ID   A1RC54_PAEAT            Unreviewed;       329 AA.
AC   A1RC54;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   08-OCT-2025, entry version 120.
DE   SubName: Full=Glyoxylate reductase {ECO:0000313|EMBL:ABM09365.1};
DE            EC=1.1.1.26 {ECO:0000313|EMBL:ABM09365.1};
GN   OrderedLocusNames=AAur_4149 {ECO:0000313|EMBL:ABM09365.1};
OS   Paenarthrobacter aurescens (strain TC1).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
OC   Micrococcaceae; Paenarthrobacter.
OX   NCBI_TaxID=290340 {ECO:0000313|EMBL:ABM09365.1, ECO:0000313|Proteomes:UP000000637};
RN   [1] {ECO:0000313|EMBL:ABM09365.1, ECO:0000313|Proteomes:UP000000637}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TC1 {ECO:0000313|EMBL:ABM09365.1,
RC   ECO:0000313|Proteomes:UP000000637};
RX   PubMed=17194220; DOI=10.1371/journal.pgen.0020214;
RA   Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B.,
RA   Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.,
RA   Wackett L.P., Nelson K.E., Sadowsky M.J.;
RT   "Secrets of soil survival revealed by the genome sequence of Arthrobacter
RT   aurescens TC1.";
RL   PLoS Genet. 2:2094-2106(2006).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC       ECO:0000256|RuleBase:RU003719}.
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DR   EMBL; CP000474; ABM09365.1; -; Genomic_DNA.
DR   RefSeq; WP_011776740.1; NC_008711.1.
DR   AlphaFoldDB; A1RC54; -.
DR   STRING; 290340.AAur_4149; -.
DR   KEGG; aau:AAur_4149; -.
DR   eggNOG; COG1052; Bacteria.
DR   HOGENOM; CLU_019796_1_2_11; -.
DR   OrthoDB; 117809at2; -.
DR   Proteomes; UP000000637; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0047964; F:glyoxylate reductase (NADH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030267; F:glyoxylate reductase (NADPH) activity; IEA:TreeGrafter.
DR   GO; GO:0016618; F:hydroxypyruvate reductase [NAD(P)H] activity; IEA:TreeGrafter.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   CDD; cd05301; GDH; 1.
DR   FunFam; 3.40.50.720:FF:000203; D-3-phosphoglycerate dehydrogenase (SerA); 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR050223; D-isomer_2-hydroxyacid_DH.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR10996:SF283; GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE B; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000637}.
FT   DOMAIN          6..324
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          109..292
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   329 AA;  34917 MW;  E093C6997CF51542 CRC64;
     MGNHYLVTTA IPEPGLQLLS DAGQVTVLPD PPDYATLAAL CASGDYDVVL TQLRDVIDEP
     LLANARVKGV SNYAVGYNNI DVDAATRHGI LVGNTPGVLT DATADVAMLL ILGTARRVVE
     SDRVVRDGKF LGWEPEFMLG RDVSGAVLGL AGFGRIARAV ARRALGFGME ELFSPRPPGD
     RPVSDEELGE FAGKVRQVPW DSLVERSDFL SLHVPLNEQT RHLVDADVLG RMKSDAILIN
     TARGPVVDES ALVEALRNGV IGGAGLDVFE DEPRLAAGLA ELPNTVLLPH VGSATVPVRA
     EMARLSALNA IAIAEGRLPL HPVNPLSRA
//