ID   A3RL32_MOUSE            Unreviewed;       155 AA.
AC   A3RL32;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   02-SEP-2026, entry version 83.
DE   RecName: Full=Interferon gamma {ECO:0000256|ARBA:ARBA00016945, ECO:0000256|PIRNR:PIRNR001936};
DE            Short=IFN-gamma {ECO:0000256|PIRNR:PIRNR001936};
GN   Name=Ifng {ECO:0000313|MGI:MGI:107656};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:ABN80441.1};
RN   [1] {ECO:0000313|EMBL:ABN80441.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Swiss Albino {ECO:0000313|EMBL:ABN80441.1};
RA   Kadam M., Goswami P.P., Chakravarthy S., Tiwari V., Prasad N.S.,
RA   Chandra Sekar S.;
RT   "Cloning and expression of a 468 bp cDNA fragment encoding 17.9 kDa gamma
RT   interferon of Mus musculus in eukaryotic bicistronic vector.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Type II interferon produced by immune cells such as T-cells
CC       and NK cells that plays crucial roles in antimicrobial, antiviral, and
CC       antitumor responses by activating effector immune cells and enhancing
CC       antigen presentation. Primarily signals through the JAK-STAT pathway
CC       after interaction with its receptor IFNGR1 to affect gene regulation.
CC       Upon IFNG binding, IFNGR1 intracellular domain opens out to allow
CC       association of downstream signaling components JAK2, JAK1 and STAT1,
CC       leading to STAT1 activation, nuclear translocation and transcription of
CC       IFNG-regulated genes. Many of the induced genes are transcription
CC       factors such as IRF1 that are able to further drive regulation of a
CC       next wave of transcription. Plays a role in class I antigen
CC       presentation pathway by inducing a replacement of catalytic proteasome
CC       subunits with immunoproteasome subunits. In turn, increases the
CC       quantity, quality, and repertoire of peptides for class I MHC loading.
CC       Increases the efficiency of peptide generation also by inducing the
CC       expression of activator PA28 that associates with the proteasome and
CC       alters its proteolytic cleavage preference. Up-regulates as well MHC II
CC       complexes on the cell surface by promoting expression of several key
CC       molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates
CC       in the regulation of hematopoietic stem cells during development and
CC       under homeostatic conditions by affecting their development,
CC       quiescence, and differentiation. {ECO:0000256|PIRNR:PIRNR001936}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR001936}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|PIRNR:PIRNR001936}.
CC   -!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
CC       {ECO:0000256|ARBA:ARBA00007566, ECO:0000256|PIRNR:PIRNR001936}.
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DR   EMBL; EF423643; ABN80441.1; -; mRNA.
DR   AlphaFoldDB; A3RL32; -.
DR   SMR; A3RL32; -.
DR   AGR; MGI:107656; -.
DR   MGI; MGI:107656; Ifng.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-ARBA.
DR   GO; GO:0005133; F:type II interferon receptor binding; IEA:InterPro.
DR   GO; GO:0001774; P:microglial cell activation; IEA:UniProtKB-ARBA.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; IEA:UniProtKB-ARBA.
DR   GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:UniProtKB-ARBA.
DR   GO; GO:0031644; P:regulation of nervous system process; IEA:UniProtKB-ARBA.
DR   GO; GO:0060333; P:type II interferon-mediated signaling pathway; IEA:UniProtKB-ARBA.
DR   FunFam; 1.20.1250.10:FF:000007; Interferon gamma; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002069; Interferon_gamma.
DR   PANTHER; PTHR11419; INTERFERON GAMMA; 1.
DR   PANTHER; PTHR11419:SF0; INTERFERON GAMMA; 1.
DR   Pfam; PF00714; IFN-gamma; 1.
DR   PIRSF; PIRSF001936; IFN-gamma; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
KW   ECO:0000256|PIRNR:PIRNR001936};
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR001936};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604,
KW   ECO:0000256|PIRNR:PIRNR001936};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001936};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..155
FT                   /note="Interferon gamma"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002658311"
SQ   SEQUENCE   155 AA;  17935 MW;  5820FBAECB4219D5 CRC64;
     MNATHCILAL QLFLMAVSGC YCHGTVIESL ESLNNYFNSS GIDVEEKSLF LDIWRNWQKD
     GDMKILQSQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT TFFSNSKARK DAFMSIAKFE
     VNNPQVQRQA FNELIRVVHQ LLPESSLRKR KRSRC
//