ID   A0AIH4_LISW6            Unreviewed;       327 AA.
AC   A0AIH4;
DT   28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2006, sequence version 1.
DT   02-SEP-2026, entry version 94.
DE   SubName: Full=Branched-chain alpha-keto acid dehydrogenase E1 subunit (2-oxoisovalerate dehydrogenase beta subunit) {ECO:0000313|EMBL:CAK20806.1};
DE            EC=1.2.4.4 {ECO:0000313|EMBL:CAK20806.1};
GN   OrderedLocusNames=lwe1388 {ECO:0000313|EMBL:CAK20806.1};
OS   Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CCUG 15529
OS   / CIP 8149 / NCTC 11857 / SLCC 5334 / V8).
OC   Bacteria; Bacillati; Bacillota; Bacilli; Caryophanales; Listeriaceae;
OC   Listeria.
OX   NCBI_TaxID=386043 {ECO:0000313|EMBL:CAK20806.1, ECO:0000313|Proteomes:UP000000779};
RN   [1] {ECO:0000313|EMBL:CAK20806.1, ECO:0000313|Proteomes:UP000000779}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35897 / DSM 20650 / CCUG 15529 / CIP 8149 / NCTC 11857 /
RC   SLCC 5334 / V8 {ECO:0000313|Proteomes:UP000000779};
RX   PubMed=16936040; DOI=10.1128/JB.00758-06;
RA   Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S.,
RA   Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O.,
RA   Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T.,
RA   Lampidis R., Kreft J., Goebel W., Chakraborty T.;
RT   "Whole-genome sequence of Listeria welshimeri reveals common steps in
RT   genome reduction with Listeria innocua as compared to Listeria
RT   monocytogenes.";
RL   J. Bacteriol. 188:7405-7415(2006).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM263198; CAK20806.1; -; Genomic_DNA.
DR   RefSeq; WP_011702186.1; NC_008555.1.
DR   AlphaFoldDB; A0AIH4; -.
DR   STRING; 386043.lwe1388; -.
DR   PaxDb; 386043-lwe1388; -.
DR   GeneID; 61189264; -.
DR   KEGG; lwe:lwe1388; -.
DR   eggNOG; COG0022; Bacteria.
DR   HOGENOM; CLU_012907_1_0_9; -.
DR   OrthoDB; 9771835at2; -.
DR   Proteomes; UP000000779; Chromosome.
DR   GO; GO:0003863; F:branched-chain 2-oxo acid dehydrogenase activity; IEA:UniProtKB-EC.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   FunFam; 3.40.50.920:FF:000001; Pyruvate dehydrogenase E1 beta subunit; 1.
DR   FunFam; 3.40.50.970:FF:000001; Pyruvate dehydrogenase E1 beta subunit; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   NCBIfam; NF006667; PRK09212.1; 1.
DR   PANTHER; PTHR43257; PYRUVATE DEHYDROGENASE E1 COMPONENT BETA SUBUNIT; 1.
DR   PANTHER; PTHR43257:SF2; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CAK20806.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000779};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          4..179
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   327 AA;  35735 MW;  50B150F9417EE577 CRC64;
     MPVISYIDAI TMALKEEMER DDKVFILGED VGKKGGVFKA TAGLYDEFGE DRVLDTPLAE
     SAIAGVGIGA AMYGYRPVAE MQFADFIMPA VNQIISEASR IRYRSNNDWS CPLVIRAPFG
     GGVHGALYHS QSVEKVFFGQ PGLKIVVPSS PYDAKGLLKA AIRDNDPVLF FEHKRAYRLL
     KGEVPETDYI VPIGEANVVR EGDDITVITY GLAVQFAQQA AERLAAEGVE AHILDLRTIY
     PLDQEAIIEA TKKTGKVLLV TEDNKQGSII SEVAAIISEH CLFDLDAPIA RLAGPDTPAM
     PFAPTMEKHF MINPDKVADA MKELAEF
//