ID   A4FDW9_SACEN            Unreviewed;       440 AA.
AC   A4FDW9;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   02-SEP-2026, entry version 92.
DE   RecName: Full=Putative proline/betaine transporter {ECO:0000256|ARBA:ARBA00039918};
GN   OrderedLocusNames=SACE_2966 {ECO:0000313|EMBL:CAM02244.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM02244.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM02244.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- FUNCTION: May be a proton symporter involved in the uptake of osmolytes
CC       such as proline and glycine betaine. {ECO:0000256|ARBA:ARBA00037295}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004429}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Metabolite:H+
CC       Symporter (MHS) family (TC 2.A.1.6) family.
CC       {ECO:0000256|ARBA:ARBA00008240}.
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DR   EMBL; AM420293; CAM02244.1; -; Genomic_DNA.
DR   RefSeq; WP_011873898.1; NC_009142.1.
DR   AlphaFoldDB; A4FDW9; -.
DR   GeneID; 306459687; -.
DR   KEGG; sen:SACE_2966; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_001265_39_5_11; -.
DR   OrthoDB; 8953821at2; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd17369; MFS_ShiA_like; 1.
DR   FunFam; 1.20.1250.20:FF:000001; Dicarboxylate MFS transporter; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004736; MHS_symport.
DR   NCBIfam; TIGR00883; 2A0106; 1.
DR   PANTHER; PTHR43045; SHIKIMATE TRANSPORTER; 1.
DR   PANTHER; PTHR43045:SF1; SHIKIMATE TRANSPORTER; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Symport {ECO:0000256|ARBA:ARBA00022847};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          11..424
FT                   /note="Major facilitator superfamily (MFS) profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
SQ   SEQUENCE   440 AA;  47348 MW;  1BEC28053C98FABB CRC64;
     MTSPGTSARR VAFASLIGTT IEWYDFFIYG TAAALVFNQL FFPDFDPIVG TVAAFATFAV
     GFLARPIGGV LFAHFGDRLG RKPMLIASLM LMGFATLLMG LLPTYSHIGV WAPVLLTLLR
     FAQGLGVGGE WGGAALMAVE HAPQGRRGFY GSWPQVGVPA GLLLGNLTFS LISSTVSEEQ
     FMAWGWRIPF LCSALLIGVG FLIRLKIAES PVFQEAAQRA QETRAERMPV VEVLRRHPRT
     ILLAAGSFLA TNATFYVGST WIVAYATKHL DYERTWVLNA NSFLAFVDIP LMIAFGLLSD
     RIGRRMMSLG GMAVLALFAV PYFMLVDSGS IVLFLLGGMV VQACRTAVYG PQSAFFSELF
     STRLRYSGAS LSYQLASILG GGIAPMICTV LYGATGSSMA IAVYVVVLCL ISFVSIYLLS
     ETYKRDLTEE PAGAAAAAGS
//