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<entry dataset="Swiss-Prot" created="2007-07-10" modified="2026-01-28" version="96" xmlns="http://uniprot.org/uniprot">
  <accession>A0L5T9</accession>
  <name>MDH_MAGMM</name>
  <protein>
    <recommendedName>
      <fullName evidence="1">Malate dehydrogenase</fullName>
      <ecNumber evidence="1">1.1.1.37</ecNumber>
    </recommendedName>
  </protein>
  <gene>
    <name evidence="1" type="primary">mdh</name>
    <name type="ordered locus">Mmc1_0813</name>
  </gene>
  <organism>
    <name type="scientific">Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)</name>
    <dbReference type="NCBI Taxonomy" id="156889"/>
    <lineage>
      <taxon>Bacteria</taxon>
      <taxon>Pseudomonadati</taxon>
      <taxon>Pseudomonadota</taxon>
      <taxon>Magnetococcia</taxon>
      <taxon>Magnetococcales</taxon>
      <taxon>Magnetococcaceae</taxon>
      <taxon>Magnetococcus</taxon>
    </lineage>
  </organism>
  <reference key="1">
    <citation type="journal article" date="2009" name="Appl. Environ. Microbiol." volume="75" first="4835" last="4852">
      <title>Complete genome sequence of the chemolithoautotrophic marine magnetotactic coccus strain MC-1.</title>
      <authorList>
        <person name="Schubbe S."/>
        <person name="Williams T.J."/>
        <person name="Xie G."/>
        <person name="Kiss H.E."/>
        <person name="Brettin T.S."/>
        <person name="Martinez D."/>
        <person name="Ross C.A."/>
        <person name="Schuler D."/>
        <person name="Cox B.L."/>
        <person name="Nealson K.H."/>
        <person name="Bazylinski D.A."/>
      </authorList>
      <dbReference type="PubMed" id="19465526"/>
      <dbReference type="DOI" id="10.1128/aem.02874-08"/>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    <source>
      <strain>ATCC BAA-1437 / JCM 17883 / MC-1</strain>
    </source>
  </reference>
  <comment type="function">
    <text evidence="1">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
  </comment>
  <comment type="catalytic activity">
    <reaction evidence="1">
      <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
      <dbReference type="Rhea" id="RHEA:21432"/>
      <dbReference type="ChEBI" id="CHEBI:15378"/>
      <dbReference type="ChEBI" id="CHEBI:15589"/>
      <dbReference type="ChEBI" id="CHEBI:16452"/>
      <dbReference type="ChEBI" id="CHEBI:57540"/>
      <dbReference type="ChEBI" id="CHEBI:57945"/>
      <dbReference type="EC" id="1.1.1.37"/>
    </reaction>
  </comment>
  <comment type="similarity">
    <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
  </comment>
  <dbReference type="EC" id="1.1.1.37" evidence="1"/>
  <dbReference type="EMBL" id="CP000471">
    <property type="protein sequence ID" value="ABK43332.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="RefSeq" id="WP_011712492.1">
    <property type="nucleotide sequence ID" value="NC_008576.1"/>
  </dbReference>
  <dbReference type="AlphaFoldDB" id="A0L5T9"/>
  <dbReference type="SMR" id="A0L5T9"/>
  <dbReference type="STRING" id="156889.Mmc1_0813"/>
  <dbReference type="KEGG" id="mgm:Mmc1_0813"/>
  <dbReference type="eggNOG" id="COG0039">
    <property type="taxonomic scope" value="Bacteria"/>
  </dbReference>
  <dbReference type="HOGENOM" id="CLU_040727_2_0_5"/>
  <dbReference type="OrthoDB" id="9802969at2"/>
  <dbReference type="Proteomes" id="UP000002586">
    <property type="component" value="Chromosome"/>
  </dbReference>
  <dbReference type="GO" id="GO:0030060">
    <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-UniRule"/>
  </dbReference>
  <dbReference type="GO" id="GO:0006108">
    <property type="term" value="P:malate metabolic process"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="InterPro"/>
  </dbReference>
  <dbReference type="GO" id="GO:0006099">
    <property type="term" value="P:tricarboxylic acid cycle"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-UniRule"/>
  </dbReference>
  <dbReference type="CDD" id="cd01338">
    <property type="entry name" value="MDH_chloroplast-like"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="FunFam" id="3.40.50.720:FF:000010">
    <property type="entry name" value="Malate dehydrogenase"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="FunFam" id="3.90.110.10:FF:000002">
    <property type="entry name" value="Malate dehydrogenase"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.90.110.10">
    <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.40.50.720">
    <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="HAMAP" id="MF_01517">
    <property type="entry name" value="Malate_dehydrog_2"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR001557">
    <property type="entry name" value="L-lactate/malate_DH"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR022383">
    <property type="entry name" value="Lactate/malate_DH_C"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR001236">
    <property type="entry name" value="Lactate/malate_DH_N"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR015955">
    <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR010945">
    <property type="entry name" value="Malate_DH_type2"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR036291">
    <property type="entry name" value="NAD(P)-bd_dom_sf"/>
  </dbReference>
  <dbReference type="NCBIfam" id="TIGR01759">
    <property type="entry name" value="MalateDH-SF1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="NCBIfam" id="NF003916">
    <property type="entry name" value="PRK05442.1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR23382">
    <property type="entry name" value="MALATE DEHYDROGENASE"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF02866">
    <property type="entry name" value="Ldh_1_C"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF00056">
    <property type="entry name" value="Ldh_1_N"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PIRSF" id="PIRSF000102">
    <property type="entry name" value="Lac_mal_DH"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF56327">
    <property type="entry name" value="LDH C-terminal domain-like"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF51735">
    <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
    <property type="match status" value="1"/>
  </dbReference>
  <proteinExistence type="inferred from homology"/>
  <keyword id="KW-0520">NAD</keyword>
  <keyword id="KW-0560">Oxidoreductase</keyword>
  <keyword id="KW-1185">Reference proteome</keyword>
  <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
  <feature type="chain" id="PRO_0000294390" description="Malate dehydrogenase">
    <location>
      <begin position="1"/>
      <end position="327"/>
    </location>
  </feature>
  <feature type="active site" description="Proton acceptor" evidence="1">
    <location>
      <position position="185"/>
    </location>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <begin position="11"/>
      <end position="17"/>
    </location>
    <ligand>
      <name>NAD(+)</name>
      <dbReference type="ChEBI" id="CHEBI:57540"/>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <position position="92"/>
    </location>
    <ligand>
      <name>substrate</name>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <position position="98"/>
    </location>
    <ligand>
      <name>substrate</name>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <position position="105"/>
    </location>
    <ligand>
      <name>NAD(+)</name>
      <dbReference type="ChEBI" id="CHEBI:57540"/>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <position position="112"/>
    </location>
    <ligand>
      <name>NAD(+)</name>
      <dbReference type="ChEBI" id="CHEBI:57540"/>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <begin position="128"/>
      <end position="130"/>
    </location>
    <ligand>
      <name>NAD(+)</name>
      <dbReference type="ChEBI" id="CHEBI:57540"/>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <position position="130"/>
    </location>
    <ligand>
      <name>substrate</name>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <position position="160"/>
    </location>
    <ligand>
      <name>substrate</name>
    </ligand>
  </feature>
  <evidence type="ECO:0000255" key="1">
    <source>
      <dbReference type="HAMAP-Rule" id="MF_01517"/>
    </source>
  </evidence>
  <sequence length="327" mass="34833" checksum="6AAAABB9195A5A08" modified="2006-12-12" version="1">MADPIRVAVTGAAGQIAYSLLVRLASGQLFGKDRKVELKLLEIPQAMGPLEGVMMELQDCAFPTLAKVEAFDNPEQAFDGINWCLMVGSRPRGPGMERSDLIKINGPIFVNQGKALNRAAQDVRAVVVGNPCNTNCMIAAHNSDVPHERFSAMMRLDQNRAKYLLASKAGAQVIDVTNVVIWGNHSNNQVPDFEFAKIGGKPVPEVIADAAWLENAFMPTVQNRGAAVIKARGASSAASAANAALDHVRSLITPTPAGDTFCAAVMANGAYGVDAGLIAGMPLTSTGHGDWSIVEGVPMSPFIKGKFDAVLDELRREREMVKDLLPG</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>