ID   AN34B_HUMAN             Reviewed;         514 AA.
AC   A5PLL1; B2RPH1; Q68D79;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 3.
DT   10-JUN-2026, entry version 124.
DE   RecName: Full=Ankyrin repeat domain-containing protein 34B;
GN   Name=ANKRD34B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-156.
RC   TISSUE=Rectum tumor;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ANKRD34 family. {ECO:0000305}.
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DR   EMBL; CR749535; CAH18341.1; -; mRNA.
DR   EMBL; AC008434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC137441; AAI37442.1; -; mRNA.
DR   EMBL; BC137442; AAI37443.1; -; mRNA.
DR   EMBL; BC142957; AAI42958.1; -; mRNA.
DR   CCDS; CCDS34194.1; -.
DR   RefSeq; NP_001004441.2; NM_001004441.3.
DR   RefSeq; XP_006714662.1; XM_006714599.4.
DR   RefSeq; XP_011541668.1; XM_011543366.3.
DR   RefSeq; XP_011541671.1; XM_011543369.2.
DR   RefSeq; XP_047273097.1; XM_047417141.1.
DR   RefSeq; XP_047273098.1; XM_047417142.1.
DR   RefSeq; XP_047273099.1; XM_047417143.1.
DR   AlphaFoldDB; A5PLL1; -.
DR   SMR; A5PLL1; -.
DR   BioGRID; 131001; 4.
DR   FunCoup; A5PLL1; 6.
DR   IntAct; A5PLL1; 2.
DR   MINT; A5PLL1; -.
DR   STRING; 9606.ENSP00000339802; -.
DR   iPTMnet; A5PLL1; -.
DR   PhosphoSitePlus; A5PLL1; -.
DR   BioMuta; ANKRD34B; -.
DR   MassIVE; A5PLL1; -.
DR   PaxDb; 9606-ENSP00000339802; -.
DR   PeptideAtlas; A5PLL1; -.
DR   Antibodypedia; 49135; 80 antibodies from 16 providers.
DR   DNASU; 340120; -.
DR   Ensembl; ENST00000338682.8; ENSP00000339802.3; ENSG00000189127.9.
DR   Ensembl; ENST00000852599.1; ENSP00000522658.1; ENSG00000189127.9.
DR   Ensembl; ENST00000852600.1; ENSP00000522659.1; ENSG00000189127.9.
DR   Ensembl; ENST00000852601.1; ENSP00000522660.1; ENSG00000189127.9.
DR   Ensembl; ENST00000852602.1; ENSP00000522661.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914945.1; ENSP00000585004.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914946.1; ENSP00000585005.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914947.1; ENSP00000585006.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914948.1; ENSP00000585007.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914949.1; ENSP00000585008.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914950.1; ENSP00000585009.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914951.1; ENSP00000585010.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914952.1; ENSP00000585011.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914953.1; ENSP00000585012.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914954.1; ENSP00000585013.1; ENSG00000189127.9.
DR   Ensembl; ENST00000914955.1; ENSP00000585014.1; ENSG00000189127.9.
DR   Ensembl; ENST00000955760.1; ENSP00000625819.1; ENSG00000189127.9.
DR   Ensembl; ENST00000955761.1; ENSP00000625820.1; ENSG00000189127.9.
DR   GeneID; 340120; -.
DR   KEGG; hsa:340120; -.
DR   MANE-Select; ENST00000338682.8; ENSP00000339802.3; NM_001004441.3; NP_001004441.2.
DR   UCSC; uc003kgw.4; human.
DR   AGR; HGNC:33736; -.
DR   ClinPGx; PA162376576; -.
DR   CTD; 340120; -.
DR   DisGeNET; 340120; -.
DR   GeneCards; ANKRD34B; -.
DR   HGNC; HGNC:33736; ANKRD34B.
DR   HPA; ENSG00000189127; Tissue enriched (brain).
DR   MIM; 618581; gene.
DR   OpenTargets; ENSG00000189127; -.
DR   VEuPathDB; HostDB:ENSG00000189127; -.
DR   eggNOG; ENOG502QRZ2; Eukaryota.
DR   GeneTree; ENSGT00390000012355; -.
DR   HOGENOM; CLU_042805_0_0_1; -.
DR   InParanoid; A5PLL1; -.
DR   OMA; AFPLDHN; -.
DR   OrthoDB; 539213at2759; -.
DR   PAN-GO; A5PLL1; 1 GO annotation based on evolutionary models.
DR   PhylomeDB; A5PLL1; -.
DR   PathwayCommons; A5PLL1; -.
DR   Agora; ENSG00000189127; -.
DR   BioGRID-ORCS; 340120; 21 hits in 1145 CRISPR screens.
DR   GenomeRNAi; 340120; -.
DR   Pharos; A5PLL1; Tbio.
DR   PRO; PR:A5PLL1; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; A5PLL1; protein.
DR   Bgee; ENSG00000189127; Expressed in nucleus accumbens and 47 other cell types or tissues.
DR   ExpressionAtlas; A5PLL1; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071546; C:pi-body; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR042637; AN34A/B/C.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24156; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24156:SF1; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34B; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF13637; Ank_4; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   1: Evidence at protein level;
KW   ANK repeat; Cytoplasm; Nucleus; Phosphoprotein; Proteomics identification;
KW   Reference proteome; Repeat.
FT   CHAIN           1..514
FT                   /note="Ankyrin repeat domain-containing protein 34B"
FT                   /id="PRO_0000319102"
FT   REPEAT          9..38
FT                   /note="ANK 1"
FT   REPEAT          42..79
FT                   /note="ANK 2"
FT   REPEAT          83..113
FT                   /note="ANK 3"
FT   REPEAT          117..146
FT                   /note="ANK 4"
FT   REGION          220..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         263
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UUF8"
FT   MOD_RES         272
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UUF8"
FT   MOD_RES         296
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UUF8"
FT   VARIANT         156
FT                   /note="L -> S (in dbSNP:rs32857)"
FT                   /evidence="ECO:0000269|PubMed:17974005"
FT                   /id="VAR_038952"
FT   CONFLICT        429
FT                   /note="R -> G (in Ref. 1; CAH18341)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   514 AA;  56414 MW;  65B1CC8F92E0730E CRC64;
     MDEGMEISSE GNSLIKAVHQ SRLRLTRLLL EGGAYINESN DRGETPLMIA CKTKHVDHQS
     VSKAKMVKYL LENNADPNIQ DKSGKTALMH ACLEKAGPEV VSLLLKSGAD LSLQDHSSYS
     ALVYAINSED TETLKVLLSA CKAKGKEVII ITTAKLPCGK HTTKQYLNMP PVDIDGCHSP
     ATCTTPSEID IKTASSPLSH SSETELTLFG FKDLELAGSN DDTWDPGSPV RKPALAPKGP
     KLPHAPPWVK SPPLLMHQNR VASLQEELQD ITPEEELSYK TNGLALSKRF ITRHQSIDVK
     DTAHLLRAFD QASSRKMSYD EINCQSYLSE GNQQCIEVPV DQDPDSNQTI FASTLRSIVQ
     KRNLGANHYS SDSQLSAGLT PPTSEDGKAL IGKKKILSPS PSQLSESKEL LENIPPGPLS
     RRNHAVLERR GSGAFPLDHS VTQTRQGFLP PLNVNSHPPI SDINVNNKIC SLLSCGQKVL
     MPTVPIFPKE FKSKKMLLRR QSLQTEQIKQ LVNF
//