ID   A2RMV4_LACLM            Unreviewed;       226 AA.
AC   A2RMV4;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   02-SEP-2026, entry version 110.
DE   RecName: Full=adenosylhomocysteine nucleosidase {ECO:0000256|ARBA:ARBA00011974};
DE            EC=3.2.2.9 {ECO:0000256|ARBA:ARBA00011974};
GN   Name=pfs {ECO:0000313|EMBL:CAL98640.1};
GN   OrderedLocusNames=llmg_2073 {ECO:0000313|EMBL:CAL98640.1};
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870 {ECO:0000313|EMBL:CAL98640.1, ECO:0000313|Proteomes:UP000000364};
RN   [1] {ECO:0000313|EMBL:CAL98640.1, ECO:0000313|Proteomes:UP000000364}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363 {ECO:0000313|EMBL:CAL98640.1,
RC   ECO:0000313|Proteomes:UP000000364};
RX   PubMed=17307855; DOI=10.1128/JB.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine;
CC         Xref=Rhea:RHEA:29859, ChEBI:CHEBI:15377, ChEBI:CHEBI:16708,
CC         ChEBI:CHEBI:17319, ChEBI:CHEBI:149540; EC=3.2.2.9;
CC         Evidence={ECO:0000256|ARBA:ARBA00050313};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29860;
CC         Evidence={ECO:0000256|ARBA:ARBA00050313};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage
CC       pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-
CC       thioadenosine (hydrolase route): step 1/2.
CC       {ECO:0000256|ARBA:ARBA00004945}.
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DR   EMBL; AM406671; CAL98640.1; -; Genomic_DNA.
DR   RefSeq; WP_011835787.1; NC_009004.1.
DR   AlphaFoldDB; A2RMV4; -.
DR   SMR; A2RMV4; -.
DR   STRING; 416870.llmg_2073; -.
DR   PaxDb; 416870-llmg_2073; -.
DR   KEGG; llm:llmg_2073; -.
DR   eggNOG; COG0775; Bacteria.
DR   HOGENOM; CLU_031248_2_2_9; -.
DR   OrthoDB; 9792278at2; -.
DR   PhylomeDB; A2RMV4; -.
DR   UniPathway; UPA00904; UER00871.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0008782; F:adenosylhomocysteine nucleosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008930; F:methylthioadenosine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0009164; P:nucleoside catabolic process; IEA:InterPro.
DR   CDD; cd09008; MTAN; 1.
DR   FunFam; 3.40.50.1580:FF:000001; MTA/SAH nucleosidase family protein; 1.
DR   Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR   InterPro; IPR010049; MTA_SAH_Nsdase.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   NCBIfam; TIGR01704; MTA_SAH-Nsdase; 1.
DR   NCBIfam; NF004079; PRK05584.1; 1.
DR   PANTHER; PTHR46832; 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR   PANTHER; PTHR46832:SF1; 5'-METHYLTHIOADENOSINE_S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Glycosidase {ECO:0000313|EMBL:CAL98640.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CAL98640.1};
KW   Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000364}.
FT   DOMAIN          2..221
FT                   /note="Nucleoside phosphorylase"
FT                   /evidence="ECO:0000259|Pfam:PF01048"
SQ   SEQUENCE   226 AA;  24323 MW;  FF9EE339C6601845 CRC64;
     MKIGIICAMD EEIRILVENL ENAEKYTRHG LVFHSGSIGR HEVVLVQSGI GKVMSALAVG
     FLVDIFDVDA IINTGSAGAV AQGLAIGDVV VADKLAYHDV DVTAFGYAYG QMAQQPLYFE
     SSKYFVSELK KVLENVHVGL ITSSDSFISS SSKIAEIKEH FPDVLAVEME GASIAQAATA
     LGKPFVIIRA MSDTADHDAN VNFDKFIIEA GKKSAQGLIR LLEEMV
//