ID TITIN_MOUSE Reviewed; 35213 AA. AC A2ASS6; A2ASS5; A2ASS7; DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot. DT 20-FEB-2007, sequence version 1. DT 02-SEP-2026, entry version 154. DE RecName: Full=Titin; DE EC=2.7.11.1; DE AltName: Full=Connectin; GN Name=Ttn {ECO:0000312|EMBL:CAM27059.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000312|EMBL:CAM23449.1} RP PROTEIN SEQUENCE OF 28297-28311 AND 34728-34734, AND IDENTIFICATION BY MASS RP SPECTROMETRY. RC STRAIN=OF1; TISSUE=Hippocampus; RA Lubec G., Sunyer B., Chen W.-Q.; RL Submitted (JAN-2009) to UniProtKB. RN [3] {ECO:0000305} RP DEVELOPMENTAL STAGE. RX PubMed=9440711; DOI=10.1161/01.res.82.1.124; RA Gautel M., Fuerst D.O., Cocco A., Schiaffino S.; RT "Isoform transitions of the myosin binding protein C family in developing RT human and mouse muscles: lack of isoform transcomplementation in cardiac RT muscle."; RL Circ. Res. 82:124-129(1998). RN [4] {ECO:0000305} RP FUNCTION. RX PubMed=16702235; DOI=10.1083/jcb.200601014; RA Weinert S., Bergmann N., Luo X., Erdmann B., Gotthardt M.; RT "M line-deficient titin causes cardiac lethality through impaired RT maturation of the sarcomere."; RL J. Cell Biol. 173:559-570(2006). RN [5] RP FUNCTION. RX PubMed=17261657; DOI=10.1161/circulationaha.106.645499; RA Peng J., Raddatz K., Molkentin J.D., Wu Y., Labeit S., Granzier H., RA Gotthardt M.; RT "Cardiac hypertrophy and reduced contractility in hearts deficient in the RT titin kinase region."; RL Circulation 115:743-751(2007). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9144, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264; THR-266; THR-299; RP SER-301; SER-307; SER-322; SER-756; SER-1251; SER-1415; SER-1420; SER-1424; RP SER-1429; SER-1434; SER-2078; SER-2080; SER-3516; SER-3784; THR-8387; RP SER-9144; SER-9459; SER-10281; THR-12869; SER-12884; SER-12972; SER-13904; RP SER-21152; SER-21895; SER-21980; SER-22390; SER-25920; SER-32870; RP THR-33859; SER-33861; SER-33875; SER-33880; SER-33915; SER-34009; RP SER-34292; SER-34464; THR-34467; SER-34470; SER-34476; THR-34481 AND RP SER-34756, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3432; SER-3636; RP SER-3678; SER-3763; SER-3827; THR-3836; SER-4672 AND SER-4720 (ISOFORM 3), RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Heart, Kidney, and Lung; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [8] RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-263; ARG-278; ARG-286; ARG-296 RP AND ARG-304, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Brain; RX PubMed=24129315; DOI=10.1074/mcp.o113.027870; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M., RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V., RA Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). CC -!- FUNCTION: Key component in the assembly and functioning of vertebrate CC striated muscles. By providing connections at the level of individual CC microfilaments, it contributes to the fine balance of forces between CC the two halves of the sarcomere. The size and extensibility of the CC cross-links are the main determinants of sarcomere extensibility CC properties of muscle. In non-muscle cells, seems to play a role in CC chromosome condensation and chromosome segregation during mitosis. CC Might link the lamina network to chromatin or nuclear actin, or both CC during interphase. {ECO:0000250|UniProtKB:Q8WZ42, CC ECO:0000269|PubMed:16702235, ECO:0000269|PubMed:17261657}. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + CC H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CC Evidence={ECO:0000250|UniProtKB:Q8WZ42}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + CC ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA- CC COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; CC Evidence={ECO:0000250|UniProtKB:Q8WZ42}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000250|UniProtKB:Q8WZ42}; CC -!- ACTIVITY REGULATION: Full activation of the protein kinase domain CC requires both phosphorylation of Tyr-33203, preventing it from blocking CC the catalytic aspartate residue, and binding of Ca/CALM to the C- CC terminal regulatory tail of the molecule which results in ATP binding CC to the kinase. {ECO:0000250|UniProtKB:Q8WZ42}. CC -!- SUBUNIT: Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts CC with actin, primarily via the PEVK domains and with MYPN. Interacts CC with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B. Interacts with CC TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N- CC terminal immunoglobulin domains. Interacts with TRIM63, TRIM55, ANKRD1, CC ANKRD2, ANKRD23, and CAPN3 through several Ig domains. Interacts with CC NBR1 through the protein kinase domain (By similarity). Interacts with CC CMYA5 (By similarity). {ECO:0000250}. CC -!- INTERACTION: CC A2ASS6; Q70IV5: Synm; NbExp=3; IntAct=EBI-9672947, EBI-9989763; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus CC {ECO:0000250|UniProtKB:Q8WZ42}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=A2ASS6-1; Sequence=Displayed; CC Name=2; CC IsoId=A2ASS6-2; Sequence=VSP_052606, VSP_052608; CC Name=3; CC IsoId=A2ASS6-3; Sequence=VSP_052606, VSP_052607, VSP_052609; CC -!- DEVELOPMENTAL STAGE: Expressed in cardiac muscle from 8 dpc and in CC skeletal muscle from 9 dpc. {ECO:0000269|PubMed:9440711}. CC -!- DOMAIN: ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for CC ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 CC could adopt a closed conformation which would block the TCAP-binding CC site (By similarity). {ECO:0000250|UniProtKB:Q8WZ42}. CC -!- DOMAIN: The PEVK region may serve as an entropic spring of a chain of CC structural folds and may also be an interaction site to other CC myofilament proteins to form interfilament connectivity in the CC sarcomere. {ECO:0000250|UniProtKB:Q8WZ42}. CC -!- PTM: Autophosphorylated. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr CC protein kinase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL928681; CAM27058.1; -; Genomic_DNA. DR EMBL; AL928721; CAM27058.1; JOINED; Genomic_DNA. DR EMBL; AL928789; CAM27058.1; JOINED; Genomic_DNA. DR EMBL; AL928681; CAM27059.1; -; Genomic_DNA. DR EMBL; AL928721; CAM27059.1; JOINED; Genomic_DNA. DR EMBL; AL928789; CAM27059.1; JOINED; Genomic_DNA. DR EMBL; AL928681; CAM27060.1; -; Genomic_DNA. DR EMBL; AL928721; CAM27060.1; JOINED; Genomic_DNA. DR EMBL; AL928721; CAM23448.1; -; Genomic_DNA. DR EMBL; AL928681; CAM23448.1; JOINED; Genomic_DNA. DR EMBL; AL928789; CAM23448.1; JOINED; Genomic_DNA. DR EMBL; AL928721; CAM23449.1; -; Genomic_DNA. DR EMBL; AL928681; CAM23449.1; JOINED; Genomic_DNA. DR EMBL; AL928789; CAM23449.1; JOINED; Genomic_DNA. DR EMBL; AL928721; CAM23450.1; -; Genomic_DNA. DR EMBL; AL928681; CAM23450.1; JOINED; Genomic_DNA. DR EMBL; AL928789; CAM24262.1; -; Genomic_DNA. DR EMBL; AL928681; CAM24262.1; JOINED; Genomic_DNA. DR EMBL; AL928721; CAM24262.1; JOINED; Genomic_DNA. DR EMBL; AL928789; CAM24263.1; -; Genomic_DNA. DR EMBL; AL928681; CAM24263.1; JOINED; Genomic_DNA. DR EMBL; AL928721; CAM24263.1; JOINED; Genomic_DNA. DR PDB; 6YJ0; NMR; -; A=9719-9809. DR PDB; 8Q6T; EM; 18.00 A; I/P=26390-27468. DR PDB; 9IBI; NMR; -; A=9631-9718. DR PDB; 9IBK; NMR; -; A=9631-9718. DR PDB; 9RHK; NMR; -; A=9633-9809. DR EMDB; EMD-18198; -. DR SMR; A2ASS6; -. DR ComplexPortal; CPX-127; Titin-Telethonin complex. DR CORUM; A2ASS6; -. DR FunCoup; A2ASS6; 230. DR IntAct; A2ASS6; 5. DR MINT; A2ASS6; -. DR STRING; 10090.ENSMUSP00000107477; -. DR CarbonylDB; A2ASS6; -. DR GlyGen; A2ASS6; 45 sites, 15 N-linked glycans (21 sites), 1 O-linked glycan (6 sites). DR iPTMnet; A2ASS6; -. DR PhosphoSitePlus; A2ASS6; -. DR SwissPalm; A2ASS6; -. DR jPOST; A2ASS6; -. DR PaxDb; 10090-ENSMUSP00000107477; -. DR PeptideAtlas; A2ASS6; -. DR ProteomicsDB; 259027; -. [A2ASS6-1] DR ProteomicsDB; 259028; -. [A2ASS6-2] DR ProteomicsDB; 259029; -. [A2ASS6-3] DR Antibodypedia; 2056; 218 antibodies from 30 providers. DR Ensembl; ENSMUST00000099980.10; ENSMUSP00000097560.4; ENSMUSG00000051747.17. [A2ASS6-3] DR UCSC; uc008kfo.1; mouse. [A2ASS6-2] DR AGR; MGI:98864; -. DR MGI; MGI:98864; Ttn. DR VEuPathDB; HostDB:ENSMUSG00000051747; -. DR eggNOG; KOG0613; Eukaryota. DR eggNOG; KOG4475; Eukaryota. DR GeneTree; ENSGT01150000286978; -. DR HOGENOM; CLU_000001_0_2_1; -. DR InParanoid; A2ASS6; -. DR OMA; TSSWPEY; -. DR OrthoDB; 6510948at2759; -. DR PhylomeDB; A2ASS6; -. DR PRO; PR:A2ASS6; -. DR Proteomes; UP000000589; Chromosome 2. DR Bgee; ENSMUSG00000051747; Expressed in vastus lateralis and 168 other cell types or tissues. DR ExpressionAtlas; A2ASS6; baseline and differential. DR GO; GO:0031672; C:A band; IDA:MGI. DR GO; GO:0000794; C:condensed nuclear chromosome; ISO:GO_Central. DR GO; GO:0031674; C:I band; IDA:MGI. DR GO; GO:0031430; C:M band; IDA:MGI. DR GO; GO:0005859; C:muscle myosin complex; TAS:MGI. DR GO; GO:0030016; C:myofibril; ISO:GO_Central. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0030017; C:sarcomere; IDA:MGI. DR GO; GO:0005865; C:striated muscle thin filament; ISO:GO_Central. DR GO; GO:1990733; C:titin-telethonin complex; ISO:GO_Central. DR GO; GO:0030018; C:Z disc; IDA:MGI. DR GO; GO:0051015; F:actin filament binding; ISO:GO_Central. DR GO; GO:0042805; F:actinin binding; ISO:GO_Central. DR GO; GO:0030506; F:ankyrin binding; IPI:UniProtKB. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; ISO:GO_Central. DR GO; GO:0005516; F:calmodulin binding; ISO:GO_Central. DR GO; GO:0019899; F:enzyme binding; ISO:GO_Central. DR GO; GO:0042802; F:identical protein binding; ISO:GO_Central. DR GO; GO:0051371; F:muscle alpha-actinin binding; ISO:GO_Central. DR GO; GO:0002020; F:protease binding; ISO:GO_Central. DR GO; GO:0042803; F:protein homodimerization activity; ISO:GO_Central. DR GO; GO:0019901; F:protein kinase binding; ISO:GO_Central. DR GO; GO:0019887; F:protein kinase regulator activity; ISO:GO_Central. DR GO; GO:0106310; F:protein serine kinase activity; ISS:UniProtKB. DR GO; GO:0004674; F:protein serine/threonine kinase activity; ISO:GO_Central. DR GO; GO:0004713; F:protein tyrosine kinase activity; ISO:MGI. DR GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI. DR GO; GO:0008307; F:structural constituent of muscle; ISO:GO_Central. DR GO; GO:0097493; F:structural molecule activity conferring elasticity; ISO:GO_Central. DR GO; GO:0031433; F:telethonin binding; ISO:GO_Central. DR GO; GO:0007512; P:adult heart development; IMP:MGI. DR GO; GO:0055013; P:cardiac muscle cell development; ISO:GO_Central. DR GO; GO:0060048; P:cardiac muscle contraction; ISO:GO_Central. DR GO; GO:0003300; P:cardiac muscle hypertrophy; ISO:GO_Central. DR GO; GO:0048738; P:cardiac muscle tissue development; IBA:GO_Central. DR GO; GO:0055008; P:cardiac muscle tissue morphogenesis; IMP:MGI. DR GO; GO:0055003; P:cardiac myofibril assembly; IMP:MGI. DR GO; GO:0035995; P:detection of muscle stretch; ISO:MGI. DR GO; GO:0043056; P:forward locomotion; IMP:MGI. DR GO; GO:0007507; P:heart development; IEP:BHF-UCL. DR GO; GO:0060419; P:heart growth; IMP:MGI. DR GO; GO:0003007; P:heart morphogenesis; IMP:MGI. DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI. DR GO; GO:0006936; P:muscle contraction; IMP:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:GO_Central. DR GO; GO:0050714; P:positive regulation of protein secretion; ISO:GO_Central. DR GO; GO:1901897; P:regulation of relaxation of cardiac muscle; IMP:BHF-UCL. DR GO; GO:0051592; P:response to calcium ion; ISO:GO_Central. DR GO; GO:0045214; P:sarcomere organization; IMP:MGI. DR GO; GO:0048769; P:sarcomerogenesis; ISO:GO_Central. DR GO; GO:0030241; P:skeletal muscle myosin thick filament assembly; ISO:GO_Central. DR GO; GO:0030240; P:skeletal muscle thin filament assembly; ISO:GO_Central. DR GO; GO:0001756; P:somitogenesis; IEP:BHF-UCL. DR GO; GO:0055002; P:striated muscle cell development; IMP:MGI. DR GO; GO:0021591; P:ventricular system development; IMP:MGI. DR CDD; cd00063; FN3; 132. DR CDD; cd00096; Ig; 28. DR CDD; cd05748; Ig_Titin_like; 26. DR CDD; cd20974; IgI_1_Titin_Z1z2-like; 1. DR CDD; cd20972; IgI_2_Titin_Z1z2-like; 1. DR CDD; cd20951; IgI_titin_I1-like; 1. DR CDD; cd05747; IgI_Titin_like; 1. DR CDD; cd20927; IgI_Titin_M1-like; 1. DR CDD; cd14104; STKc_Titin; 1. DR FunFam; 2.60.40.10:FF:000022; Cardiac titin; 47. DR FunFam; 2.60.40.10:FF:000800; Cardiac titin; 1. DR FunFam; 2.60.40.10:FF:000345; Muscle M-line assembly protein unc-89; 1. DR FunFam; 2.60.40.10:FF:001284; Myomesin 2; 1. DR FunFam; 2.60.40.10:FF:000147; Myosin light chain kinase; 2. DR FunFam; 2.60.40.10:FF:000107; Myosin, light chain kinase a; 3. DR FunFam; 2.60.40.10:FF:000031; Myosin-binding protein C, slow type; 7. DR FunFam; 1.10.510.10:FF:000329; Titin a; 1. DR FunFam; 2.60.40.10:FF:000002; Titin a; 32. DR FunFam; 2.60.40.10:FF:000112; Titin a; 8. DR FunFam; 2.60.40.10:FF:000135; Titin a; 6. DR FunFam; 2.60.40.10:FF:000160; Titin a; 1. DR FunFam; 2.60.40.10:FF:000547; Titin a; 2. DR FunFam; 2.60.40.10:FF:000672; Titin a; 1. DR FunFam; 2.60.40.10:FF:000673; Titin a; 1. DR FunFam; 2.60.40.10:FF:000811; Titin a; 1. DR FunFam; 2.60.40.10:FF:000867; Titin a; 1. DR FunFam; 2.60.40.10:FF:000891; Titin a; 1. DR FunFam; 2.60.40.10:FF:000900; Titin a; 1. DR FunFam; 2.60.40.10:FF:000981; Titin a; 1. DR FunFam; 2.60.40.10:FF:001200; Titin a; 1. DR FunFam; 2.60.40.10:FF:001399; Titin a; 1. DR FunFam; 2.60.40.10:FF:001400; Titin a; 1. DR FunFam; 2.60.40.10:FF:001459; Titin a; 1. DR FunFam; 2.60.40.10:FF:001500; Titin a; 1. DR FunFam; 2.60.40.10:FF:001579; Titin a; 1. DR FunFam; 2.60.40.10:FF:001697; Titin a; 1. DR FunFam; 3.30.200.20:FF:000286; Titin a; 1. DR FunFam; 2.60.40.10:FF:000011; Titin b; 11. DR FunFam; 2.60.40.10:FF:000629; Titin b; 1. DR FunFam; 2.60.40.10:FF:000635; Titin b; 1. DR FunFam; 2.60.40.10:FF:000779; Titin b; 1. DR FunFam; 2.60.40.10:FF:000833; Titin b; 1. DR FunFam; 2.60.40.10:FF:000859; Titin b; 1. DR FunFam; 2.60.40.10:FF:000864; Titin b; 1. DR FunFam; 2.60.40.10:FF:000901; Titin b; 1. DR FunFam; 2.60.40.10:FF:000980; Titin b; 2. DR FunFam; 2.60.40.10:FF:000986; Titin b; 1. DR FunFam; 2.60.40.10:FF:001115; Titin b; 1. DR FunFam; 2.60.40.10:FF:001190; Titin b; 1. DR FunFam; 2.60.40.10:FF:001477; Titin b; 1. DR FunFam; 2.60.40.10:FF:000034; Titin isoform A; 26. DR FunFam; 2.60.40.10:FF:000050; Titin isoform B; 8. DR FunFam; 2.60.40.10:FF:000003; Titin isoform E; 21. DR FunFam; 2.60.40.10:FF:000012; titin isoform X1; 27. DR FunFam; 2.60.40.10:FF:000073; titin isoform X1; 5. DR FunFam; 2.60.40.10:FF:000127; titin isoform X1; 4. DR FunFam; 2.60.40.10:FF:000148; titin isoform X1; 4. DR FunFam; 2.60.40.10:FF:000214; titin isoform X1; 8. DR FunFam; 2.60.40.10:FF:000218; titin isoform X1; 3. DR FunFam; 2.60.40.10:FF:000659; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:000697; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:000770; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:000792; titin isoform X1; 2. DR FunFam; 2.60.40.10:FF:000983; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001003; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001213; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001229; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001272; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001327; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001328; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001342; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001343; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001344; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001345; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001350; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001365; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001367; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001382; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001385; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001408; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001430; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001434; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001454; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001476; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001544; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001581; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001610; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001612; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:001663; titin isoform X1; 1. DR FunFam; 2.60.40.10:FF:000714; Titin novex-3; 3. DR FunFam; 2.60.40.10:FF:001082; Titin novex-3; 1. DR FunFam; 2.60.40.10:FF:001089; Titin novex-3; 1. DR FunFam; 2.60.40.10:FF:001098; Titin novex-3; 1. DR FunFam; 2.60.40.10:FF:001804; Titin, isoform CRA_a; 1. DR FunFam; 2.60.40.10:FF:001844; Titin, isoform CRA_a; 1. DR FunFam; 2.60.40.10:FF:002231; Titin, isoform CRA_a; 1. DR FunFam; 2.60.40.10:FF:002123; Titin, tandem duplicate 1; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 299. DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR040849; MyBP-C_THB. DR InterPro; IPR004168; PPAK_motif. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR015129; Titin_Z_rpt. DR InterPro; IPR008266; Tyr_kinase_AS. DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1. DR PANTHER; PTHR14340:SF13; TITIN; 1. DR Pfam; PF00041; fn3; 132. DR Pfam; PF07679; I-set; 162. DR Pfam; PF00069; Pkinase; 1. DR Pfam; PF02818; PPAK; 10. DR Pfam; PF18362; THB; 1. DR Pfam; PF09042; Titin_Z; 2. DR SMART; SM00060; FN3; 132. DR SMART; SM00409; IG; 167. DR SMART; SM00408; IGc2; 149. DR SMART; SM00406; IGv; 23. DR SUPFAM; SSF49265; Fibronectin type III; 74. DR SUPFAM; SSF48726; Immunoglobulin; 167. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS50853; FN3; 132. DR PROSITE; PS50835; IG_LIKE; 144. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PDBsum; 6YJ0; -. DR PDBsum; 8Q6T; -. DR PDBsum; 9IBI; -. DR PDBsum; 9IBK; -. DR PDBsum; 9RHK; -. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; ATP-binding; Calcium; KW Calmodulin-binding; Coiled coil; Cytoplasm; Direct protein sequencing; KW Disulfide bond; Immunoglobulin domain; Kelch repeat; Kinase; Magnesium; KW Metal-binding; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; KW Reference proteome; Repeat; Serine/threonine-protein kinase; TPR repeat; KW Transferase; WD repeat. FT CHAIN 1..35213 FT /note="Titin" FT /id="PRO_0000311696" FT DOMAIN 6..98 FT /note="Ig-like 1" FT /evidence="ECO:0000255" FT DOMAIN 104..192 FT /note="Ig-like 2" FT /evidence="ECO:0000255" FT REPEAT 412..454 FT /note="Z-repeat 1" FT /evidence="ECO:0000255" FT REPEAT 463..504 FT /note="Z-repeat 2" FT /evidence="ECO:0000255" FT REPEAT 509..548 FT /note="Z-repeat 3" FT /evidence="ECO:0000255" FT REPEAT 553..594 FT /note="Z-repeat 4" FT /evidence="ECO:0000255" FT REPEAT 599..640 FT /note="Z-repeat 5" FT /evidence="ECO:0000255" FT REPEAT 645..686 FT /note="Z-repeat 6" FT /evidence="ECO:0000255" FT DOMAIN 946..1034 FT /note="Ig-like 3" FT /evidence="ECO:0000255" FT DOMAIN 1084..1174 FT /note="Ig-like 4" FT /evidence="ECO:0000255" FT DOMAIN 1293..1384 FT /note="Ig-like 5" FT /evidence="ECO:0000255" FT DOMAIN 1463..1552 FT /note="Ig-like 6" FT /evidence="ECO:0000255" FT DOMAIN 1562..1652 FT /note="Ig-like 7" FT /evidence="ECO:0000255" FT DOMAIN 1709..1799 FT /note="Ig-like 8" FT /evidence="ECO:0000255" FT DOMAIN 1847..1934 FT /note="Ig-like 9" FT /evidence="ECO:0000255" FT DOMAIN 2084..2173 FT /note="Ig-like 10" FT /evidence="ECO:0000255" FT REPEAT 2095..2128 FT /note="TPR 1" FT /evidence="ECO:0000255" FT DOMAIN 2177..2268 FT /note="Ig-like 11" FT /evidence="ECO:0000255" FT DOMAIN 2270..2356 FT /note="Ig-like 12" FT /evidence="ECO:0000255" FT DOMAIN 2359..2449 FT /note="Ig-like 13" FT /evidence="ECO:0000255" FT DOMAIN 2436..2535 FT /note="Ig-like 14" FT /evidence="ECO:0000255" FT DOMAIN 2626..2709 FT /note="Ig-like 15" FT /evidence="ECO:0000255" FT REPEAT 2810..2844 FT /note="TPR 2" FT /evidence="ECO:0000255" FT DOMAIN 2886..2971 FT /note="Ig-like 16" FT /evidence="ECO:0000255" FT REPEAT 3028..3068 FT /note="WD 1" FT /evidence="ECO:0000255" FT DOMAIN 3064..3147 FT /note="Ig-like 17" FT /evidence="ECO:0000255" FT REPEAT 3208..3248 FT /note="WD 2" FT /evidence="ECO:0000255" FT DOMAIN 3245..3333 FT /note="Ig-like 18" FT /evidence="ECO:0000255" FT DOMAIN 3350..3438 FT /note="Ig-like 19" FT /evidence="ECO:0000255" FT DOMAIN 3509..3599 FT /note="Ig-like 20" FT /evidence="ECO:0000255" FT DOMAIN 3625..3716 FT /note="Ig-like 21" FT /evidence="ECO:0000255" FT DOMAIN 4251..4337 FT /note="Ig-like 22" FT /evidence="ECO:0000255" FT DOMAIN 4344..4432 FT /note="Ig-like 23" FT /evidence="ECO:0000255" FT DOMAIN 4439..4527 FT /note="Ig-like 24" FT /evidence="ECO:0000255" FT DOMAIN 4532..4620 FT /note="Ig-like 25" FT /evidence="ECO:0000255" FT DOMAIN 4625..4716 FT /note="Ig-like 26" FT /evidence="ECO:0000255" FT DOMAIN 4719..4807 FT /note="Ig-like 27" FT /evidence="ECO:0000255" FT DOMAIN 4812..4897 FT /note="Ig-like 28" FT /evidence="ECO:0000255" FT DOMAIN 4904..4993 FT /note="Ig-like 29" FT /evidence="ECO:0000255" FT DOMAIN 5001..5089 FT /note="Ig-like 30" FT /evidence="ECO:0000255" FT DOMAIN 5094..5182 FT /note="Ig-like 31" FT /evidence="ECO:0000255" FT REPEAT 5131..5164 FT /note="TPR 3" FT /evidence="ECO:0000255" FT DOMAIN 5186..5276 FT /note="Ig-like 32" FT /evidence="ECO:0000255" FT DOMAIN 5281..5369 FT /note="Ig-like 33" FT /evidence="ECO:0000255" FT DOMAIN 5374..5462 FT /note="Ig-like 34" FT /evidence="ECO:0000255" FT DOMAIN 5466..5555 FT /note="Ig-like 35" FT /evidence="ECO:0000255" FT DOMAIN 5563..5651 FT /note="Ig-like 36" FT /evidence="ECO:0000255" FT DOMAIN 5656..5744 FT /note="Ig-like 37" FT /evidence="ECO:0000255" FT DOMAIN 5749..5838 FT /note="Ig-like 38" FT /evidence="ECO:0000255" FT DOMAIN 5842..5931 FT /note="Ig-like 39" FT /evidence="ECO:0000255" FT DOMAIN 5936..6024 FT /note="Ig-like 40" FT /evidence="ECO:0000255" FT DOMAIN 6028..6117 FT /note="Ig-like 41" FT /evidence="ECO:0000255" FT DOMAIN 6125..6213 FT /note="Ig-like 42" FT /evidence="ECO:0000255" FT DOMAIN 6218..6308 FT /note="Ig-like 43" FT /evidence="ECO:0000255" FT DOMAIN 6311..6401 FT /note="Ig-like 44" FT /evidence="ECO:0000255" FT DOMAIN 6405..6493 FT /note="Ig-like 45" FT /evidence="ECO:0000255" FT REPEAT 6435..6468 FT /note="TPR 4" FT /evidence="ECO:0000255" FT DOMAIN 6498..6587 FT /note="Ig-like 46" FT /evidence="ECO:0000255" FT DOMAIN 6591..6682 FT /note="Ig-like 47" FT /evidence="ECO:0000255" FT REPEAT 6615..6653 FT /note="WD 3" FT /evidence="ECO:0000255" FT DOMAIN 6688..6776 FT /note="Ig-like 48" FT /evidence="ECO:0000255" FT DOMAIN 6781..6869 FT /note="Ig-like 49" FT /evidence="ECO:0000255" FT DOMAIN 6873..6962 FT /note="Ig-like 50" FT /evidence="ECO:0000255" FT DOMAIN 6966..7054 FT /note="Ig-like 51" FT /evidence="ECO:0000255" FT DOMAIN 7063..7151 FT /note="Ig-like 52" FT /evidence="ECO:0000255" FT DOMAIN 7159..7247 FT /note="Ig-like 53" FT /evidence="ECO:0000255" FT DOMAIN 7252..7343 FT /note="Ig-like 54" FT /evidence="ECO:0000255" FT DOMAIN 7346..7434 FT /note="Ig-like 55" FT /evidence="ECO:0000255" FT DOMAIN 7439..7528 FT /note="Ig-like 56" FT /evidence="ECO:0000255" FT DOMAIN 7532..7623 FT /note="Ig-like 57" FT /evidence="ECO:0000255" FT DOMAIN 7629..7717 FT /note="Ig-like 58" FT /evidence="ECO:0000255" FT DOMAIN 7722..7810 FT /note="Ig-like 59" FT /evidence="ECO:0000255" FT DOMAIN 7814..7903 FT /note="Ig-like 60" FT /evidence="ECO:0000255" FT DOMAIN 7907..7996 FT /note="Ig-like 61" FT /evidence="ECO:0000255" FT DOMAIN 8004..8094 FT /note="Ig-like 62" FT /evidence="ECO:0000255" FT DOMAIN 8099..8190 FT /note="Ig-like 63" FT /evidence="ECO:0000255" FT DOMAIN 8193..8282 FT /note="Ig-like 64" FT /evidence="ECO:0000255" FT DOMAIN 8287..8375 FT /note="Ig-like 65" FT /evidence="ECO:0000255" FT DOMAIN 8380..8469 FT /note="Ig-like 66" FT /evidence="ECO:0000255" FT DOMAIN 8473..8564 FT /note="Ig-like 67" FT /evidence="ECO:0000255" FT DOMAIN 8570..8658 FT /note="Ig-like 68" FT /evidence="ECO:0000255" FT DOMAIN 8663..8751 FT /note="Ig-like 69" FT /evidence="ECO:0000255" FT DOMAIN 8755..8844 FT /note="Ig-like 70" FT /evidence="ECO:0000255" FT DOMAIN 8849..8937 FT /note="Ig-like 71" FT /evidence="ECO:0000255" FT DOMAIN 8945..9035 FT /note="Ig-like 72" FT /evidence="ECO:0000255" FT DOMAIN 9040..9129 FT /note="Ig-like 73" FT /evidence="ECO:0000255" FT DOMAIN 9137..9226 FT /note="Ig-like 74" FT /evidence="ECO:0000255" FT REPEAT 9145..9182 FT /note="TPR 5" FT /evidence="ECO:0000255" FT DOMAIN 9233..9322 FT /note="Ig-like 75" FT /evidence="ECO:0000255" FT DOMAIN 9331..9431 FT /note="Ig-like 76" FT /evidence="ECO:0000255" FT DOMAIN 9621..9716 FT /note="Ig-like 77" FT /evidence="ECO:0000255" FT REPEAT 9662..9695 FT /note="TPR 6" FT /evidence="ECO:0000255" FT DOMAIN 9721..9812 FT /note="Ig-like 78" FT /evidence="ECO:0000255" FT REPEAT 9865..9892 FT /note="PEVK 1" FT /evidence="ECO:0000255" FT REPEAT 9940..9963 FT /note="PEVK 2" FT /evidence="ECO:0000255" FT REPEAT 9991..10024 FT /note="TPR 7" FT /evidence="ECO:0000255" FT REPEAT 10001..10050 FT /note="Kelch 1" FT /evidence="ECO:0000255" FT REPEAT 10062..10085 FT /note="PEVK 3" FT /evidence="ECO:0000255" FT REPEAT 10091..10115 FT /note="PEVK 4" FT /evidence="ECO:0000255" FT REPEAT 10145..10169 FT /note="PEVK 5" FT /evidence="ECO:0000255" FT REPEAT 10170..10197 FT /note="PEVK 6" FT /evidence="ECO:0000255" FT REPEAT 10198..10225 FT /note="PEVK 7" FT /evidence="ECO:0000255" FT REPEAT 10227..10254 FT /note="PEVK 8" FT /evidence="ECO:0000255" FT REPEAT 10255..10281 FT /note="PEVK 9" FT /evidence="ECO:0000255" FT REPEAT 10282..10307 FT /note="PEVK 10" FT /evidence="ECO:0000255" FT REPEAT 10308..10332 FT /note="PEVK 11" FT /evidence="ECO:0000255" FT REPEAT 10333..10359 FT /note="PEVK 12" FT /evidence="ECO:0000255" FT REPEAT 10397..10431 FT /note="TPR 8" FT /evidence="ECO:0000255" FT REPEAT 10404..10427 FT /note="PEVK 13" FT /evidence="ECO:0000255" FT REPEAT 10451..10476 FT /note="PEVK 14" FT /evidence="ECO:0000255" FT REPEAT 10477..10504 FT /note="PEVK 15" FT /evidence="ECO:0000255" FT REPEAT 10505..10532 FT /note="PEVK 16" FT /evidence="ECO:0000255" FT REPEAT 10533..10560 FT /note="PEVK 17" FT /evidence="ECO:0000255" FT REPEAT 10561..10588 FT /note="PEVK 18" FT /evidence="ECO:0000255" FT REPEAT 10683..10707 FT /note="PEVK 19" FT /evidence="ECO:0000255" FT REPEAT 10709..10734 FT /note="PEVK 20" FT /evidence="ECO:0000255" FT REPEAT 10739..10764 FT /note="PEVK 21" FT /evidence="ECO:0000255" FT REPEAT 10765..10790 FT /note="PEVK 22" FT /evidence="ECO:0000255" FT REPEAT 10850..10877 FT /note="PEVK 23" FT /evidence="ECO:0000255" FT REPEAT 10878..10903 FT /note="PEVK 24" FT /evidence="ECO:0000255" FT REPEAT 10904..10931 FT /note="PEVK 25" FT /evidence="ECO:0000255" FT REPEAT 10932..10959 FT /note="PEVK 26" FT /evidence="ECO:0000255" FT REPEAT 10960..10987 FT /note="PEVK 27" FT /evidence="ECO:0000255" FT REPEAT 10988..11011 FT /note="PEVK 28" FT /evidence="ECO:0000255" FT REPEAT 11084..11109 FT /note="PEVK 29" FT /evidence="ECO:0000255" FT REPEAT 11111..11135 FT /note="PEVK 30" FT /evidence="ECO:0000255" FT REPEAT 11136..11160 FT /note="PEVK 31" FT /evidence="ECO:0000255" FT REPEAT 11161..11188 FT /note="PEVK 32" FT /evidence="ECO:0000255" FT REPEAT 11201..11225 FT /note="PEVK 33" FT /evidence="ECO:0000255" FT REPEAT 11226..11248 FT /note="PEVK 34" FT /evidence="ECO:0000255" FT REPEAT 11249..11272 FT /note="PEVK 35" FT /evidence="ECO:0000255" FT REPEAT 11273..11295 FT /note="PEVK 36" FT /evidence="ECO:0000255" FT REPEAT 11373..11400 FT /note="PEVK 37" FT /evidence="ECO:0000255" FT REPEAT 11401..11425 FT /note="PEVK 38" FT /evidence="ECO:0000255" FT REPEAT 11426..11453 FT /note="PEVK 39" FT /evidence="ECO:0000255" FT REPEAT 11454..11481 FT /note="PEVK 40" FT /evidence="ECO:0000255" FT REPEAT 11508..11533 FT /note="PEVK 41" FT /evidence="ECO:0000255" FT REPEAT 11562..11587 FT /note="PEVK 42" FT /evidence="ECO:0000255" FT REPEAT 11671..11698 FT /note="PEVK 43" FT /evidence="ECO:0000255" FT REPEAT 11700..11726 FT /note="PEVK 44" FT /evidence="ECO:0000255" FT REPEAT 11727..11754 FT /note="PEVK 45" FT /evidence="ECO:0000255" FT REPEAT 11755..11782 FT /note="PEVK 46" FT /evidence="ECO:0000255" FT REPEAT 11783..11810 FT /note="PEVK 47" FT /evidence="ECO:0000255" FT REPEAT 11811..11838 FT /note="PEVK 48" FT /evidence="ECO:0000255" FT REPEAT 11839..11866 FT /note="PEVK 49" FT /evidence="ECO:0000255" FT REPEAT 11867..11895 FT /note="PEVK 50" FT /evidence="ECO:0000255" FT REPEAT 11896..11923 FT /note="PEVK 51" FT /evidence="ECO:0000255" FT REPEAT 11924..11950 FT /note="PEVK 52" FT /evidence="ECO:0000255" FT REPEAT 11954..11977 FT /note="PEVK 53" FT /evidence="ECO:0000255" FT REPEAT 11979..11999 FT /note="PEVK 54" FT /evidence="ECO:0000255" FT REPEAT 12004..12026 FT /note="PEVK 55" FT /evidence="ECO:0000255" FT REPEAT 12051..12077 FT /note="PEVK 56" FT /evidence="ECO:0000255" FT REPEAT 12080..12104 FT /note="PEVK 57" FT /evidence="ECO:0000255" FT REPEAT 12105..12126 FT /note="PEVK 58" FT /evidence="ECO:0000255" FT REPEAT 12129..12154 FT /note="PEVK 59" FT /evidence="ECO:0000255" FT REPEAT 12155..12182 FT /note="PEVK 60" FT /evidence="ECO:0000255" FT REPEAT 12183..12210 FT /note="PEVK 61" FT /evidence="ECO:0000255" FT REPEAT 12211..12238 FT /note="PEVK 62" FT /evidence="ECO:0000255" FT REPEAT 12239..12266 FT /note="PEVK 63" FT /evidence="ECO:0000255" FT REPEAT 12267..12294 FT /note="PEVK 64" FT /evidence="ECO:0000255" FT REPEAT 12295..12322 FT /note="PEVK 65" FT /evidence="ECO:0000255" FT REPEAT 12323..12351 FT /note="PEVK 66" FT /evidence="ECO:0000255" FT REPEAT 12352..12379 FT /note="PEVK 67" FT /evidence="ECO:0000255" FT REPEAT 12380..12404 FT /note="PEVK 68" FT /evidence="ECO:0000255" FT REPEAT 12405..12430 FT /note="PEVK 69" FT /evidence="ECO:0000255" FT REPEAT 12431..12458 FT /note="PEVK 70" FT /evidence="ECO:0000255" FT REPEAT 12459..12486 FT /note="PEVK 71" FT /evidence="ECO:0000255" FT REPEAT 12491..12516 FT /note="PEVK 72" FT /evidence="ECO:0000255" FT REPEAT 12517..12542 FT /note="PEVK 73" FT /evidence="ECO:0000255" FT REPEAT 12543..12570 FT /note="PEVK 74" FT /evidence="ECO:0000255" FT REPEAT 12572..12598 FT /note="PEVK 75" FT /evidence="ECO:0000255" FT REPEAT 12599..12626 FT /note="PEVK 76" FT /evidence="ECO:0000255" FT DOMAIN 12903..12995 FT /note="Ig-like 79" FT /evidence="ECO:0000255" FT DOMAIN 13000..13084 FT /note="Ig-like 80" FT /evidence="ECO:0000255" FT DOMAIN 13361..13446 FT /note="Ig-like 81" FT /evidence="ECO:0000255" FT DOMAIN 13452..13534 FT /note="Ig-like 82" FT /evidence="ECO:0000255" FT DOMAIN 13628..13712 FT /note="Ig-like 83" FT /evidence="ECO:0000255" FT DOMAIN 13807..13894 FT /note="Ig-like 84" FT /evidence="ECO:0000255" FT REPEAT 13817..13850 FT /note="TPR 9" FT /evidence="ECO:0000255" FT DOMAIN 13982..14068 FT /note="Ig-like 85" FT /evidence="ECO:0000255" FT DOMAIN 14072..14157 FT /note="Ig-like 86" FT /evidence="ECO:0000255" FT DOMAIN 14161..14246 FT /note="Ig-like 87" FT /evidence="ECO:0000255" FT DOMAIN 14250..14335 FT /note="Ig-like 88" FT /evidence="ECO:0000255" FT DOMAIN 14341..14424 FT /note="Ig-like 89" FT /evidence="ECO:0000255" FT DOMAIN 14427..14517 FT /note="Ig-like 90" FT /evidence="ECO:0000255" FT DOMAIN 14521..14610 FT /note="Ig-like 91" FT /evidence="ECO:0000255" FT REPEAT 14576..14615 FT /note="WD 4" FT /evidence="ECO:0000255" FT DOMAIN 14611..14695 FT /note="Ig-like 92" FT /evidence="ECO:0000255" FT DOMAIN 14789..14874 FT /note="Ig-like 93" FT /evidence="ECO:0000255" FT DOMAIN 14881..14976 FT /note="Fibronectin type-III 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 14946..14998 FT /note="RCC1 1" FT /evidence="ECO:0000255" FT DOMAIN 14982..15077 FT /note="Fibronectin type-III 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 15047..15100 FT /note="RCC1 2" FT /evidence="ECO:0000255" FT DOMAIN 15083..15178 FT /note="Fibronectin type-III 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 15279..15374 FT /note="Fibronectin type-III 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 15379..15476 FT /note="Fibronectin type-III 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 15477..15570 FT /note="Ig-like 94" FT /evidence="ECO:0000255" FT DOMAIN 15575..15668 FT /note="Fibronectin type-III 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 15674..15769 FT /note="Fibronectin type-III 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 15690..15738 FT /note="Kelch 2" FT /evidence="ECO:0000255" FT DOMAIN 15775..15869 FT /note="Fibronectin type-III 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 15794..15839 FT /note="Kelch 3" FT /evidence="ECO:0000255" FT REPEAT 15848..15898 FT /note="Kelch 4" FT /evidence="ECO:0000255" FT DOMAIN 15872..15969 FT /note="Fibronectin type-III 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 15975..16069 FT /note="Fibronectin type-III 10" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 16076..16172 FT /note="Fibronectin type-III 11" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 16176..16264 FT /note="Ig-like 95" FT /evidence="ECO:0000255" FT DOMAIN 16271..16365 FT /note="Fibronectin type-III 12" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 16371..16466 FT /note="Fibronectin type-III 13" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 16436..16492 FT /note="RCC1 3" FT /evidence="ECO:0000255" FT DOMAIN 16470..16586 FT /note="Ig-like 96" FT /evidence="ECO:0000255" FT DOMAIN 16593..16688 FT /note="Fibronectin type-III 14" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 16694..16793 FT /note="Fibronectin type-III 15" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 16794..16887 FT /note="Fibronectin type-III 16" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 16988..17080 FT /note="Fibronectin type-III 17" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 16996..17042 FT /note="WD 5" FT /evidence="ECO:0000255" FT DOMAIN 17086..17180 FT /note="Fibronectin type-III 18" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 17184..17282 FT /note="Ig-like 97" FT /evidence="ECO:0000255" FT DOMAIN 17289..17384 FT /note="Fibronectin type-III 19" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 17309..17355 FT /note="Kelch 5" FT /evidence="ECO:0000255" FT DOMAIN 17390..17490 FT /note="Fibronectin type-III 20" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 17496..17596 FT /note="Fibronectin type-III 21" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 17589..17696 FT /note="Ig-like 98" FT /evidence="ECO:0000255" FT DOMAIN 17703..17796 FT /note="Fibronectin type-III 22" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 17803..17903 FT /note="Fibronectin type-III 23" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 17906..18001 FT /note="Ig-like 99" FT /evidence="ECO:0000255" FT DOMAIN 18009..18102 FT /note="Fibronectin type-III 24" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 18108..18207 FT /note="Fibronectin type-III 25" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 18210..18307 FT /note="Fibronectin type-III 26" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 18311..18398 FT /note="Ig-like 100" FT /evidence="ECO:0000255" FT DOMAIN 18407..18502 FT /note="Fibronectin type-III 27" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 18508..18603 FT /note="Fibronectin type-III 28" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 18573..18631 FT /note="RCC1 4" FT /evidence="ECO:0000255" FT DOMAIN 18607..18696 FT /note="Ig-like 101" FT /evidence="ECO:0000255" FT DOMAIN 18703..18797 FT /note="Fibronectin type-III 29" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 18792..18831 FT /note="WD 6" FT /evidence="ECO:0000255" FT DOMAIN 18803..18898 FT /note="Fibronectin type-III 30" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 18868..18921 FT /note="RCC1 5" FT /evidence="ECO:0000255" FT DOMAIN 18904..19001 FT /note="Fibronectin type-III 31" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 19005..19090 FT /note="Ig-like 102" FT /evidence="ECO:0000255" FT DOMAIN 19101..19195 FT /note="Fibronectin type-III 32" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 19120..19164 FT /note="Kelch 6" FT /evidence="ECO:0000255" FT REPEAT 19165..19220 FT /note="RCC1 6" FT /evidence="ECO:0000255" FT DOMAIN 19201..19293 FT /note="Fibronectin type-III 33" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 19297..19388 FT /note="Ig-like 103" FT /evidence="ECO:0000255" FT REPEAT 19330..19363 FT /note="TPR 10" FT /evidence="ECO:0000255" FT DOMAIN 19395..19494 FT /note="Fibronectin type-III 34" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 19495..19589 FT /note="Fibronectin type-III 35" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 19595..19691 FT /note="Fibronectin type-III 36" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 19695..19786 FT /note="Ig-like 104" FT /evidence="ECO:0000255" FT DOMAIN 19793..19887 FT /note="Fibronectin type-III 37" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 19892..19986 FT /note="Fibronectin type-III 38" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 19990..20081 FT /note="Ig-like 105" FT /evidence="ECO:0000255" FT DOMAIN 20088..20183 FT /note="Fibronectin type-III 39" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 20152..20208 FT /note="RCC1 7" FT /evidence="ECO:0000255" FT DOMAIN 20187..20282 FT /note="Fibronectin type-III 40" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 20252..20305 FT /note="RCC1 8" FT /evidence="ECO:0000255" FT DOMAIN 20288..20389 FT /note="Fibronectin type-III 41" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 20393..20479 FT /note="Ig-like 106" FT /evidence="ECO:0000255" FT DOMAIN 20490..20584 FT /note="Fibronectin type-III 42" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 20509..20554 FT /note="Kelch 7" FT /evidence="ECO:0000255" FT DOMAIN 20590..20685 FT /note="Fibronectin type-III 43" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 20688..20776 FT /note="Ig-like 107" FT /evidence="ECO:0000255" FT DOMAIN 20783..20877 FT /note="Fibronectin type-III 44" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 20880..20978 FT /note="Fibronectin type-III 45" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 20981..21079 FT /note="Fibronectin type-III 46" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 21082..21173 FT /note="Ig-like 108" FT /evidence="ECO:0000255" FT DOMAIN 21180..21273 FT /note="Fibronectin type-III 47" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 21279..21374 FT /note="Fibronectin type-III 48" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 21380..21475 FT /note="Fibronectin type-III 49" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 21578..21672 FT /note="Fibronectin type-III 50" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 21675..21770 FT /note="Fibronectin type-III 51" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 21868..21963 FT /note="Fibronectin type-III 52" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 21887..21932 FT /note="Kelch 8" FT /evidence="ECO:0000255" FT DOMAIN 21967..22062 FT /note="Fibronectin type-III 53" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 22052..22093 FT /note="WD 7" FT /evidence="ECO:0000255" FT DOMAIN 22065..22161 FT /note="Fibronectin type-III 54" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 22084..22129 FT /note="Kelch 9" FT /evidence="ECO:0000255" FT DOMAIN 22165..22257 FT /note="Ig-like 109" FT /evidence="ECO:0000255" FT DOMAIN 22264..22357 FT /note="Fibronectin type-III 55" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 22363..22458 FT /note="Fibronectin type-III 56" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 22428..22482 FT /note="RCC1 9" FT /evidence="ECO:0000255" FT DOMAIN 22464..22559 FT /note="Fibronectin type-III 57" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 22659..22753 FT /note="Fibronectin type-III 58" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 22756..22848 FT /note="Fibronectin type-III 59" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 22950..23044 FT /note="Fibronectin type-III 60" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 23050..23145 FT /note="Fibronectin type-III 61" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 23148..23244 FT /note="Fibronectin type-III 62" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 23168..23212 FT /note="Kelch 10" FT /evidence="ECO:0000255" FT DOMAIN 23248..23339 FT /note="Ig-like 110" FT /evidence="ECO:0000255" FT DOMAIN 23346..23440 FT /note="Fibronectin type-III 63" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 23446..23541 FT /note="Fibronectin type-III 64" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 23547..23643 FT /note="Fibronectin type-III 65" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 23566..23612 FT /note="Kelch 11" FT /evidence="ECO:0000255" FT DOMAIN 23647..23736 FT /note="Ig-like 111" FT /evidence="ECO:0000255" FT DOMAIN 23743..23838 FT /note="Fibronectin type-III 66" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 23840..23933 FT /note="Fibronectin type-III 67" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 23903..23953 FT /note="RCC1 10" FT /evidence="ECO:0000255" FT DOMAIN 23937..24025 FT /note="Ig-like 112" FT /evidence="ECO:0000255" FT DOMAIN 24032..24126 FT /note="Fibronectin type-III 68" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 24041..24087 FT /note="WD 8" FT /evidence="ECO:0000255" FT DOMAIN 24132..24227 FT /note="Fibronectin type-III 69" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 24230..24325 FT /note="Fibronectin type-III 70" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 24330..24417 FT /note="Ig-like 113" FT /evidence="ECO:0000255" FT DOMAIN 24428..24522 FT /note="Fibronectin type-III 71" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 24513..24556 FT /note="WD 9" FT /evidence="ECO:0000255" FT DOMAIN 24528..24623 FT /note="Fibronectin type-III 72" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 24629..24725 FT /note="Fibronectin type-III 73" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 24729..24816 FT /note="Ig-like 114" FT /evidence="ECO:0000255" FT DOMAIN 24825..24919 FT /note="Fibronectin type-III 74" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 24922..25015 FT /note="Fibronectin type-III 75" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 24941..24986 FT /note="Kelch 12" FT /evidence="ECO:0000255" FT DOMAIN 25019..25108 FT /note="Ig-like 115" FT /evidence="ECO:0000255" FT DOMAIN 25114..25208 FT /note="Fibronectin type-III 76" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 25123..25169 FT /note="WD 10" FT /evidence="ECO:0000255" FT DOMAIN 25214..25308 FT /note="Fibronectin type-III 77" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 25312..25408 FT /note="Fibronectin type-III 78" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 25412..25503 FT /note="Ig-like 116" FT /evidence="ECO:0000255" FT DOMAIN 25510..25604 FT /note="Fibronectin type-III 79" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 25610..25705 FT /note="Fibronectin type-III 80" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 25711..25807 FT /note="Fibronectin type-III 81" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 25730..25778 FT /note="Kelch 13" FT /evidence="ECO:0000255" FT REPEAT 25891..25935 FT /note="WD 11" FT /evidence="ECO:0000255" FT DOMAIN 25907..26002 FT /note="Fibronectin type-III 82" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 26004..26097 FT /note="Fibronectin type-III 83" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 26101..26187 FT /note="Ig-like 117" FT /evidence="ECO:0000255" FT DOMAIN 26197..26290 FT /note="Fibronectin type-III 84" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 26281..26324 FT /note="WD 12" FT /evidence="ECO:0000255" FT DOMAIN 26296..26390 FT /note="Fibronectin type-III 85" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 26394..26489 FT /note="Fibronectin type-III 86" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 26494..26584 FT /note="Ig-like 118" FT /evidence="ECO:0000255" FT DOMAIN 26593..26687 FT /note="Fibronectin type-III 87" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 26693..26788 FT /note="Fibronectin type-III 88" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 26794..26890 FT /note="Fibronectin type-III 89" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 26894..26983 FT /note="Ig-like 119" FT /evidence="ECO:0000255" FT DOMAIN 26990..27084 FT /note="Fibronectin type-III 90" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 27087..27180 FT /note="Fibronectin type-III 91" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 27168..27272 FT /note="Ig-like 120" FT /evidence="ECO:0000255" FT DOMAIN 27279..27372 FT /note="Fibronectin type-III 92" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 27363..27406 FT /note="WD 13" FT /evidence="ECO:0000255" FT DOMAIN 27378..27475 FT /note="Fibronectin type-III 93" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 27476..27572 FT /note="Fibronectin type-III 94" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 27576..27663 FT /note="Ig-like 121" FT /evidence="ECO:0000255" FT DOMAIN 27674..27768 FT /note="Fibronectin type-III 95" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 27774..27869 FT /note="Fibronectin type-III 96" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 27875..27969 FT /note="Fibronectin type-III 97" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 27939..27989 FT /note="RCC1 11" FT /evidence="ECO:0000255" FT DOMAIN 27963..28058 FT /note="Ig-like 122" FT /evidence="ECO:0000255" FT DOMAIN 28069..28164 FT /note="Fibronectin type-III 98" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 28133..28182 FT /note="RCC1 12" FT /evidence="ECO:0000255" FT DOMAIN 28166..28259 FT /note="Fibronectin type-III 99" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 28185..28230 FT /note="Kelch 14" FT /evidence="ECO:0000255" FT DOMAIN 28361..28455 FT /note="Fibronectin type-III 100" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 28461..28556 FT /note="Fibronectin type-III 101" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 28559..28655 FT /note="Fibronectin type-III 102" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 28659..28750 FT /note="Ig-like 123" FT /evidence="ECO:0000255" FT REPEAT 28669..28706 FT /note="TPR 11" FT /evidence="ECO:0000255" FT DOMAIN 28757..28851 FT /note="Fibronectin type-III 103" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 28857..28952 FT /note="Fibronectin type-III 104" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 28923..28957 FT /note="TPR 12" FT /evidence="ECO:0000255" FT DOMAIN 28958..29054 FT /note="Fibronectin type-III 105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 29058..29148 FT /note="Ig-like 124" FT /evidence="ECO:0000255" FT DOMAIN 29157..29251 FT /note="Fibronectin type-III 106" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 29254..29346 FT /note="Fibronectin type-III 107" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 29350..29439 FT /note="Ig-like 125" FT /evidence="ECO:0000255" FT DOMAIN 29445..29542 FT /note="Fibronectin type-III 108" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 29468..29513 FT /note="Kelch 15" FT /evidence="ECO:0000255" FT REPEAT 29533..29576 FT /note="WD 14" FT /evidence="ECO:0000255" FT DOMAIN 29548..29643 FT /note="Fibronectin type-III 109" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 29646..29741 FT /note="Fibronectin type-III 110" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 29745..29836 FT /note="Ig-like 126" FT /evidence="ECO:0000255" FT DOMAIN 29844..29937 FT /note="Fibronectin type-III 111" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 29943..30039 FT /note="Fibronectin type-III 112" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 30045..30140 FT /note="Fibronectin type-III 113" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 30144..30229 FT /note="Ig-like 127" FT /evidence="ECO:0000255" FT DOMAIN 30240..30335 FT /note="Fibronectin type-III 114" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 30337..30430 FT /note="Fibronectin type-III 115" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 30399..30432 FT /note="TPR 13" FT /evidence="ECO:0000255" FT DOMAIN 30430..30523 FT /note="Ig-like 128" FT /evidence="ECO:0000255" FT DOMAIN 30532..30626 FT /note="Fibronectin type-III 116" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 30632..30727 FT /note="Fibronectin type-III 117" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 30730..30829 FT /note="Fibronectin type-III 118" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 30833..30921 FT /note="Ig-like 129" FT /evidence="ECO:0000255" FT DOMAIN 30932..31025 FT /note="Fibronectin type-III 119" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 31028..31127 FT /note="Fibronectin type-III 120" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 31133..31229 FT /note="Fibronectin type-III 121" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 31233..31322 FT /note="Ig-like 130" FT /evidence="ECO:0000255" FT DOMAIN 31329..31423 FT /note="Fibronectin type-III 122" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 31426..31521 FT /note="Fibronectin type-III 123" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 31525..31616 FT /note="Ig-like 131" FT /evidence="ECO:0000255" FT DOMAIN 31623..31717 FT /note="Fibronectin type-III 124" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 31723..31817 FT /note="Fibronectin type-III 125" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 31742..31787 FT /note="Kelch 16" FT /evidence="ECO:0000255" FT DOMAIN 31824..31920 FT /note="Fibronectin type-III 126" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 31923..32012 FT /note="Ig-like 132" FT /evidence="ECO:0000255" FT DOMAIN 32020..32116 FT /note="Fibronectin type-III 127" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 32120..32216 FT /note="Fibronectin type-III 128" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 32222..32317 FT /note="Fibronectin type-III 129" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 32322..32410 FT /note="Ig-like 133" FT /evidence="ECO:0000255" FT DOMAIN 32515..32610 FT /note="Fibronectin type-III 130" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 32601..32644 FT /note="WD 15" FT /evidence="ECO:0000255" FT DOMAIN 32616..32711 FT /note="Fibronectin type-III 131" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 32717..32807 FT /note="Ig-like 134" FT /evidence="ECO:0000255" FT REPEAT 32754..32799 FT /note="WD 16" FT /evidence="ECO:0000255" FT DOMAIN 32817..32908 FT /note="Ig-like 135" FT /evidence="ECO:0000255" FT DOMAIN 32913..33006 FT /note="Fibronectin type-III 132" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REPEAT 32932..32977 FT /note="Kelch 17" FT /evidence="ECO:0000255" FT DOMAIN 33040..33294 FT /note="Protein kinase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT REPEAT 33152..33189 FT /note="WD 17" FT /evidence="ECO:0000255" FT DOMAIN 33358..33446 FT /note="Ig-like 136" FT /evidence="ECO:0000255" FT REPEAT 33366..33411 FT /note="Kelch 18" FT /evidence="ECO:0000255" FT DOMAIN 33478..33571 FT /note="Ig-like 137" FT /evidence="ECO:0000255" FT DOMAIN 33583..33672 FT /note="Ig-like 138" FT /evidence="ECO:0000255" FT REPEAT 34097..34130 FT /note="TPR 14" FT /evidence="ECO:0000255" FT DOMAIN 34163..34253 FT /note="Ig-like 139" FT /evidence="ECO:0000255" FT DOMAIN 34350..34438 FT /note="Ig-like 140" FT /evidence="ECO:0000255" FT REPEAT 34380..34413 FT /note="TPR 15" FT /evidence="ECO:0000255" FT DOMAIN 34507..34596 FT /note="Ig-like 141" FT /evidence="ECO:0000255" FT DOMAIN 34641..34729 FT /note="Ig-like 142" FT /evidence="ECO:0000255" FT DOMAIN 34923..35011 FT /note="Ig-like 143" FT /evidence="ECO:0000255" FT DOMAIN 35118..35209 FT /note="Ig-like 144" FT /evidence="ECO:0000255" FT REGION 243..315 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 252..340 FT /note="ZIS1" FT /evidence="ECO:0000250|UniProtKB:Q8WZ42" FT REGION 854..889 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1405..1449 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1412..1446 FT /note="ZIS5" FT /evidence="ECO:0000250|UniProtKB:Q8WZ42" FT REGION 4205..4243 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 9873..9910 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 9962..9984 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 9999..10025 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 10163..10258 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 10275..10318 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 10371..10401 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 10436..10513 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 10525..10566 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 10585..10719 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 10859..11270 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 11370..11460 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 11572..11602 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 11630..11655 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 11671..12421 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 12454..12501 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 12561..12894 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 15753..15777 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 16772..16801 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 20167..20195 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 20268..20289 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 27952..27974 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 31800..31832 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 32102..32129 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 34010..34031 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 34080..34118 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 34449..34506 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 34611..34635 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 2031..2058 FT /evidence="ECO:0000255" FT COILED 9495..9538 FT /evidence="ECO:0000255" FT COMPBIAS 877..889 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1405..1420 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 4228..4237 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 9873..9892 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 9893..9907 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10002..10012 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10163..10183 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10204..10225 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10234..10258 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10289..10308 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10309..10318 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10372..10381 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10392..10401 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10445..10468 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10470..10480 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10481..10496 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10585..10616 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10617..10644 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10645..10665 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10677..10686 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10861..10921 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10938..10949 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10966..10986 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11008..11076 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11116..11159 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11165..11199 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11233..11270 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11370..11382 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11396..11424 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11432..11452 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11630..11643 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11671..11681 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11682..11694 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11705..11716 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11721..11730 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11734..11745 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11749..11758 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11761..11772 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11789..11800 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11817..11828 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11829..11854 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11859..11874 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11875..11885 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11887..11901 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11909..11922 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11923..11934 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11962..11989 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12038..12049 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12050..12061 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12111..12125 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12161..12172 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12177..12186 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12190..12201 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12205..12214 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12217..12228 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12245..12256 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12273..12284 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12285..12310 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12315..12326 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12327..12346 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12358..12369 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12386..12403 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12411..12421 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12463..12487 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12561..12589 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12612..12638 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12640..12652 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12657..12667 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12680..12689 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12698..12710 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12718..12739 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12746..12768 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12785..12799 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12811..12821 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12845..12857 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 20180..20195 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 32114..32124 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 34010..34020 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 34093..34104 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 34456..34466 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 34611..34621 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 33160 FT /note="Proton acceptor" FT /evidence="ECO:0000250|UniProtKB:P28523, FT ECO:0000255|PROSITE-ProRule:PRU00159" FT BINDING 33046..33054 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250|UniProtKB:P28523, FT ECO:0000255|PROSITE-ProRule:PRU00159" FT BINDING 33069 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250|UniProtKB:P28523, FT ECO:0000255|PROSITE-ProRule:PRU00159" FT MOD_RES 263 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0007744|PubMed:24129315" FT MOD_RES 264 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 266 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 278 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0007744|PubMed:24129315" FT MOD_RES 286 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0007744|PubMed:24129315" FT MOD_RES 296 FT /note="Asymmetric dimethylarginine; alternate" FT /evidence="ECO:0007744|PubMed:24129315" FT MOD_RES 296 FT /note="Omega-N-methylarginine; alternate" FT /evidence="ECO:0007744|PubMed:24129315" FT MOD_RES 299 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 301 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 304 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0007744|PubMed:24129315" FT MOD_RES 307 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 322 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 756 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 1251 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 1415 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 1420 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 1424 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 1429 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 1434 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 2078 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 2080 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 3516 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 3784 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 8387 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 9144 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:17242355, FT ECO:0007744|PubMed:21183079" FT MOD_RES 9164 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q8WZ42" FT MOD_RES 9168 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:Q8WZ42" FT MOD_RES 9459 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 10281 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 12869 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 12884 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 12972 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 13904 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 21152 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 21895 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 21980 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 22390 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 23387 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q8WZ42" FT MOD_RES 23396 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:Q8WZ42" FT MOD_RES 25920 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 32870 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 33203 FT /note="Phosphotyrosine" FT /evidence="ECO:0000250|UniProtKB:Q8WZ42" FT MOD_RES 33859 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 33861 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 33875 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 33880 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 33915 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 34009 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 34292 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 34464 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 34467 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 34470 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 34476 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 34481 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 34756 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT DISULFID 967..1018 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1730..1783 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2202..2252 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3265..3317 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 4365..4416 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 4460..4511 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 4553..4604 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 4647..4698 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 4740..4791 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 5022..5073 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 5209..5260 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 5584..5635 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 5771..5822 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 5864..5915 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 6146..6197 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 6333..6384 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 6426..6477 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 6709..6760 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 6988..7039 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 7084..7135 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 7180..7231 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 7274..7325 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 7367..7418 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 7650..7701 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 7929..7980 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 8025..8076 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 8121..8172 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 8215..8266 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 8308..8359 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 8591..8642 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 8870..8921 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 8966..9017 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 9062..9113 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 9255..9306 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 9654..9704 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 12929..12979 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 13473..13522 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 13828..13878 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 14095..14145 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 14184..14234 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 14273..14323 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 14633..14683 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 32343..32394 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 33378..33430 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 34526..34580 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT VAR_SEQ 556..601 FT /note="Missing (in isoform 2 and isoform 3)" FT /evidence="ECO:0000305" FT /id="VSP_052606" FT VAR_SEQ 3461..5499 FT /note="IASLLSAEEDFQTYSSDLRLPNANETLELLSEPPARSTQFDSRQEGAAPVFI FT REISDVEISVEDVAKLSVTVTGCPKPKIQWFFNGMLLTPSADYKFVFDGDTHSLIILFT FT RFQDEGEYTCLASNEYGKAVCSAHLRISPRGERSTEMESGEKKALEKPKGPCPPYFFKE FT LKPVHCGPGIPAVFEYSVHGEPAPTVLWFKEDMPLYTSVCYTIIHSPDGSGTFIVNDPQ FT RGDSGLYLCKAQNLWGESTCAAELLVLPEDTDVPDASCKEESTLGVPGDFLETSARGPL FT VQGVDSRQEITAFAEGTISKAALIAEETLQLSYERSVDDSEVGTGVTIGAQKLPPVVLS FT TPQGTGELPSIDGAVHTQPGRGPPPTLNLQAVQAQTTLPKEATLQFEEPEGVFPGASSA FT AQVSPVTIKPLITLTAEPKGNYPQSSTAAPDHALLSSVAAETLQLGEKKIPEVDKAQRA FT LLLSQSLAEGCVESLEVPDVAVSNMRSEPQVPFQHTCTEGKILMASADTLKSTGQDVAL FT RTEEGKSLSFPLALEEKQVLLKEEQSEVVAVPTSQTSKSEKEPEAIKGVKEVREQELLS FT KETLFPSMPEEQRLHLKTQVRRALQAAVAREQANLFSEWLRNIDKVEVTAVNFTQEPKR FT ILCTYLITSVSSLTEELTVTIEDIDPQMANLETGLKDALCSIVCEERNILMAEDPRIHE FT EDKIDVQGGRDHLSDAQKVETVIEAEADSKYLVSKEEVSWSKVESQLKDGDTNEVPQAE FT TLKLAEESGTQKTSTEMSQEEAEGTLADLCPAVLKHLVDTISEEGDTVHLTSSISNAKE FT VHWYFKGNLVPSDGKFKCLKEQNAYTLVIEAVKTEDEGEYVCEASNDSGKAKTSAKLTV FT GERAAPVIKRRIEPLEVALGHLAKFTCEIQGAPNVRFQWFKAGREIYESDKCSIRSSNY FT VSSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKALTTFVGKAA FT KFLCTVSGTPVIEIIWQKDGAALSPSPDCRVTDADNKHSLELSNLTVQDRGIYSCKASN FT KFGADICQAELTIIDKPHFIKELEAVQSAINKKIHLECQVDEDRKVTITWSKDGQKLPA FT GKDYKIYFEDKIASLEIPLAKLKDSGTYTCTASNEAGSSSSSAAVAVREPPSFVKKVDP FT SYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMSFVNSEAILDITDVKVDD FT SGTYSCEATNDVGSDSCSTEVVIKEPPSFIKTLEPADIVRGANALLQCEIAGTGPFEVN FT WFKDKKQIRSSKKYRLFTQKTFVYLEISSFNSADVGDYECVVANEVGKCGCVATHLLKE FT PPTFVKKVDDFTALAGQTVTLQAAVRGSEPISVMWMKGQEVIKEDGKIKMSFSNGVAVL FT TIPDVQISLGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTV FT SGTPELKPKWYKDGRPLVASKKYRISFKNNIAQLKFYSAELHDSGQYTFEISNEVGSSS FT CETTFTVLDRDIAPLFTKPLRNVDSVVGGACRLDCKIAGSLPMRVSWFKDGKELTASDR FT YQIAFVEGTASLEISRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSRDV FT LPGSAVCLKSAFQGSAPLTIKWFKGDKELVSGGSCYITKETSESSLELYAVKTSDSGTY FT TCKVSNVAGSVECSADLFVKEPATFIEKLEPSQLLKKGDGTQLACKVTGTPPIKITWFA FT NDRELRESSKHKMSFAESTAVLRLTDVAIEDSGEYMCEAQNEAGSDHCTGIVIVKESPY FT FTKEFKSIEVLKEYDVMLLAEVAGTPPFEITWFKDNTTLRSGRKYKTFLQDQLVSLQVL FT KFVAADAGEYQCRVTNEVGSSTCSARVTLREPPSFIKKIEATSSLRGGTAAFQATLKGS FT LPITVTWLKDNDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSA FT LLSVKEPATIMEEAVSIDVTQGDPATLQVKFSGTKEISAK -> ELFEGEADGSGDARG FT AFSDSEDIDHHSLMARRYANRTSSTSSWPEYFKPTFTQKLTFQYALEGEPIVFTCSLVA FT YPTPEMTWFHNNRPIPTGLRRVVRTETDLHQHSSSLEVKRVQGRDSGSYRFLAVNSEGS FT AESSASLHVIQKGQDERYLEFLKRAEQTWENTRGLGERREERIKVGLRFTGSPFNKKQD FT VEEKGMVRTIHFRSASPVRRADYVYNDEWSESKFDIRGCLSVGESFLDEETKMKLQRLR FT EARKIFLEKKKLSLLEASSEVNSVTVRSEDIVGDAPLSREEGKRGFGREFAEDRHRVDN FT SAEGVIENPYSVPNQIHQNREPPSSVRATGDEDLQTENSPDQETFLEESLQKGYLCEHV FT LVGENLQAVEWFEESVTSTVIREPLPFTSNEEVHGYKSRGICESPDKVSQVLTPYPSES FT LDTFVDAKETEDVDSGGGTQRGWQEGQCHASTKVEEFKVEHEEKTRSFENYFQKHPQRC FT PPSFLQDIESQEVYEGDSCKFVCHFQGYPQPIVTWYNNEMPVPRSQGFTTHTFENYSTL FT TFPSVQPQHGGSVTCVLFNQYGTVKATSMLRVKAKPRYESQPHKVPVWPDYADEEEELA FT LVFDQARRIHPSFSQERQEHLHMLKAHLPELPSADRELLSFPVEIQITAATPTPEQNKE FT CRELFELEPEVTPRDQAIQSPKHKFIFSSDITNEPPKMLQEMPRSASCREGNSVMLECL FT ISGEPQPVVMWFHNGVLVKPNQRFEMEEVNCSYRLYINDASSQDSGRYQCVAQNDSGIA FT ESILDLTVEPITYREYSQLENESRIYAQYSKNQQTQVQGEPVRTHFYDHTVSPFAAQSN FT IKEYTIREYFQSLETVGELEKKNEVYCPTTVEKLSKSMQHASRPTDIEKPHRMEFLQCQ FT DEEHIGERSQSLQAGATICPFVDDFSKANIRNKVSDDVGYHGPDWGNMKGHSQSDYVLN FT IHSKRTSNTVQDVEDSPVPTYEEALEEERYYPGKKVRHKVIAFEKLQRAERGVVEKRRT FT KKSFVTAPQKKWDNREFSLTQNEPGSSNMYRAEEVASHTEADSSNIIMDLKQLSSQAHE FT EFEIEERGRQEEILPLDQEKFELEAPVTFDLKQFHSQIESTGMNFQGLANGQQDKSSLK FT TQQPASEMANPEDVVFDLKQMYSHIEDPGEVFQGQETESKQETCHKEEISIYQSFQYAQ FT EENTAILKPDHVPESFSEVIHGEARALFQTPSADVEEANVSETGASVENGDKTFISQLK FT RAASEEECLEDHEMEDGPTLKPAFGMTQGYEGTLENPRGAVHGAEVPHRRLSLSQDLPF FT LMTGEQQDLKEQLSESIEASGEETYHEVHVPSESSFSTMEGEKIEKSLLENLPRLEEAQ FT TTKEGEYETSLTQYLLAEGRYEVPEVRDTKHKAQLVQSDSTTSMEVEEVTFNTVYEYYN FT QKQESVGRPYSPESDISIDVGSTSSEDLSELDQFYSPPSSVENLESPKSPDLYFKPSDR FT IEQPVANSRAEENGERYSTPSEGEIPERYSTPSGEALERYSTPPGEALERYSTPPGEAL FT ERYSTPPGEALERFSTPPGEALERFSTPPGEALERYSTPPGEALERFSTPPGEKLERGF FT IPTRGPNHARNVSRNLSELEREDSTANEHFHTPTDERSSPYETWRSDSFGTPNEAIEPK FT DNEMPPSFIEPLSRRKIYENTTLGFIIEVEGLPVPGVKWYRNKSLLEPDDRIKMERVGN FT VCSLEIANIQKGDGGEYLCHAVNIIGEAKSFAIVDVIPQEERAVALPPPVTHQHIMEFD FT VANSNSSRTPSPQEIVLEVELSEKDVKEFEKQVKIVTVPEFTPDHKSMIVSLDILPLSL FT VDPSAESQGQEGREFKIDLEAFEMPPRFITPICDFRIPENSSAVFKCSVIGIPPPEVRW FT YKEYMCIEPDDTKYVISEEKGSHSLRIQDVGPSDCATYRCRALNSAGEAICRGFLTMGD FT SQVSAVATRTSKVTLSSQKEELVLRSRYADSFFEFQVVDGPPRFIKGISDCHAPLGTAA FT YFQCLVRGSPRPTVSWYKDGKLVQGSRFSAEESGIGFHNLFITGLVKGDEGEYSCVATN FT NSGMARSSAILTLS (in isoform 3)" FT /evidence="ECO:0000305" FT /id="VSP_052607" FT VAR_SEQ 4435..12715 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_052608" FT VAR_SEQ 5500..35213 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000305" FT /id="VSP_052609" FT STRAND 9724..9726 FT /evidence="ECO:0007829|PDB:6YJ0" FT STRAND 9731..9746 FT /evidence="ECO:0007829|PDB:6YJ0" FT STRAND 9751..9756 FT /evidence="ECO:0007829|PDB:6YJ0" FT STRAND 9764..9772 FT /evidence="ECO:0007829|PDB:6YJ0" FT STRAND 9775..9782 FT /evidence="ECO:0007829|PDB:6YJ0" FT HELIX 9785..9787 FT /evidence="ECO:0007829|PDB:6YJ0" FT STRAND 9789..9796 FT /evidence="ECO:0007829|PDB:6YJ0" FT STRAND 9798..9800 FT /evidence="ECO:0007829|PDB:6YJ0" FT STRAND 9803..9809 FT /evidence="ECO:0007829|PDB:6YJ0" FT MOD_RES A2ASS6-3:3432 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES A2ASS6-3:3636 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES A2ASS6-3:3678 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES A2ASS6-3:3763 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES A2ASS6-3:3827 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES A2ASS6-3:3836 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES A2ASS6-3:4672 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES A2ASS6-3:4720 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" SQ SEQUENCE 35213 AA; 3906488 MW; C761D2E29FF1AC14 CRC64; MTTQAPMFTQ PLQSVVVLEG STATFEAHVS GSPVPEVSWF RDGQVISTST LPGVQISFSD GRARLMIPAV TKANSGRYSL RATNGSGQAT STAELLVTAE TAPPNFSQRL QSMTVRQGSQ VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN SVGRATSTAE LVVQGEEVVP AKKTKTIVST AQISETRQTR IEKKIEAHFD ARSIATVEMV IDGATGQLPH KTPPRIPPKP KSRSPTPPSI AAKAQLARQQ SPSPIRHSPS PVRHVRAPTP SPVRSVSPAG RISTSPIRSV KSPLLIRKTQ TTTMATGPEV PPPWKQEGYV ASSTEAEMRE TTMTSSTQIR REERWEGRYG VQEQVTISGA AAAAASASVS SSFTAGAITT GTKEVKQETD KSAAVATVVA AVDMARVREP AISAVEQTAQ RTTTTAVHIQ PAQEQARKEA EKTAVTKVVV AADKAKEQEL KSRTREVMVT TQEQTHISHE QIRKETEKAF VPKVVISATK AKEQETRITG EITTKQEQKR ITQETIRQET EEIAASMVVV ATAKSTKLEA AVGVQEETAI QQDQMHLTHE QMMKETRKTV VPKVIVATPK IKEQDLVSRS REAITTKRDQ VQITQEKKRK EVETTALSTI AVATAKAKEQ ETVLRSREAM ATRQEHIQVT HGQVGVGKKA EAVATVVAAV DQARVREPRE PTHVEESHSQ QTTLEYGYKE HISTTKVPEQ PRRPASEPHV VPQAVKPAVI QAPSETHIKT TDQMGMHISS QVKKTTDIST ERLVHVDKRP RTASPHFTVS KISVPKTEHG YEASIAGSAI ATLQKELSAT SSTQKITKSV KAPTVKPGET RVRAEPTPSP QFPFADMPPP DTYKSQAGIE VKKEVGVSIS GSTVREEHFE VLRGREAKVT ETARVPAPAE VPVTPPTLVS GLKNVTVIEG ESVTLECHIS GYPSPKVTWY REDYQIESSI DFQITFQGGI ARLMIREAFA EDSGRFTCSA VNEAGTVSTS CYLAVQVSEE FDKETTLTEK FATEEKRFVE SRDVVMTDTS ITEEQAGPGE PAAPFFISKP VVQKLVEGGS VVFECQIGGN PKPHVYWKKS GVPLTTGYRY KVSYNKQTGE CRLVISMTFA DDAGEYTIVI RNKHGETSAS ASLLEEADYE ALVKTQQEML YQTQMSTFIQ EPKVGEIAPG FAYSEYEKEY EKEQALIRKK MAKDTVMVRT FVEDQEFHIS SFEERLIKEI EYRIIKTTLE ELLEEDGEEK MAVDISESEA IESGFDIRIK NYRILEGMGV TFHCKMSGYP LPKIAWYKDG KRIRHGERYQ MDFLQDGRAS LRIPVVLPED EGIYTAFASN IKGNAICSGK LYVEPAAPFS APTYMPTPEA VSRIRSVSPR SLSRSPIRMS PAMSPARMSP ARMSPARMSP ARMSPGRRLE ETDESQLERL YKPVFVLKPA SFKCLEGQTA RFDLKVVGRP MPETFWFHNG QQIVNDYTHK VVIKEDGTQS LIIVPASPSD SGEWTVVAQN RAGKSTISVT LTVEAVEHQI KPAFVEKLKN VNIKEGSRLE MKVRATGNPN PDIVWLKNSD IIVPHKYPRI RIEGTRGEAA LKIDSIISQD SAWYTATAIN KAGRDTTRCK VNVEVEFAEP EPERKLIIPR GTYRAKEIAA PELEPLHLRY GQEQWEEGDL YDKEKQQKPF FKKKLTSLRL KRFGPAHFEC RLTPIGDPTM VVEWLHDGKP LEAANRLRMI NEFGYCSLDY GAAYSRDSGV ITCRATNKYG TDHTSATLIV KDEKSLVEES QLPDGKKGLQ RIEELERMAH EGALTGVTTD QKEKQKPDIV LFPEPVRVLE GETARFRCRV TGYPQPKVNW YLNGQLIRKS KRFRVRYDGI HYLDIVDCKS YDTGEVKVTA ENPEGVTEHK VKLEIQQRED FRSVLRRAPE PKPEFHVHEP GKLQFEVQKV DRPVDTSETK EVVKLKRAER ITHEKVSEES EELRSKFKRR TEEGYYEAIT AVELKSRKKD ESYEELLKKT KDELLHWTKE LTEEEKKALA EEGKITIPTF KPERIELSPS MEAPKIFERI QSQTVGQGSD AHFRVRVVGK PDPECEWYKN GVKIERSDRI YWYWPEDNVC ELVIRDVTAE DSASIMVKAI NIAGETSSHA FLLVQAKQLI TFTQELQDVV AKEKDTMATF ECETSEPFIK VKWYKDGIEV HAGDKYRMHS DRKVHFLSVL TIDTSDAEDY SCVLVEDENI KTTAKLIVEG AVVEFVKELQ DIEVPESYSG ELECIISPEN IEGKWYHNDV ELKSNGKYSI TSRRGRQNLT VKDVTKEDQG EYSFVVDGKK TTCKLKMKPR PIAILQGLSD QKVCEGDIVQ LEVKVSLENV EGVWMKDGQE VQHSDRVHIV IDKQSHMLLI EDMTKEDAGN YSFTIPALGL STSGNVSVYS VDVITPLKDV NVIEGTKAVL ECKVSVPDVT SVKWYLNDEQ IKPDDRVQSI VKGTKQRLVI NRTHASDEGP YKLMVGRVET SCNLSVEKIK IIRGLRDLTC TETQNVVFEV ELSHSGIDVV WNFKGKEIKP SSKYKIEAHG KIYKLTVLNM MKDDEGEYAF YAGENTTSGK LTVAGGAIST PLTDQTVAES QEAVFECEVA NPESEGEWLK DGKHLALSNN FRGESDGHKR RLVIAAAKLD DAGEYTYKVA TSKTSAKLKV EAVKIKKTLR NLTVTETQDA VFSVELTHPD VKGVQWIKNG VVLDSNDKYE ISVKGTLYSL KIKNCAMADE SVYGFKLGRL GASARLHVET VKIIKKPKDV TALENATVTF EVSVSHDTVP VKWFHKNVEI KPSDKHRLVS ERKVHKLMLQ SISPSDAGEY TAMVGQLECK AKLFVETLHI TKTMKSIEVP ETKAASFECE VSHFNVPSMW LKNGVEIEMS EKFKIVVQGK LHQLIIMNTS TEDSAEYTFV CGNDQVSATL TVTPIMITSM LKDINAEEKD TITFEVTVNY EGISYKWLKN GVEIKSTDRC QMRTKKLTHS LNIRNVHFGD AADYTFVAGK ATSTATLYVE ARHIEFRKHI KDIKVLEKKR AMFECEVSEP DITVQWMKDG QELQIADRIK IQKEKYVHRL LIPSTRMSDA GKYTVVAGGN MSTANLFVEG RDVRIRSIKK EVQVIEKQRA VVEFEVNEDD VDAHWYKDGI EINFQVQERH QYVVERRIHR MFISETRHSD AGEYTFVAGR NRSSVTLYVN APEPPQVLQE LQPVTVQSGK PARFCAVISG RPQPKISWYK EEQLLSTGFK CKFLHDGQEY TLLLIEAFPE DAAVYTCEAK NDYGVATTSA SLSVEVPEVV SPDQEMPVYP PAIVTPLQDT VTSEGRPARF QCQVSGTDLK VSWYCKDKKI KPSRFFRMTQ FEDTYQLEIA EAYPEDEGTY AFVANNAVGQ VSSTATLRLE APESILHERI GQQIEMEMKE IASLLSAEED FQTYSSDLRL PNANETLELL SEPPARSTQF DSRQEGAAPV FIREISDVEI SVEDVAKLSV TVTGCPKPKI QWFFNGMLLT PSADYKFVFD GDTHSLIILF TRFQDEGEYT CLASNEYGKA VCSAHLRISP RGERSTEMES GEKKALEKPK GPCPPYFFKE LKPVHCGPGI PAVFEYSVHG EPAPTVLWFK EDMPLYTSVC YTIIHSPDGS GTFIVNDPQR GDSGLYLCKA QNLWGESTCA AELLVLPEDT DVPDASCKEE STLGVPGDFL ETSARGPLVQ GVDSRQEITA FAEGTISKAA LIAEETLQLS YERSVDDSEV GTGVTIGAQK LPPVVLSTPQ GTGELPSIDG AVHTQPGRGP PPTLNLQAVQ AQTTLPKEAT LQFEEPEGVF PGASSAAQVS PVTIKPLITL TAEPKGNYPQ SSTAAPDHAL LSSVAAETLQ LGEKKIPEVD KAQRALLLSQ SLAEGCVESL EVPDVAVSNM RSEPQVPFQH TCTEGKILMA SADTLKSTGQ DVALRTEEGK SLSFPLALEE KQVLLKEEQS EVVAVPTSQT SKSEKEPEAI KGVKEVREQE LLSKETLFPS MPEEQRLHLK TQVRRALQAA VAREQANLFS EWLRNIDKVE VTAVNFTQEP KRILCTYLIT SVSSLTEELT VTIEDIDPQM ANLETGLKDA LCSIVCEERN ILMAEDPRIH EEDKIDVQGG RDHLSDAQKV ETVIEAEADS KYLVSKEEVS WSKVESQLKD GDTNEVPQAE TLKLAEESGT QKTSTEMSQE EAEGTLADLC PAVLKHLVDT ISEEGDTVHL TSSISNAKEV HWYFKGNLVP SDGKFKCLKE QNAYTLVIEA VKTEDEGEYV CEASNDSGKA KTSAKLTVGE RAAPVIKRRI EPLEVALGHL AKFTCEIQGA PNVRFQWFKA GREIYESDKC SIRSSNYVSS LEILRTQVVD CGEYTCKASN EYGSVSCTAT LTVTEAYPPT FLSRPKALTT FVGKAAKFLC TVSGTPVIEI IWQKDGAALS PSPDCRVTDA DNKHSLELSN LTVQDRGIYS CKASNKFGAD ICQAELTIID KPHFIKELEA VQSAINKKIH LECQVDEDRK VTITWSKDGQ KLPAGKDYKI YFEDKIASLE IPLAKLKDSG TYTCTASNEA GSSSSSAAVA VREPPSFVKK VDPSYLMLPG ESARLHCKLK GSPVIQVTWF KNNKELSESN TVRMSFVNSE AILDITDVKV DDSGTYSCEA TNDVGSDSCS TEVVIKEPPS FIKTLEPADI VRGANALLQC EIAGTGPFEV NWFKDKKQIR SSKKYRLFTQ KTFVYLEISS FNSADVGDYE CVVANEVGKC GCVATHLLKE PPTFVKKVDD FTALAGQTVT LQAAVRGSEP ISVMWMKGQE VIKEDGKIKM SFSNGVAVLT IPDVQISLGG KYTCLAENEA GSQTSVGELI VKEPAKIIER AELIQVTAGD PATLEYTVSG TPELKPKWYK DGRPLVASKK YRISFKNNIA QLKFYSAELH DSGQYTFEIS NEVGSSSCET TFTVLDRDIA PLFTKPLRNV DSVVGGACRL DCKIAGSLPM RVSWFKDGKE LTASDRYQIA FVEGTASLEI SRVDMNDAGN FTCRATNSVG SKDSSGALIV QEPPSFVTKP GSRDVLPGSA VCLKSAFQGS APLTIKWFKG DKELVSGGSC YITKETSESS LELYAVKTSD SGTYTCKVSN VAGSVECSAD LFVKEPATFI EKLEPSQLLK KGDGTQLACK VTGTPPIKIT WFANDRELRE SSKHKMSFAE STAVLRLTDV AIEDSGEYMC EAQNEAGSDH CTGIVIVKES PYFTKEFKSI EVLKEYDVML LAEVAGTPPF EITWFKDNTT LRSGRKYKTF LQDQLVSLQV LKFVAADAGE YQCRVTNEVG SSTCSARVTL REPPSFIKKI EATSSLRGGT AAFQATLKGS LPITVTWLKD NDEITEDDNI RMTFENNVAS LYLSGIEVKH DGKYVCQAKN DAGIQRCSAL LSVKEPATIM EEAVSIDVTQ GDPATLQVKF SGTKEISAKW FKDGQELTLG PKYKISVTDT VSILKIISTE KKDSGEYTFE VQNDVGRSSC KASINVLDLI IPPSFTKKLR KMDSIKGSFI DLECIVAGSH PISIQWFKDD QEISASDKHK FSFHDNTAFL EISQLEGTDS GTYTCSATNK AGHSQCSGHL TVKEPPYFVE KPQSQDVNPG TRVQLKALVG GTAPMTIKWF KDNKELHPGA ARSVWKDDTS TILELFSAKA ADSGTYICQL SNDVGTTSSK ATIFVKEPPQ FIKKPSPVLV LRNGQSTTFE CQVTGTPEIR VSWYLDGNEI TDLRKYGISF VDGLATFQIS NARVENSGTY VCEARNDAGT ASCSIELKVK EPPIFIRELE PVEVVKDSDV ELECEVMGTT PFEVTWLKNN KEIRSGKKYT MSEKMSVFYL HITKCDPSDV GEYQCIIANE GGSCACSARV ALKEPPSFIK KIENVTTVLK SSATFQSTVA GSPPISITWL KDDQILEEND NVHISFEDSV ATLQVRSVDN GHSGRYTCQA KNESGIERCY AFLLVQEPAQ IIEKAKSVDV TEKDPVTLEC VVAGTPELKV KWLKDGKQIV PSRYFSMSFE NNVASFRIQS VMKQDSGQYT FKVENDFGSS SCDAYLRVLD QDIPPSFTKK LTKMDKVLGS SIHMECKVSG SLPISAQWFK DGKEISTSAK YRLVCHENTV SLEVSNLELE DTANYTCKVS NVAGDNACSG ILTVKEPPSF LVKPERQQAI PDSTVEFKAV LKGTPPFKIK WLKDDVELVS GPKCFIGLEG STSFLNLYSV DSSKTGQYTC QVTNDVGSDS CTTMLLVTEP PKFVKKLEAS KIIKAGDSAR LECKITGSPE IQVVWYRNEH ELTASDKYQM TFIDSVAVIQ MNSLGTEDSG DFICEAQNPA GSTSCSTKVI VKEPPVFSSF PPIVETLKNT EVSLECELSG TPPFEVVWYK DKRQLRSSKK YKVASKNFHA SIHILNVEST DIGEYHCKAQ NEVGSDACVC AVKLKEPPKF ISKLNSLTVV AGEPAELQAS IEGAQPISVQ WLKEKEEVIR ESENIRISFV NNVATLQFAK VEPANAGKYI CQVKNDGGVR ENMATLTVLE PAVIIEKAGS MTVTVGETCA LECKVAGTPE LSVEWYKDGK LLTSSQKHKF SFYNKISSLK ILSVEKEDAG TYTFQVQNNV GKSSCTAVVD VSDRMVPPSF TRRLKDTGGV LGTSCILECK VAGSSPISIA WFHEKTKIVS GAKYQTTFSD NVCTLQLNSL DSSDMGSYTC VAANVAGSDE CRALLTVQEP PSFVKEPEPL EVLPGKNITF TSVIRGTPPF KVGWFRGARE LVKGNRCNIY FEDTVAELEL FNIDISQSGE YTCVVSNNAG QASCTTRLFV KEPATFVKKL SDHSVEPGKS IILEGTYTGT LPISVTWKKD GVSITPSERC NIVTTEKTCI LEILSSTKGD AGHYSCEIEN EAGRDACDAL VSTLEPPYFV TELEPLEASV GDSVSLQCQV AGTPEITVSW FKGDTKLRST PEYRTYFTNN VATLVFNKVS INDSGEYTCM AENSIGTAAS KTIFRIQERQ LPPSFARQLK DIEQTVGLPV TLTCRLNGSA PIQVCWYRDG VLLRDDENLQ MSFVDNVATL KILQTDLSHS GQYSCSASNP LGTASSTARL TAREPKKSPF FDIKPVSIDV IAGESADFEC HVTGAQPMRV TWSKDNKEIR PGGNYTITCV GNTPHLRILK VGKGDSGQYT CQATNDVGKD MCSAQLSVKE PPKFIKKLDA SKVAKQGESI QLECKISGSP EIKVVWFRND SELHESWKYN MSFVNSVALL TINEASAEDT GDYICEAHNG VGDASCSTAL KVKAPPVFTQ KPPPVGALKG SDVILQCEIS GTPPFEVVWV KDRKQVRSSK KFKITSKNFD TSLHIFNLEA PDIGEYHCKA TNEVGSDTCA CTVKFKEPPR FVKKLSDAST LIGDPVELQA VVEGFQPISV VWLKDKGEVI RESENVRISF VDNIATLQLG SPEASQSGKY VCQIKNDAGM RECSAVLTVL EPATIVEKPE PMTVTTGNPF TLECVVAGTP ELSAKWFKDG RELSSGSRHH ITFVRNLASL KIPSAEMNDK GLYTFEVENR VGKSSCTVSV HVSDRVVPPS FVRRLKDTSA TLGASVVLEC RVSGSAPISV GWFLDGNEII SSPKCQSSFA DNVCTLTLSS LEPSDTGAYT CVAANVAGQD ESSAVLTVQE PPSFEQTPDS VEVLPGMSLT FTSVIRGTPP FKVKWFKGSR ELVSGEACTI SLEDFVTELE LLEVEPGQSG DYSCLVTNDA GSASCTTHLF VKEPATFVKR LADTSVETGS PIVLEATYSG TPPISVSWMK NEYPLSQSPN CGITTTEKSS ILEILESTIE DYAQYACLIE NEAGQDICEA LVSVLEPPYF IEPLEHVEAA IGEPITLQCK VDGTPEIRIS WYKEHTKLRS APAYKMQFKN NVASLVINKV DHSDVGEYTC KAENSVGAVA SSAVLVIKER KLPPSFARKL KDVHETLGFP VAFECRINGS EPLQVSWYKD GELLKDDANL QMSFVHHVAT LQILQTDQSH VGQYNCSASN PLGTASSSAK LILSEHEVPP FFDLKPVSVD LALGESGSFK CHVTGTAPIK ITWAKDNREI RPGGNYKMTL VENTATLTVL KVAKGDAGQY TCYASNVAGK DSCSAQLGVQ EPPRFIKKLD QSRIVKQDEY TRYECKIGGS PEIKVLWYKD EVEIQESSKF RMSFEDSVAI LEMHSLSVED SGDYTCEARN AAGSASSSTS LKVKEPPVFR KKPFPVETLK GADVHLECEL QGTPPFQVSW HKDKRELRSG KKYKIMSENL LTSIHILNVD TADIGEYQCK ATNDVGSDTC VGSVTMKAPP QFVKKLTDIS TIIGKEVQLQ TTIEGAEPIS VAWFKDKGEI VRESDNIWIS YSENIATLQF SRAEPANAGK YTCQIKNDAG MQECYATLSV LEPAAIVEKP ESIKVTTGDT CTLECTVSGT PELSTKWFKD GKELTSDNKY KISFFNKVSG LKIINVVPGD SGVYSFEVQN PVGKDSCKVS IQVSDRIIPP SFTRKLKETN GLSGSSVVME CKVYGSPPIS VLWFHDGNEI SSGRKYQTTL TDNTCALTVN MLEEADAGDY TCIATNVAGS DECSAPLTVR EPPSFVQKPD PMDVLTGSNV TFTSIVKGSP PFTVSWFKGS TELVPGARCN VSLQDSVGEL ELFDVDTSQS GEYTCIVSNE AGRASCTTRL FVKAPAIFVK RLNDYSIEKG KPLILEGTFS GTPPISVTWK KNGINVIASQ RCNITTTEKS AILEILSSTV EDSGQYNCYI ENASGKDSCS AQILILEPPY FVKQLEPVKV TVGDSASLQC QLAGTPEIGV SWYKGDTKLR PTATCKMHFK NNVATLVFTQ VDSSDSGEYI CRAENSVGEV SSSTFLTVQE QKLPPSFSRQ LRDVQETVGL PVVFECAVSG SEPISVSWYK DGKPLKDSPN IQTSFLDNIA TLNIFKTDRS LSGQYSCTAT NPIGSASSGA KLILTEGKNP PFFDIPLAPM DAVVGESADL ECHVTGTQPI KVTWAKDNRE IRSGGNYQIS YLENSAHLTI VKVDKGDSGQ YTCYAVNEVG KDSCTAQLNI KERLIPPSFT KKLSETVEET EGNSFKLEGR VAGSQPITVA WYKNNVEIHP TSNCEIMFKN NALLLQVKRA SMADAGLYTC KATNDAGSAL CTSSIVIKEP KKPPVFDQHL APVTASEGDS VQLSCHVQGS EPIRIQWLKA GREVKPSDRC SFSFASGTAM LELKETAKAD SGDYVCKASN VAGSDTSKCK VTIKEKPAAA PAAKKAAVDG KLFFVSEPQS IRVVEKTTAT FIAKVGGDPI PNVKWTKGKW RQLNQGGRIL IHQKGDEAKL EIRDTTKTDS GLYRCVAFNK HGEIESNVNL QVDERKKQEK IEGDLRAMLK KTPALKKGSG EEEEIDIMEL LKNVDPKEYE KYARMYGITD FRGLLQAFEL LKQSQEEETH RLEIEELEKS ERDEKEFEEL VAFIQQRLTQ TEPVTLIKDI ENQTVLKDND AIFEIDIKIN YPEIKLSWYK GTEKLEPSNK YEISIDGDRH TLRVKNCQPK DQGNYRLVCG PHIASAKLTV IEPAWERHLQ DVTLKEGQTC TMTCQFSVPN VKSEWFRNGR VLKPQGRVKT EVEHKVHKLT IADVRAEDQG QYTCKHEDLE TSAELRIEAE PIQFTKRIQN IVVSEHQSAT FECEVSFDDA IVTWYKGPTE LTESQKYNFR NDGRCHYMTI HNVTPDDEGV YSVIARLEPR GEARSTAELY LTTKEIKLEM KPPDIPDSRV PIPTMPIRAV PPEEIPPAVA PSIPLLLPLP EEKKPPAKRI EVTKKGVKKD TKKVVTKPKE EAPPPPVAKK PPPPTPMIPA KASEIIDVSS KAEEVKITTI TRKKEVHKEK EAVYEREEAV YEKKVHIEPW EEPYEELETE PYTEPYEEPY YEEPDEDYEE IKVEAKKQVH EEWEEDFEEG QEYYEREEGY DEGEEEWEEI YHEREIIQVQ KEVHEELHEK KIPAKVPEKK VPPPKVVKKP VVEKVEKTTR RMEEEKVQVI KVPEVSKKIV PQKPSRTPVQ EEIIEVKVPA VHTKKMVISE EKMFFASHTE EEVSVSVPEV QKKTVTEEKI HVAVSKKIEP PPKVPEPPKK PVPEEVVPVP IPKKVEPPAA KVPEAPKKPV PEEKKPVPIP KKKEPAAPPQ VPEAPKKPAP EEKIPVPVTK KKEAPPAKVP EVQKKVVTEE KIAIITQREE SPPPAVPEIP KKKVPEEKRP VPRKEEVPPP KVPVPPKKAV PEAVVPAPIP KKAPPRAEVS KKTVVEEKRF AAEEKLSVAV PQRVELMRHE EEEWTYSEEE ERVSVSVYRE EERDEEEAEI TEYEVLEEPE EYVVEEKMHF ISKKVEVEPA KVPEKKIIPK PKVPAKIEEP PPTKVPEPPK KIVPEKKVPA PAPKKVPPAK APEESKRPVP EKRAPAEEVG IEEPPPTKVA ERHMKITQEE KVLVAVTKKE APPRARVPEE PKKVAPEERF PKLKPRREEE PPAKVTEVRK RAVKEEKVSI EVPKREPRPT KEVTVTEEKK WSYTREEETV SEHREEEYED YEDYEEYKEF EEYEPTEEYD QYDEYAEREV EHYEEHEEYV TEPKKPVPVK PAQEPVPAKP KAPPPKVLKK AVPEEKAPLP IQKKLKPLPP KAPEEPKKVV EEKIQISITK REKQQVTEPV AKVPMKPKRV VPEAKIPAPT KEVAVPVRVP GVPKKRELEE VVVFKEEVEA HEEYIVEEEE EYVHEEEYVH KEEYVHEEEY VHKEEYIHEE EEHLHEEEET IAEEEVVPVA PVKVPVVPKK PVPEEKKPVP VPKKKEAPPA KVPEIPKKPE EKVPVPIPKK EKAPPAKVPE VPKKPVPEEK PPVPVPKKVE PPPAKVPEVP KKPVPEKKVP APTPKKVEAP PAKVPEVPKK PIPEEKKPTA LLKKMEAPPP KAPKKREVVP VPVALPREEE EEEVPFEEVP EEEILPEEEV PSEEEAPPEE VPPEEEEVLP EEEEVLPEEE EVLPEEEEVQ PEEEALPEIK PKVPKPAPVP KKTVPEKKVP VPVPKKVEPP PPPKVPEIKK KVPEKKVVVP KKEEAPPTKV PEVSKKVEER RIIPPKEEEV PPAEVYEEAE EPTPEEIPEE PPSIEEEEIV EEEEEEEEVL PPRAPEVVKK AVPEAPTPVP KKAEAPPAKV PKKIPEEKVP VPVQKKEAPP AKVPEKKKIP EKKVPVPKKE AVPPAKGKAV FEEKISVAYQ QEELVQERIE LELVEAKVEE AFEEEEFHEV QEYFEEEEFH EVEEFIRVEE RRFQEEHKVE EVHRVIEFLE AEEVEVYEKP KIPPKKGPEV SEKVIPPKKP PTKVIPRKEP PAKVPEVTKK TVVEEKIRAP EEPKVPAPKA PEVPKKITPE EKVREAVPKK PEVPPPKVPE VPKKIIQEEK LPVVLPEDTE IYMYEASEET VIEEEHVTLP QKARLKVAKV PAPPQTVVTE EKTYVTIRKT RETLALKESE TTREAFPELK SYKAVPEIPE PPSPEDLEII EDVLPEKRPP ASKRRKTQLP TAPEAPREMP PEMNTFEEIS VEPEMLPTQV LDTYQEATVE KKTLRISRKK PELPSDEEVP EAPREVVAKK KVLPPQVPEV VPVKVPGAPK EVVSERKSLE EPPKKPAVRP VTVPEEPKEV IPEKKVSLVP PKKPAAPPVT VPEAPEEVFS EDEETLAPPQ EPEAPPAKVP EAPKEVVPEK KVSVVPPKKP EAPPAKVPEA PKEAAPEKKV PVAPKKKPEA PPVKVPEAPK KVVPEKKLPV AAPKKPEAPA AEVPEVPKTA VPQKKIPEAI PPKPESPPLE VPEVPPKEVT PEKKVPAAPP TKPEIPPPKV PEAPQAAVVE EKTPEALPKK AEAAPVPVPQ VQETVPEKTR PVGPPKKPEA TTVPVPKVQK TIPEKTRPEA PPKRPEARTV PETVPEKTRP MAPPKKPEAT TLPVPEVQET VPEKTRPVGP PKKPEATTVP VPEVQETIPE KTRPPKKPEA TPVPVPEVQE TVPEKTRPVG PPKKPEATTV SVPEVQETIP EKTRPAAPPK KPEATAVPET IPEKTRPEAP PKRPEATTVP VPEADQAVVP EKKVPRVPPK KVEAPPITVP EEPKEVIPEK KVSLVPPKKP AAPPVTVPEA PEEVFSEDEE TLAPPQEPEA PPAKVPEAPK EVVPEKKVSV VPPKKPEAPP AKVPEAPKEA APEKKVPVAP KKKPEAPPVK VPEAPKKVVP EKKLPVAAPK KPEAPAAEVP EVPKAAVPQK KIPEAIPPKP ESPPPEVYEE PEEEIVPEEP PEEAVEEPVP APPPKVTEPP KKPVPEKKAP PAVVKKPEPP PAKVPEVPKE APPEKKVPPK KPEAPPAKVP EVPKEVVTEK KVAVPKKPEV PPAKVPEVPK KPVIEEKPAI PVVEKVASPP AEVYEEPEEV TAEEEEPAPA VEEEEYEAPP PPAPVPEEPK KVVPEKKFPV IKKPEAPPPK VPEVPKKAVP VKKVPVVKKP EPPEAEVPEV PKKLVPVKKE PVPVTKKTEV LPEKVPEAPK KITPEKKESV PVPEEPEAPP ASVEETPEET IYEEKATITI GRKETPPVEE REIEKFIQPE EPELEPEPEE IPVQEPEPEK KVIEKPKLKP RPPARPPSPP KEDVKEKMFQ LKAVSKKKVP EKPEVVEKVE PAPLKVPTAE KKVRKLLPEP KPQPKEEVVL KSVLRKKPEE EEPKVEPKKV EKAKKPEEPQ PPPKAVEVEA PPEPTPKERK VPEPAKVPEI KPAIPLPGPE PKPKPEPEVK TMKAPPIEPA PTPIAAPVTA PVVGKKAEAK PKDEAAKPKG PIKGVAKKTP SPIEAERKKL RPGSGGEKPP DEAPFTYQLK AVPLKFVKEI KDIVLTEAES VGSSAIFECL VSPSTAITTW MKDGSNIRES PKHRFIADGK DRKLHIIDVQ LSDAGEYTCV LRLGNKEKTS TAKLIVEELP VRFVKTLEEE VTVVKGQPLY LSCELNKERD VVWRKDGKIV VEKPGRIVPG VIGLMRALTI NDADDTDAGT YTVTVENANN LECSSCVKVV EIIREWLVKP IRDQHVKPKG TAVFTCDIAK DTPNIKWFKG YDEIPLEPND KTEILKEGNH LFLKVKNAMP EDIDEYAVEI EGKRYPAKLT LGEREVELLK PIEDVTIYEK ESASFDAEIS EEDIPGEWKL KGELLRPSPT CEIKAEGGKR FLTLHKVKLD QAGEVLYQAC NAITTAILTV KEIELDFAVP LKDVTVPEKR QARFECVLTR EANVIWSKGP DIIKASDKFD IIADGKKHIL VINDSQFDDE GVYTAEVEGK KTSAQLFVTG IRLKFISPLE DQTVKEGQTA TFVCELSHEK MHVVWFKNDV KLHTTRTVLM SSEGKTYKLE IRETTLDDIS QIKAQVKNLS STANLKVLEA DPYFTVKLHD KTGVEKDEII LKCEVSKDVP VKWFKDGEEI VPSPKHSVKT DGLRRILKIK KAELKDKGEY VCDCGTDTTK ANVTVEARLI KVEKPLYGVE VFVGETARFE IELSEPDVHG QWKLKGEPLT ASPDCEIIED GKKHVLVLYN CQLDMTGEIS FQAANAKSAA NLKVKELPLI FITPLSDVKV FEKDEAKFEC EVSREPKTFR WLKGTQEITG DDRFELIKDG TRHSLVIKSA AFEDEAKYMF EAEDKRTSGK LIIEGIRLKF LTPLKDVTAK ERENAVFTVE LSHDNIPVSW FKNDQRLHTS KRVSMHDEGK THSITFKDLS IDDTSQIRVE AMGISSEAKL TVLEGDPYFT GKLQDYTGVE KDEVILQCEI SKADAPVKWF KDGKEIKPSK NVVIKADGKK RMLILKKALK SDIGQYTCDC GTDQTSGKLD IEDREIKLVR PLYSVEVMET ETARFETEIS EDDIHANWKL KGEALLQTPE CEIKEEGKIH VLILHNCRLD QTGGVDFQAA NVKSSAHLRV KPRVIGLLRP LKDVTVTAGE TATFDCELSY EDIPVEWYLK GKKLEPNDKV VTRSEGRVHT LTLRDVKLED AGEVQLTAKD FKTQANLFVK EPPVEFTKPL EDQTVEEEAT AVLECEVSRE NAKVKWFKNG TEILKSKKYE IVADGRVRKL IIHGCTPEDI KTYTCDAKDF KTSCNLNVVP PHVEFLRPLT DLQVKEKETA RFECEISKEN EKVQWFKDGA EIKKGKKYDI ISKGAVRILV INKCLLNDEA EYSCEVRTAR TSGMLTVLEE EAVFTKNLAN LEVSEGDTIK LVCEVSKPGA EVIWYKGDEE IIETGRFEIL TDGRKRILII QNAQLEDAGS YNCRLPSSRT DSKVKVHELA AEFISKPQNL EILEGEKAEF VCTISKESFE VQWKRDDQTL ESGDKYDIIA DGKKRVLVVK DATLQDMGTY VVMVGAARAA AHLTVIEKLR IIVPLKDTKV KEQQEVVFNC EVNTEGAKAK WFRNEEAIFD SSKYIILQKD LVYTLRIRDA RLDDQANFNV SLTNHRGENV KSAANLIVEE EDLRIVEPLK DIETMEKKSV TFWCKVNRLN VTLKWTKNGE EVAFDNRISY RIDKYKHSLI IKDCGFPDEG EYVVTAGQDK SVAELLIIEA PTEFVEHLED QTVTEFDDAV FSCQLSREKA NVKWYRNGRE IKEGKKYKFE KDGSIHRLII KDCRLEDECE YACGVEDRKS RARLFVEEIP VEIIRPPQDI LEAPGADVIF LAELNKDKVE VQWLRNNMIV VQGDKHQMMS EGKIHRLQIC DIKPRDQGEY RFIAKDKEAR AKLELAAAPK IKTADQDLVV DAGQPLTMVV PYDAYPKAEA EWFKENEPLS TKTVDTTAEQ TSFRISEAKK DDKGRYKIVL QNKHGKAEGF INLQVIDVPG PVRNLEVTET FDGEVSLAWE EPLTDGGSKI IGYVVERRDI KRKTWVLVTD RADSCEFTVT GLQKGGVEYL FRVSARNRVG TGEPVETDSP VEARSKYDVP GPPLNVTITD VNRFGVSLTW EPPEYDGGAE ITNYVIELRD KTSIRWDTAM TVRAEDLSAT VTDVVEGQEY SFRVRAQNRI GVGKPSAATP FVKVADPIER PSPPVNLNAS EQTQSSVQLT WEPPLKDGGS PILGYIIERR EEGKDNWIRC NMKPVPELTY KVTGLQKGNK YLYRVSAENA AGVSDPSEIL GPLTADDAFV EPTMDLSAFK DGLEVIVPNP IKILVPSTGY PRPKATWTFG DQVLEEGDRV KMKTISAYAE LVISPSERTD KGIYTLTLEN PVKSISGEIN VNVIAPPSAP KELKFSDITK DSVHLTWEPP DDDGGSPLTG YVVEKRDMSR KTWTKVMDFV TDLEFTVPDL VQGKEYLFKV CARNKCGPGE PAYTDEPVNM SAPATVPDPP ENVKWRDRTA NSIFLTWDPP KNDGGSRIKG YIVEKCPRGS DKWVACGEPV PDTKMEVTGL EEGKWYAYRV KALNRQGASK PSKPTEEIQA VDTQEAPEIF LDVKLLAGIT VKAGTKIELP ATVTGKPEPK ITWTKADTLL KPDQRITIEN VPKKSTVTIT DSKRSDTGTY IIEAVNVCGR ATAVVEVNVL DKPGPPAAFD ITDVTNESCL LTWNPPRDDG GSKITNYVVE RKATDSDVWH KLSSTVKDTN FKATKLTPNK EYIFRVAAEN MYGVGEPVQA APIIAKYQFD PPGPPTRLEP SDITKDAVTL TWCEPDDDGG SPITGYWVER LDPDTDKWVR CNKMPVKDTT YRVKGLTNKK KYRFRVLAEN LAGPGKPSRS TEPILIKDPI DPPWPPGKPT VKDIGKTSLV LNWTKPEHDG GAKIESYVIE MLKTGTDEWV RVAEGVPTTE HLLTGLMEGQ EYSFRVRAVN KAGESEPSEP SDPVLCREKL YPPSPPRWLE VINITKNTAD LKWTVPEKDG GSPITNYIVE KRDVRRKGWQ TVDTTVKDTK CTVTPLTEGS LYVFRVAAEN AIGQSDYTEI GDSVLAKDTF TTPGPPYALT VVDVTKRHVD LKWEPPKNDG GRPIQRYIIE KKEKLGTRWV KAGKTSGPDC NFRVTDVIEG TEVQFQVRAE NEAGVGHPSE PTEILSIEDP TSPPSPPLDL HVTDAGRKHI AIAWKPPEKN GGSPIIGYHV EMCPVGTEKW MRVNSRPIKD LKFKVEEGIV PDKEYVLRVR AVNAVGVSEP SEISENVVAK DPDCKPTIDL ETHDIVVIEG EKLNIPVPFR AVPVPTVSWH KDGKEVKASD RLTMKNDHIS AHLEVPKSVH ADAGVYTITL ENKLGSATAS INVKVIGLPG PCKDIKASDI TKSSCKLTWE PPEFDGGSPI LHYVLERREA GRRTYIPVMS GENKLSWTVK DLIPNGEYFF RVKAVNKIGG GEYIELKNPV IAQDPKQPPD PPVDVEVHNP TAKAMTITWK PPLYDGGSKI MGYIIEKITK GEDRWKRCNE HLVPVLTYTA KGLEEGKEYQ FRVRAENAAG IGEPSRATPP TKAVDPIDAP KVILRTSLEV KRGDEIALDA TISGSPYPTI TWIKDENVIV PEEIKKRAAP PVRRKKGEAE EEEPFSLPLT ERLSINNSKQ GESQLRIRDS LRPDHGQYMI KVENDHGVAK APCSVSVLDT PGPPINFVFE DIRKDSVLCK WEPPLDDGGS EIINYTLEKK DKTKPDSDWI VITSTLRNCK YSVTKLIEGK EYLFRVRAEN RFGPGPPCVS KPLLAKDPFE PPDAPDKPIV EDVTSNSMLV KWNEPKDNGS PILGYWLEKR EVNSTHWSRV NKTLLSSLKT KVDGLLEGLT YVFRVCAENA AGPGKFSPPS DPKTARDPIS PPGPPVPRVA DTSSTTIELE WEPPAFNGGG EIMGYFVDKQ LVGTNEWSRC TEKMIKVRQF TVKEIREGAD YKLRVSAVNA AGEGPPGETE PVTVAEPQEP PTVELDVSVK GGIQIMAGKT LRIPAEVTGR PVPTKVWTIE EGELDKERVI IENVGTKSEL IIKNALRKDH GRYVITATNS CGSKFAAVRV EVFDVPGPVL DLKPVVTNRK MCLLNWSDPA DDGGSDITGF IIERKDAKMH TWRQPIETER SKCDITGLIE GQEYKFRVIA KNKFGCGPPV EIGPILAVDP LGPPTSPERL TYTERTKSTI TLDWKEPRSD GGSPIQGYII EKRRHDKPDF ERVNKRLCPT TSFLVENLDE HQMYEFRVKA VNDVGESEPS LPLNVVIQDD EVPPTIKLRL AVRGDTIKVK AGEPVNIPAD VTGLPMPKIE WSKNEKVIDK PTDTLNITKE EVSRSEAKTE LSIPKAARED KGTYTITASN RLGSVFRNVH VEVYDRPSPP RNLAVTDIKA ESCYLTWDAP LDNGGSEITH YIIDKRDASR KKSEWEEVTN TAVERRYGIW KLIPNGQYEF RVRAVNKYGI SDECKSDKVV IQDPYRLPGP PGKPKVLERT KGSMLVSWTP PLDNGGSPIT GYWLEKREEG GTYWSRVSRA PITKVGLKGV EFNVPRLIEG VKYQFRAMAI NAAGIGPPSE PSDPAVAGDP IYPPGPPSCP EVKDKTKSSI SLAWKPPAKD GGSPIKGYIV EMQEEGTTDW KPVNEPDKLL TACECVVPNL KELRKYRFRV KAVNEAGESE PSDTTGEIPA TDIQEVPEVF IDIGAQDCLV CKAGSQVKIP AVIKGRPTPK SSWEFDGKAK KAMKDGVHDI PEDAQLETAE NSSVIIIPEC TRAHSGKYSI TAKNKAGQKT ANCRVKVMDA PGPPKDLKVS DITRGSCRLS WKMPDDDGGD RIKGYVIEKK TIDGKAWTKV NPNCGSTTFV VPDLISEQQY FFRVRAENRF GIGPPAETIQ RTTARDPIYP PDPPIKLKIG LITKNTVHLS WKPPKNDGGS PVTHYIVECL AWDPTGKKKE AWRQCNRRDV EELEFTVEDL IEGGEYEFRV KAVNEAGVSK PSATVGPVIV KDQTCPPAIE LKEFMEVEEG TDVNIVAKIK GVPFPTLTWF KAPPKKPDSK EPVVYDTHVN KQVVDDTCTL VIPQSRRSDT GLYSITAVNN LGTASKEMRL NVLGRPGPPV GPIKFESISA DQMTLSWLPP KDDGGSKITN YVIEKREANR KTWVRVSSEP KECMYTIPKL LEGHEYVFRI MAQNKYGIGE PLDSEPETAR NLFSVPGAPD KPTVSSVTRN SMTVNWEEPE YDGGSPVTGY WLEMKDTTSK RWKRVNRDPI KAMTLGVSYK VTGLIEGSDY QFRVYAINAA GVGPASLPSD PVTARDPVAP PGPPFPKVTD WTKSSVDLEW SPPLKDGGSK ITGYIVEYKE EGKEEWEKGK DKEVRGTKLV VTGLKEGAFY KFRVRAVNVA GVGEPGEVTD VIEMKDRIVS PDLQLDASVR DRIVVHAGGV IRIIAYVSGK PPPTVTWSMN ERALPQEAAI ETTAISSSMV IKNCQRSHQG VYSLLAKNEG GERKKTIIVD VLDVPGPVGI PFLSDNLTND SCKLTWFSPE DDGGSPITNY VIQKREADRR AWTPVTYTVT RQNATVQGLI QGKSYFFRIA AENSIGMGPF VETPNALVIR DPITVPERPE DLEVKEVTKN TVSLTWNPPK YDGGSEIINY VLESRLIGTE KFHKVTNDNL LSRKYTVKGL KEGDTYEYRV SAVNIVGQGK PSFCTKPITC KDELAPPTLD LDFRDKLTVR VGESFALTGR YSGKPKPKID WFKDEADVLE DDRTHIKTTP TTLALEKTKA KRSDSGKYCV VVENSTGSRK GFCQVNVVDR PGPPVGPVIF DEVTKEYMVI SWKPPLDDGG SEITNYIIEK KELGKDIWMP VTSASAKTTC KVPKLLEGKD YIFRIHAENL YGISDPLVSD SMKAKDRFRV PDAPEQPVVT EVTKDSALVT WNKPNDGGKP ITNYILEKRE TMSKRWVRVT KEPIHPYTKY RVPDLLEGCQ YEFRVSAENE IGIGDPSPPS KPVFARDPIA KPSPPINPEA IDTTCNSVEL TWQPPRHDGG SKILGYIVEY QKVGDEEWRR ANHTPESCPE TKYKVTGLRD GQSYKFRVLA VNEAGESDPA HVPEPVLVKD RLEPPELILD ANMAREQHIR VGDTLRLSAI IKGVPFPKVT WKKEDREAPT KAQIDVTPVG SKLEIRNAAH EDGGIYSLTV ENPAGTKTVS VKVLVLDKPG PPRDLEVSEI RKDSCYLTWK EPLDDGGSVV TNYVVERKDV ATAQWSPLST TSKKKSHMAK HLTEGNQYLF RVAAENQYGR GPFVETPKPI KALDPLHPPG PPKDLHHVDV DKTEVSLVWN KPDRDGGSPI TGYLVEYQEE GDKDWIKFKT VKNLDCVVTG LQQGKTYRFR VKAENIIGLG LPDTTIPIEC QEKLVPPSVE LDVKLIEGLV VKAGTTVRFP AIIRGVPVPT AKWTTDGTEI KTDDHYTVET DSFSSVLTIK NCLRKDTGEY QLTVSNAAGT KTVAVHLTVL DVPGPPTGPI NILDVTPEYM TISWQPPKDD GGSPVINYIV EKQDTRKGTW GVVSAGSSKL KLKVPHLQKG CEYVFRVKAE NKMGVGPPLD SIPTVAKHKF SPPSPPGKPV VTDITENAAT VSWTLPKSDG GSPITGYYVE RREITGKWVR VNKTPIADLK FRVTGLYEGN TYEFRVFAEN LAGLSNPSPS SDPIKACRPI KPPGPPINPK LKDKSKESAD LVWTKPLSDG GSPILGYVVE YQKPGTAQWD RINKDELIRQ CAFRVPGLIE GNEYRFRIRA ANIVGEGEPR ELAESVIAKD ILHPPEVELD VTCRDVITVR VGQTIRILAR VKGRPEPDIT WSKEGKVLVK DKRVDLIHDL PRVELQIKEA VRADHGKYII SAKNSSGHAQ GSAIVNVLDR PGPCQNLKVS NVTKENCTIS WENPLDNGGS EITNFIVEYR KPNQKGWSIV ASDVTKRLVK ANLLANNEYY FRVCAENKVG VGPTIETKTP ILAINPIDRP GEPENLHIAD KGKTFVYLKW RRPDYDGGSP NLSYHVERRL KGSADWERVH KGSIKETHYM VDKCVENQIY EFRVQTKNEG GESDWVRTEE VVVKEDLQKP VLDLKLSGVL TVKAGDTIRL EAGVRGKPFP EVAWTKDKDA TDLTRSPRVK IDTSAESSKF SLTKAKRSDG GKYVITATNP AGSFVAYATV NVLDKPGPVR NLKITDVSSD RCTIRWDPPE DDGGCEIQNY ILEKCESKRM VWSTYSANVL TPSATVTRLI EGNEYIFRVR AENKIGTGPP TESKPVIAKT KYDRPGRPDP PEVTKVSKEE MTVVWNAPEY DGGKSITGYY LEKKEKHAVR WVPVNKSAIP ERRLKVQNLL PGHEYQFRVK AENEVGIGEP SLPSRPVVAK DPIEPPGPPT NFKVVDTTKS SITLAWGKPV YDGGAPIIGY VVEMRPKIAD ASPDEGWKRC NAAAQLIRME FTVTSLDENQ EYEFRVCAQN QVGIGRPAEL KEAIKPKEIL EPPEIDLDAS MRKLVVVRAG CPIRLFAIVR GRPAPKVTWR KVGIDNVVRK GQVDLVDTMA FLVIPNSTRD DSGKYSLTLV NPAGEKAVFV NVKVLDTPGP VADLKVSDVT KTSCHVSWAP PENDGGSQVT HYIVEKREAE RKTWSTVTPE VKKTSFNVTN LVPGNEYFFR VTAVNEYGPG VPTDIPKPVL ASDPLSEPDP PRKLEVTEMT KNSATLAWLP PLRDGGAKID GYIISYREED QPADRWTEYS VVKDLSLIVT GLKEGKKYKF RVAARNAVGV SMPREAEGVY EAKEQLLPPK ILMPEQITIK AGKKLRVEAH VYGKPNPICK WKKGDDEVVT SSHLAIHKAD GSSVLIIKDV TRKDSGYYSL TAENSSGSDT QKIKVTVMDA PGPPQPPFDI SEIDADACSL SWHIPLEDGG SNITNYIVEK CDVSRGDWVT ALASVTKTSC RVGKLIPGQE YIFRVRAENR FGISEPLTSP KMLAKFPFDV PSEPKNARVT KVNKDCIFVA WDRPDSDGGS PITGYLIERK ERNSLLWVKA NDTIVRSTEY PCAGLVEGLE YSFRIYALNK AGSSPPSKPT EYVTARMPVD PPGKPEVVDV TKNSASLIWA RPKHDGGSRI IGYFVEACKL PGDKWVRCNT TPHQIPQEEY TATGLEENAQ YQFRAIAKTA VNISQPSEPS DPVTILAENV PPRIELSVEM KSLLTVKAGT NVCLDATVFG KPMPTVSWKK DTTPIKQAEG IKMAMKRNLC TLELFSVNRK DSGDYTITAE NSSGSKSATI KLKVLDKPGP PASVKINKMY ADRAMLSWEP PLEDGGSEIT NYIIDKRETS RPNWAQVSAT VPITSCTVEK LIEGHEYQFR ICAENKYGVG DPILTEPAIA KNPYDPPGRC DPPVISNITK DHMTVSWKAP ADDGGSPITG YLVEKRETQA VNWTKVNRKP VIERTLKATG LQEGTEYEFR VTAINKAGPG KPSDASKAVY AQDPLYPPGP PAFPKVYDTT RSSVSLSWGK PAYDGGSPII GYLVEVKRAD SDHWVRCNLP EKLQKTRFEV TGLMENTEYQ FRVYAVNKIG YSDPSDVPDK HCPKDILIPP EGELDAELRK TLILRAGVTM RLYVPVKGRP PPKITWSKPN VNLRERIGLD IKSTDFDTFL RCENVNKYDA GKYILTLENS CGKKEYTIVV KVLDTPGPPV NVTVKEVSKD SAYVTWDPPI IDGGSPIINY VVEKRDAERK SWSTVTTECS KTSFRVSNLE EGKSYFFRVF AENEYGIGDP GETRDAVKAS ETPGPVVDLK ALAITKSSCT IGWKKPRSDG GSRITGYVVD FLTEENKWQR VMKSLSLQYS TKDLKEGKEY TFRVSAENEN GEGTPSEIVV VAKDDVVAPD LDLKDLPDLC YLAKENSNFR LKIPIKGKPA PSVSWKKGED PLATDTRVSV ESTAVNTTLV VYDCQKSDAG KYTITLKNVA GTKEGTLSIK VVGKPGIPTG PIKFDEVTAE AMTLKWGPPK DDGGSEITNY VLEKRDSVNN KWVTCASAVQ KTTFRVTRLH EGIEYTFRVS AENKYGVGEG LKSEPIVAKH PFDVPDAPPP PNIVDVRHDS VSLTWTDPKK TGGSPITGYH IEFKERNSLL WKRANKTPIR MKDFKVTGLT EGLEYEFRVM AINLAGVGKP SLPSEPVVAL DPIDPPGKPE VISVTRNSVT LIWTEPKYDG GHKLTGYIVE KRDLPSKSWM KANHVNVPDC AFTVTDLVEG GKYEFRIRAK NTAGAISAPS ESTGTIICKD EYEAPTIVLD PTIKDGLTVK AGDSIVLSAI SILGKPLPKS SWSRAGKDIR PSDIAQITST PTSSMLTVKY ATRKDAGEYT ITATNPFGTK EEHVKVSVLD VPGPPGPIEI SNVSAEKATL TWTPPLEDGG SPIKAYVLEK RETSRLLWTV VSEDIQACRH VVTKLIQGNE YLFRVSAVNH YGKGEPVQSE PVKMVDRFGP PGPPGKPEIS NVTKNTATVS WKRPTDDGGS EITGYHVERR EKKGLRWVRA TKTPVSDLRC KVTGLQEGNT YEFRVSAENR AGIGPPSDAS NPVLMKDVAY PPGPPSNAHV TDTTKKSASL AWGKPHYDGG LEITGYVVEH QKVGDDAWIK DTTGTALRIT QFVVPDLQTK EKYNFRISAI NDAGVGEPAV IPNVEIVEKE VAPDFELDAE LRRTLVVRAG LSIRIFVPIK GRPAPEVTWT KDNINLKHRA NIENTESFTL LIIPECNRYD TGKFVMTIEN PAGKKSGFVN VRVLDTPGPV LNLRPTDITK DSVTLHWDLP LIDGGSRITN YIVEKREATR KSYSTVTTKC HKCTYKVTGL TEGCEYFFRV MAENEYGVGE PTETTEPVRA SEAPLPPDSL NIMDITKNTV SLAWPKPRHD GGSKITGYVI EAQRKGSDQW THISTVKGLE CVVRNLTEGE EYTFQVMAVN SAGRSAPRES RPVIVKEQTM LPELDLRGIY QKLVIARAGD NIKVEIPVLG RPKPTVTWKK GDQILKQTQR VNVENTATST ILNINECVRS DSGPYPLTAK NTVGEVGDVI TIQVHDIPGP PTGPIKFDEV SSDFVTFSWE PPENDGGVPI SNYVVEMRQT DSTTWVELAT TVIRTTYKAT RLTTGVEYQF RVRAQNRYGV GPGITSASVV ANYPFKVPGP PGTPQVTAVT KDSMTISWHE PLSDGGSPIL GYHIERKERN GILWQTVSKA LVPGNIFKST GLTDGIAYEF RVIAENMAGK SKPSKPSEPM FALDPIDPPG KPVPLNITRH TVALKWAKPE YTGGFKITSY VVEKRDLPNG RWLKANFSNI LENEFTVSGL TEDAAYEFRV IAKNAAGAIS PPSEPSDAIT CRDDLEAPRI MVDVRFKDTI TLKAGEAFKL EADVSGRPPP TMEWTKDGKE LEGTGKLEIK IADFSTHLIN KDSSRTDSGA YILTATNPGG FAKHIFNVKV LDRPGPPEGP LAVSDVTSEK CVLSWLPPLD DGGAKIDHYI VQKRETSRLA WTNVATEVQV TKLKVTKLLK GNEYIFRVMA VNKYGVGEPL ESEPVLAVDP YGPPDPPKNP EVTTITKDSM VVCWGHPDSD GGSEIINYIV ERRDKAGQRW VKCNKKALTD LRFKVSGLTE GHEYEFRIMA ENAAGISAPS ATSPFYKACD TVFKPGPPGN PRVLDTSRSS ISIAWNKPIY DGGSEITGYM VEIALPEEDE WQVVTPPAGL KATSYTITSL IENQEYKIRI YAMNSEGLGE PALVPGTPKA EERMLPPEIE LDADLRKVVT IRACCTLRLF VPIKGRPAPE VKWAREHGES LDKASIESTS SYTLLVVGNV NRFDSGKYIL TVENSSGSKS AFVNVRVLDT PGPPQNLKIK EVTKTSVTLT WEPPLLDGGS KIKNYIVEKR ESTRKAYSTV ATNCHKTSWK VDQLQEGCSY YFRVLAENEY GIGLPAETAE SVKASERPLP PGKITLTDVT RNSVSLSWEK PEHDGGSRIL GYIVEMQSKG SDRWATCATV KVTEATITGL IQGEEYSFRV SAQNEKGISD PRQLSVPVIA KDLVIPPAFK LLFNTFTVLA GEDLKIDVPF IGRPPPAVTW HKDDIPLKQT TRVNAESTEN NSLLTIKEAC REDVGHYTVK LTNSAGEATE TLNVIVLDKP GPPTGPVKMD EVTADSVTLS WEPPKYDGGS SINNYIVEKR DTSTTAWQIV SATVARTTIK ACRLKTGCEY QFRIAAENRY GKSTYLNSEP VVAQYPFKVP GPPGTPFVTL ASKDSMEVQW HEPVSDGGSK VIGYHLERKE RNSILWVKLN KTPIPQTKFK TTGLEEGIEY EFRVSAENIV GIGKPSKPSE CYAAHDPCDP PGRPEAIIVT RNSVTLQWKK PTYDGGSKIT GYIVEKKELP DGRWMKASFT NIIDTQFEVT GLLEDHRYEF RVIARNAAGV FSEPSESTGA ITARDEVEPP RISMDPKYRD TVVVQAGESF KIDADIYGKP IPTTQWVKGD QELSSTARLE IKSTDFATSL SVKDAVRVDS GNYILKAKNV AGEKSVTINV KVLDRPGPPE GPVAISGVTA EKCTLAWKPP LQDGGSDITN YIVERRETSR LVWTLVDANV QTLSCKVLKL LEGNEYIFRI MAVNKYGVGE PLESESLIAK NPFVVPDAPK APEVTAVTKD SMIVVWERPA SDGGSEILGY VLEKRDKEGI RWTRCHKRLI GELRLRVTGL LENHNYEFRV SAENAAGLSE PSPPSAYQKA CDPIYKPGPP NNPKVMDVTR SSVFLSWTKP IYDGGCEIQG YIVEKCDVSV GEWTMCTPPT GINKTNLEVE KLLEKHEYNF RICAINKAGV GEHADVPGPV MVEEKLEAPD IDLDLELRKV INIRAGGSLR LFVPIKGRPT PEVKWGKVDG DIRDAAIIDV TSSFTSLVLD NVNRYDSGKY TLTLENSSGT KSAFVTVRVL DTPSPPVNLK VTEITKDSVS ITWEPPLLDG GSKIKNYIVE KREATRKSYA AVVTNCHKNS WKIDQLQEGC SYYFRVTAEN EYGIGLPART ADPIKVAEVP QPPGKITVDD VTRNSVSLSW TKPEHDGGSK IIQYIVEMQA KNTDKWSECA RVKSLDAVIT NLTQGEEYLF RVIAVNEKGR SDPRSLAVPI IAKDLVIEPD VRPAFSSYSV QVGQDLKIEV PISGRPKPSI SWTKDGMPLK QTTRINVTDS LDLTTLSIKE THKDDGGQYG ITVSNVVGQK TAAIEIITLD KPDPPKGPVK FDEISAESIT LSWNPPLYTG GCQITNYIVQ KRDTTTTVWD VVSATVARTT LKVTKLKTGT EYQFRIFAEN RYGQSFALES EPVVAQYPYK EPGPPGTPFV TAISKESMVV QWHEPINNGG SPVIGYHLER KERNSILWTK VNKTIIHDTQ FKALNLEEGI EYEFRVYAEN IVGVGKASKN SECYVARDPC DPPGTPEAII VKRNEITLQW TKPVYDGGSM ITGYIVEKRD LPEGRWMKAS FTNVIETQFT VSGLTEDQRY EFRVIAKNAA GAISKPSDST GPITAKDEVE LPRISMDPKF RDTIVVNAGE TFRLEADVHG KPLPTIEWLR GDKEIEESAR CEIKNTDFKA LLIVKDAIRI DGGQYILRAS NVAGSKSFPV NVKVLDRPGP PEGPVQVTGV TAEKCTLAWS PPLQDGGSDI SHYVVEKRET SRLAWTVVAS EVVTNSLKVT KLLEGNKYIF RIMAVNKYGV GEPLESAPVL MKNPFVLPGP PKSLEVTNIA KDSMTVCWNR PDSDGGSEII GYIVEKRDRS GIRWIKCNKR RITDLRLRVT GLTEDHEYEF RVSAENAAGV GEPSPATVYY KACDPVFKPG PPTNAHVVDT TKNSITLAWS KPIYDGGSEI LGYVVEICKA DEEEWQIVTP QTGLRVTRFE IAKLIEHQEY KIRVCALNKV GLGEAASVPG TVKPEDKLEA PELDLDSELR KGIVVRAGGS ARIHIPFKGR PTPEITWSKE EGEFTDKVQI EKGINFTQLS IDNCDRNDAG KYILKLENSS GSKSAFVTVK VLDTPGPPQN LAVKEVRKDS VLLVWEPPII DGGAKVKNYV IDKRESTRKA YANVSSKCNK TSFRVENLTE GAIYYFRVMA ENEFGVGVPT ETSDAVKASE PPSPPGKVTL TDVSQTSASL MWEKPEHDGG SRILGYVVEM QPKGTEKWSV VAESKVCNAV VSGLSSGQEY QFRVKAYNEK GKSDPRVLGI PVIAKDLTIQ PSFKLPFNTY SVQAGEDLKI EIPVIGRPRP KISWVKDGEP LKQTTRVNVE ETATSTILHI KESSKDDFGK YSVTATNSAG TATENLSVIV LEKPGPPVGP VKFDEVSADF VVISWEPPAY TGGCQISNYI VEKRDTTTTN WQMVSATVAR TTIKISKLKT GTEYQFRIFA ENRYGKSTPL DSKPVVVQYP FKEPGPPGTP FVTSISKDQM LVQWHEPVND GGSKVTGYHL EQKEKNSILW VKLNKIPIQD TKFKTTGLDE GLEYEFRVSA ENIVGIGKPS KVSECYVARD PCDPPGRPEA IVITRNSVTL KWKKPVYDGG SKITGYIVEK KDLPDGRWMK ASFTNVVETE FTVTGLVEDQ RYEFRVIARN AADNFSEPSE SSGAITARDE IDAPNASLDP KYRDVIIVHA GETFVLEADI RGKPIPDIIW SKDGNELEET AARMEIKSTL QKTTLIVKDC IRTDGGQYTL KLSNVGGTKT IPITVKVLDR PGPPEGPLKV TGVTAEKCYL AWNPPLQDGG ASISHYIIEK RETSRLSWTQ VSNEVQALNY KVTKLLPGNE YIFRVMAVNK YGIGEALESE PVIACNPYKR PGPPSTPEAS AITKDSMVLT WTRPVDDGGA EIEGYILEKR DKEGIRWTKC NKKTLTDLRF RVTGLTEGHS YEFRVAAENA AGVGEPSEPS VFYRACDALY PPGPPSNPKV TDTSRSSVSL AWNKPIYDGG APVRGYVIEL KKAAADEWTT CTPPSGLQGK QFTVTKLKEN TEYNFRICAF NTEGVGEPAT IPGSVVAQER MEAPEIELDA DLRKVVTLRA SATLRLFVTI KGRPEPEVKW EKAEGILTER AQIEVTSSYT MLVIDNVTRF DSGRYNLTLE NNSGSKTAFV NVRVLDSPSA PVNLTIREVK KDSVTLSWEP PLIDGGAKIT NYIVEKRETT RKAYATITNN CTKNTFKIEN LQEGCSYYFR VLASNEYGIG LPAETAEPVK VSEPPLPPGR VTLVDVTRNT ATIKWEKPES DGGSKITGYV VEMQTKGSEK WSACTQVKTL ETTISGLTAG EEYVFRVAAV NEKGRSDPRQ LGVPVIAKDI EIKPSVELPF NTFNVKANDQ LKIDIPFKGR PQATVAWKKD GQVLRETTRV NVASSKTVTT LSIKEASRED VGTYELCVSN TAGSITVPIT VIVLDRPGPP GPIRIDEVSC DNVSISWNPP EYDGGCQISN YIVEKRETTS TTWQVVSQAV ARTSIKIVRL TTGSEYQFRV CAENRYGKSS YSESSAVVAE YPFSPPGPPG TPKVVHATKS TMVVSWQVPV NDGGSQVIGY HLEYKERSSI LWSKANKVLI ADTQMKVSGL DEGLMYEYRV YAENIAGIGK CSKACEPVPA RDPCDPPGQP EVTNITRKSV SLKWSKPRYD GGAKITGYIV ERRELPDGRW LKCNFTNVQE TYFEVTELTE DQRYEFRVFA RNAADSVSEP SESTGPITVK DDVEAPRIMM DVKFRDVIIV KAGEVLKINA DIAGRPLPVI SWAKDGVEIE ERAKTEIVST DYTTTLTVKD CVRRDTGQYV LTLKNVAGTR TMAVNCKVLD KPGPPAGPLE INGLTAEKCS LSWGRPQEDG GADIDYYIVE KRETSRLAWT ICEAELRTTS CKVTKLLKGN EYIFRVTGVN KYGVGEPLES MAVKALDPFT TPSPPTSLEI TSVTKDSMTL CWSRPETDGG SDISGYIIER REKNSLRWMR VNKKPVYDLR VKSTGLREGC EYEYRVFAEN AAGLSLPSET SPLVRAEDPV FLPSPPSKPK IVDSGKTTIT IGWVKPLFDG GAPITGYTVE YKKSEETDWK VAIQSFRGTE YTMSGLTTGD EYVFRVRSLN KMGASDPSDS SDPQVAKERE EEPVFDVDSE MRKTLIVKAG SSFTMTVPFR GRPIPNVSWS KPDTDLRTRA YIDSTDSRTL LTIENANRND SGKYTLTIQN VLSAASMTFV VKVLDSPGPP ANITVREVTK ETAMLSWDVP ENDGGAPVKN YHIEKREASK KAWVSVTNNC NRLSYKVTNL QEGAIYYFRV SGENEFGVGV PAETKEGVKI TEKPSPPEKL GVTSVSKDSV SLSWLKPEHD GGSRIIHYVV EALEKGQKTW VKCAVVKTTH HVVSGLRESH EYFFRVFAEN QAGLSDPREL LLPVLIKDQL EPPEIDMKNF PSHTVYVRAG SNLKVDIPIS GKPLPKVTLS RDGVPLKATM RFNTEITAEN LTINLKESVT TDAGRYEITA ANSSGTTKTF INIIVLDRPG PPTGPVAISD ITEESVTLKW EPPKYDGGSH VTNYIVLKRE TSTAVWSEVS ATVARTMIKV MKLTTGEEYQ FRIKAENRFG ISDHIDSVCV VVKLPYTTPG PPSTPWVSNV TRESITVGWH EPVSNGGSAV TGYHLEMKDR NSILWQKANK MIIRTTHFKV TTISAGLIYE FRVYAENAAG IGKPSHPSEP VLAIDACEPP RNVRITDISK NSVNLSWQQP AFDGGSKITG YIVERRDLPD GRWTKASFTN VIETQFTVSG LTQNSQYEFR VFARNAVGSV SNPSEVVGPI TCIDSYGGPV IDLPLEYTEV VKYRAGTSVK LRAGISGKPE PTIEWYKDDK ELQTNALVCV ENSTDLASIL IKDANRLNSG SYELKLRNAM GSASATIRVQ ILDKPGPPGG PIEFKTVTAE KITLLWRPPA DDGGAKITHY IVEKRETSRV VWSMVAENLE ECIVTTTKII KGNEYVFRVR AVNKYGIGEP LESEPVVAKN AFVTPGPPSI PEVTKITKNS MTVVWDRPTV DGGSEINGYF LERRDKKSLA WLKVLKETIR DTRQKVTGLT ENSDYQYRVC AVNAAGVGPF SEPSDFYKAA DPIDPPGPPA KIRIADSTKS SITLGWSKPV YDGGSDVTGY VVEMKQGDEE EWTIVSTRGE VRTTEYVVSN LKPGVNYYFQ VSAVNCAGQG EPITMTEPAQ AKDVLEEPEI DLDVALRTSV IAKAGEDVQL LIPFKGRPPP TVTWRKDEKN LGSDTRYSIQ NTDSSSLLVI PQVTRNDTGK YILTIENGVG QPKSSTVSVK VLDTPAACQK LQVKHVSLGT VTLLWDPPLI DGGSPIINYV IEKRDATKRT WSVVSHKCSG TSFKVTDLSE KTPFFFRVLA ENEIGIGEPC ETTEPVKAAE VPAPIRDLSM KDSTKTSVVL SWTKPDFDGG SIITDYLVER KGKGEQAWSH AGISKTCEIE IGQLKEQSVL EFRVSARNEK GQSDPVTIGP LTVKELVITP EVDLSEIPGA QISVRIGHNV HLELPYKGKP KPSISWLKDG LPLKESEYVR FSKTENKITL SIKNSKKEHG GKYTVILDNA VCRNSFPITI ITLGPPSKPK GPIRFDEIKA DSAIMSWDIP EDDGGGEITC YSIEKREASQ TNWKMVCSSV ARTTFKVSNL VKDSEYQFRV RAENRYGVSE PLASNIIVAK HQFRIPGPPG KPVIYNVTSD GMSLTWDAPV YDGGSEVTGF HVEKKERNSI LWQRVNTSPI SGREYRATGL IEGLDYQFRV YAENSAGLSS PSDPSKFTLA VSPVDPPGTP DYIDVTRETI TLKWNPPLRD GGSKIVAYSI EKRQGSDRWV RCNFTDVSEC QYTVTGLSPG DRYEFRIIAR NAVGTISPPS QSSGLIMTRD ENVPPTVEFG PEYFDGLVIK SGDSLRIKAL VQGRPVPRVT WFKDGVEIER RMNMEITDVL GSTSLFVRDA TRDHRGVYTV EAKNVSGSTK AEVTVKVQDT PGKVVGPIRF TNITGEKMTL WWEAPLNDGC APVTHYIIEK RETSRLAWAL IEDNCEALSY TAIKLITGNE YQFRISAVNK FGVGRPLESD PVVAQIQYTI PDAPGVPEPS NVTGNSITLT WTRPESDGGS EIQHYILERR EKKSTRWVKV ISKRPISETR FKVTGLVEGN EYEFHVMAEN AAGIGPASGI SRLIKCREPV NPPSAPSVVK VTDTSKTTVS LEWARPVFDG GMEIIGYIIE MCKADLGDWH KVNTEPCVKT RYTVTDLQAG EEYKFRVSAV NGAGKGDSCE VTGTIKAVDR LSAPELDIDA NFKQTHIVRA GVSIRLFIAY QGRPTPTAVW SKPDSNLSIR ADIHTTDSFS TLTVENCNRN DAGKYTLTVE NNSGKKSITF TVKVLDSPGP PGPITFKDVT RGSATLMWDA PLLDGGARIH HYVIEKREAS RRSWQVVSEK CTRQILKVSE LTEGVPYYFR VSAENEYGVG EPYEMPEPIV ATEQPAPPRR LDVVDTSKSS AVLAWLKPDH DGGSRITSYL LEMRQKGSDF WVEAGHTKQL TFTVERLVEN TEYEFRVKAK NDAGYSEPRE AFSSVIIKEP QIEPTADLTG ITNQLITCKA GSTFTIDVPI SGRPAPKVTW KLEEMRLKET DRMSIATTKD RTTLTVKDSM RGDSGRYFLT LENTAGVKTF TITVVVIGRP GPVTGPIEVS SVSAESCVLS WTEPKDDGGT EITNYIVEKR ESGTTAWQLI NSSVKRTQIK VTHLTKYKEY CFRVSSENRF GVSKPLESVP IVAEHPFVPP SAPTRPEVYY VSANAMSIRW EEPYHDGGSK IVGYWVEKKE RNTILWVKEN KVPCLECNYK VTGLVEGLEY QFRTYALNAA GVSKASEASR PIMAQNPVDP PGRPEVTDVT RSTVSLIWSA PVYDGGSKVV GYIIERKPVS EVGDGRWLKC NYTIVSDNFF TVTALSEGDT YEFRVLAKNA AGVISKGSES TGPVTCRDEY APPKAELDAR LQGDLVTIRA GSDLVLDAAV GGKPEPKIIW TKGDKELDLC EKISLQYTGK RATAVIKYCD RSDSGKYTLT VKNASGTKSV SVMVKVLDSP GPCGKLTVSR VTEEKCTLAW SLPQEDGGAE ITHYIVERRE TSRLNWVIVE GECLTASYVV TRLIKNNEYT FRVRAVNKYG LGVPVESEPI VARNSFTIPS QPGIPEEVGA GKEHIIIQWT KPESDGGNEI SNYLVDKREK KSLRWTRVNK DYVVYDTRLK VTSLMEGCDY QFRVTAVNAA GNSEPSEASN FISCREPSYT PGPPSAPRVV DTTKRSISLA WTKPMYDGGT DIIGYVLEMQ EKDTDQWCRV HTNATIRNNE FTVPDLKMGQ KYSFRVAAVN AKGMSDYSET TAEIEPVERL EIPDLELADD LKKTVIVRAG ASLRLMVSVS GRPSPVITWS KKGIDLANRA IIDNTESYSL LIVDKVNRYD AGKYTIEAEN QSGKKSATVL VKVYDTPGPC PSVSVKEVSR DSVTITWEIP TIDGGAPVNN YIIEKREAAM RAFKTVTTKC SKTLYRISGL VEGTMYYFRV LPENIYGIGE PCETSDAVLV SEVPLVPTKL EVVDVTKSTV TLAWEKPLYD GGSRLTGYVL EACKAGTERW MKVVTLKPTV LEHTVISLNE GEQYLFRVRA QNEKGVSEPR EIVTPVTVQD LRVLPTIDLS TMPQKTIHVP AGRPIELVIP ITGRPPPTAS WFFAGSKLRE SERVTVETHT KVTKLTIRET TIRDTGEYTL ELKNVTGTTS ETIKVIILDK PGPPTGPIKI DEIDATSVTI SWEPPELDGG APLSGYVVEQ RDAHRPGWLP VSESVTRPTF KFTRLTEGNE YVFRVAATNR FGIGSYLQSE VIECRSSISI PGPPETLQIF DVSRDGMTLT WYPPEDDGGS QVTGYIVERK EVRADRWVRV NKVPVTMTRY RSTGLIEGLE YEHRVTAINA RGTGKPSRPS KPTVAMDPIA PPGKPQNPRV TDTTRTSVSL AWSVPEDEGG SKVTGYLIEM QKVDQREWTK CNTTPTKIRE YTLTHLPQGA EYRFRVLACN AGGPGEPAEV PGTVKVTEML EYPDYELDER YQEGVFVRQG GVIRLTIPIK GKPFPVCKWT KEGQDISKRA MIATSETHTE LVIKEADRND SGTYDLVLEN KCGKKTVYIK VKVIGSPNTP EGPLEYDDIQ ARSVRVSWRP PADDGGADIL GYILERREVP KAAWYTIDSR VRGTSLVVKG LKENVEYHFR VSAENQFGIS KPLKSEEPVI PKTPLNPPEP PSNPPEVLDV TKSSVSLSWS RPKDDGGSRV TGYYIERKET STDKWVRHNK TQITTTMYTV TGLVPDAEYQ FRIIAQNDVG LSETSPASEP VVCKDPFDKP SQPGELEILS ISKDSVTLQW EKPECDGGKE ILGYWVEYRQ SGDSAWKKSN KERIKDRQFT IGGLLEATEY EFRVFAENET GLSRPRRTAM SVKTKLTSGE APGVRKEMAD VTTKLGEAAQ LSCQIVGRPL PDIKWYRFGK ELIQSRKYKM SSDGRTHTLT VMTDEQEDEG VYTCVATNEV GEVESSSKLL LQAAPQFHPG YPLKEKYYGA VGSTLRLHVM YIGRPVPAMT WFHGQKLLQN SEKITIENTE HYTHLVMKNV QRKTHAGKYK VQLSNAFGTV DATLDVEIQD KPDKPTGPIV IEALLKNSVV ISWKPPADDG GSWITNYVVE KCEAKEGAEW QLVSSAISVT TCRIVNLTEN AGYYFRVSAQ NTFGISEPLE VASIVIIKSP FEKPGVPGKP TITAVTKDSC VVAWKPPASD GGAKIRNYYL ERREKKQNKW IAVTTEEIRE TVFSVQNLIE GLEYEFRVKC ENLGGESEWS EISEPVTPKS DVPIQAPHFK EELRNLNVRY QSNATLVCKV TGHPKPIVKW YRQGKEIIAD GLKYRIQEFK GGYHQLIIAS VTDDDATVYQ VRATNQGGSV SGTASLEVEV PAKIHLPKTL EGMGAVHALR GEVVSIKIPF SGKPDPVITW QKGQDLIDNN GHYQVIVTRS FTSLVFSNGV ERKDAGFYVV CAKNRFGIDQ KTVELDVADV PDPPRGVKVS DVSRDSVNLT WTEPASDGGS KVTNYIVEKC ATTAERWLRV GQARETRYTV INLFGKTSYQ FRVIAENKFG LSKPSEPSEP TVTKEDKTRA MNYDDEVDET REVTTTKASH SKTKELYEKY MIAEDLGRGE FGIVHRCVET SSKRTFMAKF VKVKGTDQVL VKKEISILNI ARHRNILYLH ESFESMEELV MIFEFISGLD IFERINTSAF ELNEREIVSY VRQVCEALEF LHSQNIGHFD IRPENIIYQT RKNSTIKIIE FGQARQLKPG DNFRLLFTAP EYYAPEVHQH DVVSTATDMW SLGTLVYVLL SGINPFLAET NQQMIENIMN AEYTFDEEAF KEISLEAMDF VDRLLVKERK SRMTASEALQ HPWLKQRIDR VSTKVIRTLK HRRYYHTLIK KDLNMVVSAA RISCGGAIRS QRGVSVAKVK VASIEIGPVS GQIMHAIGEE GGYVKYVCKI ENYDQSTQVT WYFGVRQLEN SEKYEITYED GVATMYVKDI TKFDDGTYRC KVVNDYGEDS SYAELFVKGV REVYDYYCRR TKKVKRRTDA MRLLERPPEF TLPLYNKTAY VGENVRFGVT ITVHPEPRVT WYKSGQKIKP GDDEKKYTFE SDKGLYQLTI NSVTTDDDAE YTVVARNKHG EDSCKAKLTV TLHPPPTETT LRPMFKRLLA NAECHEGQSV CFEIRVSGIP APTLKWEKDG QPLSLGPHIE IVHEGLDYYA LHIRDTLPED TGYYRVTATN TAGSTSCQAH LQVERLRYVK QEFQSKEERE RHVQKQIDKT LRMAEILSGT ETVPLTPVAQ EALREAAILY KPAVSTKTVK GEYRLQTEEK KEERKLRMPY EVPEPRRFKQ ATVEEDQRIK QFVPMSDMKW YKKIRDQYEM PGKLDRVVQK RPKRIRLSRW EQFYVMPLPR ITDQYRPKWR IPKLTQDDLE MVRPARRRTP SPDYDLYYYR RRRRSLGDMS DEELLLPIDD YLAMKRTEEE RLRLEEELEL GFSASPPSRS PPRFELSSLR YSSPPAHVKV EDRRRDFRYS TYHVPTKEET STSYAELRER HAQASYRQPK LRQRIMAEKE EEELLRPVTT TQRLSEYKSE LDYMSKEEKS KKKSKRQRQV TEITEIEEEY EISRRAQRES SSSVSRLLRR RRSLSPTYIE LMRPVSELIR SHPRPAEEYE DDAERRSPTP ERTRPRSPSP VSSERSLSRF ERSARFDIFS RYESMKAALK TQKTSERKYE VLSQQPFTLD HAPRITLRMR SHRVPCGQNT RFILNVQSKP TAEVKWYHNG VELQESSKIH YTNTSGVLTL EILDCQTEDG GTYRAVCTNY KGEASDYATL DVTGGAYTTY ASQRRDEEVP KSVFPELTKT EAYAVSSFKR TSELEAASSV REVKSQMTET RESLSTYEHY ASAEMKSATS EEKSLEEKAT VRKIKTTLAA RILTKPRSIT VHEGESARFS CDTDGEPVPT VTWLREGQVV STSARHQVTT TKYKSTFEIS SVQASDEGNY SVVVENSDGK QEAQFTLTVQ KARVIEKAVT SPPRVKSPEP RVKSPETVKS PKRVKSPEPV TSHPKAVSPT ETKPTEKGQH LPVSAPPKIT QSLKAEASKD IAKLTCAVES SALCAKEVAW YKDGKKLKEN GHFQFHYSAD GTYELKIHNL SESDCGEYVC EVSGEGGTSK TSFQFTGQSF KSIHEQVSSI SETTKSVQKT AESPEAKKQE PIAPESISSK PVIVTGLRDT TVSSDSVAKF TIKVTGEPQP TITWTKDGKA IAQGSKYKLS SNKEEFILEI LKTETSDGGL YACTVTNSAG SVSSSCKLTI KAVKDTEAQK VSTQKTSEVT SQKKASAQEE ISQKALTSEE IKMSEVKSHE TLAIKEEASK VLIAEEVKRS AAASLEKSIV HEEVTKTSQA SEEVKTHAEI KTLSTQMNIT KGQRATLKAN IAGATDVKWV LNGTELPNSE EYRYGVSGSD QTLTIKQASH REEGILSCIG KTSQGVVKCQ FDLTLSEELS DAPSFITQPR SQNINEGQNV LFSCEVSGEP SPEIEWFKNN LPISISSNIS VSRSRNVYTL EIRNAAVSDS GKYTIKAKNF HGQCSATASL TVLPLVEEPP REVVLKTSSD VSLHGSVSSQ SVQMSASKQE ASFSSFSSSS ASSMTEMKFA SMSAQSMSSM QESFVEMSSS SFMGKSSMTQ LESSTSRMLK AGGRGIPPKI EALPSDISID EGKVLTVACA FTGEPTPEIT WSCGGRKIQN QEQQGRFHIE NTDDLTTLII MDVQKQDGGL YTLSLGNEFG SDSATVNINI RSM //