ID   ANR63_MOUSE             Reviewed;         390 AA.
AC   A2ARS0;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   28-JAN-2026, entry version 113.
DE   RecName: Full=Ankyrin repeat domain-containing protein 63 {ECO:0000250|UniProtKB:C9JTQ0};
GN   Name=Ankrd63 {ECO:0000250|UniProtKB:C9JTQ0};
GN   Synonyms=Gm1337 {ECO:0000312|MGI:MGI:2686183};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:CAM17417.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193 AND SER-304, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
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DR   EMBL; AL845470; CAM17417.1; -; Genomic_DNA.
DR   CCDS; CCDS38201.1; -.
DR   RefSeq; NP_001075440.1; NM_001081971.1.
DR   AlphaFoldDB; A2ARS0; -.
DR   SMR; A2ARS0; -.
DR   STRING; 10090.ENSMUSP00000100542; -.
DR   GlyGen; A2ARS0; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; A2ARS0; -.
DR   PhosphoSitePlus; A2ARS0; -.
DR   PaxDb; 10090-ENSMUSP00000100542; -.
DR   ProteomicsDB; 282123; -.
DR   Antibodypedia; 70339; 52 antibodies from 9 providers.
DR   DNASU; 383787; -.
DR   Ensembl; ENSMUST00000104937.2; ENSMUSP00000100542.2; ENSMUSG00000078137.2.
DR   GeneID; 383787; -.
DR   KEGG; mmu:383787; -.
DR   UCSC; uc008lsh.1; mouse.
DR   AGR; MGI:2686183; -.
DR   CTD; 100131244; -.
DR   MGI; MGI:2686183; Ankrd63.
DR   VEuPathDB; HostDB:ENSMUSG00000078137; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000163025; -.
DR   HOGENOM; CLU_042924_0_0_1; -.
DR   InParanoid; A2ARS0; -.
DR   OMA; QPWQAGT; -.
DR   OrthoDB; 5406014at2759; -.
DR   PhylomeDB; A2ARS0; -.
DR   BioGRID-ORCS; 383787; 1 hit in 76 CRISPR screens.
DR   CD-CODE; CE726F99; Postsynaptic density.
DR   PRO; PR:A2ARS0; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; A2ARS0; protein.
DR   Bgee; ENSMUSG00000078137; Expressed in olfactory tubercle and 47 other cell types or tissues.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR050776; Ank_Repeat/CDKN_Inhibitor.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24201; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24201:SF8; CYCLIN-DEPENDENT KINASE 4 INHIBITOR B; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   1: Evidence at protein level;
KW   ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..390
FT                   /note="Ankyrin repeat domain-containing protein 63"
FT                   /id="PRO_0000411003"
FT   REPEAT          11..40
FT                   /note="ANK 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          46..79
FT                   /note="ANK 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          83..112
FT                   /note="ANK 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          116..145
FT                   /note="ANK 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          153..182
FT                   /note="ANK 5"
FT                   /evidence="ECO:0000255"
FT   REGION          181..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         193
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         304
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   390 AA;  41068 MW;  8577D68BDFAE633B CRC64;
     MLKPKDLCPR AGTRTFLEAM QAGKVHLARF VLDALDRSII DCRAEQGRTP LMVAVGLPDP
     AMRSRFVRLL LEQGAAVNLR DERGRTALSL ACERGHLDAV QLLVQFSGDP EATDSAGNSP
     VMWAAACGHG AVLEFLVRSF RRLGLRLDRT NRAGLTALQL AASRGHGTCV QALTGPWGRA
     AAAAAARGSN SDSPPGHPAP APSPERRRPS PRRLPRPLLA RFARAAGGHG HGHGHGHGHG
     GELASAGKGS VRYRAQGNER PELGRSMSLA LGTMTEEETA RLRAGALMAR PNSPQSSGSG
     RWRSQEVLEG APLALMQAPV GLSPHPEGCP GSGRLGLRRR STAPDIPSLV GEASGPESGP
     ELENNALPFS VPGPKPWQAG TEAVVLQAQR
//