ID   A0LSI3_ACIC1            Unreviewed;       517 AA.
AC   A0LSI3;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   05-FEB-2025, entry version 77.
DE   SubName: Full=Diguanylate cyclase {ECO:0000313|EMBL:ABK52393.1};
GN   OrderedLocusNames=Acel_0620 {ECO:0000313|EMBL:ABK52393.1};
OS   Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Acidothermales;
OC   Acidothermaceae; Acidothermus.
OX   NCBI_TaxID=351607 {ECO:0000313|EMBL:ABK52393.1, ECO:0000313|Proteomes:UP000008221};
RN   [1] {ECO:0000313|EMBL:ABK52393.1, ECO:0000313|Proteomes:UP000008221}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43068 / DSM 8971 / 11B
RC   {ECO:0000313|Proteomes:UP000008221};
RX   PubMed=19270083; DOI=10.1101/gr.084848.108;
RA   Barabote R.D., Xie G., Leu D.H., Normand P., Necsulea A., Daubin V.,
RA   Medigue C., Adney W.S., Xu X.C., Lapidus A., Parales R.E., Detter C.,
RA   Pujic P., Bruce D., Lavire C., Challacombe J.F., Brettin T.S., Berry A.M.;
RT   "Complete genome of the cellulolytic thermophile Acidothermus
RT   cellulolyticus 11B provides insights into its ecophysiological and
RT   evolutionary adaptations.";
RL   Genome Res. 19:1033-1043(2009).
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DR   EMBL; CP000481; ABK52393.1; -; Genomic_DNA.
DR   RefSeq; WP_011719456.1; NC_008578.1.
DR   AlphaFoldDB; A0LSI3; -.
DR   STRING; 351607.Acel_0620; -.
DR   KEGG; ace:Acel_0620; -.
DR   eggNOG; COG2205; Bacteria.
DR   eggNOG; COG3706; Bacteria.
DR   HOGENOM; CLU_492402_0_0_11; -.
DR   InParanoid; A0LSI3; -.
DR   OrthoDB; 23692at2; -.
DR   Proteomes; UP000008221; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0052621; F:diguanylate cyclase activity; IEA:TreeGrafter.
DR   GO; GO:0043709; P:cell adhesion involved in single-species biofilm formation; IEA:TreeGrafter.
DR   GO; GO:1902201; P:negative regulation of bacterial-type flagellum-dependent cell motility; IEA:TreeGrafter.
DR   CDD; cd01949; GGDEF; 1.
DR   FunFam; 3.30.70.270:FF:000001; Diguanylate cyclase domain protein; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR050469; Diguanylate_Cyclase.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR   PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008221};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        43..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        126..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          377..505
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
SQ   SEQUENCE   517 AA;  56149 MW;  DF7A648A4B158070 CRC64;
     MARTQDIDLV PLSERLRTTQ LCRYGLGVVM VLLWYAVPQY RGLPLVSLAG FTAGYLAVTA
     PTAYAARLSR RTILTVFSAS LVIDGIYLAI TSYATTGYVS PQVTLVLVHA VTVTLLASFR
     TGLKIAVWHS LLAFVVYQYL RAGVLHSPHH STGAEVGAFV AAVWLVTLAT AAFASVNERE
     LRRRNYDLLG LARLSQRLEE ALHPADVGRV LVEAVHDDFL APRAAIVVKS GPGDVILASV
     KTTPNRLSPA EDRSIQSVRR ERRTWRLGHI DRHRDRWLAA SFPGAQRLLL VPMSAGNNVD
     GVLVAEHNAR FGSRVDRRVV AMLERYASQT ALALANSWLL EQITLLAATD MLTGVANRRT
     LEENLDRMFA QASRAAQPIS VVMVDIDHFK HINDTFGHQV GDQTLQRVAR ALQQGCRSSD
     LVARYGGEEF VVVLPDTDLA GAATAAENLR RRIFGLDAEP RVTVSLGVAT FPLHGGSPDH
     ILSAADAALY QSKSAGRNRV TLAGVGSQVL PGSPQPA
//