ID   A1T856_MYCVP            Unreviewed;       341 AA.
AC   A1T856;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   02-SEP-2026, entry version 106.
DE   SubName: Full=Transcriptional regulator, LacI family {ECO:0000313|EMBL:ABM13356.1};
GN   OrderedLocusNames=Mvan_2545 {ECO:0000313|EMBL:ABM13356.1};
OS   Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 /
OS   KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Mycobacteriaceae; Mycolicibacterium.
OX   NCBI_TaxID=350058 {ECO:0000313|EMBL:ABM13356.1, ECO:0000313|Proteomes:UP000009159};
RN   [1] {ECO:0000313|EMBL:ABM13356.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PYR-1 {ECO:0000313|EMBL:ABM13356.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Anderson I.J., Miller C., Richardson P.;
RT   "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP000511; ABM13356.1; -; Genomic_DNA.
DR   RefSeq; WP_011779765.1; NC_008726.1.
DR   AlphaFoldDB; A1T856; -.
DR   STRING; 350058.Mvan_2545; -.
DR   GeneID; 307644039; -.
DR   KEGG; mva:Mvan_2545; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_1_11; -.
DR   Proteomes; UP000009159; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:TreeGrafter.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:TreeGrafter.
DR   CDD; cd01392; HTH_LacI; 1.
DR   CDD; cd06267; PBP1_LacI_sugar_binding-like; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR30146:SF109; HTH-TYPE TRANSCRIPTIONAL REGULATOR GALS; 1.
DR   PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00111}; Reference proteome {ECO:0000313|Proteomes:UP000009159};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|PROSITE-
KW   ProRule:PRU00111};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PROSITE-ProRule:PRU00111}.
FT   DOMAIN          7..61
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50932"
FT   DNA_BIND        9..28
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   341 AA;  36360 MW;  231AAFCCA6388CE4 CRC64;
     MIPKQTVNMT DVARRSGVSI ASVSRALRGE SGVSAATRDR ILSAARELAY VVSPEASRLS
     GGPTGRVGVI VPRVDAWFYS TILAGIADEF DTVGMDLILC TLPTSAARHR FFEALPLRRK
     VDAAVVVSLP LSARERTRLD QLAVPTVFVG GHRTEDHRPW VGIDDERAAQ QAVGHLLRIG
     HHDIAMIQAA DDTDIPWATD QARIRGFHQT MQEAGLADPT VVTVKWSVDG GSHGMETLLS
     RSRPPTAVFC HSDEIALGAL RTLRRSGISV PQQVSVIGVD DHPAAELSDL TTVAQPVREQ
     GRIAARVVLG GLGDGDASGP PASVTTLPTR LVVRGSTAPP R
//