ID   PUR7_MYCUA              Reviewed;         297 AA.
AC   A0PLI0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   02-SEP-2026, entry version 92.
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase {ECO:0000255|HAMAP-Rule:MF_00137};
DE            EC=6.3.2.6 {ECO:0000255|HAMAP-Rule:MF_00137};
DE   AltName: Full=SAICAR synthetase {ECO:0000255|HAMAP-Rule:MF_00137};
GN   Name=purC {ECO:0000255|HAMAP-Rule:MF_00137};
GN   OrderedLocusNames=MUL_0497;
OS   Mycobacterium ulcerans (strain Agy99).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Mycobacteriaceae; Mycobacterium; Mycobacterium ulcerans group.
OX   NCBI_TaxID=362242;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Agy99;
RX   PubMed=17210928; DOI=10.1101/gr.5942807;
RA   Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T.,
RA   Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J.,
RA   Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.,
RA   Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.;
RT   "Reductive evolution and niche adaptation inferred from the genome of
RT   Mycobacterium ulcerans, the causative agent of Buruli ulcer.";
RL   Genome Res. 17:192-200(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-
CC         aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-
CC         ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+);
CC         Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC         ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00137};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC       {ECO:0000255|HAMAP-Rule:MF_00137}.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00137}.
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DR   EMBL; CP000325; ABL03199.1; -; Genomic_DNA.
DR   RefSeq; WP_011738824.1; NC_008611.1.
DR   AlphaFoldDB; A0PLI0; -.
DR   SMR; A0PLI0; -.
DR   KEGG; mul:MUL_0497; -.
DR   eggNOG; COG0152; Bacteria.
DR   HOGENOM; CLU_045637_0_0_11; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000000765; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01414; SAICAR_synt_Sc; 1.
DR   FunFam; 3.30.200.20:FF:000199; Phosphoribosylaminoimidazole-succinocarboxamide synthase; 1.
DR   FunFam; 3.30.470.20:FF:000015; Phosphoribosylaminoimidazole-succinocarboxamide synthase; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR001636; SAICAR_synth.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   NCBIfam; NF010568; PRK13961.1; 1.
DR   NCBIfam; TIGR00081; purC; 1.
DR   PANTHER; PTHR43700; PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE; 1.
DR   PANTHER; PTHR43700:SF1; PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE; 1.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; Purine biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..297
FT                   /note="Phosphoribosylaminoimidazole-succinocarboxamide
FT                   synthase"
FT                   /id="PRO_1000018740"
SQ   SEQUENCE   297 AA;  32717 MW;  4454B51D13DDEBF4 CRC64;
     MRPQLSDYQH LASGKVRELY RVDDEHLLVV ASDRISAYDY VLDSMIPDKG RILTAMSVFF
     FGLVDAPNHL AGPPDDPRIP DEVLGRALVV RQLEMLPVEC VARGYLTGSG LLDYQASGKV
     CGIALPPGLV GASKFAEPLF TPATKAELGD HDENISFAQV IETVGGVRAN QLRDRTLQIY
     VKAADHALTR GVIIADTKFE FGADRDGNLL LADEIFTPDS SRYWPADEYR AGVVQNSFDK
     QFVRNWLTSA ESGWDRGGDQ PPPPLPDHII EATRERYIEA YERISGLGFG EWIGPGA
//