ID   MTD_META3               Reviewed;         277 AA.
AC   A6UWS1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   04-NOV-2026, entry version 82.
DE   RecName: Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00058};
DE            Short=MTD {ECO:0000255|HAMAP-Rule:MF_00058};
DE            EC=1.5.98.1 {ECO:0000255|HAMAP-Rule:MF_00058};
DE   AltName: Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00058};
GN   Name=mtd {ECO:0000255|HAMAP-Rule:MF_00058};
GN   OrderedLocusNames=Maeo_1367;
OS   Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS   Nankai-3).
OC   Archaea; Methanobacteriati; Methanobacteriota; Methanomada group;
OC   Methanococci; Methanococcales; Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=419665;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA   Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to
CC       methylene-H(4)MPT. {ECO:0000255|HAMAP-Rule:MF_00058}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methylenetetrahydromethanopterin + oxidized coenzyme
CC         F420-(gamma-L-Glu)(n) + 2 H(+) = 5,10-methenyl-5,6,7,8-
CC         tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n);
CC         Xref=Rhea:RHEA:16721, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58337,
CC         ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00058};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-
CC       tetrahydromethanopterin (coenzyme F420 route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00058}.
CC   -!- SIMILARITY: Belongs to the MTD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00058}.
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DR   EMBL; CP000743; ABR56943.1; -; Genomic_DNA.
DR   RefSeq; WP_011974075.1; NC_009635.1.
DR   AlphaFoldDB; A6UWS1; -.
DR   SMR; A6UWS1; -.
DR   STRING; 419665.Maeo_1367; -.
DR   GeneID; 5327444; -.
DR   KEGG; mae:Maeo_1367; -.
DR   eggNOG; arCOG04382; Archaea.
DR   HOGENOM; CLU_1006890_0_0_2; -.
DR   OMA; AAAHEMM; -.
DR   OrthoDB; 49844at2157; -.
DR   UniPathway; UPA00640; UER00695.
DR   Proteomes; UP000001106; Chromosome.
DR   GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.
DR   GO; GO:0030268; F:methylenetetrahydromethanopterin dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniRule.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 6.10.140.120; -; 1.
DR   Gene3D; 3.40.50.10830; F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD); 1.
DR   HAMAP; MF_00058; MTD; 1.
DR   InterPro; IPR002844; MTD.
DR   InterPro; IPR036080; MTD_sf.
DR   NCBIfam; NF002162; PRK00994.1; 1.
DR   Pfam; PF01993; MTD; 1.
DR   PIRSF; PIRSF005627; MTD; 1.
DR   SUPFAM; SSF102324; F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD); 1.
PE   3: Inferred from homology;
KW   Methanogenesis; One-carbon metabolism; Oxidoreductase; Reference proteome.
FT   CHAIN           1..277
FT                   /note="F420-dependent methylenetetrahydromethanopterin
FT                   dehydrogenase"
FT                   /id="PRO_1000007670"
FT   REGION          249..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..277
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   277 AA;  29631 MW;  85C779579521D808 CRC64;
     MVVKIGIIKC GNIGMSPLID LALDERADRT NIDVISIGSG AKMGPNQVVE VTTKMVEDIK
     PDFIIYVGPN PAAPGPAKAR EILSASDIPS VIIGDAPGIK AKDKMAEEGL GYILIKCDPM
     IGARRQFLDP VEMAMFNADV IRVLAGTGAA RVVQNAIDDI VEAIEAGNEI ELPKIVVTDA
     KSVAAAEFSN PYAKAKAMAA FAMAEQVANI DVKGCFMTKE MEKYIPIVAS AHEMIRTAAK
     LVDEARELEK ATDSVSRKPH GADGKRLNKT KLMEKPE
//