ID   A5DF66_PICGU            Unreviewed;      1349 AA.
AC   A5DF66;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 2.
DT   02-SEP-2026, entry version 112.
DE   RecName: Full=Cell division control protein 25 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PGUG_01917 {ECO:0000313|EMBL:EDK37819.2};
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes;
OC   Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK37819.2, ECO:0000313|Proteomes:UP000001997};
RN   [1] {ECO:0000313|EMBL:EDK37819.2, ECO:0000313|Proteomes:UP000001997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC   Y-324 {ECO:0000313|Proteomes:UP000001997};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
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DR   EMBL; CH408156; EDK37819.2; -; Genomic_DNA.
DR   FunCoup; A5DF66; 258.
DR   STRING; 294746.A5DF66; -.
DR   KEGG; pgu:PGUG_01917; -.
DR   VEuPathDB; FungiDB:PGUG_01917; -.
DR   eggNOG; KOG3417; Eukaryota.
DR   HOGENOM; CLU_002171_1_0_1; -.
DR   InParanoid; A5DF66; -.
DR   OMA; SEHEYSL; -.
DR   OrthoDB; 546434at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0030447; P:filamentous growth; IEA:UniProtKB-ARBA.
DR   GO; GO:0007265; P:Ras protein signal transduction; IEA:TreeGrafter.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   CDD; cd11883; SH3_Sdc25; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23113:SF368; CELL DIVISION CONTROL PROTEIN 25; 1.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00022618};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001997};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          22..86
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          922..1056
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          1087..1324
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          128..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          707..732
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1323..1349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        713..732
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1326..1349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1349 AA;  153517 MW;  2735AB879A890C23 CRC64;
     MAYDEVPPDE VQPQETKVQH LKQLDTVIAL YDFPGTQPSH LPLRLGDSVN VLSKSDTGWW
     DGVIVGNNAD LQRGWFPHNY VRSVNYVQPV LNKLQSNKEI DSITAANTAA NVLIPSFTSL
     LQKNLLGDSE KNTPNNSTRK NSVVSFASSE TSLHSDGKQE RRPSKVHQDD EPLIAEDDPN
     ISLQTFQEPE TEHKGSISTQ SDSIHAYGGS VSMDQEPSIP PINVVSVEEA ESMAEKYCSE
     HHENVVWHPK STTGGDLIFY SHQLDIYCEI MPLTQYNNDN LNFETFSVPP PEVLENASTV
     VLHSTSSSSN NNTSNTNQLL NADYGDASGH KFHRNASQES LKRDSATPSM ASSQSTTHYH
     HFKQPFFAMS DLFYKHPTDL TQWSELRAQI HYILELCLKA LKDYSKQLFN AHFSMLNKLV
     SLLASAARLQ QNDFLSTKYE LSLKRKLRRI VSSYAQIYIN GALHLNVMHH SPHISDSQLF
     SNDINALNRS DANDSCKSSL STIGNNEEGT FPLRNPSVST ITGKTYIQQI VLEVETLRYN
     LDNFVKIFMK ITKDKRVKKS DYDGSDVSDD DGEERYDILP QLYPRFLTDE FNGGNWCNPF
     FATSNPVLNA SGNDLKNRHH SKVLIDRDAH EKVVTQKTEA EKIANSLLEV LDPANQHMYY
     NKALVKERNT EILRSAYKYL FHAGLIMDVL ESFDFTIFCL IRKWDTSSSP GEQEERSDKG
     LKDAPSEESL KDGVGEYERS GLTFDYPVVL DFFQFKQQFH DHVSKVVMTT QALTLEDPDV
     FRAVKEDDDL LYDRDVIKMP TERASRMLAR LMTEKIEKEK GESMSLNPDT TMTKTLHGGL
     KLLDSMSDIV QHLIEERETI LNYATRVMHD DVNMQLLVIE RNNTSLSEKA EEGHSFYGSK
     KQTTNVPWYL EGDEEFDLLL DLKGNIKGGT KEALVAHLTH HDQTDSSFTS SFLFSFSTVT
     TLGELLTLMI NRFNIEAPEG LSFEEYNTWI SQKQAPIRLK VISVMRLLLE KYWVDSYYQE
     QILERWLAFA QSPAVQSLSG GKILSADIQR VLDGEKICFE REPSVVSGRP PAPLTRGSKK
     FKLLDIDYVE LARQLTIREF KLYSKITKHA CIAKVWGRKS GLSESTESIT HFIKASNQLT
     NFVAYMILRK PDVKKRVQVI RYFVQVAEKC RQYNNFSSMT AIISALYSSS VHRLKKTWRY
     VSPETAMHLQ SMNRLMNSSR NFNEYRDVLK FIGSEPCVPF FGVYLSDLTF VYHGNPDYLL
     NRTRMINFAK RSKTTEIVSG IDRFKTTAYN LQEVSEIQAY LDSWFDKCPS IDEQYQLSLN
     LEPRESSQGG SSGPRNQKSS LGNFVFNKS
//