ID   A2ATS6_MOUSE            Unreviewed;       426 AA.
AC   A2ATS6;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   02-SEP-2026, entry version 138.
DE   SubName: Full=Reticulon 4 receptor-like 2 {ECO:0000313|Ensembl:ENSMUSP00000118362.2};
DE   Flags: Fragment;
GN   Name=Rtn4rl2 {ECO:0000313|Ensembl:ENSMUSP00000118362.2,
GN   ECO:0000313|MGI:MGI:2669796};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000118362.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000118362.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118362.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG   Mouse Genome Sequencing Consortium;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000118362.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118362.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=21750661;
RA   Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA   Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA   Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA   Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA   Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA   Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA   Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT   "Modernizing reference genome assemblies.";
RL   PLoS Biol. 9:e1001091-e1001091(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000118362.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118362.2};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC       Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Cell
CC       projection {ECO:0000256|ARBA:ARBA00004316}. Membrane raft
CC       {ECO:0000256|ARBA:ARBA00004285}. Perikaryon
CC       {ECO:0000256|ARBA:ARBA00004484}.
CC   -!- SIMILARITY: Belongs to the Nogo receptor family.
CC       {ECO:0000256|ARBA:ARBA00038236}.
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DR   AlphaFoldDB; A2ATS6; -.
DR   SMR; A2ATS6; -.
DR   PeptideAtlas; A2ATS6; -.
DR   ProteomicsDB; 320460; -.
DR   Antibodypedia; 62766; 149 antibodies from 23 providers.
DR   Ensembl; ENSMUST00000151799.8; ENSMUSP00000118362.2; ENSMUSG00000050896.13.
DR   AGR; MGI:2669796; -.
DR   MGI; MGI:2669796; Rtn4rl2.
DR   VEuPathDB; HostDB:ENSMUSG00000050896; -.
DR   GeneTree; ENSGT00940000158505; -.
DR   OrthoDB; 6363818at2759; -.
DR   PhylomeDB; A2ATS6; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000050896; Expressed in lumbar dorsal root ganglion and 123 other cell types or tissues.
DR   ExpressionAtlas; A2ATS6; baseline and differential.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022038; P:corpus callosum development; IEA:UniProtKB-ARBA.
DR   GO; GO:0010977; P:negative regulation of neuron projection development; IEA:UniProtKB-ARBA.
DR   FunFam; 3.80.10.10:FF:000018; Reticulon 4 receptor; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR050541; LRR_TM_domain-containing.
DR   PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR24369:SF196; RETICULON 4 RECEPTOR LIKE 1; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 8.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A2ATS6,
KW   ECO:0007829|ProteomicsDB:A2ATS6}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           37..426
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002642049"
FT   DOMAIN          267..317
FT                   /note="LRRCT"
FT                   /evidence="ECO:0000259|SMART:SM00082"
FT   REGION          292..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..312
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..366
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000118362.2"
SQ   SEQUENCE   426 AA;  46843 MW;  A993E1C379EB5B15 CRC64;
     PDRRDKMLPG LRRLLQGPAS ACLLLTLLAL PSVTPSCPML CTCYSSPPTV SCQANNFSSV
     PLSLPPSTQR LFLQNNLIRS LRPGTFGPNL LTLWLFSNNL STIHPGTFRH LQALEELDLG
     DNRHLRSLEP DTFQGLERLQ SLHLYRCQLS SLPGNIFRGL VSLQYLYLQE NSLLHLQDDL
     FADLANLSHL FLHGNRLRLL TEHVFRGLGS LDRLLLHGNR LQGVHRAAFH GLSRLTILYL
     FNNSLASLPG EALADLPALE FLRLNANPWA CDCRARPLWA WFQRARVSSS DVTCATPPER
     QGRDLRALRD SDFQACPPPT PTRPGSRARG NSSSNHLYGV AEAGAPPADP STLYRDLPAE
     DSRGRQGGDA PTEDDYWGGY GGEDQRGEQT CPGAACQAPA DSRGPALSAG LRTPLLCLLP
     LALHHL
//