ID   A5FGA8_FLAJ1            Unreviewed;       216 AA.
AC   A5FGA8;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   02-SEP-2026, entry version 101.
DE   SubName: Full=DNA-(Apurinic or apyrimidinic site) lyase / endonuclease III {ECO:0000313|EMBL:ABQ05762.1};
DE            EC=3.2.2.- {ECO:0000313|EMBL:ABQ05762.1};
DE            EC=4.2.99.18 {ECO:0000313|EMBL:ABQ05762.1};
GN   OrderedLocusNames=Fjoh_2740 {ECO:0000313|EMBL:ABQ05762.1};
OS   Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / BCRC
OS   14874 / CCUG 350202 / NBRC 14942 / NCIMB 11054 / UW101) (Cytophaga
OS   johnsonae).
OC   Bacteria; Pseudomonadati; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=376686 {ECO:0000313|EMBL:ABQ05762.1, ECO:0000313|Proteomes:UP000006694};
RN   [1] {ECO:0000313|EMBL:ABQ05762.1, ECO:0000313|Proteomes:UP000006694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17061 / DSM 2064 / JCM 8514 / BCRC 14874 / CCUG 350202 /
RC   NBRC 14942 / NCIMB 11054 / UW101 {ECO:0000313|Proteomes:UP000006694};
RX   PubMed=19717629; DOI=10.1128/AEM.01495-09;
RA   McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G.,
RA   Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R.,
RA   Cheng Y.Q., Stein J.L.;
RT   "Novel features of the polysaccharide-digesting gliding bacterium
RT   Flavobacterium johnsoniae as revealed by genome sequence analysis.";
RL   Appl. Environ. Microbiol. 75:6864-6875(2009).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the Nth/MutY family.
CC       {ECO:0000256|ARBA:ARBA00008343}.
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DR   EMBL; CP000685; ABQ05762.1; -; Genomic_DNA.
DR   RefSeq; WP_012024801.1; NC_009441.1.
DR   AlphaFoldDB; A5FGA8; -.
DR   STRING; 376686.Fjoh_2740; -.
DR   GeneID; 31765655; -.
DR   KEGG; fjo:Fjoh_2740; -.
DR   eggNOG; COG0177; Bacteria.
DR   HOGENOM; CLU_012862_3_3_10; -.
DR   OrthoDB; 9800977at2; -.
DR   Proteomes; UP000006694; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0019104; F:DNA N-glycosylase activity; IEA:TreeGrafter.
DR   GO; GO:0006285; P:base-excision repair, AP site formation; IEA:TreeGrafter.
DR   CDD; cd00056; ENDO3c; 1.
DR   FunFam; 1.10.340.30:FF:000001; Endonuclease III; 1.
DR   Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR   Gene3D; 1.10.340.30; Hypothetical protein, domain 2; 1.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR003651; Endonuclease3_FeS-loop_motif.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR023170; HhH_base_excis_C.
DR   PANTHER; PTHR10359; A/G-SPECIFIC ADENINE GLYCOSYLASE/ENDONUCLEASE III; 1.
DR   PANTHER; PTHR10359:SF18; ENDONUCLEASE III; 1.
DR   Pfam; PF00730; HhH-GPD; 1.
DR   PIRSF; PIRSF001435; Nth; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SMART; SM00525; FES; 1.
DR   SUPFAM; SSF48150; DNA-glycosylase; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Endonuclease {ECO:0000313|EMBL:ABQ05762.1};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000313|EMBL:ABQ05762.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ABQ05762.1};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Lyase {ECO:0000313|EMBL:ABQ05762.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000313|EMBL:ABQ05762.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006694}.
FT   DOMAIN          42..189
FT                   /note="HhH-GPD"
FT                   /evidence="ECO:0000259|SMART:SM00478"
SQ   SEQUENCE   216 AA;  24516 MW;  1AF5E613A499A00D CRC64;
     MDLFGETENW ETKLKPILKK YKHKKHPLDY QNTYQLLVMV VLSAQDSDAN INKIAPALFE
     KYPTLKSLSK ADIDTFISYI SKVRNYPTKA QWLLEIAHTI QNDNDIPLTM SGLTALKGIG
     RKSANVILRE TEQPAEGIIA DLHVIRVAPR IGIIKESKDG NKVEKDLMQA LPKSIWSEIG
     MAISFLGREI CRPKPKCEEC LLTEICLYYN TVVLKN
//