ID   A5FML4_FLAJ1            Unreviewed;       284 AA.
AC   A5FML4;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   04-NOV-2026, entry version 83.
DE   SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:ABQ03550.1};
GN   OrderedLocusNames=Fjoh_0515 {ECO:0000313|EMBL:ABQ03550.1};
OS   Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / BCRC
OS   14874 / CCUG 350202 / NBRC 14942 / NCIMB 11054 / UW101) (Cytophaga
OS   johnsonae).
OC   Bacteria; Pseudomonadati; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=376686 {ECO:0000313|EMBL:ABQ03550.1, ECO:0000313|Proteomes:UP000006694};
RN   [1] {ECO:0000313|EMBL:ABQ03550.1, ECO:0000313|Proteomes:UP000006694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17061 / DSM 2064 / JCM 8514 / BCRC 14874 / CCUG 350202 /
RC   NBRC 14942 / NCIMB 11054 / UW101 {ECO:0000313|Proteomes:UP000006694};
RX   PubMed=19717629; DOI=10.1128/AEM.01495-09;
RA   McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G.,
RA   Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R.,
RA   Cheng Y.Q., Stein J.L.;
RT   "Novel features of the polysaccharide-digesting gliding bacterium
RT   Flavobacterium johnsoniae as revealed by genome sequence analysis.";
RL   Appl. Environ. Microbiol. 75:6864-6875(2009).
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DR   EMBL; CP000685; ABQ03550.1; -; Genomic_DNA.
DR   RefSeq; WP_012022606.1; NC_009441.1.
DR   AlphaFoldDB; A5FML4; -.
DR   STRING; 376686.Fjoh_0515; -.
DR   GeneID; 31763387; -.
DR   KEGG; fjo:Fjoh_0515; -.
DR   eggNOG; COG0287; Bacteria.
DR   HOGENOM; CLU_055968_2_0_10; -.
DR   OMA; AACEPLM; -.
DR   OrthoDB; 9802008at2; -.
DR   Proteomes; UP000006694; Chromosome.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:UniProtKB-UniRule.
DR   FunFam; 3.40.50.720:FF:000208; Prephenate dehydrogenase; 1.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR050812; Preph/Arog_dehydrog.
DR   InterPro; IPR003099; Prephen_DH.
DR   NCBIfam; NF006307; PRK08507.1; 1.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00522};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00522};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|PROSITE-
KW   ProRule:PRU00522}; Reference proteome {ECO:0000313|Proteomes:UP000006694};
KW   Tyrosine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00522}.
FT   DOMAIN          1..284
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   284 AA;  31595 MW;  C298178E4E9F83FC CRC64;
     MKVYVIGIGL IGGSMVLDIK DQHPDSTILG IDNNEKHLQE AIDLGVVDQA GSFEDLAEAD
     FVIVSVPVDV ALTVLPKVLD LVGDKTIVFE VGSTKKPICE AVASHPKRRN FIATHPIAGT
     EFSGPSAAIR GLFKGKTNII CEVEKTTFKL QEKALKLFSE IGMRIRYMDP VSHDKHIAYV
     SHLSHISSFM LGKTVMNKEK DEQDIFDMAG SGFESTVRLA KSSPAMWTPI FKQNKEHVLE
     TLEAYISNLS RFRDLLKEED YNAIFEEMES TNKIKEILNG LIKK
//