeq; XP_001609005.1; XM_001608955.2. DR AlphaFoldDB; A7AWK9; -. DR FunCoup; A7AWK9; 39. DR STRING; 5865.A7AWK9; -. DR GeneID; 5477221; -. DR KEGG; bbo:BBOV_I003550; -. DR VEuPathDB; PiroplasmaDB:BBOV_I003550; -. DR eggNOG; ENOG502QQI5; Eukaryota. DR InParanoid; A7AWK9; -. DR OMA; MRYAGEM; -. DR UniPathway; UPA00138; -. DR Proteomes; UP000002173; Unassembled WGS sequence. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004612; F:phosphoenolpyruvate carboxykinase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway. DR CDD; cd00484; PEPCK_ATP; 1. DR FunFam; 2.170.8.10:FF:000001; Phosphoenolpyruvate carboxykinase (ATP); 1. DR Gene3D; 3.90.228.20; -; 1. DR Gene3D; 3.40.449.10; Phosphoenolpyruvate Carboxykinase, domain 1; 1. DR Gene3D; 2.170.8.10; Phosphoenolpyruvate Carboxykinase, domain 2; 1. DR HAMAP; MF_00453; PEPCK_ATP; 1. DR InterPro; IPR001272; PEP_carboxykinase_ATP. DR InterPro; IPR013035; PEP_carboxykinase_C. DR InterPro; IPR008210; PEP_carboxykinase_N. DR InterPro; IPR015994; PEPCK_ATP_CS. DR NCBIfam; TIGR00224; pckA; 1. DR NCBIfam; NF006820; PRK09344.1-2; 1. DR NCBIfam; NF006821; PRK09344.1-3; 1. DR PANTHER; PTHR30031:SF0; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); 1. DR PANTHER; PTHR30031; PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP; 1. DR Pfam; PF01293; PEPCK_ATP; 1. DR PIRSF; PIRSF006294; PEP_crbxkin; 1. DR SUPFAM; SSF68923; PEP carboxykinase N-terminal domain; 1. DR SUPFAM; SSF53795; PEP carboxykinase-like; 1. DR PROSITE; PS00532; PEPCK_ATP; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793}; KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432}; KW Kinase {ECO:0000313|EMBL:EDO05437.1}; KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:EDO05437.1}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Pyruvate {ECO:0000313|EMBL:EDO05437.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000002173}; KW Transferase {ECO:0000313|EMBL:EDO05437.1}. FT REGION 1..43 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..19 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 589 AA; 65741 MW; 7E106C09C740FA3F CRC64; MESKGSVNSE SSSSSSSSEK SCHDQSLPKK LKRNLMPTSP TARSMDESAL ISLSQDVYFS KCSQQINEYG IKVASIWRNT SAAILTHHAL LYEPNTVLST SGAVCCKSGE KTGRSPSDKR TVMDSVSKNT VWWGKVNIEI PEIAYSINRE RAIDYINLQQ RIYVTDAYAG WDDEHRIRVR VISTRAYHAL FMKNLLIEPT DEELESFTPD FVLYNAGAFP CNRYTKGVSS STSICLNYKR MEMVILGSEY AGEMKKGIFT LMMYLMPLRG LLPLHSSCNV GEKGDVTLFF GLSGTGKTTL SADPRRRLIG DDEHVWTESG VFNIEGGCYA KCKDLCREKE PEIFNAIKFG SVVENVVYDP ATHEIDFTDC SITENTRCAY PLEYIPNVMI PAKVDHHPSN IIFLTCDAFG VIPPVSKLTI EQAMYHFVSG YTSKMIGTEM GVTKPTATFS ACYAEPFLAM HPMVYAKLLE DKLKAHSTDI WLLNTGWIQG TIDSEKGRRI PLRYTRAMVN AIHDGSLKKA KFKPMDVFGL MVPTAIEGIP AEVLDQRLGW GSAAYDTQLK ELANKFAENF KQYQSEANES ILRGGPVHL //