ID   A2AD74_MOUSE            Unreviewed;       121 AA.
AC   A2AD74;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   02-SEP-2026, entry version 133.
DE   SubName: Full=Protein kinase C, zeta {ECO:0000313|Ensembl:ENSMUSP00000116042.2};
DE   Flags: Fragment;
GN   Name=Prkcz {ECO:0000313|Ensembl:ENSMUSP00000116042.2,
GN   ECO:0000313|MGI:MGI:97602};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000116042.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000116042.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116042.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG   Mouse Genome Sequencing Consortium;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000116042.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116042.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=21750661;
RA   Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA   Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA   Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA   Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA   Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA   Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA   Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT   "Modernizing reference genome assemblies.";
RL   PLoS Biol. 9:e1001091-e1001091(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000116042.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116042.2};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
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DR   AlphaFoldDB; A2AD74; -.
DR   SMR; A2AD74; -.
DR   ProteomicsDB; 369304; -.
DR   Antibodypedia; 3869; 875 antibodies from 48 providers.
DR   Ensembl; ENSMUST00000131975.8; ENSMUSP00000116042.2; ENSMUSG00000029053.17.
DR   AGR; MGI:97602; -.
DR   MGI; MGI:97602; Prkcz.
DR   VEuPathDB; HostDB:ENSMUSG00000029053; -.
DR   GeneTree; ENSGT00940000153497; -.
DR   HOGENOM; CLU_2043451_0_0_1; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000029053; Expressed in superior frontal gyrus and 178 other cell types or tissues.
DR   ExpressionAtlas; A2AD74; baseline and differential.
DR   FunFam; 3.30.60.20:FF:000012; Protein kinase C; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR020454; DAG/PE-bd.
DR   InterPro; IPR002219; PKC_DAG/PE.
DR   PANTHER; PTHR22968:SF14; PROTEIN KINASE C; 1.
DR   PANTHER; PTHR22968; PROTEIN KINASE C, MU; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   1: Evidence at protein level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00226};
KW   Proteomics identification {ECO:0007829|ProteomicsDB:A2AD74};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00226};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00226}.
FT   DOMAIN          22..72
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   ZN_FING         22..72
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00226"
FT   REGION          78..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         121
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000116042.2"
SQ   SEQUENCE   121 AA;  14038 MW;  AB30911A8AFF4E60 CRC64;
     MVGESIYRRG ARRWRKLYRA NGHLFQAKRF NRGAYCGQCS ERIWGLSRQG YRCINCKLLV
     HKRCHVLVPL TCRRHMDSVM PSQEPPVDDK NDGVDLPSEE TDGIAYISSS RKHDNIKDDS
     E
//