ID   A2STJ4_METLZ            Unreviewed;       206 AA.
AC   A2STJ4;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   05-FEB-2025, entry version 86.
DE   RecName: Full=phosphoribosylglycinamide formyltransferase 1 {ECO:0000256|ARBA:ARBA00012254};
DE            EC=2.1.2.2 {ECO:0000256|ARBA:ARBA00012254};
DE   AltName: Full=5'-phosphoribosylglycinamide transformylase {ECO:0000256|ARBA:ARBA00041682};
DE   AltName: Full=GAR transformylase {ECO:0000256|ARBA:ARBA00041324};
GN   OrderedLocusNames=Mlab_1486 {ECO:0000313|EMBL:ABN07650.1};
OS   Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z).
OC   Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC   Methanomicrobia; Methanomicrobiales; Methanocorpusculaceae;
OC   Methanocorpusculum.
OX   NCBI_TaxID=410358 {ECO:0000313|EMBL:ABN07650.1, ECO:0000313|Proteomes:UP000000365};
RN   [1] {ECO:0000313|EMBL:ABN07650.1, ECO:0000313|Proteomes:UP000000365}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43576 / DSM 4855 / Z {ECO:0000313|Proteomes:UP000000365};
RX   PubMed=21304657; DOI=10.4056.sigs.35575;
RA   Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A.,
RA   Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L.,
RA   Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT   "Complete genome sequence of Methanocorpusculum labreanum type strain Z.";
RL   Stand. Genomic Sci. 1:197-203(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-
CC         formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-
CC         ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+);
CC         Xref=Rhea:RHEA:15053, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453,
CC         ChEBI:CHEBI:143788, ChEBI:CHEBI:147286, ChEBI:CHEBI:195366;
CC         EC=2.1.2.2; Evidence={ECO:0000256|ARBA:ARBA00047664};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-
CC       formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-
CC       ribosyl)glycinamide (10-formyl THF route): step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005054}.
CC   -!- SIMILARITY: Belongs to the GART family.
CC       {ECO:0000256|ARBA:ARBA00038440}.
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DR   EMBL; CP000559; ABN07650.1; -; Genomic_DNA.
DR   RefSeq; WP_011833853.1; NC_008942.1.
DR   AlphaFoldDB; A2STJ4; -.
DR   STRING; 410358.Mlab_1486; -.
DR   GeneID; 4796009; -.
DR   KEGG; mla:Mlab_1486; -.
DR   eggNOG; arCOG02825; Archaea.
DR   HOGENOM; CLU_038395_1_0_2; -.
DR   OrthoDB; 27277at2157; -.
DR   UniPathway; UPA00074; UER00126.
DR   Proteomes; UP000000365; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd08645; FMT_core_GART; 1.
DR   FunFam; 3.40.50.170:FF:000007; Phosphoribosylglycinamide formyltransferase; 1.
DR   Gene3D; 3.40.50.170; Formyl transferase, N-terminal domain; 1.
DR   HAMAP; MF_01930; PurN; 1.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR004607; GART.
DR   InterPro; IPR001555; GART_AS.
DR   NCBIfam; TIGR00639; PurN; 1.
DR   PANTHER; PTHR43369; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; 1.
DR   PANTHER; PTHR43369:SF2; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   SUPFAM; SSF53328; Formyltransferase; 1.
DR   PROSITE; PS00373; GART; 1.
PE   3: Inferred from homology;
KW   Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000365};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABN07650.1}.
FT   DOMAIN          2..182
FT                   /note="Formyl transferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00551"
SQ   SEQUENCE   206 AA;  22455 MW;  E50E2190213ECAC2 CRC64;
     MKRIAVLASG RGSNFQAILD ALAAGKINGE IVALLTDNRD AYAIERADAA GIPAIVLNYK
     DYPSKEAYER DLLTAMQDIC ADLFVCAGYM RIIGSKIARE FSGKMINIHP ALLPAFSGLH
     GQRQALEYGV KIAGCTVHFV DEGLDSGPII LQKSVEVLDD DDEDSLSERI LEQEHRAFPE
     AVALFCADRL TVVGRHVKIL PEANNQ
//