ID   A5CRT2_CLAM3            Unreviewed;       256 AA.
AC   A5CRT2;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   08-OCT-2025, entry version 84.
DE   RecName: Full=6-phosphogluconolactonase {ECO:0000256|ARBA:ARBA00020337, ECO:0000256|RuleBase:RU365095};
DE            Short=6PGL {ECO:0000256|RuleBase:RU365095};
DE            EC=3.1.1.31 {ECO:0000256|ARBA:ARBA00013198, ECO:0000256|RuleBase:RU365095};
GN   Name=pglA {ECO:0000313|EMBL:CAN01795.1};
GN   Synonyms=pgl {ECO:0000256|RuleBase:RU365095};
GN   OrderedLocusNames=CMM_1739 {ECO:0000313|EMBL:CAN01795.1};
OS   Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
OC   Microbacteriaceae; Clavibacter.
OX   NCBI_TaxID=443906 {ECO:0000313|EMBL:CAN01795.1, ECO:0000313|Proteomes:UP000001564};
RN   [1] {ECO:0000313|EMBL:CAN01795.1, ECO:0000313|Proteomes:UP000001564}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCPPB 382 {ECO:0000313|EMBL:CAN01795.1,
RC   ECO:0000313|Proteomes:UP000001564};
RX   PubMed=18192381; DOI=10.1128/JB.01595-07;
RA   Gartemann K.H., Abt B., Bekel T., Burger A., Engemann J., Flugel M.,
RA   Gaigalat L., Goesmann A., Grafen I., Kalinowski J., Kaup O., Kirchner O.,
RA   Krause L., Linke B., McHardy A., Meyer F., Pohle S., Ruckert C.,
RA   Schneiker S., Zellermann E.M., Puhler A., Eichenlaub R., Kaiser O.,
RA   Bartels D.;
RT   "The genome sequence of the tomato-pathogenic actinomycete Clavibacter
RT   michiganensis subsp. michiganensis NCPPB382 reveals a large island involved
RT   in pathogenicity.";
RL   J. Bacteriol. 190:2138-2149(2008).
CC   -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC       {ECO:0000256|ARBA:ARBA00002681, ECO:0000256|RuleBase:RU365095}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC         Evidence={ECO:0000256|ARBA:ARBA00000832,
CC         ECO:0000256|RuleBase:RU365095};
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3. {ECO:0000256|ARBA:ARBA00004961, ECO:0000256|RuleBase:RU365095}.
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily.
CC       {ECO:0000256|ARBA:ARBA00010662, ECO:0000256|RuleBase:RU365095}.
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DR   EMBL; AM711867; CAN01795.1; -; Genomic_DNA.
DR   RefSeq; WP_012038427.1; NC_009480.1.
DR   AlphaFoldDB; A5CRT2; -.
DR   KEGG; cmi:CMM_1739; -.
DR   eggNOG; COG0363; Bacteria.
DR   HOGENOM; CLU_053947_1_0_11; -.
DR   OrthoDB; 9810967at2; -.
DR   UniPathway; UPA00115; UER00409.
DR   Proteomes; UP000001564; Chromosome.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   CDD; cd01400; 6PGL; 1.
DR   Gene3D; 3.40.50.1360; -; 1.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR039104; 6PGL.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   NCBIfam; TIGR01198; pgl; 1.
DR   PANTHER; PTHR11054; 6-PHOSPHOGLUCONOLACTONASE; 1.
DR   PANTHER; PTHR11054:SF0; 6-PHOSPHOGLUCONOLACTONASE; 1.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU365095, ECO:0000313|EMBL:CAN01795.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001564}.
FT   DOMAIN          11..235
FT                   /note="Glucosamine/galactosamine-6-phosphate isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01182"
SQ   SEQUENCE   256 AA;  27382 MW;  A65C14E2461ED937 CRC64;
     MTNDRRVLVH PDKKAMTGSV AARFLTKLVD ILDEEETANV VLTGGTVGPS ILAAVNESAA
     RDSVDWTRVH FWFGDERWLP QGDPERNDTT VRAALLDHIE LPAENVHAMG ASDAGLSLGE
     AVAAYTAELA AHANGETGLP RFDITFLGVG PDGHVASLFP DSEGIRTMDA AVIPVRNSPK
     PPAERISLTL PVLNSSLRIW MVLAGPDKAF ALGLALAGAD RTEVPVAGIK GRKRTVFFID
     REAAADVPEN LRLSSY
//