ID   A0EC59_PARTE            Unreviewed;       399 AA.
AC   A0EC59;
DT   28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2006, sequence version 1.
DT   02-SEP-2026, entry version 85.
DE   RecName: Full=ATP-dependent DNA ligase family profile domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=GSPATT00025612001 {ECO:0000313|EMBL:CAK92876.1};
OS   Paramecium tetraurelia.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX   NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK92876.1, ECO:0000313|Proteomes:UP000000600};
RN   [1] {ECO:0000313|EMBL:CAK92876.1, ECO:0000313|Proteomes:UP000000600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK92876.1,
RC   ECO:0000313|Proteomes:UP000000600};
RX   PubMed=17086204; DOI=10.1038/nature05230;
RG   Genoscope;
RA   Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA   Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA   Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA   Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA   Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA   Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA   Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA   Cohen J., Wincker P.;
RT   "Global trends of whole-genome duplications revealed by the ciliate
RT   Paramecium tetraurelia.";
RL   Nature 444:171-178(2006).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|ARBA:ARBA00001968};
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DR   EMBL; CT868670; CAK92876.1; -; Genomic_DNA.
DR   RefSeq; XP_001460273.1; XM_001460236.1.
DR   AlphaFoldDB; A0EC59; -.
DR   STRING; 5888.A0EC59; -.
DR   GeneID; 5046058; -.
DR   KEGG; ptm:GSPATT00025612001; -.
DR   eggNOG; ENOG502QTYC; Eukaryota.
DR   HOGENOM; CLU_661337_0_0_1; -.
DR   InParanoid; A0EC59; -.
DR   OMA; YWVSEKL; -.
DR   OrthoDB; 411785at2759; -.
DR   Proteomes; UP000000600; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
DR   GO; GO:0003911; F:DNA ligase (NAD+) activity; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd07896; Adenylation_kDNA_ligase_like; 1.
DR   CDD; cd08041; OBF_kDNA_ligase_like; 1.
DR   Gene3D; 3.30.1490.70; -; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 2.20.140.10; WGR domain; 1.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR029319; DNA_ligase_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR050326; NAD_dep_DNA_ligaseB.
DR   InterPro; IPR008893; WGR_domain.
DR   NCBIfam; NF006592; PRK09125.1; 1.
DR   PANTHER; PTHR47810; DNA LIGASE; 1.
DR   PANTHER; PTHR47810:SF1; DNA LIGASE B; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF14743; DNA_ligase_OB_2; 1.
DR   Pfam; PF05406; WGR; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000600}.
FT   DOMAIN          9..72
FT                   /note="WGR"
FT                   /evidence="ECO:0000259|Pfam:PF05406"
FT   DOMAIN          150..317
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|Pfam:PF01068"
FT   DOMAIN          331..396
FT                   /note="DNA ligase OB-like"
FT                   /evidence="ECO:0000259|Pfam:PF14743"
FT   REGION          81..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   399 AA;  46077 MW;  B841A16EAC849173 CRC64;
     MKKYLQCDSK FWSITIEEND ETKLFIRYGN LCDYEELNVK KVEKQFPSKE ECQKYCEEAS
     KTKEDKGYQE VVPGQQIQQQ IQKNDSPIQN RPVQTKQQQK QSNAIKRTGS LKPDTIAAIT
     DDALNGRQQA IKGPAVDLGK GTIPLGKVML AQTWNEEIDP KGYYLSEKLD GMRMIWTGSK
     MYSRNGNPIQ FPDFFVQGWP KSYLDGELWL ERDQFSKLVS ITKRQVPVED DWRKVKYMVF
     DAPGLKLPFK DRYLRFKQAC EQANQYIVYV PHIVCKGYDH LIDELEAVQD LEGEGLMLRD
     PDSTYEQRRS DKLLKVKTFM DDEATVLAHE EGTGRCQGML GSLKVKNTSG IVFNIGSGLT
     DDIRQKPPKI GSRITYKYYG VSKNNVPRFP IYLRERPKE
//