ID   HXA7_PANTR              Reviewed;         230 AA.
AC   A2T7F3;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   02-SEP-2026, entry version 87.
DE   RecName: Full=Homeobox protein Hox-A7;
GN   Name=HOXA7;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; DQ977437; ABM92108.1; -; Genomic_DNA.
DR   RefSeq; NP_001129067.1; NM_001135595.1.
DR   STRING; 9598.ENSPTRP00000032500; -.
DR   PaxDb; 9598-ENSPTRP00000032500; -.
DR   GeneID; 745634; -.
DR   CTD; 3204; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; A2T7F3; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   FunFam; 1.10.10.60:FF:000017; Homeobox protein antennapedia; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR050296; Antp_homeobox.
DR   InterPro; IPR001356; HD.
DR   InterPro; IPR020479; HD_metazoa.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR009057; Homeodomain-like_sf.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF12; HOMEOBOX PROTEIN HOX-A7; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..230
FT                   /note="Homeobox protein Hox-A7"
FT                   /id="PRO_0000285421"
FT   DNA_BIND        130..189
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          187..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           119..124
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        194..213
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..230
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   230 AA;  25294 MW;  4284CF2D0ECEC564 CRC64;
     MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP
     LYXSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKADEGALH GAAEANFRIY
     PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN
     RRMKWKKEHK DDGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE
//