ID   A2CAC2_PROM3            Unreviewed;       236 AA.
AC   A2CAC2;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   10-JUN-2026, entry version 89.
DE   RecName: Full=6-phosphogluconolactonase {ECO:0000256|ARBA:ARBA00020337, ECO:0000256|RuleBase:RU365095};
DE            Short=6PGL {ECO:0000256|RuleBase:RU365095};
DE            EC=3.1.1.31 {ECO:0000256|ARBA:ARBA00013198, ECO:0000256|RuleBase:RU365095};
GN   Name=pgl {ECO:0000256|RuleBase:RU365095};
GN   OrderedLocusNames=P9303_16881 {ECO:0000313|EMBL:ABM78432.1};
OS   Prochlorococcus marinus (strain MIT 9303).
OC   Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC   Prochlorococcaceae; Prochlorococcus.
OX   NCBI_TaxID=59922 {ECO:0000313|EMBL:ABM78432.1, ECO:0000313|Proteomes:UP000002274};
RN   [1] {ECO:0000313|EMBL:ABM78432.1, ECO:0000313|Proteomes:UP000002274}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9303 {ECO:0000313|EMBL:ABM78432.1,
RC   ECO:0000313|Proteomes:UP000002274};
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC       {ECO:0000256|ARBA:ARBA00002681, ECO:0000256|RuleBase:RU365095}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC         Evidence={ECO:0000256|ARBA:ARBA00000832,
CC         ECO:0000256|RuleBase:RU365095};
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3. {ECO:0000256|ARBA:ARBA00004961, ECO:0000256|RuleBase:RU365095}.
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily.
CC       {ECO:0000256|ARBA:ARBA00010662, ECO:0000256|RuleBase:RU365095}.
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DR   EMBL; CP000554; ABM78432.1; -; Genomic_DNA.
DR   RefSeq; WP_011826320.1; NC_008820.1.
DR   AlphaFoldDB; A2CAC2; -.
DR   STRING; 59922.P9303_16881; -.
DR   KEGG; pmf:P9303_16881; -.
DR   HOGENOM; CLU_053947_2_0_3; -.
DR   BioCyc; PMAR59922:G1G80-1466-MONOMER; -.
DR   UniPathway; UPA00115; UER00409.
DR   Proteomes; UP000002274; Chromosome.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   CDD; cd01400; 6PGL; 1.
DR   Gene3D; 3.40.50.1360; -; 1.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR039104; 6PGL.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   NCBIfam; TIGR01198; pgl; 1.
DR   PANTHER; PTHR11054; 6-PHOSPHOGLUCONOLACTONASE; 1.
DR   PANTHER; PTHR11054:SF0; 6-PHOSPHOGLUCONOLACTONASE; 1.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU365095, ECO:0000313|EMBL:ABM78432.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002274}.
FT   DOMAIN          11..223
FT                   /note="Glucosamine/galactosamine-6-phosphate isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01182"
SQ   SEQUENCE   236 AA;  25356 MW;  14E042DF768DC73E CRC64;
     MTTYKVERGS DPEDLARRAA QRIASHIDLV LDQRDRVQIA LSGGTTPAIA YRLLGQERLP
     WDRVDVFLGD ERWVDASDDA SNARMLRTTL LAEGPGSQAA FHPVPTVELP DPEASAEAYA
     KIIQESCAGD PPVFDLMVLG LGEDGHTASL FPGTEAPSVV DRWATVGRGK GLERITLTAP
     VLSSAREVIF LVSGVGKQLA LKRLLDSAES AERTPARLVQ PRSPILVLAD EAALLG
//