ID   A2STA6_METLZ            Unreviewed;       255 AA.
AC   A2STA6;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   02-SEP-2026, entry version 92.
DE   RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE            EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
GN   OrderedLocusNames=Mlab_1396 {ECO:0000313|EMBL:ABN07562.1};
OS   Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z).
OC   Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC   Methanomicrobia; Methanomicrobiales; Methanocorpusculaceae;
OC   Methanocorpusculum.
OX   NCBI_TaxID=410358 {ECO:0000313|EMBL:ABN07562.1, ECO:0000313|Proteomes:UP000000365};
RN   [1] {ECO:0000313|EMBL:ABN07562.1, ECO:0000313|Proteomes:UP000000365}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43576 / DSM 4855 / Z {ECO:0000313|Proteomes:UP000000365};
RX   PubMed=21304657; DOI=10.4056.sigs.35575;
RA   Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A.,
RA   Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L.,
RA   Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT   "Complete genome sequence of Methanocorpusculum labreanum type strain Z.";
RL   Stand. Genomic Sci. 1:197-203(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001633};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
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DR   EMBL; CP000559; ABN07562.1; -; Genomic_DNA.
DR   RefSeq; WP_011833765.1; NC_008942.1.
DR   AlphaFoldDB; A2STA6; -.
DR   STRING; 410358.Mlab_1396; -.
DR   GeneID; 4796074; -.
DR   KEGG; mla:Mlab_1396; -.
DR   eggNOG; arCOG01088; Archaea.
DR   HOGENOM; CLU_034247_0_1_2; -.
DR   OrthoDB; 15223at2157; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000000365; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:TreeGrafter.
DR   GO; GO:0000162; P:L-tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR   PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:ABN07562.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000365};
KW   Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT   DOMAIN          29..250
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /evidence="ECO:0000259|Pfam:PF00218"
SQ   SEQUENCE   255 AA;  28204 MW;  A4CFDC77BEC42825 CRC64;
     MILDDICARS RERAALLDPS IRKTSEETTY VPQSLIKSVK NCQGRKNAVI AEIKYKTPSD
     KTLDSRRDPA NLSRLYESGG ACAVSVLTEP FYFSGSAENL TKAKSGTRLP ILRKDFIVDE
     KQIYETYVMQ ADSVLLIADV LQDRLEEFIL LCQSLHLEPL VEVRNREDAE NAVKSGALLT
     GINNRNLHDM SVDTKTTEEL SCLLRDAGLT VISESGIKTP EDVLGLKNLC DGFLIGTSLM
     KSADPQKTLE AFVCV
//