ID   S5A1_BOVIN              Reviewed;         257 AA.
AC   A5PJS2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   26-FEB-2008, entry version 7.
DE   3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.99.5) (Steroid 5-
DE   alpha-reductase 1) (SR type 1).
GN   Name=SRD5A1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts testosterone into 5-alpha-dihydrotestosterone
CC       and progesterone or corticosterone into their corresponding 5-
CC       alpha-3-oxosteroids. It plays a central role in sexual
CC       differentiation and androgen physiology (By similarity).
CC   -!- CATALYTIC ACTIVITY: A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-
CC       Delta(4)-steroid + reduced acceptor.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
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DR   EMBL; BC142219; AAI42220.1; -; mRNA.
DR   RefSeq; NP_001092607.1; -.
DR   UniGene; Bt.27694; -.
DR   GeneID; 614612; -.
DR   InterPro; IPR001104; 3-oxo-5-alpha-steroid_4-DH_C.
DR   Pfam; PF02544; Steroid_dh; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   2: Evidence at transcript level;
KW   Differentiation; Endoplasmic reticulum; Membrane; Microsome;
KW   Oxidoreductase; Sexual differentiation; Transmembrane.
FT   CHAIN         1    257       3-oxo-5-alpha-steroid 4-dehydrogenase 1.
FT                                /FTId=PRO_0000317710.
FT   TRANSMEM      7     27       Potential.
FT   TRANSMEM     50     70       Potential.
FT   TRANSMEM     84    104       Potential.
FT   TRANSMEM    109    129       Potential.
FT   TRANSMEM    149    169       Potential.
FT   TRANSMEM    208    228       Potential.
SQ   SEQUENCE   257 AA;  29186 MW;  2A49937DFB45FFB0 CRC64;
     MELAERFLLD ALAYLECALG VVCYVLLKLV GSPYGRYASS GSAFGLPARA AWTVQELPSL
     ALPLLACAGA GAPAERLNRW PNCILLAMFL VHYAQRSLVF PFLIRGGKPM PLYAFLLAFI
     FCTYNGYLQS RYLSQYAVYA DDWLSDPRFL TGSALWLIGM LINIHSDHVL RNLRKPGETG
     YKIPRGGLFE YISAANYFGE VVEWCGYALA SWSIQGWAFA VFTFCVLFTR AQQHHKWYHE
     KFEDYPKFRK IMIPFLV
//