ID   A2ADM8_MOUSE            Unreviewed;      1628 AA.
AC   A2ADM8;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   02-SEP-2026, entry version 132.
DE   SubName: Full=Zinc finger protein 831 {ECO:0000313|Ensembl:ENSMUSP00000060255.6};
GN   Name=Zfp831 {ECO:0000313|Ensembl:ENSMUSP00000060255.6,
GN   ECO:0000313|MGI:MGI:3641861};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000060255.6, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000060255.6, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000060255.6,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG   Mouse Genome Sequencing Consortium;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000060255.6, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000060255.6,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=21750661;
RA   Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA   Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA   Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA   Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA   Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA   Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA   Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT   "Modernizing reference genome assemblies.";
RL   PLoS Biol. 9:e1001091-e1001091(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000060255.6}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000060255.6};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000256|ARBA:ARBA00006991}.
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DR   RefSeq; NP_001092798.1; NM_001099328.1.
DR   RefSeq; XP_011237537.1; XM_011239235.1.
DR   AlphaFoldDB; A2ADM8; -.
DR   SMR; A2ADM8; -.
DR   FunCoup; A2ADM8; 170.
DR   STRING; 10090.ENSMUSP00000060255; -.
DR   GlyGen; A2ADM8; 4 sites.
DR   iPTMnet; A2ADM8; -.
DR   PhosphoSitePlus; A2ADM8; -.
DR   PaxDb; 10090-ENSMUSP00000060255; -.
DR   ProteomicsDB; 365318; -.
DR   Antibodypedia; 5844; 8 antibodies from 7 providers.
DR   Ensembl; ENSMUST00000059452.6; ENSMUSP00000060255.6; ENSMUSG00000050600.6.
DR   GeneID; 100043757; -.
DR   KEGG; mmu:100043757; -.
DR   UCSC; uc008ofh.1; mouse.
DR   AGR; MGI:3641861; -.
DR   CTD; 100043757; -.
DR   MGI; MGI:3641861; Zfp831.
DR   VEuPathDB; HostDB:ENSMUSG00000050600; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000161664; -.
DR   HOGENOM; CLU_243145_0_0_1; -.
DR   InParanoid; A2ADM8; -.
DR   OMA; MSQHQVS; -.
DR   OrthoDB; 6077919at2759; -.
DR   PhylomeDB; A2ADM8; -.
DR   BioGRID-ORCS; 100043757; 5 hits in 76 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; A2ADM8; protein.
DR   Bgee; ENSMUSG00000050600; Expressed in granulocyte and 16 other cell types or tissues.
DR   FunFam; 3.30.160.60:FF:000710; Zinc finger protein 768; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR47166; ZINC FINGER PROTEIN 831; 1.
DR   PANTHER; PTHR47166:SF1; ZINC FINGER PROTEIN 831; 1.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   1: Evidence at protein level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Proteomics identification {ECO:0007829|ProteomicsDB:A2ADM8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00042}.
FT   DOMAIN          143..170
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          171..200
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          505..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          623..945
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          963..1005
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1172..1233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1289..1347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1360..1387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1399..1419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1480..1533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1575..1628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..213
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..327
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        623..634
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        707..716
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        717..736
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        791..811
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        856..870
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        986..1005
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1177..1211
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1222..1233
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1334..1347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1367..1378
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1509..1519
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1520..1529
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1575..1587
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1600..1613
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1628 AA;  174114 MW;  2812377D23B2BBED CRC64;
     MEASEPTHPT PSATDQPASV PGIPGGLGGQ ASPRLTLGPV ILPPEQGLAP TVFLKALPVP
     LYHTVPPGGL QPRAPLVTGS LEGASVPFIL SPLLQPEGPS ATQVGKPATP ALTVNIVGTL
     PVLSSGVGSA LVSTGRVKNT GKYLCPHCGR DCLKPSVLEK HIRSHTGERP FPCPTCGIAF
     KTQSNLYKHR RTQTHLNNSR LSLESEGSGS SLLEEGDRPG ETASVDSRGD EGAPERALSP
     GALPALAAQN RERKVESAPS LGATLSHREA SADHTQMVSP EFSLASPQPR RKLPEPKPCF
     LQRQQETCSE KPWDPKALEG QLRKCESTDS GYLSRSDSVE QPPVASSPLH SLSEHSAESE
     GEGGPGCSSS GNRAERGTPG PSLELEKKKL EERIAQLISH NQAVVDDPQL DHVRPRKTVL
     SKQGSIDLPM PYTYKDSFHF DIRALEPSRR RAALSPARST FTPLEKARPL FFHSVPTQLS
     TTVECVPVTR SNSLPFVEGS KLWPEQRDPQ DAVPGMQKAL SPRPTPARLG CRPGLTLASI
     SSGHPRALVR QAAVEDLPCT PTGDPSAAAE ELDGKRAVAK EGVVYKGRAS KKCSQRKQRM
     FSQEKWQVYG NETFKRIYQK MKTNHQGGQK HRQVKQGQGT ELDFPPPPPP QKQGGGGEDT
     GLSQDSRIPI LGDTTAGCKL ESWGSRPSLE DSLEAESPKQ LKVVTRVKSS PTLGSTDSLC
     LSGKSSLLSP SGKLDLGCQP PPVPTACQAG DLEAPETASP DSSGEAIKET SPGAQTVLRR
     SSDGSVALQL AEDKLPSERK RLKVEGLDHQ EQPGPLEADT SGGSVQADPP PSERQDSDSE
     ELLGCSNKST LHVTTAPEPS DVSSAASPVA LQWPGIGDKD SPLPSVPRTP GLHSLLPAQP
     QDPGVPNARS GGFFPPKYLL RLPQGENPSP IVAAGPEKGS DSLCTSTQPV EQALLVGSEL
     GMLRPPGAYS GPGEAGGSPD DPSWSRLRDG KEEAQTGREK RDRTKDNILV VGHSPVPITS
     TTQEIASVLS THTCDIRVAQ DVVSKTHAIH CLCTDSPPAR ARTYGNLLNP WTSSQKLGIP
     PKSALEGPPS ETKEGLPAFF SSQAHYFLTT FTKPQDISLN QQKPALSHVL GTPRSCEAPS
     SFPSLKTEPQ LTWCCLSRSL PLPAEQRRIA PGHLASSLPN RNLQGDSNKT LPKSNGGRTQ
     TSQGGEVSTQ APELPYPSVP ELRAEDQVSR PRWKKEQLWR RKVKTSRENT KQKKLRLHSK
     RCEGSFWQRA KRLCKPPWLP RRSCLPHRLE GLEPRGTLGR SSAEVAGRNV QGEPSCASKD
     LSVSHGNKEK EGDCSQTSRP MSPGMSSKTM LEMDKSALKD ISPTTGEHND CSQEKEHAGG
     SGLSPQSNTF LAVFQEDVPQ GKGLDVGPPE TQLPPSQDQV SITPNLCFSP DVPELPSSFK
     PKGTFPHHDV ATSVAAICVS AGIRTGRKTL RAHSAESCAE ETLARNSPDR RGTPDSIPRV
     LLPGRPSPGK QSPGQTLEIP SSGPSSVSSL QEEARAQADF PWWGQYGCGD LTVQGAASGS
     ESRTCQAEGL ITSKTVTAPS DPGQPSQVPE EAPLRSIRKR SLEGMRKQTR VELSDTSSDD
     EDRLVIEI
//