ID A3DC42_ACET2 Unreviewed; 480 AA. AC A3DC42; DT 20-MAR-2007, integrated into UniProtKB/TrEMBL. DT 20-MAR-2007, sequence version 1. DT 10-JUN-2026, entry version 105. DE RecName: Full=Glycogen synthase {ECO:0000256|HAMAP-Rule:MF_00484}; DE EC=2.4.1.21 {ECO:0000256|HAMAP-Rule:MF_00484}; DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000256|HAMAP-Rule:MF_00484}; GN Name=glgA {ECO:0000256|HAMAP-Rule:MF_00484}; GN OrderedLocusNames=Cthe_0282 {ECO:0000313|EMBL:ABN51521.1}; OS Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC OS 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum). OC Bacteria; Bacillati; Bacillota; Clostridia; Acetivibrionales; OC Acetivibrionaceae; Acetivibrio. OX NCBI_TaxID=203119 {ECO:0000313|EMBL:ABN51521.1, ECO:0000313|Proteomes:UP000002145}; RN [1] {ECO:0000313|Proteomes:UP000002145} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / RC NRRL B-4536 / VPI 7372 {ECO:0000313|Proteomes:UP000002145}; RG US DOE Joint Genome Institute; RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., RA Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Wu J.H.D., RA Newcomb M., Richardson P.; RT "Complete sequence of Clostridium thermocellum ATCC 27405."; RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ABN51521.1, ECO:0000313|Proteomes:UP000002145} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / RC NRRL B-4536 / VPI 7372 {ECO:0000313|Proteomes:UP000002145}; RX PubMed=24295562; DOI=10.1186/1754-6834-6-179; RA Wilson C.M., Rodriguez M.Jr., Johnson C.M., Martin S.L., Chu T.M., RA Wolfinger R.D., Hauser L.J., Land M.L., Klingeman D.M., Syed M.H., RA Ragauskas A.J., Tschaplinski T.J., Mielenz J.R., Brown S.D.; RT "Global transcriptome analysis of Clostridium thermocellum ATCC 27405 RT during growth on dilute acid pretreated Populus and switchgrass."; RL Biotechnol. Biofuels 6:179-179(2013). CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose. CC {ECO:0000256|ARBA:ARBA00002764, ECO:0000256|HAMAP-Rule:MF_00484}. CC -!- CATALYTIC ACTIVITY: CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)- CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA- CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444, CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21; CC Evidence={ECO:0000256|ARBA:ARBA00001478, ECO:0000256|HAMAP- CC Rule:MF_00484}; CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_00484}. CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family. CC Bacterial/plant glycogen synthase subfamily. CC {ECO:0000256|ARBA:ARBA00010281, ECO:0000256|HAMAP-Rule:MF_00484}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000568; ABN51521.1; -; Genomic_DNA. DR RefSeq; WP_003512440.1; NC_009012.1. DR AlphaFoldDB; A3DC42; -. DR STRING; 203119.Cthe_0282; -. DR GeneID; 35803445; -. DR KEGG; cth:Cthe_0282; -. DR eggNOG; COG0297; Bacteria. DR HOGENOM; CLU_009583_18_2_9; -. DR OrthoDB; 9808590at2; -. DR UniPathway; UPA00164; -. DR Proteomes; UP000002145; Chromosome. DR GO; GO:0009011; F:alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity; IEA:UniProtKB-UniRule. DR GO; GO:0004373; F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity; IEA:InterPro. DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule. DR CDD; cd03791; GT5_Glycogen_synthase_DULL1-like; 1. DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2. DR HAMAP; MF_00484; Glycogen_synth; 1. DR InterPro; IPR001296; Glyco_trans_1. DR InterPro; IPR011835; GS/SS. DR InterPro; IPR013534; Starch_synth_cat_dom. DR NCBIfam; TIGR02095; glgA; 1. DR NCBIfam; NF001898; PRK00654.1-1; 1. DR NCBIfam; NF001899; PRK00654.1-2; 1. DR PANTHER; PTHR45825:SF11; ALPHA AMYLASE DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR45825; GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC; 1. DR Pfam; PF08323; Glyco_transf_5; 1. DR Pfam; PF00534; Glycos_transf_1; 1. DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1. PE 3: Inferred from homology; KW Glycogen biosynthesis {ECO:0000256|ARBA:ARBA00023056, ECO:0000256|HAMAP- KW Rule:MF_00484}; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, ECO:0000256|HAMAP- KW Rule:MF_00484}; Reference proteome {ECO:0000313|Proteomes:UP000002145}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP- KW Rule:MF_00484}. FT DOMAIN 5..240 FT /note="Starch synthase catalytic" FT /evidence="ECO:0000259|Pfam:PF08323" FT DOMAIN 297..443 FT /note="Glycosyl transferase family 1" FT /evidence="ECO:0000259|Pfam:PF00534" FT BINDING 18 FT /ligand="ADP-alpha-D-glucose" FT /ligand_id="ChEBI:CHEBI:57498" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00484" SQ SEQUENCE 480 AA; 55729 MW; C19CC6D394766955 CRC64; MKKIKVLFAS SEVDPFAKTG GLADVASSLP KALCKLGHDV RVVMPKYKDI PFQYVEKMQK VGEIGVYVSW RRQYCGILKL EMDNITYYFI DNEYYFKRDG YYGYYDEAER FAFFSKAVLE ILPVIGFKPD IIHCNDWQTG VVSAFLNAWY KGLDFYKDIK TVFTIHNLKY QGIFPKEVFG EVLGLPWDYF HADGIEFYDK VNYLKAGIVY SDIITTVSKT YAEEIKTDFF GENLNNVLRK RSNDLYGILN GIDMEENDPA VDNRIFANYS VDNLEGKLTN KQMLQKSLGL QERIDIPLIG IISRLVAQKG FDLIDYVMDE ILKMDIQFVL LGAGEYRYEQ MFRYYQEKYP GKISVNLKYD AVLAQRIYAG ADMFLMPSLF EPCGLSQMFS LRYGTIPIVR ETGGLKDTIT PYNDITHEGN GFTFSRYNAH DMLYAIKEAV HYYYHRSTWT YLMKKGMTTD FSWEKSAKEY LELYEKLAGN //