ID A2ADM9_MOUSE Unreviewed; 272 AA. AC A2ADM9; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 02-SEP-2026, entry version 136. DE RecName: Full=Cerberus {ECO:0000256|ARBA:ARBA00069704}; DE AltName: Full=Cerberus-related protein {ECO:0000256|ARBA:ARBA00078779}; GN Name=Cer1 {ECO:0000313|EMBL:AAI32432.1, ECO:0000313|MGI:MGI:1201414}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI32432.1}; RN [1] {ECO:0000313|EMBL:AAI32432.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI32432.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBUNIT: Forms monomers and predominantly dimers. CC {ECO:0000256|ARBA:ARBA00065670}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, CC ECO:0000256|PIRNR:PIRNR027807}. CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872, CC ECO:0000256|PIRNR:PIRNR027807}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC132431; AAI32432.1; -; mRNA. DR EMBL; BC145993; AAI45994.1; -; mRNA. DR RefSeq; NP_034017.1; NM_009887.2. DR AlphaFoldDB; A2ADM9; -. DR SMR; A2ADM9; -. DR Antibodypedia; 10019; 268 antibodies from 33 providers. DR DNASU; 12622; -. DR GeneID; 12622; -. DR KEGG; mmu:12622; -. DR AGR; MGI:1201414; -. DR CTD; 9350; -. DR MGI; MGI:1201414; Cer1. DR VEuPathDB; HostDB:ENSMUSG00000038192; -. DR HOGENOM; CLU_104447_0_0_1; -. DR OMA; KKFWDHF; -. DR OrthoDB; 9950584at2759; -. DR BioGRID-ORCS; 12622; 2 hits in 77 CRISPR screens. DR ExpressionAtlas; A2ADM9; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0036122; F:BMP binding; IEA:Ensembl. DR GO; GO:0016015; F:morphogen activity; IEA:Ensembl. DR GO; GO:0140311; F:protein sequestering activity; IEA:Ensembl. DR GO; GO:0141069; F:receptor ligand inhibitor activity; IEA:Ensembl. DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl. DR GO; GO:0048263; P:determination of dorsal identity; IEA:Ensembl. DR GO; GO:0032926; P:negative regulation of activin receptor signaling pathway; IEA:Ensembl. DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl. DR GO; GO:2000381; P:negative regulation of mesoderm development; IEA:Ensembl. DR GO; GO:0007399; P:nervous system development; IEA:Ensembl. DR FunFam; 2.10.90.10:FF:000042; Cerberus 1 homolog (Xenopus laevis); 1. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR016860; Cerberus. DR InterPro; IPR006207; Cys_knot_C. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR004133; DAN_dom. DR PANTHER; PTHR15273:SF4; CERBERUS; 1. DR PANTHER; PTHR15273; DAN DOMAIN FAMILY MEMBER 5; 1. DR Pfam; PF03045; DAN; 1. DR PIRSF; PIRSF027807; Cerberus; 1. DR SMART; SM00041; CT; 1. DR PROSITE; PS01225; CTCK_2; 1. PE 2: Evidence at transcript level; KW Cytokine {ECO:0000256|ARBA:ARBA00022514}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR027807}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR027807}. FT SIGNAL 1..17 FT /evidence="ECO:0000256|PIRNR:PIRNR027807" FT CHAIN 18..272 FT /note="Cerberus" FT /evidence="ECO:0000256|PIRNR:PIRNR027807" FT /id="PRO_5014296784" FT DOMAIN 162..246 FT /note="CTCK" FT /evidence="ECO:0000259|PROSITE:PS01225" SQ SEQUENCE 272 AA; 30431 MW; DD0842A2619AF057 CRC64; MHLLLVQLLV LLPLGKADLC VDGCQSQGSL SFPLLERGRR DLHVANHEEA EDKPDLFVAV PHLMGTSLAG EGQRQRGKML SRLGRFWKKP ETEFYPPRDV ESDHVSSGMQ AVTQPADGRK VERSPLQEEA KRFWHRFMFR KGPAFQGVIL PIKSHEVHWE TCRTVPFNQT IAHEDCQKVV VQNNLCFGKC SSIRFPGEGA DAHSFCSHCS PTKFTTVHLM LNCTSPTPVV KMVMQVEECQ CMVKTERGEE RLLLAGSQGS FIPGLPASKT NP //