ID   A2AT93_MOUSE            Unreviewed;       255 AA.
AC   A2AT93;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   02-SEP-2026, entry version 130.
DE   SubName: Full=Phospholipase C, beta 4 {ECO:0000313|Ensembl:ENSMUSP00000117578.2};
DE   Flags: Fragment;
GN   Name=Plcb4 {ECO:0000313|Ensembl:ENSMUSP00000117578.2,
GN   ECO:0000313|MGI:MGI:107464};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000117578.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000117578.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117578.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG   Mouse Genome Sequencing Consortium;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000117578.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117578.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=21750661;
RA   Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA   Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA   Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA   Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA   Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA   Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA   Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT   "Modernizing reference genome assemblies.";
RL   PLoS Biol. 9:e1001091-e1001091(2011).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000117578.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117578.2};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
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DR   AlphaFoldDB; A2AT93; -.
DR   SMR; A2AT93; -.
DR   PeptideAtlas; A2AT93; -.
DR   ProteomicsDB; 351007; -.
DR   Antibodypedia; 24070; 40 antibodies from 17 providers.
DR   Ensembl; ENSMUST00000147744.2; ENSMUSP00000117578.2; ENSMUSG00000039943.17.
DR   UCSC; uc008mof.1; mouse.
DR   AGR; MGI:107464; -.
DR   MGI; MGI:107464; Plcb4.
DR   VEuPathDB; HostDB:ENSMUSG00000039943; -.
DR   GeneTree; ENSGT00940000156426; -.
DR   HOGENOM; CLU_1092107_0_0_1; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000039943; Expressed in vestibular membrane of cochlear duct and 241 other cell types or tissues.
DR   ExpressionAtlas; A2AT93; baseline and differential.
DR   FunFam; 1.20.1230.10:FF:000002; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; 1.
DR   Gene3D; 1.20.1230.10; Phospholipase C beta, distal C-terminal domain; 1.
DR   InterPro; IPR042531; PLC-beta_C_sf.
DR   SUPFAM; SSF69989; C-terminal domain of PLC-beta; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A2AT93,
KW   ECO:0007829|ProteomicsDB:A2AT93};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   REGION          143..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          219..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..155
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000117578.2"
SQ   SEQUENCE   255 AA;  29456 MW;  A0B6B3541DB3F8C7 CRC64;
     NSLKKKHAKE HSTMQKLHCT QVDKIVAQYD KEKSTHEKIL EKAMKKKGGS NCLEIKKETE
     IKIQTLTTDH KSKVKEIVAQ HTKEWSEMIN THSAEEQEIR DLHLSQQCEL LRKLLINAHE
     QQTQQLKLSH DRESKEMRAH QAKISMENSK AISQDKSIKN KAERERRVRE LNSSNTKKFL
     EERKRLAMKQ SKEMDQLKKV QLEHLEFLEK QNEQLLKSCH AVSQTQGEGD AADGEIGSRD
     GPQTSNSSMK LQSAN
//