ID   A4HXM4_LEIIN            Unreviewed;       385 AA.
AC   A4HXM4; A0A2K4YRP7; A0A381MEY6;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   02-SEP-2026, entry version 98.
DE   SubName: Full=Ferrochelatase-like protein {ECO:0000313|EMBL:CAM59843.1};
DE            EC=4.99.1.1 {ECO:0000313|EMBL:CAM59843.1};
GN   ORFNames=LINJ_17_1580 {ECO:0000313|EMBL:CAM59843.1};
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM59843.1, ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM59843.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM59843.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM59843.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM59843.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC       biosynthesis. {ECO:0000256|ARBA:ARBA00004744}.
CC   -!- SIMILARITY: Belongs to the ferrochelatase family.
CC       {ECO:0000256|RuleBase:RU004185}.
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DR   EMBL; FR796449; CAM59843.1; -; Genomic_DNA.
DR   RefSeq; XP_001464815.1; XM_001464778.1.
DR   AlphaFoldDB; A4HXM4; -.
DR   SMR; A4HXM4; -.
DR   FunCoup; A4HXM4; 289.
DR   STRING; 5671.A4HXM4; -.
DR   GeneID; 5068219; -.
DR   KEGG; lif:LINJ_17_1580; -.
DR   VEuPathDB; TriTrypDB:LINF_170022100; -.
DR   eggNOG; KOG1321; Eukaryota.
DR   InParanoid; A4HXM4; -.
DR   OMA; RFLSGYC; -.
DR   UniPathway; UPA00252; -.
DR   Proteomes; UP000008153; Chromosome 17.
DR   GO; GO:0004325; F:protoporphyrin ferrochelatase activity; IEA:InterPro.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:InterPro.
DR   CDD; cd00419; Ferrochelatase_C; 1.
DR   CDD; cd03411; Ferrochelatase_N; 1.
DR   FunFam; 3.40.50.1400:FF:000012; Ferrochelatase; 1.
DR   Gene3D; 3.40.50.1400; -; 2.
DR   HAMAP; MF_00323; Ferrochelatase; 1.
DR   InterPro; IPR001015; Ferrochelatase.
DR   InterPro; IPR033644; Ferrochelatase_C.
DR   InterPro; IPR033659; Ferrochelatase_N.
DR   NCBIfam; TIGR00109; hemH; 1.
DR   PANTHER; PTHR11108; FERROCHELATASE; 1.
DR   PANTHER; PTHR11108:SF1; FERROCHELATASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00762; Ferrochelatase; 2.
DR   SUPFAM; SSF53800; Chelatase; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:CAM59843.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ   SEQUENCE   385 AA;  42239 MW;  531482644879B1C4 CRC64;
     MSCAPGPTKA VLLVNLGTTT APTAPAVRRF LREFLSDRRV IDVPRFLWHS VLYGFILPFR
     PRSITPLYKA IWIKSDSGVV INGKTEGSPL TLYSESLAAK VQASVEKTSG GAVVARHAMR
     YGVKNIPSTL KALHDEFATL RELVVLPLFP QYTSTTSASI YDEVFKFYTD TRRRSIPSLR
     TIRDYAEHPV YVEALGSSLL SSIKAHVTAK AGAAKDWKSA LSDQLPEIGI IITYHSIPVR
     YVEEHDDYPQ RCEATTAAIK AYIEAESGVS LSGCLVHVYQ SQFGNQPWLG PTLNAAATAF
     PLPPHDPRKH AFSDAHRNTA LLTKQANVCF AMAPGFAVDC VETLNEIERE AGEVFKQSGG
     REFIYVPCLN DSDTHVKVLT SVVGA
//