ID   A4IDL3_LEIIN            Unreviewed;       353 AA.
AC   A4IDL3; A0A2K4Z802; A0A381MWN4;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   02-SEP-2026, entry version 88.
DE   RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362025};
DE            EC=2.1.1.- {ECO:0000256|RuleBase:RU362025};
GN   ORFNames=LINJ_36_2520 {ECO:0000313|EMBL:CAM72944.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM72944.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM72944.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72944.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM72944.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72944.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Erg6/SMT family. {ECO:0000256|ARBA:ARBA00038188,
CC       ECO:0000256|PROSITE-ProRule:PRU01022, ECO:0000256|RuleBase:RU362025}.
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DR   EMBL; FR796468; CAM72944.1; -; Genomic_DNA.
DR   RefSeq; XP_001469832.1; XM_001469795.1.
DR   AlphaFoldDB; A4IDL3; -.
DR   SMR; A4IDL3; -.
DR   FunCoup; A4IDL3; 105.
DR   STRING; 5671.A4IDL3; -.
DR   GeneID; 5073936; -.
DR   KEGG; lif:LINJ_36_2520; -.
DR   VEuPathDB; TriTrypDB:LINF_360031300; -.
DR   eggNOG; KOG1269; Eukaryota.
DR   InParanoid; A4IDL3; -.
DR   OMA; AFNKAMH; -.
DR   Proteomes; UP000008153; Chromosome 36.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:TreeGrafter.
DR   GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IEA:TreeGrafter.
DR   GO; GO:0016126; P:sterol biosynthetic process; IEA:TreeGrafter.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   FunFam; 3.40.50.150:FF:000334; Methyltransferase; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR050447; Erg6_SMT_methyltransf.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR030384; MeTrfase_SMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR013705; Sterol_MeTrfase_C.
DR   PANTHER; PTHR44068:SF1; HYPOTHETICAL LOC100005854; 1.
DR   PANTHER; PTHR44068; ZGC:194242; 1.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   Pfam; PF08498; Sterol_MT_C; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01022}; Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01022};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01022}.
FT   DOMAIN          56..349
FT                   /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51685"
SQ   SEQUENCE   353 AA;  39903 MW;  155921DA28A17457 CRC64;
     MSAGGRETAP TNLIRRRNKD ETNGDVSAAA DRFRDRFEKA TLEERKAATT TMVNEYYDLV
     TDFYEYGWGQ NFHFAPRYAG ETFFESLARH EYFLAARGGF MEGDHIVDVG CGVGGPARNM
     VRLTRCNVIG VNNNDYQISR ARRHDALAGM SSKIDYVKTD FCNMSLADNT FDGAYAIEAT
     CHAKDKVKCY SEVFRVIKPG TCFVLYEWCM TDKYNPNDEY HRTIKHRIEL GDGLPEMETC
     KQVIEYMKQA GFVVEEAIDV ISQFESSPIK SIPWYQPLVG DYSSLQGLRS TPIGRILTNV
     MCRVLEFVRL APKGTYKATE ILEEAAESLV VGGQLGIFTP SFYIRARKPS KQA
//