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<entry dataset="TrEMBL" created="2007-07-10" modified="2026-09-02" version="88" xmlns="http://uniprot.org/uniprot">
  <accession>A5U5T9</accession>
  <name>A5U5T9_MYCTA</name>
  <protein>
    <recommendedName>
      <fullName evidence="7">4-aminobutyrate aminotransferase</fullName>
      <ecNumber evidence="6">2.6.1.19</ecNumber>
      <ecNumber evidence="5">2.6.1.22</ecNumber>
    </recommendedName>
    <alternativeName>
      <fullName evidence="13">(S)-3-amino-2-methylpropionate transaminase</fullName>
    </alternativeName>
    <alternativeName>
      <fullName evidence="14">GABA aminotransferase</fullName>
    </alternativeName>
    <alternativeName>
      <fullName evidence="12">Gamma-amino-N-butyrate transaminase</fullName>
    </alternativeName>
    <alternativeName>
      <fullName evidence="16">Glutamate:succinic semialdehyde transaminase</fullName>
    </alternativeName>
    <alternativeName>
      <fullName evidence="11">L-AIBAT</fullName>
    </alternativeName>
  </protein>
  <gene>
    <name evidence="18" type="primary">gabT</name>
    <name evidence="18" type="ordered locus">MRA_2618</name>
  </gene>
  <organism evidence="18 19">
    <name type="scientific">Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)</name>
    <dbReference type="NCBI Taxonomy" id="419947"/>
    <lineage>
      <taxon>Bacteria</taxon>
      <taxon>Bacillati</taxon>
      <taxon>Actinomycetota</taxon>
      <taxon>Actinomycetes</taxon>
      <taxon>Mycobacteriales</taxon>
      <taxon>Mycobacteriaceae</taxon>
      <taxon>Mycobacterium</taxon>
      <taxon>Mycobacterium tuberculosis complex</taxon>
    </lineage>
  </organism>
  <reference evidence="18 19" key="1">
    <citation type="journal article" date="2008" name="PLoS ONE" volume="3" first="E2375" last="E2375">
      <title>Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.</title>
      <authorList>
        <person name="Zheng H."/>
        <person name="Lu L."/>
        <person name="Wang B."/>
        <person name="Pu S."/>
        <person name="Zhang X."/>
        <person name="Zhu G."/>
        <person name="Shi W."/>
        <person name="Zhang L."/>
        <person name="Wang H."/>
        <person name="Wang S."/>
        <person name="Zhao G."/>
        <person name="Zhang Y."/>
      </authorList>
      <dbReference type="PubMed" id="18584054"/>
      <dbReference type="DOI" id="10.1371/journal.pone.0002375"/>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    <source>
      <strain evidence="19">ATCC 25177 / H37Ra</strain>
    </source>
  </reference>
  <comment type="catalytic activity">
    <reaction evidence="1">
      <text>(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate</text>
      <dbReference type="Rhea" id="RHEA:13993"/>
      <dbReference type="ChEBI" id="CHEBI:16810"/>
      <dbReference type="ChEBI" id="CHEBI:29985"/>
      <dbReference type="ChEBI" id="CHEBI:57700"/>
      <dbReference type="ChEBI" id="CHEBI:58655"/>
      <dbReference type="EC" id="2.6.1.22"/>
    </reaction>
  </comment>
  <comment type="catalytic activity">
    <reaction evidence="15">
      <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
      <dbReference type="Rhea" id="RHEA:23352"/>
      <dbReference type="ChEBI" id="CHEBI:16810"/>
      <dbReference type="ChEBI" id="CHEBI:29985"/>
      <dbReference type="ChEBI" id="CHEBI:57706"/>
      <dbReference type="ChEBI" id="CHEBI:59888"/>
      <dbReference type="EC" id="2.6.1.19"/>
    </reaction>
  </comment>
  <comment type="cofactor">
    <cofactor evidence="2">
      <name>pyridoxal 5'-phosphate</name>
      <dbReference type="ChEBI" id="CHEBI:597326"/>
    </cofactor>
  </comment>
  <comment type="pathway">
    <text evidence="3">Amino-acid degradation; 4-aminobutanoate degradation.</text>
  </comment>
  <comment type="similarity">
    <text evidence="4 17">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
  </comment>
  <dbReference type="EC" id="2.6.1.19" evidence="6"/>
  <dbReference type="EC" id="2.6.1.22" evidence="5"/>
  <dbReference type="EMBL" id="CP000611">
    <property type="protein sequence ID" value="ABQ74389.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="RefSeq" id="WP_003413395.1">
    <property type="nucleotide sequence ID" value="NC_009525.1"/>
  </dbReference>
  <dbReference type="AlphaFoldDB" id="A5U5T9"/>
  <dbReference type="SMR" id="A5U5T9"/>
  <dbReference type="GeneID" id="45426591"/>
  <dbReference type="KEGG" id="mra:MRA_2618"/>
  <dbReference type="eggNOG" id="COG0160">
    <property type="taxonomic scope" value="Bacteria"/>
  </dbReference>
  <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
  <dbReference type="Proteomes" id="UP000001988">
    <property type="component" value="Chromosome"/>
  </dbReference>
  <dbReference type="GO" id="GO:0047298">
    <property type="term" value="F:(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-EC"/>
  </dbReference>
  <dbReference type="GO" id="GO:0034386">
    <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-EC"/>
  </dbReference>
  <dbReference type="GO" id="GO:0047589">
    <property type="term" value="F:5-aminovalerate:2-oxoglutarate transaminase activity"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-ARBA"/>
  </dbReference>
  <dbReference type="GO" id="GO:0042802">
    <property type="term" value="F:identical protein binding"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="TreeGrafter"/>
  </dbReference>
  <dbReference type="GO" id="GO:0030170">
    <property type="term" value="F:pyridoxal phosphate binding"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="InterPro"/>
  </dbReference>
  <dbReference type="CDD" id="cd00610">
    <property type="entry name" value="OAT_like"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="FunFam" id="3.40.640.10:FF:000013">
    <property type="entry name" value="4-aminobutyrate aminotransferase"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="FunFam" id="3.90.1150.10:FF:000022">
    <property type="entry name" value="4-aminobutyrate aminotransferase"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.90.1150.10">
    <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.40.640.10">
    <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR004632">
    <property type="entry name" value="4NH2But_aminotransferase_bac"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR005814">
    <property type="entry name" value="Aminotrans_3"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR049704">
    <property type="entry name" value="Aminotrans_3_PPA_site"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR050103">
    <property type="entry name" value="Class-III_PLP-dep_AT"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR015424">
    <property type="entry name" value="PyrdxlP-dep_Trfase"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR015421">
    <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR015422">
    <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
  </dbReference>
  <dbReference type="NCBIfam" id="TIGR00700">
    <property type="entry name" value="GABAtrnsam"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="NCBIfam" id="NF004714">
    <property type="entry name" value="PRK06058.1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR11986">
    <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF00202">
    <property type="entry name" value="Aminotran_3"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PIRSF" id="PIRSF000521">
    <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF53383">
    <property type="entry name" value="PLP-dependent transferases"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PROSITE" id="PS00600">
    <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
    <property type="match status" value="1"/>
  </dbReference>
  <proteinExistence type="inferred from homology"/>
  <keyword evidence="8 18" id="KW-0032">Aminotransferase</keyword>
  <keyword evidence="10 17" id="KW-0663">Pyridoxal phosphate</keyword>
  <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
  <keyword evidence="9" id="KW-0808">Transferase</keyword>
  <evidence type="ECO:0000256" key="1">
    <source>
      <dbReference type="ARBA" id="ARBA00001750"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="2">
    <source>
      <dbReference type="ARBA" id="ARBA00001933"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="3">
    <source>
      <dbReference type="ARBA" id="ARBA00005176"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="4">
    <source>
      <dbReference type="ARBA" id="ARBA00008954"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="5">
    <source>
      <dbReference type="ARBA" id="ARBA00012876"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="6">
    <source>
      <dbReference type="ARBA" id="ARBA00012912"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="7">
    <source>
      <dbReference type="ARBA" id="ARBA00018543"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="8">
    <source>
      <dbReference type="ARBA" id="ARBA00022576"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="9">
    <source>
      <dbReference type="ARBA" id="ARBA00022679"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="10">
    <source>
      <dbReference type="ARBA" id="ARBA00022898"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="11">
    <source>
      <dbReference type="ARBA" id="ARBA00029760"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="12">
    <source>
      <dbReference type="ARBA" id="ARBA00030204"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="13">
    <source>
      <dbReference type="ARBA" id="ARBA00030857"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="14">
    <source>
      <dbReference type="ARBA" id="ARBA00031787"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="15">
    <source>
      <dbReference type="ARBA" id="ARBA00048021"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="16">
    <source>
      <dbReference type="ARBA" id="ARBA00050054"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="17">
    <source>
      <dbReference type="RuleBase" id="RU003560"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="18">
    <source>
      <dbReference type="EMBL" id="ABQ74389.1"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="19">
    <source>
      <dbReference type="Proteomes" id="UP000001988"/>
    </source>
  </evidence>
  <sequence length="449" mass="46813" checksum="9EB88A968B3D8719" modified="2007-07-10" version="1">MASLQQSRRLVTEIPGPASQALTHRRAAAVSSGVGVTLPVFVARAGGGIVEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAVRTQVAEFTHTCFMVTPYEGYVAVAEQLNRITPGSGPKRSVLFNSGAEAVENAVKIARSYTGKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLDKQLATNGELAAARAIGVIDKQVGANNLAALVIEPIQGEGGFIVPAEGFLPALLDWCRKNHVVFIADEVQTGFARTGAMFACEHEGPDGLEPDLICTAKGIADGLPLSAVTGRAEIMNAPHVGGLGGTFGGNPVACAAALATIATIESDGLIERARQIERLVTDRLTTLQAVDDRIGDVRGRGAMIAVELVKSGTTEPDAGLTERLATAAHAAGVIILTCGMFGNIIRLLPPLTIGDELLSEGLDIVCAILADL</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>