ID   A6WDR2_KINRD            Unreviewed;       656 AA.
AC   A6WDR2;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   04-NOV-2026, entry version 90.
DE   RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE            EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN   OrderedLocusNames=Krad_3488 {ECO:0000313|EMBL:ABS04951.1};
OS   Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kineosporiales;
OC   Kineosporiaceae; Kineococcus.
OX   NCBI_TaxID=266940 {ECO:0000313|EMBL:ABS04951.1, ECO:0000313|Proteomes:UP000001116};
RN   [1] {ECO:0000313|Proteomes:UP000001116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-149 / DSM 14245 / SRS30216
RC   {ECO:0000313|Proteomes:UP000001116};
RX   PubMed=19057647; DOI=10.1371/journal.pone.0003878;
RA   Bagwell C.E., Bhat S., Hawkins G.M., Smith B.W., Biswas T., Hoover T.R.,
RA   Saunders E., Han C.S., Tsodikov O.V., Shimkets L.J.;
RT   "Survival in nuclear waste, extreme resistance, and potential applications
RT   gleaned from the genome sequence of Kineococcus radiotolerans SRS30216.";
RL   PLoS ONE 3:e3878-e3878(2008).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; CP000750; ABS04951.1; -; Genomic_DNA.
DR   RefSeq; WP_012086789.1; NC_009664.2.
DR   AlphaFoldDB; A6WDR2; -.
DR   STRING; 266940.Krad_3488; -.
DR   KEGG; kra:Krad_3488; -.
DR   eggNOG; COG0365; Bacteria.
DR   HOGENOM; CLU_000022_3_6_11; -.
DR   OMA; AAEKYYP; -.
DR   OrthoDB; 9803968at2; -.
DR   Proteomes; UP000001116; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0003987; F:acetyl-CoA synthetase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0006085; P:acetyl-CoA biosynthetic process; IEA:InterPro.
DR   FunFam; 3.40.50.12780:FF:000001; Acetyl-coenzyme A synthetase; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR045851; AMP-b_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_synth/lig_dom.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   NCBIfam; NF001208; PRK00174.1; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ABS04951.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001116}.
FT   DOMAIN          34..85
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          89..480
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          538..615
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   656 AA;  70893 MW;  3FBC7E27A7D3A4FF CRC64;
     MTSTPPADPG ATAQDLVFPP SAAFTAQANV GADEHERAAA DPEAFWAEQA RRLQWDEPFT
     TVFDGSTLPT AQWFTGGKLN VAVNCVDRHV AAGRGDKVAL HWEGEPGDAR TITYAQLQDE
     VCRLANALEE LGVGHGDRVV LYLPVLPETI VTTMACARIG AVVSLVFGGF SAEALRFRVE
     DTGAKLLVCT DGQFRRGTAV AVKAAADAAV EGLDHVEHVL VLRRTGEQTP DVPWTEGRDV
     WWHDLVDRQP STHVAPSFDS ENPLFIIYTS GTTGKPKGLV HTSGGYLTHT SWSHWAVFDV
     KDDDVYWCQA DLAWVTAHSY EMYGPLSNGV TQVIYEGSPL TPHPGRHFEV IEKYGVTIYY
     TAPTLVRTFM KHGPELPARF DLSSLRLLGS VGEAINPEAW SWLHREVGGG RCPIVDTWWQ
     SETGAAVVAP LPGVTPLKPG SGTVPLPGLS ATVVDDEGNE TAPGEQGVLV ITKPWPGMAR
     TVWRDHARFV KSYWEPYAAQ GYYLAGDAAT KDADGYIWIG GRIDDVLNVS GHRLSSIELE
     SALVSHPRVA EAAVVGAPDD TTGQRIVAFV ILRGAGPEDG VAAELREHVA REIGPVARPR
     DVVVVPDLPK TRSGKIMRRL MADLTAGRGG GDVTSLQDET ALAAVETAWA QYVRSR
//