ID   A3LU37_PICST            Unreviewed;       306 AA.
AC   A3LU37;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 2.
DT   28-JAN-2026, entry version 109.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1 {ECO:0000256|ARBA:ARBA00021935};
GN   Name=PIC2 {ECO:0000313|EMBL:ABN66174.2};
GN   ORFNames=PICST_59616 {ECO:0000313|EMBL:ABN66174.2};
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes;
OC   Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN66174.2, ECO:0000313|Proteomes:UP000002258};
RN   [1] {ECO:0000313|EMBL:ABN66174.2, ECO:0000313|Proteomes:UP000002258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC   {ECO:0000313|Proteomes:UP000002258};
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria.
CC       {ECO:0000256|ARBA:ARBA00002238}.
CC   -!- FUNCTION: Transport of phosphate groups from the cytosol to the
CC       mitochondrial matrix. {ECO:0000256|ARBA:ARBA00054508}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004448}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000498; ABN66174.2; -; Genomic_DNA.
DR   RefSeq; XP_001384203.2; XM_001384166.1.
DR   AlphaFoldDB; A3LU37; -.
DR   FunCoup; A3LU37; 830.
DR   STRING; 322104.A3LU37; -.
DR   GeneID; 4838772; -.
DR   KEGG; pic:PICST_59616; -.
DR   eggNOG; KOG0767; Eukaryota.
DR   HOGENOM; CLU_039456_2_0_1; -.
DR   InParanoid; A3LU37; -.
DR   OMA; PERAYAW; -.
DR   OrthoDB; 427452at2759; -.
DR   Proteomes; UP000002258; Chromosome 4.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005375; F:copper ion transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0005315; F:phosphate transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0006878; P:intracellular copper ion homeostasis; IEA:EnsemblFungi.
DR   GO; GO:1990547; P:mitochondrial phosphate ion transmembrane transport; IEA:InterPro.
DR   FunFam; 1.50.40.10:FF:000076; Mitochondrial phosphate carrier protein 2; 1.
DR   FunFam; 1.50.40.10:FF:000131; Mitochondrial phosphate carrier protein 2; 1.
DR   Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR   InterPro; IPR023395; MCP_dom_sf.
DR   InterPro; IPR018108; MCP_transmembrane.
DR   InterPro; IPR044677; SLC25A3/Pic2/Mir1-like.
DR   PANTHER; PTHR45671; SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED; 1.
DR   PANTHER; PTHR45671:SF10; SOLUTE CARRIER FAMILY 25 MEMBER 3; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT   REPEAT          17..100
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          113..198
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          214..298
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ   SEQUENCE   306 AA;  33419 MW;  C2D938EFA5C20F32 CRC64;
     MTDSLKSPKK IELFSRDYYV ACTVGGIIAC GPTHSAVTPL DLVKCRRQVD PKLYKSNIQG
     WSTIMKTSGD SILTGFGATL IGYSLQGAGK YGFYEYFKKT YSDLVGPDIA NKYKTGIYLS
     ASASAEFLAD LALCPLETIK VKTQTTIPPF ANSVFDGYSK ITKAEGFGGL YKGLVPLWFR
     QIPYTMVKFA TFEKTVEQIY KYLGKPVTSY SPLQQTGVSF LGGYIAGIFC AVISHPADVM
     VSKINSSKKP SESVGAALSR IYGEIGFKGV WNGLPVRIVM IGTLTGFQWL IYDSFKVYVG
     LPTTGH
//