ID   A2CDX6_PROM3            Unreviewed;       376 AA.
AC   A2CDX6;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   02-SEP-2026, entry version 110.
DE   RecName: Full=RNA polymerase sigma factor {ECO:0000256|RuleBase:RU362124};
GN   OrderedLocusNames=P9303_29561 {ECO:0000313|EMBL:ABM79686.1};
OS   Prochlorococcus marinus (strain MIT 9303).
OC   Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC   Prochlorococcaceae; Prochlorococcus.
OX   NCBI_TaxID=59922 {ECO:0000313|EMBL:ABM79686.1, ECO:0000313|Proteomes:UP000002274};
RN   [1] {ECO:0000313|EMBL:ABM79686.1, ECO:0000313|Proteomes:UP000002274}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9303 {ECO:0000313|EMBL:ABM79686.1,
RC   ECO:0000313|Proteomes:UP000002274};
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. {ECO:0000256|RuleBase:RU362124}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family.
CC       {ECO:0000256|ARBA:ARBA00007788, ECO:0000256|RuleBase:RU362124}.
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DR   EMBL; CP000554; ABM79686.1; -; Genomic_DNA.
DR   RefSeq; WP_011827524.1; NC_008820.1.
DR   AlphaFoldDB; A2CDX6; -.
DR   STRING; 59922.P9303_29561; -.
DR   KEGG; pmf:P9303_29561; -.
DR   HOGENOM; CLU_014793_3_4_3; -.
DR   BioCyc; PMAR59922:G1G80-2595-MONOMER; -.
DR   Proteomes; UP000002274; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016987; F:sigma factor activity; IEA:InterPro.
DR   GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR   CDD; cd06171; Sigma70_r4; 1.
DR   FunFam; 1.10.601.10:FF:000001; RNA polymerase sigma factor SigA; 1.
DR   Gene3D; 1.20.120.1810; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR017848; RNA_pol_sigma_RpoD/SigA_cyanob.
DR   InterPro; IPR050239; Sigma-70_RNA_pol_init_factors.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   NCBIfam; TIGR02997; Sig70-cyanoRpoD; 1.
DR   NCBIfam; TIGR02937; sigma70-ECF; 1.
DR   PANTHER; PTHR30603; RNA POLYMERASE SIGMA FACTOR RPO; 1.
DR   PANTHER; PTHR30603:SF60; RNA POLYMERASE SIGMA FACTOR RPOD; 1.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR   SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 2.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002274};
KW   Sigma factor {ECO:0000256|ARBA:ARBA00023082,
KW   ECO:0000256|RuleBase:RU362124};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU362124};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU362124}.
FT   DOMAIN          164..177
FT                   /note="RNA polymerase sigma-70"
FT                   /evidence="ECO:0000259|PROSITE:PS00715"
FT   DOMAIN          332..358
FT                   /note="RNA polymerase sigma-70"
FT                   /evidence="ECO:0000259|PROSITE:PS00716"
FT   COILED          53..80
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   376 AA;  43290 MW;  9C56D59DB58A9377 CRC64;
     MKSSPQQTKT SLVRRSGSTD PVRLYLQDIG RVELLTHEEE VTLARLVQRR EALLKQERQL
     ASSQEAIKEL QRLEELQQRE ANHSCHWPTK QEWAMAAGLT LAELQDKIET GYKTWGALTG
     LDPLELKRSL RAGRRAKDQM IQANLRLVVA VAKKYQQRGI ELLDLVQEGT LGLERAVEKF
     DPARGFRFST YAYWWIRQGI TRAIATQSRT IRLPMHITEK LNRIKRVQQE IASNQGRLAS
     IADLAKALGL SEETVRLTLM RVPRSISLET RIGQEQDSQL GDLLEDSNAT PEEKLTRDQL
     HNDLEILLDE LSNREATVIR RRFGLEDDTP QTLTQIGEAM HLSRERVRQI ESHALLKLRQ
     PQRRCKVRDY IQNLDS
//