ID   A6L217_PHOV8            Unreviewed;       391 AA.
AC   A6L217;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   02-SEP-2026, entry version 79.
DE   RecName: Full=cysteine-S-conjugate beta-lyase {ECO:0000256|ARBA:ARBA00012224};
DE            EC=4.4.1.13 {ECO:0000256|ARBA:ARBA00012224};
GN   OrderedLocusNames=BVU_2066 {ECO:0000313|EMBL:ABR39731.1};
OS   Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS   NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC   Bacteria; Pseudomonadati; Bacteroidota; Bacteroidia; Bacteroidales;
OC   Bacteroidaceae; Phocaeicola.
OX   NCBI_TaxID=435590 {ECO:0000313|EMBL:ABR39731.1, ECO:0000313|Proteomes:UP000002861};
RN   [1] {ECO:0000313|EMBL:ABR39731.1, ECO:0000313|Proteomes:UP000002861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 /
RC   NCTC 11154 {ECO:0000313|Proteomes:UP000002861};
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent
CC       aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily.
CC       {ECO:0000256|ARBA:ARBA00037974}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000139; ABR39731.1; -; Genomic_DNA.
DR   RefSeq; WP_005842558.1; NC_009614.1.
DR   AlphaFoldDB; A6L217; -.
DR   STRING; 435590.BVU_2066; -.
DR   PaxDb; 435590-BVU_2066; -.
DR   GeneID; 5303031; -.
DR   KEGG; bvu:BVU_2066; -.
DR   eggNOG; COG1168; Bacteria.
DR   HOGENOM; CLU_017584_15_0_10; -.
DR   BioCyc; BVUL435590:G1G59-2159-MONOMER; -.
DR   Proteomes; UP000002861; Chromosome.
DR   GO; GO:0047804; F:cysteine-S-conjugate beta-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR004839; Aminotransferase_I/II_large.
DR   InterPro; IPR027619; C-S_lyase_PatB-like.
DR   InterPro; IPR051798; Class-II_PLP-Dep_Aminotrans.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR04350; C_S_lyase_PatB; 1.
DR   PANTHER; PTHR43525; PROTEIN MALY; 1.
DR   PANTHER; PTHR43525:SF1; PROTEIN MALY; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:ABR39731.1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002861};
KW   Transferase {ECO:0000313|EMBL:ABR39731.1}.
FT   DOMAIN          30..370
FT                   /note="Aminotransferase class I/classII large"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   391 AA;  44768 MW;  473B89BA8F6ADC4E CRC64;
     MKYNFDKVID RSGTSAEKVE GLKHIWGRTD LIPLWVADMD FATAPFVTDA IRKRCENEVL
     GYTGKPDSYY NAIINWVKQR YDLIVTKEVI NFVPGIVPGI GMAMNCFTQK GDKVMIQPPV
     YHPFAWVTTR NERTLVINPL RWENGMYRMD LDAFREQIKG CKLFILCNPH NPGGVVWTEA
     ELRAIADICY DEKVLVFSDE IHADLTLPPH THRPFATVSE KARMNSVTFM SPSKAFNMPG
     LSASHALIFN EDLRKRFRIY MDAGELDMGH VFAFLSVEAA YSHGTEWLDQ CLAYIQGNID
     FVDEFLKKHA PKIKAIRPEA SYLVWLDCRE LELSQKDLNE FFVDKAHLAL NDGEMFGKEG
     IGFMRLNVAS PRCIIEKAMK QLADAYQLYI K
//