format-version: 1.2
date: 08:04:2025 12:33
default-namespace: uniprot:locations

[Typedef]
id: part_of
name: part_of
is_cyclic: false
is_transitive: true

[Term]
id: SL-0002
name: Acidocalcisome
namespace: uniprot:locations:cellular_component
def: "The acidocalcisome is an electron-dense acidic organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations. Its limiting membrane possesses a number of pumps and exchangers for the uptake and release of these elements. The acidocalcisome does not belong to the endocytic pathway and may represent a branch of the secretory pathway in trypanosomatids and apicomplexan parasites. The acidocalcisome is possibly involved in polyphosphate and cation storage and in adaptation of these microoganisms to environmental stress." []
xref: GO:0020022 "acidocalcisome"

[Term]
id: SL-0003
name: Acidocalcisome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane of an acidocalcisome." []
synonym: "Acidocalcisomal membrane" [UniProt]
xref: GO:0033102 "acidocalcisome membrane"
is_a: SL-0162
relationship: part_of SL-0002
relationship: part_of SL-0147

[Term]
id: SL-0004
name: Acrosome inner membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the acrosomal membrane closely associated with the anterior region of the nuclear envelope." []
synonym: "Acrosomal inner membrane" [UniProt]
synonym: "IAM" [UniProt]
synonym: "Inner acrosomal membrane" [UniProt]
xref: GO:0002079 "inner acrosomal membrane"
relationship: part_of SL-0006

[Term]
id: SL-0005
name: Acrosome lumen
namespace: uniprot:locations:cellular_component
def: "The lumen of the acrosome." []
synonym: "Acrosomal lumen" [UniProt]
xref: GO:0043160 "acrosomal lumen"
is_a: SL-0347
relationship: part_of SL-0007

[Term]
id: SL-0006
name: Acrosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane of the acrosome." []
synonym: "Acrosomal membrane" [UniProt]
xref: GO:0002080 "acrosomal membrane"
is_a: SL-0245
relationship: part_of SL-0007
relationship: part_of SL-0147

[Term]
id: SL-0007
name: Acrosome
namespace: uniprot:locations:cellular_component
def: "The acrosome is a large lysosome-like vesicle overlying the sperm nucleus. This spermatid specific organelle, derived from the Golgi during spermatogenesis, contains both unique acrosomal enzymes and common enzymes associated with lysosomes in somatic cells. Only sperm that have undergone the acrosome reaction can fuse with egg plasma membrane. The acrosome reaction is characterized by multiple fusions of the outer acrosomal membrane with the sperm cell membrane." []
synonym: "Acrosomal vesicle" [UniProt]
xref: GO:0001669 "acrosomal vesicle"
is_a: SL-0244

[Term]
id: SL-0008
name: Actin patch
namespace: uniprot:locations:cellular_component
def: "The actin patch is a highly dynamic actin structure in fungi required primarily for endocytosis but possibly also coupled to exocytosis. Actin patches are highly motile, they first assemble at sites of polarized cell growth and then move slowly and nondirectionally along the cell cortex." []
synonym: "Actin cortical patch" [UniProt]
xref: GO:0030479 "actin cortical patch"
relationship: part_of SL-0090

[Term]
id: SL-0009
name: Adherens junction
namespace: uniprot:locations:cellular_component
def: "The adherens junction is an adhesion complex that localizes close to the apical membrane in epithelial cells. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. AJs mediate both cell adhesion and signaling." []
synonym: "AJ" [UniProt]
synonym: "ZA" [UniProt]
synonym: "Zonula adherens" [UniProt]
xref: GO:0005912 "adherens junction"
is_a: SL-0038

[Term]
id: SL-0010
name: Aleurone grain
namespace: uniprot:locations:cellular_component
def: "The aleurone grain (protein body), is a specialized dry vacuole where storage proteins accumulate in a stable form in seeds, usually in the endosperm. Cells containing aleurones form the aleurone layer. These act as a source of amino acids for various synthetic activities during germination, but also represent immensely important nutritional sources for humans and ruminants. In most seeds, the aleuron grains contain three morphologically distinct regions: the matrix, crystalloid, and globoid." []
synonym: "Protein body" [UniProt]
xref: GO:0033095 "aleurone grain"
is_a: SL-0272

[Term]
id: SL-0011
name: Aleurone grain membrane
namespace: uniprot:locations:cellular_component
def: "The membrane of an aleurone grain." []
synonym: "Protein body membrane" [UniProt]
xref: GO:0032578 "aleurone grain membrane"
is_a: SL-0271
relationship: part_of SL-0010

[Term]
id: SL-0012
name: Amyloplast
namespace: uniprot:locations:cellular_component
def: "The amyloplast is a colorless plant plastid that forms and stores starch. Amyloplasts are found in many tissues, particularly in storage tissues. They are found in both photosynthetic and parasitic plants, i.e. even in plants that are not capable of photosynthesis. Many amyloplast proteins are also expressed in photosynthetic tissue." []
xref: GO:0009501 "amyloplast"
is_a: SL-0209

[Term]
id: SL-0013
name: Amyloplast inner membrane
namespace: uniprot:locations:cellular_component
def: "The inner membrane of an amyloplast." []
synonym: "Inner amyloplastic membrane" [UniProt]
xref: GO:0033098 "amyloplast inner membrane"
is_a: SL-0014
is_a: SL-0211

[Term]
id: SL-0014
name: Amyloplast membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the amyloplast. Also used when it is not clear in which amyloplast membrane a protein is found." []
xref: GO:0033097 "amyloplast membrane"
is_a: SL-0213
relationship: part_of SL-0012

[Term]
id: SL-0015
name: Apical cell membrane
namespace: uniprot:locations:cellular_component
def: "The fraction of the cell membrane at the apical end of the cell, which faces the outside world or the lumen of the cavity." []
synonym: "Apical plasma membrane" [UniProt]
xref: GO:0016324 "apical plasma membrane"
relationship: part_of SL-0039

[Term]
id: SL-0016
name: Apical lamina
namespace: uniprot:locations:cellular_component
def: "In the sea urchin embryos the apical lamina is a fibrous meshwork that remains after removal of hyalin from the hyalin layer." []
xref: GO:0032579 "apical lamina of hyaline layer"
is_a: SL-0111

[Term]
id: SL-0017
name: Apicolateral cell membrane
namespace: uniprot:locations:cellular_component
def: "The fraction of the cell membrane at the apical end of the lateral plasma membrane of the cell." []
synonym: "Apicolateral plasma membrane" [UniProt]
xref: GO:0016327 "apicolateral plasma membrane"
relationship: part_of SL-0039

[Term]
id: SL-0018
name: Apicoplast
namespace: uniprot:locations:cellular_component
def: "The apicoplast is a plastid found in some apicocomplexan parasites which is a non-photosynthetic plastid relict. Apicoplasts do not contain thylakoids; it is not yet clear if they contain internal membranes." []
synonym: "Golgi-adjunct organelle" [UniProt]
synonym: "Thick-walled organelle" [UniProt]
xref: GO:0020011 "apicoplast"
is_a: SL-0209

[Term]
id: SL-0019
name: Apoplast
namespace: uniprot:locations:cellular_component
def: "The apoplast is the \"non-living\" extracellular space that surrounds the symplast. It consists of cell walls and spaces between cells. Water and solutes can move freely in this framework, except at the endodermis in roots and stems where the apoplastic flow of ions is interrupted by the Casparian strip, forcing water to flow to symplast." []
xref: GO:0048046 "apoplast"
is_a: SL-0112

[Term]
id: SL-0020
name: Attachment organelle
namespace: uniprot:locations:cellular_component
def: "The attachment organelle is a multifunctional polar structure found in several Mycoplasma species. This large and complex cell extension, whose predicted mass is greater than that of a vertebrate nuclear pore complex, is essential for adherence to host cells, is involved in gliding motility, and is associated with cell division." []
synonym: "Terminal organelle" [UniProt]
xref: GO:0033099 "attachment organelle"
is_a: SL-0280

[Term]
id: SL-0021
name: Attachment organelle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the attachment organelle." []
synonym: "Terminal organelle membrane" [UniProt]
xref: GO:0033111 "attachment organelle membrane"
relationship: part_of SL-0020
relationship: part_of SL-0039

[Term]
id: SL-0022
name: Autophagosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the autophagosome." []
synonym: "Autophagic vacuolar membrane" [UniProt]
synonym: "Autophagic vacuole membrane" [UniProt]
synonym: "Autophagosomal membrane" [UniProt]
xref: GO:0000421 "autophagosome membrane"
is_a: SL-0089
relationship: part_of SL-0023

[Term]
id: SL-0023
name: Autophagosome
namespace: uniprot:locations:cellular_component
def: "The autophagosome is a double membrane vesicle involved in the degradation of long-lived proteins, unnecessary or damaged organelles as well as other cellular constituents such as lipids or carbohydrates. Crescent-shape isolation membranes or phagophores can sequester cytoplasm and organelles giving rise to autophagosomes. The outer membrane of the autophagosomes then fuse with vacuoles and/or lysosomes and the inner membrane vesicles (termed autophagic bodies) are released into the vacuole/lysosome lumen. These vesicles are then lysed and the contents are degraded by resident hydrolases." []
synonym: "Autophagic vacuole" [UniProt]
xref: GO:0005776 "autophagosome"
is_a: SL-0088

[Term]
id: SL-0024
name: Basal cell membrane
namespace: uniprot:locations:cellular_component
def: "The basal cell membrane is the fraction of the plasma membrane at the basal side of the cell, which faces the underlying connective tissue." []
synonym: "Basal plasma membrane" [UniProt]
xref: GO:0009925 "basal plasma membrane"
relationship: part_of SL-0039

[Term]
id: SL-0025
name: Basement membrane
namespace: uniprot:locations:cellular_component
def: "The basement membrane is a highly specialized extracellular matrix structure undelying the basal surface of cells exhibiting polarity (epithelial, endothelial and mesothelial cells) and surrounding certain cell types such as muscle, adipose and Schwann cells." []
xref: GO:0005604 "basement membrane"
is_a: SL-0111

[Term]
id: SL-0026
name: Basolateral cell membrane
namespace: uniprot:locations:cellular_component
def: "The basolateral cell membrane is the fraction of the plasma membrane at the basolateral side of the cell, which faces adjacent cells and the underlying connective tissue." []
synonym: "Basolateral plasma membrane" [UniProt]
xref: GO:0016323 "basolateral plasma membrane"
relationship: part_of SL-0039

[Term]
id: SL-0027
name: Bud
namespace: uniprot:locations:cellular_component
def: "A growing bud is an asexual reproductive structure, as in yeast or a hydra, that consists of an outgrowth capable of developing into a new individual." []
synonym: "Growing bud" [UniProt]
xref: GO:0005933 "cellular bud"

[Term]
id: SL-0028
name: Bud membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a bud." []
synonym: "Cellular bud membrane" [UniProt]
xref: GO:0033101 "cellular bud membrane"
relationship: part_of SL-0027
relationship: part_of SL-0039

[Term]
id: SL-0029
name: Bud neck
namespace: uniprot:locations:cellular_component
def: "The bud neck is a constriction between the mother and the daughter cell (bud) in an organism that reproduces by budding. This structure comprises the septin ring, an hourglass-shaped collar around the mother-bud neck, which splits into two rings flanking the division plane at cytokinesis and that acts as a diffusion barrier to maintain polarity factors in the bud and as a scaffold to recruit actomyosin contractile ring components." []
synonym: "Cellular bud neck" [UniProt]
xref: GO:0005935 "cellular bud neck"
relationship: part_of SL-0027

[Term]
id: SL-0030
name: Bud tip
namespace: uniprot:locations:cellular_component
def: "The bud tip is the distal tip of the bud opposite to the site of attachment to the mother cell." []
synonym: "Cellular bud tip" [UniProt]
xref: GO:0005934 "cellular bud tip"
relationship: part_of SL-0027

[Term]
id: SL-0031
name: Cajal body
namespace: uniprot:locations:cellular_component
def: "The nuclear Cajal bodies (CBs) are small subnuclear membraneless organelles present either free in the nucleoplasm and/or physically associated to specific regions of chromatin. CBs contain newly assembled small nuclear ribonucleoproteins (snRNPs) and small nucleolar ribonucleoproteins (snoRNPs) particles, which are involved in pre-mRNA splicing and in ribosomal RNA processing, respectively. Mammalian nucleus in interphase, show 2-6 CBs, as irregular, punctuate structures, which vary in size and shape and which are often juxtaposed to nucleoli. At the electronic-microscope level, they are composed of heterogeneous mixture of electro-dense particles with diameters ranging from 20-25 nm and are called coiled body. Structures similar to CBs have been identified in the amphibian oocyte nucleus (called sphere organelles) and in insect (called endobodies). CBs are motile and dynamic structures. Both their protein and RNA-protein components can cycle continuously between CBs and other nuclear locations depending on the transcriptional state of the cell." []
synonym: "Cajal bodies" [UniProt]
synonym: "Coiled body" [UniProt]
synonym: "Endobodies" [UniProt]
synonym: "Nucleolar accessory bodies" [UniProt]
synonym: "Sphere organelles" [UniProt]
xref: GO:0015030 "Cajal body"
is_a: SL-0494
relationship: part_of SL-0191

[Term]
id: SL-0032
name: Calyx
namespace: uniprot:locations:cellular_component
def: "The calyx is a large cytoskeletal component of the perinuclear theca of the mammalian sperm head." []
synonym: "Calyces" [UniProt]
synonym: "Cytoskeletal calyx" [UniProt]
xref: GO:0033150 "cytoskeletal calyx"
relationship: part_of SL-0199

[Term]
id: SL-0033
name: Capsule
namespace: uniprot:locations:cellular_component
def: "The capsule is a protective structure surrounding some bacteria or fungi. The bacterial capsule is a layer of material, usually polysaccharide, attached to the cell wall possibly via covalent attachments to either phospholipid or lipid-A molecules. It has several functions: promote bacterial adhesion to surfaces or interaction with other organisms; act as a permeability barrier, as a defense mechanism against phagocytosis and/or as a nutrient reserve. Among pathogens, capsule formation often correlates with pathogenicity. The fungal capsule is an extracellular layer which lies outside the cell wall and it is usually composed of polysaccharides. It protects the cell from different environmental dangers such as phagocytosis, dessication, etc." []
xref: GO:0042603 "capsule"
relationship: part_of SL-0036
relationship: part_of SL-0243

[Term]
id: SL-0034
name: Carboxysome
namespace: uniprot:locations:cellular_component
def: "Carboxysomes are bacterial microcompartments in which ribulose bisphosphate carboxylase (RuBisCO)-mediated CO(2) fixation occurs. The cytoplasmic polyhedral inclusion bodies are surrounded by a thin protein coat. They enhance autotrophic CO(2) fixation in air by increasing the CO(2) concentration around RuBisCO, thus reducing its reaction with O(2), a competing substrate. They contain carbonic anhydrase as part of the CO(2) concentration mechanism." []
xref: GO:0031470 "carboxysome"
is_a: SL-0544

[Term]
id: SL-0035
name: Caveola
namespace: uniprot:locations:cellular_component
def: "The caveola is a small (apparently) uncoated pit mostly found in the cell membrane of many highly differentiated mammalian cells, such as adipocytes, endothelial cells and muscle cells. These flask-shaped invaginations are defined by the presence of caveolins and contains a subset of lipid-raft components, including cholesterol and sphingolipids. Caveolae each comprise a caveolar bulb with a diameter of 60-80 nm, connected to an opening of fairly constant diameter. Caveolae might exists as single pits or can form a cluster of caveolae with non-caveolar membrane between the pits. In many tissues, and particularly in adipocytes, multiple caveolae are arranged around a central vacuolar domain. In developing muscle fibres, multiple caveolae are connected by a single neck to the cell membrane, producing large chains of interconnected caveolae. Another structural feature of caveolae in certain endothelia is the presence of a stomatal diaphragm, which consists of a central density and radial spikes, in the neck of the caveolae. Mature caveolae might be assembled in the Golgi apparatus. Caveolae can flatten out into the cell membrane, thereby loosing their caveolar identity." []
synonym: "Caveolae" [UniProt]
synonym: "Membrane microdomain" [UniProt]
synonym: "Plasmalemmal vesicle" [UniProt]
xref: GO:0005901 "caveola"
relationship: part_of SL-0147

[Term]
id: SL-0036
name: Cell envelope
namespace: uniprot:locations:cellular_component
def: "The cell envelope comprises the cell membrane, the cell wall and an outer membrane if present. In bacteria with 1 membrane (Gram-positive) the cell envelope consists of the cytoplasmic membrane, cell wall and capsule. In bacteria with 2 membranes (Gram-negative) the envelope consists of the cytoplasmic membrane, cell wall, periplasmic space, outer membrane and capsule. The archaeal cell envelope generally consists of single membrane covered by a surface layer (S-layer). Ignicoccus species exceptionally have an outer membrane which encloses a large periplasmic space. Extreme thermophiles and acidophiles have tetraether type glycerophospholipids with C40 isoprenoid chains. The yeast cell envelope is a protecting capsule which consists of the cytoplasmic membrane, the periplasmic space, and the cell wall." []
synonym: "Envelope" [UniProt]
xref: GO:0030313 "cell envelope"
xref: http://www.cf.ac.uk/biosi/staff/ehrmann/tools/ecce/ecce.htm

[Term]
id: SL-0037
name: Cell inner membrane
namespace: uniprot:locations:cellular_component
def: "The prokaryotic inner cell membrane is the selectively permeable membrane which separates the cytoplasm from the periplasm in prokaryotes with 2 membranes." []
synonym: "Cytoplasmic membrane" [UniProt]
synonym: "Inner membrane" [UniProt]
synonym: "Plasma membrane" [UniProt]
xref: GO:0005886 "plasma membrane"
is_a: SL-0039

[Term]
id: SL-0038
name: Cell junction
namespace: uniprot:locations:cellular_component
def: "The cell junction is a cell-cell or cell-extracellular matrix contact within a tissue of a multicellular organism, especially abundant in epithelia. In vertebrates, there are three major types of cell junctions: anchoring junctions (e.g. adherens junctions), communicating junctions (e.g. gap junctions) and occluding junctions (e.g. tight junctions)." []
xref: GO:0070161 "anchoring junction"
xref: https://www.ncbi.nlm.nih.gov/books/NBK26857/

[Term]
id: SL-0039
name: Cell membrane
namespace: uniprot:locations:cellular_component
def: "The cell membrane is the selectively permeable membrane which separates the cytoplasm from its surroundings. Known as the cell inner membrane in prokaryotes with 2 membranes." []
synonym: "Cytoplasmic membrane" [UniProt]
synonym: "Plasma membrane" [UniProt]
synonym: "Plasmalemma" [UniProt]
xref: GO:0005886 "plasma membrane"
is_a: SL-0162
relationship: part_of SL-0036
relationship: part_of SL-0147

[Term]
id: SL-0040
name: Cell outer membrane
namespace: uniprot:locations:cellular_component
def: "The prokaryotic outer cell membrane is the selectively permeable membrane which separates the prokaryotic periplasm from its cell surroundings. Traditionally only Gram-negative bacteria were thought of as having an outer membrane, but recent work has shown some Actinobacteria, including Mycobacterium tuberculosis, as well as at least 1 archaea (Ignicoccus hospitalis) have a cell outer membrane." []
synonym: "Outer membrane" [UniProt]
xref: GO:0009279 "cell outer membrane"
is_a: SL-0162

[Term]
id: SL-0041
name: Cell wall
namespace: uniprot:locations:cellular_component
def: "The complex and rigid layer surrounding the cell. Cell walls are found in bacteria, archaea, fungi, plants, and algae. The cell wall envelopes the inner or plasma membrane in all bacteria and is surrounded by the outer membrane in bacteria with 2 membranes (Gram- negative). Bacterial cell walls contain peptidoglycan while those of archaea are not made of peptidoglycan, but some archaea may contain pseudopeptidoglycan, which is composed of N-acetyltalosaminuronic acid, instead of N-acetyl muramic acid in peptidoglycan. The plant cell wall is made of fibrils of cellulose embedded in a matrix of several other kinds of polymers such as pectin and lignin. Algal cell walls are usually composed of cellulose, glycoproteins, sporopollenin, calcium and various polysaccharides such as manosyl, xylanes, alginic acid. Diatom cell walls (or frustules) contain silica. The cell wall plays a role in cell shape, cell stability and development, and protection against environmental dangers." []
xref: GO:0005618 "cell wall"
relationship: part_of SL-0036
relationship: part_of SL-0243

[Term]
id: SL-0042
name: Cellular chromatophore membrane
namespace: uniprot:locations:cellular_component
def: "The cellular chromatophore membrane is the plasma-membrane derived internal, photosynthetic membrane found in the cytoplasm in purple photosynthetic bacteria. They contain the reaction centers, antennae complexes, cytochrome bc1 complex and the F(0)F(1)-ATPase." []
synonym: "Chromatophore membrane" [UniProt]
xref: GO:0042717 "plasma membrane-derived chromatophore membrane"
is_a: SL-0162
relationship: part_of SL-0147

[Term]
id: SL-0043
name: Cellular thylakoid
namespace: uniprot:locations:cellular_component
def: "A bacterial thylakoid membrane usually formed by extensive invaginations of the cell inner (plasma) membrane. In cyanobacteria thylakoids house the photosynthetic machinery and pigments. In Synechocystis sp. strain PCC 6803 the thylakoid membranes are physically discontinuous from the plasma membrane, and thus represent bona fide intracellular organelles." []
synonym: "Bacterial thylakoid" [UniProt]
xref: GO:0030075 "bacterial thylakoid"
is_a: SL-0450

[Term]
id: SL-0044
name: Cellular thylakoid lumen
namespace: uniprot:locations:cellular_component
def: "The lumen of the cellular thylakoid." []
xref: GO:0031979 "plasma membrane-derived thylakoid lumen"
relationship: part_of SL-0043

[Term]
id: SL-0045
name: Cellular thylakoid membrane
namespace: uniprot:locations:cellular_component
def: "The membrane of the cellular thylakoid." []
xref: GO:0031676 "plasma membrane-derived thylakoid membrane"
is_a: SL-0162
relationship: part_of SL-0043
relationship: part_of SL-0147

[Term]
id: SL-0046
name: Centriole
namespace: uniprot:locations:cellular_component
def: "The centriole is a barrel-shaped microtubule-based structure. A pair of centrioles, embedded in the so-called pericentriolar material, constitute the centrosome, a microtubule organizing center of an eukaryotic cell. Centrioles are barrel-shaped microtubule-based structures organized in a 9-fold radial symmetry. Centriolar microtubule arrays usually consist of triplet microtubules, although doublets or singlets are present in some species. Centrioles are structurally related to (and often interconvertible with) basal bodies, the organelles required for the assembly of a cilium or flagellum." []
xref: GO:0005814 "centriole"
relationship: part_of SL-0048

[Term]
id: SL-0047
name: Centromere
namespace: uniprot:locations:cellular_component
def: "The centromere is a region of replicated eukaryotic chromosomes where the two chromatids are joined together." []
synonym: "Chromosome, pericentric region" [UniProt]
xref: GO:0000775 "chromosome, centromeric region"
relationship: part_of SL-0468

[Term]
id: SL-0048
name: Centrosome
namespace: uniprot:locations:cellular_component
def: "The centrosome is a microtubule organizing center (MTOC) responsible for the nucleation and organisation of  microtubules. It is composed of two orthogonally arranged centrioles, each one having a barrel shaped microtubule structure, and their surrounding pericentriolar material (PCM)." []
xref: GO:0005813 "centrosome"
relationship: part_of SL-0484

[Term]
id: SL-0049
name: Chloroplast
namespace: uniprot:locations:cellular_component
def: "The most common form of plastid, the chloroplast is a photosynthetic organelle found in all photosynthetic eukaryotes except glaucocystophyte algae (where it is called a cyanelle) and Paulinella species (where it is called an organellar chromatophore). In green (photosynthetic) tissue they house the machinery necessary for pigment biosynthesis, amino acid synthesis, lipid metabolism etc, as well as the machinery for photosynthesis and CO(2) fixation. They are surrounded by between 2 and 4 membranes and contain thylakoids in green tissue." []
xref: GO:0009507 "chloroplast"
is_a: SL-0209

[Term]
id: SL-0050
name: Chloroplast envelope
namespace: uniprot:locations:cellular_component
def: "The envelope of a chloroplast comprises the inner and outer chloroplast membrane including the intermembrane space." []
synonym: "Chloroplastic envelope" [UniProt]
xref: GO:0009941 "chloroplast envelope"
is_a: SL-0210
relationship: part_of SL-0049

[Term]
id: SL-0051
name: Chloroplast inner membrane
namespace: uniprot:locations:cellular_component
def: "The inner membrane of a chloroplast is the membrane which separates the chloroplast stroma from the intermembrane space." []
synonym: "Chloroplastic inner membrane" [UniProt]
xref: GO:0009706 "chloroplast inner membrane"
is_a: SL-0053
is_a: SL-0211

[Term]
id: SL-0052
name: Chloroplast intermembrane space
namespace: uniprot:locations:cellular_component
def: "The intermembrane space between the inner and the outer chloroplast membranes." []
synonym: "Chloroplastic intermembrane space" [UniProt]
xref: GO:0031972 "chloroplast intermembrane space"
is_a: SL-0212
relationship: part_of SL-0050

[Term]
id: SL-0053
name: Chloroplast membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a chloroplast. Also used when it is not clear in which chloroplast membrane (outer membrane, inner membrane or thylakoid) a protein is found." []
synonym: "Chloroplastic membrane" [UniProt]
xref: GO:0031969 "chloroplast membrane"
is_a: SL-0213
relationship: part_of SL-0050

[Term]
id: SL-0054
name: Chloroplast outer membrane
namespace: uniprot:locations:cellular_component
def: "The outer membrane of a chloroplast is the chloroplast membrane facing the cytoplasm." []
synonym: "Chloroplastic outer membrane" [UniProt]
xref: GO:0009707 "chloroplast outer membrane"
is_a: SL-0053
is_a: SL-0214

[Term]
id: SL-0055
name: Chloroplast stroma
namespace: uniprot:locations:cellular_component
def: "The internal space enclosed by the chloroplast double membrane but excluding the thylakoid space. This space, filled with a colorless hydrophilic matrix, contains DNA, ribosomes and some temporary products of photosynthesis." []
synonym: "Chloroplastic stroma" [UniProt]
xref: GO:0009570 "chloroplast stroma"
is_a: SL-0215
relationship: part_of SL-0049

[Term]
id: SL-0056
name: Chloroplast thylakoid
namespace: uniprot:locations:cellular_component
def: "The thylakoid of a chloroplast is an internal system of interconnected membranes, that carry out the light reactions of photosynthesis. They are arranged into stacked and unstacked regions called grana and stroma thylakoids, respectively, that are differentially enriched in photosystem I and II complexes. Although extensive, the thylakoid network in an individual chloroplast is thought to comprise a single lumenal compartment." []
xref: GO:0009534 "chloroplast thylakoid"
is_a: SL-0278
relationship: part_of SL-0049

[Term]
id: SL-0057
name: Chloroplast thylakoid lumen
namespace: uniprot:locations:cellular_component
def: "The chloroplast thylakoid lumen is the chloroplast compartment bounded by the thylakoid membranes." []
xref: GO:0009543 "chloroplast thylakoid lumen"
is_a: SL-0309
relationship: part_of SL-0056

[Term]
id: SL-0058
name: Chloroplast thylakoid membrane
namespace: uniprot:locations:cellular_component
def: "The thylakoid membranes of a chloroplast is an internal system of interconnected membranes, that carry out the light reactions of photosynthesis. They are arranged into stacked and unstacked regions called grana and stroma thylakoids, respectively, that are differentially enriched in photosystem I and II complexes. Although extensive, the thylakoid network in an individual chloroplast is thought to comprise a single lumenal compartment." []
xref: GO:0009535 "chloroplast thylakoid membrane"
is_a: SL-0216
relationship: part_of SL-0056

[Term]
id: SL-0059
name: Chlorosome
namespace: uniprot:locations:cellular_component
def: "The chlorosome is a photosynthetic light-harvesting complex found in anoxygenic green bacteria. Chlorosomes are flattened ellipsoidal organelles appressed to the cytoplasmic face of the cell membrane. They typically contain highly aggregated bacteriochlorophyll c, d, or e (Bchl), a small amount of Bchl a, carotenoids, quinones, and occasionally wax esters. The chlorosome envelope of green sulfur bacteria is an asymmetric membrane containing galactolipids with the galactosyl moieties exposed on the outer surface. The farnesyl tails of the BChl molecules within the chlorosome probably comprise the inner leaflet of this membrane." []
xref: GO:0046858 "chlorosome"

[Term]
id: SL-0060
name: Chlorosome envelope
namespace: uniprot:locations:cellular_component
def: "The chlorosome envelope of green sulfur bacteria is an asymmetric membrane containing galactolipids with the galactosyl moieties exposed on the outer surface. The farnesyl tails of the BChl c molecules within the chlorosome probably comprise the inner leaflet of this membrane." []
synonym: "Chlorosomal envelope" [UniProt]
xref: GO:0033105 "chlorosome envelope"
relationship: part_of SL-0059

[Term]
id: SL-0061
name: Chromaffin granule
namespace: uniprot:locations:cellular_component
def: "A chromaffin granule is a specialized secretory vesicle characteristic of chromaffin cells." []
xref: GO:0042583 "chromaffin granule"
is_a: SL-0244

[Term]
id: SL-0062
name: Chromaffin granule membrane
namespace: uniprot:locations:cellular_component
def: "The chromaffin granule membrane is the membrane surrounding a chromaffin granule, a specialized secretory vesicle characteristic of chromaffin cells." []
synonym: "Chromaffin granular membrane" [UniProt]
xref: GO:0042584 "chromaffin granule membrane"
is_a: SL-0245
relationship: part_of SL-0061

[Term]
id: SL-0063
name: Chromoplast
namespace: uniprot:locations:cellular_component
def: "A chromoplast is a plastid containing pigments other than chlorophyll. Found in flower, petals and fruit." []
xref: GO:0009509 "chromoplast"
is_a: SL-0209

[Term]
id: SL-0064
name: Chromoplast membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the chromoplast. Also used when it is not clear in which chromoplast membrane (outer membrane, inner membrane or thylakoid) a protein is found." []
synonym: "Chromoplastic membrane" [UniProt]
xref: GO:0046862 "chromoplast membrane"
is_a: SL-0213
relationship: part_of SL-0063

[Term]
id: SL-0065
name: Chromoplast stroma
namespace: uniprot:locations:cellular_component
def: "The chromoplast stroma is the space enclosed by the chromoplast double membrane but excluding the photosynthetic material. The chromoplast is a plastid containing pigments other than chlorophyll." []
synonym: "Chromoplastic stroma" [UniProt]
xref: GO:0009575 "chromoplast stroma"
relationship: part_of SL-0063

[Term]
id: SL-0066
name: Cilium
namespace: uniprot:locations:cellular_component
def: "The cilium is a cell surface projection found at the surface of a large proportion of eukaryotic cells. The two basic types of cilia, motile (alternatively named flagella) and non-motile, collectively perform a wide variety of functions broadly encompassing cell/fluid movement and sensory perception. Their most prominent structural component is the axoneme which consists of nine doublet microtubules, with all motile cilia - except those at the embryonic node - containing an additional central pair of microtubules. The axonemal microtubules of all cilia nucleate and extend from a basal body, a centriolar structure most often composed of a radial array of nine triplet microtubules. In most cells, basal bodies associate with cell membranes and cilia are assembled as 'extracellular' membrane-enclosed compartments." []
synonym: "Cilia" [UniProt]
xref: GO:0005929 "cilium"
is_a: SL-0280

[Term]
id: SL-0067
name: cis-Golgi network
namespace: uniprot:locations:cellular_component
def: "The cis-Golgi network is an extensive tubulovesicular network bound to the cis face of the Golgi stack and which function is to receive process the biosynthetic output from the ER." []
synonym: "CGN" [UniProt]
synonym: "cis-Golgi" [UniProt]
synonym: "cis-Golgi complex" [UniProt]
synonym: "Golgi cis-face" [UniProt]
xref: GO:0005801 "cis-Golgi network"
relationship: part_of SL-0132

[Term]
id: SL-0068
name: cis-Golgi network membrane
namespace: uniprot:locations:cellular_component
def: "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network." []
synonym: "CGN membrane" [UniProt]
synonym: "cis-Golgi complex membrane" [UniProt]
synonym: "cis-Golgi membrane" [UniProt]
synonym: "Golgi cis-face membrane" [UniProt]
xref: GO:0033106 "cis-Golgi network membrane"
is_a: SL-0134
relationship: part_of SL-0067

[Term]
id: SL-0069
name: Clathrin-coated pit
namespace: uniprot:locations:cellular_component
def: "Coated pits are regions of the cell membrane specialized in receptor- mediated endocytosis. Their cytoplasmic surface is coated with a bristlelike structure made of clathrin. During the first steps of endocytosis, clathrin-coated pits are internalized to form clathrin- coated vesicles which transport proteins from organelle to organelle." []
xref: GO:0005905 "clathrin-coated pit"
is_a: SL-0072

[Term]
id: SL-0070
name: Clathrin-coated vesicle
namespace: uniprot:locations:cellular_component
def: "Clathrin coated vesicles (CCVs) mediate the vesicular transport of cargo such as proteins between organelles in the post-Golgi network connecting the trans-Golgi network, endosomes, lysosomes and the cell membrane. CCVs that bud from the cell membrane reveal a striking polyhedral pattern reminiscent of a fullerene which arises from the outermost protein in the coat, clathrin. Clathrin assembles from three-legged individual components called triskelions to form a polygonal lattice around the vesicle. Clathrin is a large heterohexameric protein complex composed of three heavy chains and three light chains. Clathrin molecules self-assemble together to make a spherical clathrin lattice structure, a polyhedron made of regular pentagons and hexagons. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. The connection of the clathrin scaffold to the membrane is mediated by clathrin adaptors, which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes. Clathrin-associated adaptor protein (AP) complexes are a stoichiometric coat component of CCVs alongside clathrin itself, and are considered a major clathrin adaptor contributing the CCV formation." []
synonym: "CCV" [UniProt]
xref: GO:0030136 "clathrin-coated vesicle"
is_a: SL-0088

[Term]
id: SL-0071
name: Clathrin-coated vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a clathrin-coated vesicle (CCV). CCVs mediate the vesicular transport of cargo such as proteins between organelles in the post-Golgi network connecting the trans-Golgi network, endosomes, lysosomes and the cell membrane. CCVs that bud from the cell membrane reveal a striking polyhedral pattern reminiscent of a fullerene which arises from the outermost protein in the coat, clathrin. Clathrin assembles from three-legged individual components called triskelions to form a polygonal lattice around the vesicle. Clathrin is a large heterohexameric protein complex composed of three heavy chains and three light chains. Clathrin molecules self-assemble together to make a spherical clathrin lattice structure, a polyhedron made of regular pentagons and hexagons. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. The connection of the clathrin scaffold to the membrane is mediated by clathrin adaptors, which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes. Clathrin-associated adaptor protein (AP) complexes are a stoichiometric coat component of CCVs alongside clathrin itself, and are considered a major clathrin adaptor contributing the CCV formation." []
synonym: "Clathrin-coated vesicular membrane" [UniProt]
xref: GO:0030665 "clathrin-coated vesicle membrane"
is_a: SL-0089
relationship: part_of SL-0070

[Term]
id: SL-0072
name: Coated pit
namespace: uniprot:locations:cellular_component
def: "Coated pits are regions of the donor membrane where the assembly of the vesicle coat take place. The coat assembles from soluble protomers such as coat protein complex-I and coat protein complex-II. The components of the coat often define the intracellular sorting station, and contribute to both membrane deformation and local movement of the resulting transport intermediate following scission. During the first steps of the vesicle-mediated membrane transport, coated pits are internalized to form coated vesicles which transport proteins between distinct membrane-bound organelles." []
relationship: part_of SL-0147

[Term]
id: SL-0073
name: Contractile vacuole
namespace: uniprot:locations:cellular_component
def: "A contractile vacuole (CV) complex is a membrane-bound osmoregulatory organelle of fresh water and soil amoebae and protozoa which segregates excess cytosolic water, acquired osmotically, and expel it to the cell exterior, so that the cytosolic osmolarity is kept constant under a given osmotic condition. Depending on the organism, the CV complex (CVC) shows different degrees of specialization of its tubular and vesicular elements. In the most elaborate CVCs of certain ciliates, e.g. Paramecium, a central vacuole, the contractile vacuole or cisterna, is surrounded by radially oriented ampullae or radial arms. These ampullae are connected to a network of channels. Excess cytosolic water, acquired osmotically, is segregated by the radial arms and enters the vacuole, so that the vacuole swells (the fluid- filling phase). The vacuole then rounds (the rounding phase) and the radial arms sever from the vacuole. The vacuole membrane then fuses with the plasma membrane at the pore region and the pore opens. The vacuole shrinks as its fluid is discharged through the pore (the fluid-discharging phase). The pore closes when the fluid has been discharged. The radial arms then reattach to the vacuole, so that the vacuole swells again as the fluid enters from the arms (the next fluid-filling phase)." []
synonym: "Contracile vacuole complex" [UniProt]
synonym: "CV" [UniProt]
synonym: "CVC" [UniProt]
xref: GO:0000331 "contractile vacuole"
is_a: SL-0272

[Term]
id: SL-0074
name: Contractile vacuole membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a contractile vacuole. A contractile vacuole (CV) complex is a membrane-bound osmoregulatory organelle of fresh water and soil amoebae and protozoa which segregates excess cytosolic water, acquired osmotically, and expel it to the cell exterior, so that the cytosolic osmolarity is kept constant under a given osmotic condition." []
synonym: "Contractile vacuolar membrane" [UniProt]
xref: GO:0031164 "contractile vacuolar membrane"
is_a: SL-0271
relationship: part_of SL-0073

[Term]
id: SL-0075
name: COPI-coated vesicle
namespace: uniprot:locations:cellular_component
def: "COPI-coated vesicles mediate the vesicular transport of cargo such as proteins. COPI-coated vesicles are believed to bud from the cis- cisternae of the Golgi apparatus, mediate traffic from the cis-Golgi back to the ER (retrograde), and govern the flow pattern of materials within the Golgi stack. COPI is composed of the coatomer, which is a seven-subunit protein complex that participates in the formation of Golgi-derived coated vesicles. Evidence has also been presented for anterograde intra-Golgi transport mediated by COPI in yeast and mammals." []
synonym: "Coat protein complex I" [UniProt]
xref: GO:0030137 "COPI-coated vesicle"
is_a: SL-0088

[Term]
id: SL-0076
name: COPI-coated vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a COPI-coated vesicle. COPI-coated vesicles mediate the vesicular transport of cargo such as proteins. COPI-coated vesicles are believed to bud from the cis-cisternae of the Golgi apparatus, mediate traffic from the cis-Golgi back to the ER (retrograde), and govern the flow pattern of materials within the Golgi stack. COPI is composed of the coatomer, which is a seven- subunit protein complex that participates in the formation of Golgi- derived coated vesicles. Evidence has also been presented for anterograde intra-Golgi transport mediated by COPI in yeast and mammals." []
xref: GO:0030663 "COPI-coated vesicle membrane"
is_a: SL-0089
relationship: part_of SL-0075

[Term]
id: SL-0077
name: COPII-coated vesicle
namespace: uniprot:locations:cellular_component
def: "COPII-coated vesicles mediate the vesicular transport of cargo such as proteins. COPII-coated vesicles are believed to bud from the endoplasmic reticulum be involved in the anterograde transport between the ER to Golgi and travel toward the Endoplasmic reticulum-Golgi intermediate compartment, where they fuse and release their contents (anterograde transport). The COPII coat has five main functional components that are highly conserved in all eukaryotic cells." []
synonym: "Coat protein complexes II" [UniProt]
synonym: "ER to Golgi transport vesicle" [UniProt]
xref: GO:0030134 "COPII-coated ER to Golgi transport vesicle"
is_a: SL-0088

[Term]
id: SL-0078
name: COPII-coated vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a COPII-coated vesicle. COPII-coated vesicles mediate the vesicular transport of cargo such as proteins. COPII- coated vesicles are believed to bud from the endoplasmic reticulum be involved in the anterograde transport between the ER to Golgi and travel toward the Endoplasmic reticulum-Golgi intermediate compartment, where they fuse and release their contents (anterograde transport). The COPII coat has five main functional components that are highly conserved in all eukaryotic cells." []
synonym: "Coat protein complexes II membrane" [UniProt]
synonym: "ER to Golgi transport vesicle membrane" [UniProt]
xref: GO:0012507 "ER to Golgi transport vesicle membrane"
is_a: SL-0089
relationship: part_of SL-0077

[Term]
id: SL-0079
name: Cornified envelope
namespace: uniprot:locations:cellular_component
def: "The cornified envelope is a structure which is formed beneath the plasma membrane in terminally differentiating stratified squamous epithelia. It provides a vital physical barrier to these tissues in mammals and consists of a 10 nm thick layer of highly crosslinked insoluble proteins. In the specialized case of the epidermis, a 5 nm thick layer of ceramide lipids is covalently bound to the proteins. These organize extracellular lipids into orderly lamellae and, together, the cell envelope and extracellular lipids are essential for effective physical and water barrier function in the skin." []
xref: GO:0001533 "cornified envelope"

[Term]
id: SL-0080
name: Cvt vesicle
namespace: uniprot:locations:cellular_component
def: "A cvt vesicle is a double membrane-layered vesicle implicated in the cytoplasm to vacuole targeting pathway." []
xref: GO:0033107 "Cvt vesicle"
is_a: SL-0088

[Term]
id: SL-0081
name: Cvt vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a cvt vesicle. A cvt vesicle is a double membrane-layered vesicle implicated in the cytoplasm to vacuole targeting pathway." []
xref: GO:0033110 "Cvt vesicle membrane"
is_a: SL-0089
relationship: part_of SL-0080

[Term]
id: SL-0082
name: Cyanelle
namespace: uniprot:locations:cellular_component
def: "A cyanelle is a photosynthetic organelle of glaucocystophyte algae. Cyanelles are surrounded by a double membrane and, in between, a peptidoglycan wall. Thylakoid membrane architecture is cyanobacteria- like. Historically, the term cyanelle is derived from a classification as endosymbiotic cyanobacteria, and thus is not fully correct." []
synonym: "Cyanoplast" [UniProt]
synonym: "Muroplast" [UniProt]
xref: GO:0009842 "cyanelle"
is_a: SL-0209

[Term]
id: SL-0083
name: Cyanelle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a cyanelle, a photosynthetic organelle of glaucocystophyte algae. Also used when it is not clear in which cyanelle membrane (outer membrane, inner membrane or thylakoid) a protein is found." []
xref: GO:0033113 "cyanelle membrane"
is_a: SL-0213
relationship: part_of SL-0082

[Term]
id: SL-0084
name: Cyanelle thylakoid lumen
namespace: uniprot:locations:cellular_component
def: "The cyanelle thylakoid lumen is the cyanelle compartment bounded by the thylakoid membranes." []
xref: GO:0033114 "cyanelle thylakoid lumen"
is_a: SL-0309
relationship: part_of SL-0277

[Term]
id: SL-0085
name: Cyanelle thylakoid membrane
namespace: uniprot:locations:cellular_component
def: "The lipid bilayer membrane of any thylakoid within a cyanelle, a photosynthetic organelle of glaucocystophyte algae." []
xref: GO:0033115 "cyanelle thylakoid membrane"
is_a: SL-0216
relationship: part_of SL-0277

[Term]
id: SL-0086
name: Cytoplasm
namespace: uniprot:locations:cellular_component
def: "The cytoplasm is the content of a cell within the plasma membrane and, in eukaryotics cells, surrounding the nucleus. This three-dimensional, jelly-like lattice interconnects and supports the other solid structures. The cytosol (the soluble portion of the cytoplasm outside the organelles) is mostly composed of water and many low molecular weight compounds. In eukaryotes, the cytoplasm also contains a network of cytoplasmic filaments (cytoskeleton)." []
xref: GO:0005737 "cytoplasm"

[Term]
id: SL-0087
name: Cilium basal body
namespace: uniprot:locations:cellular_component
def: "The basal body is a barrel-shaped microtubule-based structure required for the formation of cilia. Basal bodies, structuraly related to and often interconvertible with centrioles, serves as a nucleation site for axoneme growth." []
synonym: "Ciliary basal body" [UniProt]
synonym: "Ciliary kinetosome" [UniProt]
synonym: "Cilium kinetosome" [UniProt]
relationship: part_of SL-0066
relationship: part_of SL-0090

[Term]
id: SL-0088
name: Cytoplasmic vesicle
namespace: uniprot:locations:cellular_component
def: "The cytoplasmic vesicles mediate vesicular transport among the organelles of secretory and endocytic systems. These transport vesicles are classified by the identity of the protein coat used in their formation and also by the cargo they contain, e.g. clathrin-, COPI-, and COPII-coated vesicles, synaptic vesicles, secretory vesicles, phagosomes, etc." []
is_a: SL-0498

[Term]
id: SL-0089
name: Cytoplasmic vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a cytoplasmic vesicle. The cytoplasmic vesicles mediate vesicular transport among the organelles of secretory and endocytic systems." []
xref: GO:0030659 "cytoplasmic vesicle membrane"
is_a: SL-0162
relationship: part_of SL-0088
relationship: part_of SL-0147

[Term]
id: SL-0090
name: Cytoskeleton
namespace: uniprot:locations:cellular_component
def: "The cytoskeleton is a dynamic three-dimensional filamentous structure in the cytoplasm. Its roles include maintenance of cell shape, cell movement (in eukaryotes), cytokinesis, and the organization of organelles or organelle-like structures within the cell. The cytoskeleton includes microfilaments (actin-like proteins), microtubules (tubulin-like proteins), the intermediate filaments (mostly in eukaryotes) and the MinD-ParA proteins, which appear to be unique to prokaryotes." []
xref: GO:0005856 "cytoskeleton"
relationship: part_of SL-0086

[Term]
id: SL-0091
name: Cytosol
namespace: uniprot:locations:cellular_component
def: "The cytosol is the unstructured aqueous phase of the cytoplasm excluding organelles, membranes, and insoluble cytoskeletal components." []
xref: GO:0005829 "cytosol"
relationship: part_of SL-0086

[Term]
id: SL-0092
name: Desmosome
namespace: uniprot:locations:cellular_component
def: "A desmosome (DS) is a button-like adhesion complex that stabilizes epithelial sheets by anchoring the intermediate filament cytoskeleton to the cell junction. Desmosomes are found particularly in tissues subjected to mechanical stress." []
synonym: "DS" [UniProt]
synonym: "Macula adherens" [UniProt]
xref: GO:0030057 "desmosome"
xref: http://celljunctions.med.nyu.edu/desmosomes/desframe.html
is_a: SL-0038

[Term]
id: SL-0093
name: Early endosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the early endosomes, which form a tubulovesicular network spread throughout the cortical cytoplasm of the cell." []
synonym: "Early endosomal membrane" [UniProt]
xref: GO:0031901 "early endosome membrane"
is_a: SL-0100
relationship: part_of SL-0094

[Term]
id: SL-0094
name: Early endosome
namespace: uniprot:locations:cellular_component
def: "Early endosomes form a tubulovesicular network spread throughout the cortical cytoplasm of the cell. Early endosomes are the primary sorting station in the endocytic pathway from which endocytosed molecules can be recycled back to the cell membrane or targeted to degradation in the lysosomes. Loaded by endocytosed molecules in 1 to 4 minutes, their acidic luminal pH around 6.0 allows ligand release from recycling receptors." []
xref: GO:0005769 "early endosome"
relationship: part_of SL-0101

[Term]
id: SL-0095
name: Endoplasmic reticulum
namespace: uniprot:locations:cellular_component
def: "The endoplasmic reticulum (ER) is an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products. The membrane is a continuation of the outer nuclear membrane, it encloses the cytosol cisternal spaces (or internal lumen), which are continuous with the nuclear periplasmic space. The ER sustains many general functions, including protein synthesis, protein modification, protein folding, insertion of membrane proteins, sequestration of calcium, production of phospholipids and steroids and transport of proteins destined for membranes and secretion." []
xref: GO:0005783 "endoplasmic reticulum"

[Term]
id: SL-0096
name: Endoplasmic reticulum lumen
namespace: uniprot:locations:cellular_component
def: "The lumen of the endoplasmic reticulum (ER) is the area enclosed by the endoplasmic reticulum membrane, an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products." []
xref: GO:0005788 "endoplasmic reticulum lumen"
relationship: part_of SL-0095

[Term]
id: SL-0097
name: Endoplasmic reticulum membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the endoplasmic reticulum (ER). The endoplasmic reticulum is an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products." []
xref: GO:0005789 "endoplasmic reticulum membrane"
is_a: SL-0162
relationship: part_of SL-0095
relationship: part_of SL-0147

[Term]
id: SL-0098
name: Endoplasmic reticulum-Golgi intermediate compartment
namespace: uniprot:locations:cellular_component
def: "The ER-Golgi intermediate compartment is a collection of tubulovesicular membrane clusters in the vicinity of ER exit sites. The ERGIC mediates transport between the endoplasmic reticulum and the Golgi and is the first anterograde/retrograde sorting station in the secretory pathway. ERGIC has not been observed in yeast and plants." []
synonym: "ER-Golgi intermediate compartment" [UniProt]
synonym: "ERGIC" [UniProt]
synonym: "IC" [UniProt]
synonym: "Intermediate compartment" [UniProt]
synonym: "Vesiculo-tubular cluster" [UniProt]
synonym: "VTC" [UniProt]
xref: GO:0005793 "endoplasmic reticulum-Golgi intermediate compartment"

[Term]
id: SL-0099
name: Endoplasmic reticulum-Golgi intermediate compartment membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the ER-Golgi intermediate compartment, which is a collection of tubulovesicular membrane clusters in the vicinity of ER exit sites." []
synonym: "ER-Golgi intermediate compartment membrane" [UniProt]
synonym: "ERGIC membrane" [UniProt]
synonym: "IC membrane" [UniProt]
synonym: "Intermediate compartment membrane" [UniProt]
synonym: "Vesiculo-tubular cluster membrane" [UniProt]
synonym: "VTC membrane" [UniProt]
xref: GO:0033116 "endoplasmic reticulum-Golgi intermediate compartment membrane"
is_a: SL-0162
relationship: part_of SL-0098
relationship: part_of SL-0147

[Term]
id: SL-0100
name: Endosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the endosome. Endosomes are highly dynamic membrane systems involved in transport within the cell, they receive endocytosed cell membrane molecules and sort them for either degradation or recycling back to the cell surface." []
synonym: "Endosomal membrane" [UniProt]
xref: GO:0010008 "endosome membrane"
is_a: SL-0162
relationship: part_of SL-0101
relationship: part_of SL-0147

[Term]
id: SL-0101
name: Endosome
namespace: uniprot:locations:cellular_component
def: "Endosomes are highly dynamic membrane systems involved in transport within the cell, they receive endocytosed cell membrane molecules and sort them for either degradation or recycling back to the cell surface. They also receive newly synthesised proteins destined for vacuolar/lysosomal compartments. In certain cell types, endosomal multivesicular bodies may fuse with the cell surface in an exocytic manner. These released vesicles are called exosomes." []
xref: GO:0005768 "endosome"

[Term]
id: SL-0108
name: Esterosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the esterosome, a crystalline inclusion body is a vesicle filled with crystals of proteins showing sequence similarities with various esterases." []
synonym: "Esterosomal membrane" [UniProt]
xref: GO:0033118 "esterosome membrane"
is_a: SL-0089
relationship: part_of SL-0109
relationship: part_of SL-0147

[Term]
id: SL-0109
name: Esterosome
namespace: uniprot:locations:cellular_component
def: "The esterosome is a crystalline inclusion body. This vesicle is filled with crystals of proteins showing sequence similarities with various esterases. The enclosing membrane has the characteristics of RER." []
xref: GO:0033117 "esterosome"
is_a: SL-0088

[Term]
id: SL-0110
name: Etioplast
namespace: uniprot:locations:cellular_component
def: "The etioplast is a plastid found in plants grown in the dark." []
xref: GO:0009513 "etioplast"
is_a: SL-0209

[Term]
id: SL-0111
name: Extracellular matrix
namespace: uniprot:locations:cellular_component
def: "The extracellular matrix (ECM) is a vague term used to refer to all the material surrounding cells in a multicellular organism, except circulating fluids such as blood or lymph. In some cases, the ECM accounts for more of the organism's bulk than its cells. In plants, arthropods and fungi the ECM is primarily composed of nonliving material such as cellulose or chitin. In vertebrates the ECM consists of a complex network including the basement membrane, collage, elastin, proteoglycans and hyaluronan." []
synonym: "Proteinaceous extracellular matrix" [UniProt]
relationship: part_of SL-0112

[Term]
id: SL-0112
name: Extracellular space
namespace: uniprot:locations:cellular_component
def: "The extracellular space is the space outside of the cell membrane but part of a multicellular organism. The term is typically used for a secreted protein that remains associated with the cell, e.g. as part of the extracellular matrix. It is not used for a protein that is secreted into the blood stream (or other body fluids) of eukaryotic, multicellular organisms, such as insulin or fibroblast growth factors." []
synonym: "Intercellular space" [UniProt]
xref: GO:0005576 "extracellular region"
relationship: part_of SL-0243

[Term]
id: SL-0113
name: Fimbrium
namespace: uniprot:locations:cellular_component
def: "A fimbrium or pilus is a hair-like, non-flagellar, polymeric filamentous appendage that extend from the bacterial or archaeal cell surface, such as type 1 pili, P-pili, type IV pili or curli. Pili perform a variety of functions, including surface adhesion, motility, cell-cell interactions, biofilm formation, conjugation, DNA uptake, and twitching motility." []
synonym: "Fimbria" [UniProt]
synonym: "Pili" [UniProt]
synonym: "Pilus" [UniProt]
xref: GO:0009289 "pilus"

[Term]
id: SL-0114
name: Flagellum axoneme
namespace: uniprot:locations:cellular_component
def: "The flagellum axoneme is the most prominent structural component of the flagellum, which is a long whip-like or feathery structure which propels the cell through a liquid medium. The flagellum axoneme consists of a characteristic axial '9+2' microtubular array." []
synonym: "Flagellar axoneme" [UniProt]
is_a: SL-0304
relationship: part_of SL-0117

[Term]
id: SL-0115
name: Flagellum membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding the flagellum, a long whip-like or feathery structure which propels the cell through a liquid medium." []
synonym: "Flagellar membrane" [UniProt]
is_a: SL-0305
relationship: part_of SL-0117

[Term]
id: SL-0116
name: Flagellar pocket
namespace: uniprot:locations:cellular_component
def: "The flagellar pocket is a structure found in trypanosomes. The flagellar pocket is formed by an invagination in the plasma membrane where the flagellum emerges from the cell body. This pocket provides the portal through which most of the dynamic interactions with the host occur." []
xref: GO:0020016 "ciliary pocket"

[Term]
id: SL-0117
name: Flagellum
namespace: uniprot:locations:cellular_component
def: "The flagellum is a long whip-like or feathery structure which propels the cell through a liquid medium. This motile cilium is produced by the unicellular eukaryotes, and by the motile male gametes of many eukaryotic organisms. The flagella commonly have a characteristic axial '9+2' microtubular array (axoneme) and bends are generated along the length of the flagellum by restricted sliding of the nine outer doublets." []
synonym: "Flagella" [UniProt]
synonym: "Motile cilia" [UniProt]
synonym: "Motile cilium" [UniProt]
synonym: "Undulipodia" [UniProt]
synonym: "Undulipodium" [UniProt]
xref: GO:0031514 "motile cilium"
xref: http://www.ciliome.com
is_a: SL-0066

[Term]
id: SL-0118
name: Focal adhesion
namespace: uniprot:locations:cellular_component
def: "Focal adhesions are sites of tightest adhesion made to the underlying extracellular matrix by cells in culture. They serve a structural role, linking the ECM on the outside to the actin cytoskeleton on the inside. In addition, they are sites of signal transduction, initiating signaling pathways in response to adhesion. Focal adhesions are formed around a transmembrane core of an alpha-beta integrin heterodimer, which binds to a component of the extracellular matrix on its extracellular region, constitutes the site of anchorage of the actin cytoskeleton to the cytoplasmic side of the membrane, and mediates various intracellular signaling pathways." []
xref: GO:0005925 "focal adhesion"
xref: http://www-cellbio.med.unc.edu/grad/depttest/burridge.htm
is_a: SL-0038

[Term]
id: SL-0119
name: Forespore
namespace: uniprot:locations:cellular_component
def: "Sporulation leads to the formation of an asymmetrically positioned division septum (the polar septum) which divides the developing cell into two adjacent, but unequal-sized compartments called the forespore (the smaller cell) and the mother cell." []
synonym: "Prespore" [UniProt]
xref: GO:0042763 "intracellular immature spore"

[Term]
id: SL-0120
name: Forespore inner membrane
namespace: uniprot:locations:cellular_component
def: "The inner membrane of the smaller compartment, the forespore, of a sporulating cell." []
synonym: "Prespore inner membrane" [UniProt]
is_a: SL-0122
relationship: part_of SL-0119

[Term]
id: SL-0121
name: Forespore intermembrane space
namespace: uniprot:locations:cellular_component
def: "The intermembrane space between the inner and outer forespore membranes." []
synonym: "Prespore intermembrane space" [UniProt]
relationship: part_of SL-0119

[Term]
id: SL-0122
name: Forespore membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a forespore. This term is used when it is not known if the protein is found in or associated with the inner or outer forespore membrane." []
synonym: "Prespore membrane" [UniProt]
is_a: SL-0162
relationship: part_of SL-0119

[Term]
id: SL-0123
name: Forespore outer membrane
namespace: uniprot:locations:cellular_component
def: "The outer membrane of the smaller compartment, the forespore, of a sporulating cell." []
synonym: "Prespore outer membrane" [UniProt]
is_a: SL-0122
relationship: part_of SL-0119

[Term]
id: SL-0124
name: Gap junction
namespace: uniprot:locations:cellular_component
def: "A gap junction (GJ) is a communicating junction between certain cell types that allows the passive passage of ions and small molecules providing a direct pathway for electrical and metabolic signaling. In vertebrates GJs are patches of channels, each cell membrane contains a 'hemichannel', so that each GJ channel is composed of two hemichannels (connexons), which in turn are composed of six membrane proteins (connexins (Cxs)). In invertebrates, GJ channels are formed by another large family of integral membrane proteins, the innexins. GJ exists in all metazoans (multi-cellular organisms) and in almost all cell types in these organisms." []
synonym: "Connexons" [UniProt]
xref: GO:0005921 "gap junction"
is_a: SL-0038

[Term]
id: SL-0125
name: Gas vesicle
namespace: uniprot:locations:cellular_component
def: "Gas vesicles (GV) are hollow, watertight, gas-permeable proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. By regulating their relative GV content, aquatic microbes can perform vertical migrations. The GV is impermeable to liquid water but is highly permeable to gases and is normally filled with air. As they scatter light, they may also protect against UV light. Two main proteins are present in the gas vesicle: GvpA, an extremely hydrophobic protein which makes the ribs that form the structure, and GvpC, which binds to the outside of the ribs, helps shape the GV and stiffens it against collapse." []
xref: GO:0031411 "gas vesicle"

[Term]
id: SL-0126
name: Gas vesicle shell
namespace: uniprot:locations:cellular_component
def: "The protein shell surrounding a gas vesicle." []
relationship: part_of SL-0125

[Term]
id: SL-0127
name: Gem
namespace: uniprot:locations:cellular_component
def: "Gems are nuclear bodies, often found paired or juxtaposed to Cajal bodies, called gems for \"gemini of CBs\". It is not clear if Cajal bodes and gems are distinct nuclear bodies or if they should be considered as two manifestations of the same structure." []
xref: GO:0097504 "Gemini of coiled bodies"
is_a: SL-0494
relationship: part_of SL-0191

[Term]
id: SL-0128
name: Glycosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the the glycosome, a specialized peroxisome found in all members of the protist order Kinetoplastida examined." []
synonym: "Glycosomal membrane" [UniProt]
xref: GO:0046860 "glycosome membrane"
is_a: SL-0203
relationship: part_of SL-0129
relationship: part_of SL-0147

[Term]
id: SL-0129
name: Glycosome
namespace: uniprot:locations:cellular_component
def: "The glycosome is a specialized peroxisome found in all members of the protist order Kinetoplastida examined. Nine enzymes involved in glucose and glycerol metabolism are associated with these organelles. These enzymes are involved in pathways which, in other organisms, are usually located in the cytosol." []
xref: GO:0020015 "glycosome"
is_a: SL-0204

[Term]
id: SL-0130
name: Glyoxysome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the glyoxysome, a plant peroxisome, especially found in germinating seeds, involved in the breakdown and conversion of fatty acids to acetyl-CoA for the glyoxylate bypass." []
synonym: "Glyoxysomal membrane" [UniProt]
xref: GO:0046861 "glyoxysomal membrane"
is_a: SL-0203
relationship: part_of SL-0131
relationship: part_of SL-0147

[Term]
id: SL-0131
name: Glyoxysome
namespace: uniprot:locations:cellular_component
def: "The glyoxysome is a plant peroxisome, especially found in germinating seeds, involved in the breakdown and conversion of fatty acids to acetyl-CoA for the glyoxylate bypass. Since it is also rich in catalase, the glyoxysome may be related to the microbodies or peroxisomes or derived from them." []
xref: GO:0009514 "glyoxysome"
is_a: SL-0204

[Term]
id: SL-0132
name: Golgi apparatus
namespace: uniprot:locations:cellular_component
def: "The Golgi apparatus is a series of flattened, cisternal membranes and similar vesicles usually arranged in close apposition to each other to form stacks. In mammalian cells, the Golgi apparatus is juxtanuclear, often pericentriolar. The stacks are connected laterally by tubules to create a perinuclear ribbon structure, the 'Golgi ribbon'. In plants and lower animal cells, the Golgi exists as many copies of discrete stacks dispersed throughout the cytoplasm. The Golgi is a polarized structure with, in most higher eukaryotic cells, a cis-face associated with a tubular reticular network of membranes facing the endoplasmic reticulum, the cis-Golgi network (CGN), a medial area of disk-shaped flattened cisternae, and a trans-face associated with another tubular reticular membrane network, the trans-Golgi network (TGN) directed toward the plasma membrane and compartments of the endocytic pathway. The Golgi apparatus receives the entire output of de novo synthesized polypeptides from the ER, and functions to posttranslationally process and sort them within vesicles destined to their proper final destination (e.g. plasma membrane, endosomes, lysosomes)." []
synonym: "Apparatus golgiensis" [UniProt]
synonym: "Complexus golgiensis" [UniProt]
synonym: "Golgi" [UniProt]
synonym: "Golgi complex" [UniProt]
xref: GO:0005794 "Golgi apparatus"

[Term]
id: SL-0133
name: Golgi apparatus lumen
namespace: uniprot:locations:cellular_component
def: "The Golgi lumen consist of the cisternal spaces (or internal lumen) of the Golgi apparatus." []
synonym: "Apparatus golgiensis lumen" [UniProt]
synonym: "Complexus golgiensis lumen" [UniProt]
synonym: "Golgi complex lumen" [UniProt]
synonym: "Golgi lumen" [UniProt]
xref: GO:0005796 "Golgi lumen"
relationship: part_of SL-0132

[Term]
id: SL-0134
name: Golgi apparatus membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the Golgi apparatus." []
synonym: "Apparatus golgiensis membrane" [UniProt]
synonym: "Complexus golgiensis membrane" [UniProt]
synonym: "Golgi complex membrane" [UniProt]
synonym: "Golgi membrane" [UniProt]
xref: GO:0000139 "Golgi membrane"
is_a: SL-0162
relationship: part_of SL-0132
relationship: part_of SL-0147

[Term]
id: SL-0135
name: Golgi stack
namespace: uniprot:locations:cellular_component
def: "The Golgi stack consist of a series of flattened curved and parallel series saccules, called cisternae or dictyosomes, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." []
synonym: "Dictyosome" [UniProt]
synonym: "Golgi bodies" [UniProt]
synonym: "Golgi body" [UniProt]
xref: GO:0005795 "Golgi stack"
relationship: part_of SL-0132

[Term]
id: SL-0136
name: Golgi stack membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the Golgi stack." []
synonym: "Dictyosome membrane" [UniProt]
synonym: "Golgi bodies membrane" [UniProt]
synonym: "Golgi body membrane" [UniProt]
synonym: "Golgi cisterna membrane" [UniProt]
xref: GO:0032580 "Golgi cisterna membrane"
is_a: SL-0134
relationship: part_of SL-0135

[Term]
id: SL-0137
name: Hemidesmosome
namespace: uniprot:locations:cellular_component
def: "The hemidesmosome is an integrin-containing adhesive junction located along the basal layer of cells where they abut the basement membrane zone. As the name implies, only half the desmosome is present; only one cell is participating, the second cell being represented by the basement membrane." []
xref: GO:0030056 "hemidesmosome"
xref: http://celljunctions.med.nyu.edu/hemidesmosomes/hemimain.html
is_a: SL-0038

[Term]
id: SL-0138
name: Cell cortex
namespace: uniprot:locations:cellular_component
def: "The cell cortex is the cytoplasmic region under the cell membrane." []
xref: GO:0005938 "cell cortex"
relationship: part_of SL-0086

[Term]
id: SL-0139
name: Chloroplast nucleoid
namespace: uniprot:locations:cellular_component
def: "The chloroplast nucleoid is the chloroplastic pseudocompartment formed by the chromatin-dense area. This region, which is functionally equivalent to the eukaryotic nucleus, is not surrounded by a membrane." []
synonym: "Chloroplastic nucleoid" [UniProt]
xref: GO:0042644 "chloroplast nucleoid"
relationship: part_of SL-0055

[Term]
id: SL-0140
name: Plastid nucleoid
namespace: uniprot:locations:cellular_component
def: "The plastid nucleoid is the plastidic pseudocompartment formed by the chromatin-dense area. This region, which is functionally equivalent to the eukaryotic nucleus, is not surrounded by a membrane." []
synonym: "Plastidic nucleoid" [UniProt]
xref: GO:0042646 "plastid nucleoid"
relationship: part_of SL-0215

[Term]
id: SL-0141
name: Uropodium
namespace: uniprot:locations:cellular_component
def: "The uropodium is a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated, found on the opposite side of the cell from the lamellipodium or immunological synapse, respectively." []
synonym: "Uropod" [UniProt]
synonym: "Uropodia" [UniProt]
xref: GO:0001931 "uropod"
is_a: SL-0280

[Term]
id: SL-0142
name: Bacterial flagellum basal body
namespace: uniprot:locations:cellular_component
def: "The basal body of a bacterial flagellum is a rod and a system of rings embedded in the cell envelope. Gram-negative flagella usually have an L ring in the plane of the lipopolysaccharide in the outer membrane, a periplasmic P ring in the plane of the peptidoglycan around the flagellar rod and a MS ring that is located within and above the cytoplasmic membrane. A C ring extends into the cytoplasm. The rod is a major component of the flagellar basal body and it spans the bacterial periplasm. The L and P rings are not found in Gram-positive bacteria." []
synonym: "Bacterial flagellar basal body" [UniProt]
synonym: "Bacterial flagellar kinetosome" [UniProt]
synonym: "Bacterial flagellar motor" [UniProt]
xref: GO:0009425 "bacterial-type flagellum basal body"
relationship: part_of SL-0307

[Term]
id: SL-0143
name: Hyaline layer
namespace: uniprot:locations:cellular_component
def: "The hyaline layer is a multilayered extracellular matrix that coats the external surfaces of sea urchin and starfish embryos." []
xref: GO:0033166 "hyaline layer"
is_a: SL-0111

[Term]
id: SL-0144
name: Hydrogenosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the hydrogenosome, a redox organelle found in anaerobic unicellular eukaryotes." []
synonym: "Hydrogenosomal membrane" [UniProt]
xref: GO:0046859 "hydrogenosomal membrane"
is_a: SL-0162
relationship: part_of SL-0145

[Term]
id: SL-0145
name: Hydrogenosome
namespace: uniprot:locations:cellular_component
def: "The hydrogenosome is a redox organelle of anaerobic unicellular eukaryotes which contains hydrogenase and produces hydrogen and ATP by glycolysis. They are found in various unrelated eukaryotes, such as anaerobic flagellates, chytridiomycete fungi and ciliates. Most hydrogenosomes lack a genome, but some like that of the anaerobic ciliate Nyctotherus ovalis, have retained a rudimentary genome." []
xref: GO:0042566 "hydrogenosome"

[Term]
id: SL-0146
name: Interphotoreceptor matrix
namespace: uniprot:locations:cellular_component
def: "In vertebrates, the photoreceptors are separated from the retinal pigment epithelium by the subretinal space, which contains a specialized extracellular material referred to as interphotoreceptor matrix. The IPM mediates key interactions between the photoreceptors and RPE including adhesion, phagocytosis, outer segment stability, nutrient exchange, development, and vitamin A trafficking in the visual cycle." []
synonym: "IPM" [UniProt]
xref: GO:0033165 "interphotoreceptor matrix"
is_a: SL-0111

[Term]
id: SL-0147
name: Endomembrane system
namespace: uniprot:locations:cellular_component
def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi apparatus, vesicles and cell membrane and nuclear envelope. The endomembrane system does not include the membranes of mitochondria or plastids." []
synonym: "Endomembrane" [UniProt]
xref: GO:0012505 "endomembrane system"
is_a: SL-0162

[Term]
id: SL-0148
name: Invadopodium
namespace: uniprot:locations:cellular_component
def: "The invadopodium is a localized and persitent cell protrusion similar to the highly dynamic podosome, but larger. These structures protrudes into the extracellular matrix. Invadopodial protrusions are enriched in integrins, tyrosine kinase signaling machinery, soluble and membrane proteases including matrix metalloproteases, actin and actin- associated proteins. Essential for physiological and pathological cell invasion and metastasis these structures are involved in focalized degradation of the extracellular matrix. Invadopodia form underneath the cell body, often close to the nucleus and proximal to the Golgi complex, and are rarely found at the cell periphery. Their half-life is quite extended. As invadopodia and podosomes are similar in appearance, location and composition, it is likely that a thin line separates these two entities in time and function." []
synonym: "Invadopodia" [UniProt]
is_a: SL-0038
is_a: SL-0280

[Term]
id: SL-0149
name: Kinetochore
namespace: uniprot:locations:cellular_component
def: "The kinetochore is a protein complex assembled on the centromeric region of DNA. It provides the major attachment point for the spindle microtubules during mitotic or meiotic division to pull the chromosomes apart. In monocentric chromosomes, the kinetochores of point centromeres bind a single microtubule and the larger kinetochores of regional centromeres interact with a number of microtubules. In holocentric chromosomes, the kinetochores bind the diffuse centromere along the length of the chromosomes." []
relationship: part_of SL-0047

[Term]
id: SL-0150
name: Kinetoplast
namespace: uniprot:locations:cellular_component
def: "The mitochondrial DNA of trypanosomatid protozoa is termed kinetoplast DNA (kDNA). kDNA is a massive network, composed of thousands of topologically interlocked DNA circles. Each cell contains one network condensed into a disk-shaped structure within the matrix of its single mitochondrion. The kDNA circles are of two types, maxicircles present in a few dozen copies and minicircles present in several thousand copies." []
xref: GO:0020023 "kinetoplast"
relationship: part_of SL-0170

[Term]
id: SL-0151
name: Late endosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the late endosomes." []
synonym: "Late endosomal membrane" [UniProt]
xref: GO:0031902 "late endosome membrane"
is_a: SL-0100
relationship: part_of SL-0152

[Term]
id: SL-0152
name: Late endosome
namespace: uniprot:locations:cellular_component
def: "Late endosomes are pleiomorphic with cisternal, tubular and multivesicular regions. They are found in juxtanuclear regions and concentrated at the microtubule organizing center. They are an important sorting station in the endocytic pathway. Recycling to the plasma membrane and to the Golgi occurs in late endosomes. More acidic than early endosomes they are also loaded more slowly in a range of 4 to 30 minutes depending on the cell type. They can be distinguished from lysosome for their enrichment in M6PR." []
xref: GO:0005770 "late endosome"
relationship: part_of SL-0101

[Term]
id: SL-0153
name: Lateral cell membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the plasma membrane at the lateral side of the cell." []
synonym: "Lateral plasma membrane" [UniProt]
xref: GO:0016328 "lateral plasma membrane"
relationship: part_of SL-0039

[Term]
id: SL-0154
name: Lipid droplet
namespace: uniprot:locations:cellular_component
def: "The lipid droplet is a dynamic cytoplasmic organelle which consists of an heterogeneous macromolecular assembly of lipids and proteins covered by a unique phospholipid monolayer. Lipid droplets may play a role in lipid metabolism and storage, and they may be involved in the regulation of intracellular trafficking and signal transduction." []
synonym: "Adiposome" [UniProt]
synonym: "Lipid bodies" [UniProt]
synonym: "Lipid body" [UniProt]
synonym: "Lipid particle" [UniProt]
synonym: "Monolayer-surrounded lipid storage body" [UniProt]
synonym: "Oil bodies" [UniProt]
synonym: "Oil body" [UniProt]
synonym: "Oleosome" [UniProt]
synonym: "Spherosome" [UniProt]
xref: GO:0005811 "lipid droplet"

[Term]
id: SL-0156
name: Lysosome lumen
namespace: uniprot:locations:cellular_component
def: "The lumen of a lysosome is the volume enclosed within the lysosomal membrane." []
synonym: "Lysosomal lumen" [UniProt]
xref: GO:0043202 "lysosomal lumen"
relationship: part_of SL-0158

[Term]
id: SL-0157
name: Lysosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a lysosome." []
synonym: "Lysosomal membrane" [UniProt]
xref: GO:0005765 "lysosomal membrane"
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0158

[Term]
id: SL-0158
name: Lysosome
namespace: uniprot:locations:cellular_component
def: "The lysosome is a membrane-limited organelle present in all eukaryotic cells, which contains a large number of hydrolytic enzymes that are used for degrading almost any kind of cellular constituent, including entire organelles. The mechanisms responsible for delivering cytoplasmic cargo to the lysosome/vacuole are known collectively as autophagy and play an important role in the maintenance of homeostasis." []
xref: GO:0005764 "lysosome"

[Term]
id: SL-0159
name: Lytic vacuole
namespace: uniprot:locations:cellular_component
def: "The lytic vacuole is a plant specialized vacuole equivalent to animal lysosomes or yeast vacuoles, functioning as compartments for degradation and waste storage." []
xref: GO:0000323 "lytic vacuole"
is_a: SL-0272

[Term]
id: SL-0160
name: Melanosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a melanosome." []
synonym: "Melanosomal membrane" [UniProt]
xref: GO:0033162 "melanosome membrane"
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0161

[Term]
id: SL-0161
name: Melanosome
namespace: uniprot:locations:cellular_component
def: "The melanosome is a melanin-containing organelle found in melanocytes and melanophores. Fish and amphibians possess specialized cells, called melanophores, which contain hundreds of melanin-filled pigment granules, termed melanosomes. The sole function of these cells is pigment aggregation in the center of the cell or dispersion throughout the cytoplasm. This alternative transport of pigment allows the animal to effect color changes important for camouflage and social interactions. Melanophores transport their pigment in response to extracellular cues: neurotransmitters in the case of fish and hormonal stimuli in the case of frogs. In both cases, melanosome dispersion is induced by elevation of intracellular cAMP levels, while aggregation is triggered by depression of cAMP. The regulatory mechanisms downstream of these second-messengers are poorly understood. Mammalian melanocytes also produce melanosomes but, unlike melanophores, pigment in these cells is transported to the cell periphery for subsequent exocytosis to surrounding epithelial cells." []
xref: GO:0042470 "melanosome"
xref: http://www.proweb.org/kinesin/Melanophore.html

[Term]
id: SL-0162
name: Membrane
namespace: uniprot:locations:cellular_component
def: "A membrane is a lipid bilayer which surrounds enclosed spaces and compartments. This selectively permeable structure is essential for effective separation of a cell or organelle from its surroundings. Membranes are composed of various types of molecules such as phospholipids, integral membrane proteins, peripheral proteins, glycoproteins, glycolipids, etc. The relative amounts of these components as well as the types of lipids are non-randomly distributed from membrane to membrane as well as between the two leaflets of a membrane." []
xref: GO:0016020 "membrane"

[Term]
id: SL-0163
name: Microneme
namespace: uniprot:locations:cellular_component
def: "The microneme is an Apicomplexan parasite organelle. Apicomplexa are named for the unique set of morphologically distinct secretory organelles (refered to as the apical complex)- micronemes, rhoptries and dense granules - whose sequential secretion is required for the invasion of host cells. Micronemes are the smallest, they are involved in the early stages of invasion." []
xref: GO:0020009 "microneme"
is_a: SL-0244

[Term]
id: SL-0164
name: Microneme membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a microneme." []
synonym: "Micronemal membrane" [UniProt]
xref: GO:0033163 "microneme membrane"
is_a: SL-0245
relationship: part_of SL-0163

[Term]
id: SL-0165
name: Microsome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the microsome." []
synonym: "Microsomal membrane" [UniProt]
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0166

[Term]
id: SL-0166
name: Microsome
namespace: uniprot:locations:cellular_component
def: "The microsomes are a heterogenous set of vesicles 20-200nm in diameter and formed from the endoplasmic reticulum when cells are disrupted. The vesicles are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles and ribosomes. Numerous enzyme activities are associated with the microsomal fraction." []
relationship: part_of SL-0095

[Term]
id: SL-0167
name: Mitochondrion envelope
namespace: uniprot:locations:cellular_component
def: "The mitochondrial envelope comprises the inner and outer mitochondrial membrane including the intermembrane space." []
synonym: "Mitochondrial envelope" [UniProt]
xref: GO:0005740 "mitochondrial envelope"
relationship: part_of SL-0173

[Term]
id: SL-0168
name: Mitochondrion inner membrane
namespace: uniprot:locations:cellular_component
def: "The inner membrane of a mitochondrion is the membrane which separates the mitochondrial matrix from the intermembrane space." []
synonym: "Inner mitochondrial membrane" [UniProt]
synonym: "Mitochondrial inner membrane" [UniProt]
xref: GO:0005743 "mitochondrial inner membrane"
is_a: SL-0171

[Term]
id: SL-0169
name: Mitochondrion intermembrane space
namespace: uniprot:locations:cellular_component
def: "The mitochondrial intermembrane space is the space between inner and outer mitochondrial membrane." []
synonym: "Mitochondrial intermembrane space" [UniProt]
synonym: "Mitochondrial periplasm" [UniProt]
synonym: "Mitochondrial periplasmic space" [UniProt]
xref: GO:0005758 "mitochondrial intermembrane space"
relationship: part_of SL-0167

[Term]
id: SL-0170
name: Mitochondrion matrix
namespace: uniprot:locations:cellular_component
def: "The matrix of a mitochondrion is the mitochondrion internal spaces enclosed by the inner membrane. Several of the steps in cellular respiration occur in the matrix due to its high concentration of enzymes." []
synonym: "Mitochondrial matrix" [UniProt]
xref: GO:0005759 "mitochondrial matrix"
relationship: part_of SL-0173

[Term]
id: SL-0171
name: Mitochondrion membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a mitochondrion. This term is used when it is not known if the protein is found in or associated with the inner or outer mitochondrial membrane." []
synonym: "Mitochondrial membrane" [UniProt]
xref: GO:0031966 "mitochondrial membrane"
is_a: SL-0162
relationship: part_of SL-0167

[Term]
id: SL-0172
name: Mitochondrion outer membrane
namespace: uniprot:locations:cellular_component
def: "The outer membrane of a mitochondrion is the mitochondrial membrane facing the cytoplasm." []
synonym: "Mitochondrial outer membrane" [UniProt]
synonym: "Outer mitochondrial membrane" [UniProt]
xref: GO:0005741 "mitochondrial outer membrane"
is_a: SL-0171

[Term]
id: SL-0173
name: Mitochondrion
namespace: uniprot:locations:cellular_component
def: "The mitochondrion is a semiautonomous, self-reproducing organelle that occurs in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. The size and coding capacity of the mitochondrial DNA varies considerably in different organisms, and encodes rRNAs, tRNAs and essential mitochondrial proteins." []
xref: GO:0005739 "mitochondrion"

[Term]
id: SL-0174
name: Multivesicular body
namespace: uniprot:locations:cellular_component
def: "The multivesicular bodies are a type of late endosome containing internal vesicles formed following the inward budding of the outer endosomal membrane. The contents of the MVBs are then released into the lysosome lumen. The proteins found in the limiting membrane of MVBs are recycled to other compartments." []
synonym: "Corpuscula multivesicularis" [UniProt]
synonym: "ECV" [UniProt]
synonym: "Endosomal carrier vesicle" [UniProt]
synonym: "Multivesicular bodies" [UniProt]
synonym: "MVB" [UniProt]
xref: GO:0005771 "multivesicular body"
xref: http://www.uni-mainz.de/FB/Medizin/Anatomie/workshop/EM/EMMVBE.html
is_a: SL-0152

[Term]
id: SL-0175
name: Multivesicular body membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the multivesicular bodies." []
synonym: "Corpuscula multivesicularis membrane" [UniProt]
synonym: "ECV membrane" [UniProt]
synonym: "Endosomal carrier vesicle membrane" [UniProt]
synonym: "Multivesicular bodies membrane" [UniProt]
synonym: "MVB membrane" [UniProt]
xref: GO:0032585 "multivesicular body membrane"
is_a: SL-0100
relationship: part_of SL-0174

[Term]
id: SL-0176
name: Myelin membrane
namespace: uniprot:locations:cellular_component
def: "The myelin membrane is the white matter coating our nerves, enabling them to conduct impulses between the brain and other parts of the body. It consists of a layer of proteins packed between two layers of lipids. This specialized cell membrane is produced by oligodendrocytes in the central nervous system, and Schwann cells in the peripheral nervous system. Myelin sheaths wrap themselves around axons, the threadlike extensions of neurons that make up nerve fibers. Each oligodendrocyte can myelinate several axons. The major function of myelin is to increase the velocity of propagation of nerve impulses." []
synonym: "Myelin" [UniProt]
synonym: "Myelin sheath" [UniProt]
xref: GO:0043209 "myelin sheath"
xref: https://www.myelin.org/
is_a: SL-0039

[Term]
id: SL-0177
name: Nematocyst
namespace: uniprot:locations:cellular_component
def: "The nematocyst is an organelle found in nematoblast (cnidoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the nematocyst) is stimulated by a prey or another stimulus. These proteins are principally found in anemones and jellyfishes." []
synonym: "Cnidocyst" [UniProt]
xref: GO:0042151 "nematocyst"

[Term]
id: SL-0178
name: Nucleus envelope
namespace: uniprot:locations:cellular_component
def: "The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space." []
synonym: "Karyotheca" [UniProt]
synonym: "Nuclear envelope" [UniProt]
synonym: "Nucleolemma" [UniProt]
synonym: "Perinuclear envelope" [UniProt]
xref: GO:0005635 "nuclear envelope"
relationship: part_of SL-0191

[Term]
id: SL-0179
name: Nucleus inner membrane
namespace: uniprot:locations:cellular_component
def: "The inner membrane of the nucleus is the membrane which separates the nuclear matrix from the intermembrane space. In mammals, the inner nuclear membrane is associated with heterochromatin and the nuclear lamina." []
synonym: "Inner nuclear membrane" [UniProt]
synonym: "Nuclear inner membrane" [UniProt]
xref: GO:0005637 "nuclear inner membrane"
is_a: SL-0182

[Term]
id: SL-0180
name: Nucleus lamina
namespace: uniprot:locations:cellular_component
def: "The nuclear lamina is a meshwork of intermediate filament proteins called lamins and lamin-binding proteins that are embedded in the inner nuclear membrane." []
synonym: "Nuclear lamina" [UniProt]
xref: GO:0005652 "nuclear lamina"
relationship: part_of SL-0178

[Term]
id: SL-0181
name: Nucleus matrix
namespace: uniprot:locations:cellular_component
def: "The nuclear matrix is a three-dimensional filamentous protein network, found in the nucleoplasm, which provides a structural framework for organising chromatin, while facilitating transcription and replication." []
synonym: "Nuclear matrix" [UniProt]
synonym: "Nuclear scaffold" [UniProt]
synonym: "Nuclear skeleton" [UniProt]
xref: GO:0016363 "nuclear matrix"
relationship: part_of SL-0191

[Term]
id: SL-0182
name: Nucleus membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane." []
synonym: "Nuclear membrane" [UniProt]
xref: GO:0031965 "nuclear membrane"
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0178

[Term]
id: SL-0183
name: Nucleus outer membrane
namespace: uniprot:locations:cellular_component
def: "The outer membrane of the nucleus is the membrane facing the cytoplasm. In mammals, the outer nuclear membrane is continuous in many places with the rough endoplasmic reticulum and is dotted with ribosomes." []
synonym: "Nuclear outer membrane" [UniProt]
synonym: "Outer nuclear membrane" [UniProt]
xref: GO:0005640 "nuclear outer membrane"
is_a: SL-0182

[Term]
id: SL-0184
name: Nucleus intermembrane space
namespace: uniprot:locations:cellular_component
def: "The nuclear intermembrane space is the space between the inner and outer nuclear membranes." []
synonym: "Nuclear envelope lumen" [UniProt]
synonym: "Nuclear intermembrane space" [UniProt]
synonym: "Nuclear periplasm" [UniProt]
synonym: "Nuclear periplasmic space" [UniProt]
synonym: "Nucleus envelope lumen" [UniProt]
synonym: "Perinuclear space" [UniProt]
xref: GO:0005641 "nuclear envelope lumen"
relationship: part_of SL-0178

[Term]
id: SL-0185
name: Nuclear pore complex
namespace: uniprot:locations:cellular_component
def: "The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport in eukaryotes during interphase. NPCs allow the passive diffusion of ions and small molecules (up to about 20 kDa or 5 nm) and the active, nuclear transport receptor (karyopherin: importin and exportin)-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoprotein (RNPs), and ribosomal subunits (up to about 10 MDa) across the double-membrane nuclear envelope. NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. The NPC is composed of at least 30 distinct subunits, shows 8-fold rotational symmetry with specialized structures on the cyto- and nucleoplasmic side and in the nuclear envelope embedded core. The MW varies from about 44-60 MDa in S. cerevisiae to 60-120 MDa in vertebrates, yet the overall architecture is conserved." []
synonym: "NPC" [UniProt]
synonym: "Nuclear pore" [UniProt]
xref: GO:0005643 "nuclear pore"
relationship: part_of SL-0178

[Term]
id: SL-0186
name: Nucleus speckle
namespace: uniprot:locations:cellular_component
def: "The nuclear speckles are small subnuclear membraneless organelles or structures, also called the splicing factor (SF) compartments that correspond to nuclear domains located in interchromatin regions of the nucleoplasm of mammalian cells. Protein found in speckles serves as a reservoir of factors that participate in transcription and pre-mRNA processing. Speckles appear, at the immunofluorescence-microscope level, as irregular, punctuate structures, which vary in size and shape. Usually 25-50 speckles are observed per interphase mammalian nucleus. At the electronic-microscope level, they are composed of heterogeneous mixture of electro-dense particles with diameters ranging from 20-25 nm and are called interchromatin granules clusters (IGCs). Speckles are dynamic structures. Both their protein and RNA- protein components can cycle continuously between speckles and other nuclear locations depending on the transcriptional state of the cell. Structures similar to nuclear speckles have been identified in the amphibian oocyte nucleus (called B snurposomes) and in Drosophila melanogaster embryos, but not in yeast." []
synonym: "B snurposome" [UniProt]
synonym: "IGC" [UniProt]
synonym: "Interchromatin granules clusters" [UniProt]
synonym: "Nuclear speck" [UniProt]
synonym: "Nuclear speckle" [UniProt]
synonym: "SF compartments" [UniProt]
synonym: "Splicing Factor compartments" [UniProt]
synonym: "Splicing speckle" [UniProt]
xref: GO:0016607 "nuclear speck"
is_a: SL-0494
relationship: part_of SL-0191

[Term]
id: SL-0187
name: Nucleoid
namespace: uniprot:locations:cellular_component
def: "The nucleoid is the prokaryotic pseudocompartment formed by the chromatin-dense area. This region, which is functionally equivalent to the eukaryotic nucleus, is not surrounded by a membrane." []
xref: GO:0009295 "nucleoid"
relationship: part_of SL-0086

[Term]
id: SL-0188
name: Nucleolus
namespace: uniprot:locations:cellular_component
def: "The nucleolus is a non-membrane bound nuclear compartment found in eukaryotic cells which is the site of ribosome biogenesis. The interphase nucleolus is organized around the tandemly repeated genes for preribosomal RNA (rRNA). It is composed of at least 2 sub- compartments: the dense fibrillar component (DFC, also called pars fibrosa) and the granular component (GC or pars granulosa). The DFC contains newly synthesized preribosomal RNA and a collection of proteins; the GC is made up of nearly completed preribosomal particles destined for the cytoplasm. In most metazoans, but generally not in lower eukaryotes, a third component, the fibrillar center (FC), can be seen. Plant and animal nuclei can contain more than one nucleolus." []
synonym: "Nucleoli" [UniProt]
xref: GO:0005730 "nucleolus"
relationship: part_of SL-0191

[Term]
id: SL-0189
name: Nucleomorph
namespace: uniprot:locations:cellular_component
def: "Nucleomorphs are vestigial endosymbiont found in cryptomonads and chlorachniophytes algae. These organisms respectively retain an enslaved red or green algal nucleus." []
xref: GO:0033009 "nucleomorph"

[Term]
id: SL-0190
name: Nucleoplasm
namespace: uniprot:locations:cellular_component
def: "The nucleoplasm is a highly viscous liquid contained within the nucleus that surrounds the chromosomes and other subnuclear organelles. A network of fibers known as the nuclear matrix can also be found in the nucleoplasm." []
synonym: "Karyolymph" [UniProt]
synonym: "Karyoplasm" [UniProt]
xref: GO:0005654 "nucleoplasm"
relationship: part_of SL-0191

[Term]
id: SL-0191
name: Nucleus
namespace: uniprot:locations:cellular_component
def: "The nucleus is the most obvious organelle in any eukaryotic cell. It is a membrane-bound organelle surrounded by double membranes which contains most of the cell's genetic material. It communicates with the surrounding cytosol via numerous nuclear pores." []
synonym: "Nuclear" [UniProt]
synonym: "Nuclei" [UniProt]
xref: GO:0005634 "nucleus"

[Term]
id: SL-0192
name: Paranodal septate junction
namespace: uniprot:locations:cellular_component
def: "The paranodal septate junction (PSJ) in vertebrate species is an occluding complex which occurs between neurons and the glial cells that myelinate them, the oligodendrocytes and the Schwann cells. Each glial cell wraps around and contacts the neuron multiple times in a spiral pattern to form the paranodal loops. The paranodal loops tightly adhere to the axon through a continuous spiral of axo-glial junctions that resemble invertebrate septate junctions (SJs). The paranodal loops are a spiraled cytoplasmic channel that is contiguous with the perikaryon of the myelin forming cell and thus can serve as a conduit for transmitting axonally induced signals that could regulate glial gene transcription. These junctions also form a physical barrier that prevents diffusion of nodal sodium channels and juxtaparanodal potassium channels. Axo-glial paranodal junctions, therefore, share adhesion, diffusion barrier and putative intercellular communication functions with invertebrate SJs." []
synonym: "Paranodal junction" [UniProt]
synonym: "PSJ" [UniProt]
xref: GO:0033010 "paranodal junction"
is_a: SL-0038

[Term]
id: SL-0193
name: Parasitophorous vacuole membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the parasitophorous vacuole." []
synonym: "Parasitophorous vacuolar membrane" [UniProt]
xref: GO:0020005 "symbiont-containing vacuole membrane"
is_a: SL-0162
relationship: part_of SL-0194

[Term]
id: SL-0194
name: Parasitophorous vacuole
namespace: uniprot:locations:cellular_component
def: "The parasitophorous vacuole is a vacuole found in the host cells where most apicomplexan parasites reside and develop. During host cell invasion, the apicomplexan parasites initiate the formation of a membrane (the parasitophorous vacuolar membrane), which surrounds the intracellular parasite." []
xref: GO:0020003 "symbiont-containing vacuole"

[Term]
id: SL-0195
name: Peribacteroid membrane
namespace: uniprot:locations:cellular_component
def: "Symbiosis leads to the formation of a new compartment in the plant cell when bacteria enter the plant cell by endocytosis, the symbiosome. This compartment harbours the bacteroids surrounded by a peribacteroid membrane (PMB) originating from the plant plasma membrane. The space between this membrane and the bacteroid membrane is called the peribacteroid space." []
xref: GO:0043661 "peribacteroid membrane"
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0256

[Term]
id: SL-0196
name: Peribacteroid space
namespace: uniprot:locations:cellular_component
def: "Symbiosis lead to the formation of a new compartment in the plant cell when bacteria enter the plant cell by endocytosis. This compartment harbours the bacteroids surrounded by a peribacteroid membrane (PMB) originating from the plant plasma membrane. The space between this membrane and the bacteroid membrane is called the peribacteroid space." []
xref: GO:0043662 "peribacteroid fluid"
relationship: part_of SL-0256

[Term]
id: SL-0197
name: Perikaryon
namespace: uniprot:locations:cellular_component
def: "The perikaryon is the cell body of a neuron." []
synonym: "cell body" [UniProt]
synonym: "Perikarya" [UniProt]
synonym: "soma" [UniProt]
xref: GO:0043204 "perikaryon"

[Term]
id: SL-0198
name: Perinuclear region
namespace: uniprot:locations:cellular_component
def: "The perinuclear region is the cytoplasmic region just around the nucleus." []
synonym: "Nuclear periphery" [UniProt]
synonym: "Perinuclear region of cytoplasm" [UniProt]
xref: GO:0048471 "perinuclear region of cytoplasm"
relationship: part_of SL-0086

[Term]
id: SL-0199
name: Perinuclear theca
namespace: uniprot:locations:cellular_component
def: "The perinuclear theca is a cytoskeletal structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer or perforatorium and, continuing caudally beyond the acrosomic system, the postacrosomal sheath." []
xref: GO:0033011 "perinuclear theca"
relationship: part_of SL-0090

[Term]
id: SL-0200
name: Periplasm
namespace: uniprot:locations:cellular_component
def: "The periplasm is the space between the inner and outer membrane in Gram-negative bacteria. In Gram-positive bacteria a smaller periplasmic space is found between the inner membrane and the peptidoglycan layer. Also used for the intermembrane spaces of fungi and organelles." []
synonym: "Periplasmic space" [UniProt]
xref: GO:0042597 "periplasmic space"
relationship: part_of SL-0036

[Term]
id: SL-0201
name: Periplasmic flagellum
namespace: uniprot:locations:cellular_component
def: "Spirochetes have a flagellum that resides inside the cell within the periplasmic space. The number of flagella varies from species to species. The rotation of these structures results in specific movements of the cell body, which in turn enable the locomotion of the cell. In particular they impart spirochetes the ability to propel themselves through viscous media that would inhibit the rotation of external flagellar filaments." []
synonym: "Endoflagellum" [UniProt]
synonym: "Periplasmic fibril" [UniProt]
xref: GO:0055040 "periplasmic flagellum"
is_a: SL-0307

[Term]
id: SL-0202
name: Peroxisome matrix
namespace: uniprot:locations:cellular_component
def: "The matrix of a peroxisome is the area enclosed by the peroxisomal membrane." []
synonym: "Peroxisomal matrix" [UniProt]
xref: GO:0005782 "peroxisomal matrix"
relationship: part_of SL-0204

[Term]
id: SL-0203
name: Peroxisome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a peroxysome." []
synonym: "Peroxisomal membrane" [UniProt]
xref: GO:0005778 "peroxisomal membrane"
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0204

[Term]
id: SL-0204
name: Peroxisome
namespace: uniprot:locations:cellular_component
def: "The peroxisome is a small eukaryotic organelle limited by a single membrane, specialized for carrying out oxidative reactions. Contains mainly peroxidases, several other oxidases and catalase. The catalase regulates the contents of the produced toxic hydrogen peroxide thus protecting the cell. Beta-oxidation of fatty acids is another major function of peroxisomes. In plants and fungi this degradation occurs only in this cellular compartment." []
xref: GO:0005777 "peroxisome"

[Term]
id: SL-0205
name: Phagosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a phagosome." []
synonym: "Phagocytic vesicle membrane" [UniProt]
synonym: "Phagosomal membrane" [UniProt]
xref: GO:0030670 "phagocytic vesicle membrane"
is_a: SL-0089
relationship: part_of SL-0206

[Term]
id: SL-0206
name: Phagosome
namespace: uniprot:locations:cellular_component
def: "The phagosome is a phagocytic cell-specific compartment. These large endocytic membrane-bound vesicles form upon ingestion by the cell of extracellular materials." []
synonym: "Phagocytic vesicle" [UniProt]
xref: GO:0045335 "phagocytic vesicle"
is_a: SL-0088

[Term]
id: SL-0207
name: Phragmoplast
namespace: uniprot:locations:cellular_component
def: "The phragmoplast is a plant cell specific structure that forms during late cytokinesis. This complex assembly of microtubules, actin filaments and associated molecules acts as a framework for cell plate assembly and subsequent formation of the future cell wall separating the two daughter cells." []
xref: GO:0009524 "phragmoplast"
relationship: part_of SL-0090

[Term]
id: SL-0208
name: Plasmodesma
namespace: uniprot:locations:cellular_component
def: "The plasmodesma (plural plasmodesmata) is a plasma membrane-lined channel that crosses the cell wall between two adjacent plant cells and which allows a cytoplasmic exchange between the cells. It provides passage of ions and small molecules, but also of macromolecules such as RNA or proteins. Plasmodesmata are sheathed by a plasma membrane that is simply an extension of the cell membrane of the adjoining cells. Most plasmodesmata have a narrow cylindrical desmotubule at the center that is derived from the ER and appears to be continuous with the ER of both cells." []
synonym: "PD" [UniProt]
synonym: "Plasmodesmata" [UniProt]
xref: GO:0009506 "plasmodesma"
is_a: SL-0038

[Term]
id: SL-0209
name: Plastid
namespace: uniprot:locations:cellular_component
def: "The plastid is a semi-autonomous, self-reproducing organelle. Plastids are remnants of a photosynthetic organism that was engulfed by the host, although not all are now photosynthetic. Plastid genomes encode genes for rRNAs, tRNAs and between about 28 and 150 proteins. Plastids can be categorized in 4 main groups: chloroplasts, cyanelles, apicoplasts and non-photosynthetic. The latter are found is some land plants (Epifagus virginiana), chlorophyte algae (Prototheca wickerhamii) and euglenoids (Astasis longa), which do not encode the genes necessary for photosynthesis and so are not photosynthetic but still contain a plastid. Non-photosynthetic plastids probably do not contain thylakoids." []
xref: GO:0009536 "plastid"

[Term]
id: SL-0210
name: Plastid envelope
namespace: uniprot:locations:cellular_component
def: "The envelope of a plastid comprises the inner and outer plastid membrane including the intermembrane space." []
synonym: "Plastidic envelope" [UniProt]
xref: GO:0009526 "plastid envelope"
relationship: part_of SL-0209

[Term]
id: SL-0211
name: Plastid inner membrane
namespace: uniprot:locations:cellular_component
def: "The inner membrane of a plastid separates the plastid stroma from the intermembrane space." []
synonym: "Inner plastid membrane" [UniProt]
synonym: "Inner plastidic membrane" [UniProt]
synonym: "Plastidic inner membrane" [UniProt]
xref: GO:0009528 "plastid inner membrane"
is_a: SL-0213

[Term]
id: SL-0212
name: Plastid intermembrane space
namespace: uniprot:locations:cellular_component
def: "The plastid intermembrane space is the space between the plastid inner and outer membranes." []
synonym: "Plastidic intermembrane space" [UniProt]
xref: GO:0009529 "plastid intermembrane space"
relationship: part_of SL-0210

[Term]
id: SL-0213
name: Plastid membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding or within a plastid. Also used when it is not clear in which plastid membrane (outer membrane, inner membrane or thylakoid) a protein is found." []
synonym: "Plastidic membrane" [UniProt]
xref: GO:0042170 "plastid membrane"
is_a: SL-0162
relationship: part_of SL-0210

[Term]
id: SL-0214
name: Plastid outer membrane
namespace: uniprot:locations:cellular_component
def: "The outer membrane of a plastid is the membrane facing the cytoplasm." []
synonym: "Outer plastid membrane" [UniProt]
synonym: "Outer plastidic membrane" [UniProt]
synonym: "Plastidic outer membrane" [UniProt]
xref: GO:0009527 "plastid outer membrane"
is_a: SL-0213

[Term]
id: SL-0215
name: Plastid stroma
namespace: uniprot:locations:cellular_component
def: "The stroma of a plastid is the internal space enclosed by the plastid double membrane but excluding the thylakoid space. This space, filled with a colorless hydrophilic matrix." []
synonym: "Plastidic stroma" [UniProt]
xref: GO:0009532 "plastid stroma"
relationship: part_of SL-0209

[Term]
id: SL-0216
name: Plastid thylakoid membrane
namespace: uniprot:locations:cellular_component
def: "The thylakoid membranes of a plastid is an internal system of interconnected membranes found in a plastid." []
synonym: "Plastid thylakoidal membrane" [UniProt]
xref: GO:0055035 "plastid thylakoid membrane"
is_a: SL-0162
relationship: part_of SL-0278

[Term]
id: SL-0217
name: Plastoglobule
namespace: uniprot:locations:cellular_component
def: "A plastoglobule is a conspicuous lipid-containing structure in the chloroplast stroma thought to serve as lipid reservoirs for thylakoid membranes." []
xref: GO:0010287 "plastoglobule"
relationship: part_of SL-0049

[Term]
id: SL-0218
name: Porosome
namespace: uniprot:locations:cellular_component
def: "The porosome is an actin-regulated dynamic structure at the cell membrane, where membrane-bound secretory vesicles dock and fuse to release their contents." []
xref: GO:0033012 "porosome"
relationship: part_of SL-0039

[Term]
id: SL-0219
name: Postsynaptic cell membrane
namespace: uniprot:locations:cellular_component
def: "In a chemical synapse, specialized area of the membrane that receives a signal (binds neurotransmitter) from the presynaptic cell and responds via depolarization or hyperpolarization. The postsynaptic membrane is separated from the presynaptic membrane by the synaptic cleft." []
synonym: "Postsynaptic membrane" [UniProt]
xref: GO:0045211 "postsynaptic membrane"
is_a: SL-0531
relationship: part_of SL-0515

[Term]
id: SL-0220
name: Preautophagosomal structure
namespace: uniprot:locations:cellular_component
def: "The pre-autophagosomal structure is the potential site of organization for autophagosome formation located near the vacuole." []
synonym: "PAS" [UniProt]
synonym: "Phagophore assembly site" [UniProt]
synonym: "Pre-autophagosomal structure" [UniProt]
xref: GO:0000407 "phagophore assembly site"

[Term]
id: SL-0221
name: Preautophagosomal structure membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the pre-autophagosomal structure." []
synonym: "PAS membrane" [UniProt]
synonym: "Pre-autophagosomal structure membrane" [UniProt]
xref: GO:0034045 "phagophore assembly site membrane"
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0220

[Term]
id: SL-0222
name: Presynaptic cell membrane
namespace: uniprot:locations:cellular_component
def: "In a chemical synapse, the presynaptic membrane is the cell membrane of an axon terminal that faces the receiving cell. The postsynaptic membrane is separated from the presynaptic membrane by the synaptic cleft." []
synonym: "Presynaptic membrane" [UniProt]
xref: GO:0042734 "presynaptic membrane"
is_a: SL-0531
relationship: part_of SL-0516

[Term]
id: SL-0223
name: Prevacuolar compartment
namespace: uniprot:locations:cellular_component
def: "The prevacuolar compartment is an endocytic multivesiculate compartment involved in Golgi-vacuole trafficking." []
synonym: "PVC" [UniProt]

[Term]
id: SL-0224
name: Prevacuolar compartment membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the prevacuolar compartment." []
synonym: "PVC membrane" [UniProt]
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0223

[Term]
id: SL-0225
name: Primary cell wall
namespace: uniprot:locations:cellular_component
def: "Trimary cell wall is the first-formed wall layer of still growing plant cells (at least potentially). This wall is part of the apoplast which itself is largely self-contiguous and contains everything that is located between the plasma membrane and the cuticle. Primary walls are composed predominantly of polysaccharides, smaller proportions of glycoproteins and, in some specialized cell types, various noncarbohydrate substances such as lignin, suberin, cutin, cutan or silica. It is strong but usually thin, flexible, and capable of both plastic and elastic extension. It governs the rate and direction of cell expansion, and thus the ultimate size and shape of the cell." []
xref: GO:0009530 "primary cell wall"
is_a: SL-0041

[Term]
id: SL-0226
name: Prolamellar body
namespace: uniprot:locations:cellular_component
def: "The prolamellar body is a paracrystalline lattice found in the plastids of etiolated plants (etioplasts). Upon greening it gives rise to thylakoids." []
synonym: "Etioplast prolamellar body" [UniProt]
xref: GO:0009541 "etioplast prolamellar body"
relationship: part_of SL-0110

[Term]
id: SL-0227
name: Protein storage vacuole membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a protein storage vacuole." []
synonym: "Protein storage vacuolar membrane" [UniProt]
xref: GO:0032586 "protein storage vacuole membrane"
is_a: SL-0271
relationship: part_of SL-0228

[Term]
id: SL-0228
name: Protein storage vacuole
namespace: uniprot:locations:cellular_component
def: "The protein storage vacuole (PSV) is a specialized vacuole where storage proteins accumulate. These act as a source of amino acids for various SYnthetic activities." []
synonym: "PSV" [UniProt]
synonym: "Storage vacuole" [UniProt]
xref: GO:0000326 "protein storage vacuole"
is_a: SL-0272

[Term]
id: SL-0229
name: Protoplasm
namespace: uniprot:locations:cellular_component
def: "The protoplasm is the viscid, translucent, polyphasic colloid with water as the continuous phase that makes up the essential material of all plant and animal cells. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts. The protoplasm surrounding the nucleus is known as the cytoplasm and that composing the nucleus is the nucleoplasm." []
xref: GO:0005622 "intracellular anatomical structure"

[Term]
id: SL-0230
name: P-body
namespace: uniprot:locations:cellular_component
def: "P-bodies are dynamic non-membrane bound cytoplasmic structures. These discrete foci function in mRNA decay (decapping and breakdown), RNA- mediated gene silencing (microRNA and siRNA-based gene silencing), mRNA surveillance (or quality control) and translational control. In addition to being sites of mRNA degradation, P-bodies can temporarily sequester mRNAs away from the translation machinery. P-bodies are present in unstressed cells, but are further induced in response to various stresses." []
synonym: "Cytoplasmic mRNA processing body" [UniProt]
synonym: "DCP bodies" [UniProt]
synonym: "Dcp body" [UniProt]
synonym: "Gawky bodies" [UniProt]
synonym: "Gawky body" [UniProt]
synonym: "GW bodies" [UniProt]
synonym: "GW body" [UniProt]
synonym: "GW182 bodies" [UniProt]
synonym: "GW182 body" [UniProt]
synonym: "GWB" [UniProt]
synonym: "mRNA processing bodies" [UniProt]
synonym: "mRNA processing body" [UniProt]
synonym: "mRNA-decay foci" [UniProt]
synonym: "P bodies" [UniProt]
synonym: "P body" [UniProt]
synonym: "P-bodies" [UniProt]
synonym: "PB" [UniProt]
synonym: "Processing bodies" [UniProt]
synonym: "Processing body" [UniProt]
xref: GO:0000932 "P-body"
is_a: SL-0495

[Term]
id: SL-0231
name: Recycling endosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the recycling endosomes." []
synonym: "Recycling endosomal membrane" [UniProt]
xref: GO:0055038 "recycling endosome membrane"
is_a: SL-0100
relationship: part_of SL-0232

[Term]
id: SL-0232
name: Recycling endosome
namespace: uniprot:locations:cellular_component
def: "The recycling endosome is a membrane network composed of narrow diameters tubules which concentrate in the vicinity of the microtubule organizing center. Recycling receptors after release of their ligands accumulate in those membranes which are devoid of fluid markers. Recycling endosomes may be an intermediate station for receptors before recycling back to the cell surface." []
synonym: "Endosomal recycling compartment" [UniProt]
synonym: "ERC" [UniProt]
xref: GO:0055037 "recycling endosome"
relationship: part_of SL-0101

[Term]
id: SL-0233
name: Rhoptry
namespace: uniprot:locations:cellular_component
def: "The rhoptry is an Apicomplexan parasite organelle. Apicomplexa are named for the unique set of morphologically distinct secretory organelles (refered to as the apical complex)- micronemes, rhoptries and dense granules - whose sequential secretion is required for the invasion of host cells. Rhoptries are twin, membrane-bound, pear- shaped organelles that secrete proteins through their elongated necks at the apical tip of the parasite." []
synonym: "Rhoptries" [UniProt]
xref: GO:0020008 "rhoptry"
is_a: SL-0244

[Term]
id: SL-0234
name: Rhoptry membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a rhoptry." []
xref: GO:0033016 "rhoptry membrane"
is_a: SL-0245
relationship: part_of SL-0233

[Term]
id: SL-0235
name: Rough endoplasmic reticulum
namespace: uniprot:locations:cellular_component
def: "The rough endoplasmic reticulum (RER) is the portion of the ER which is covered with ribosomes." []
synonym: "RER" [UniProt]
synonym: "Rough ER" [UniProt]
xref: GO:0005791 "rough endoplasmic reticulum"
relationship: part_of SL-0095

[Term]
id: SL-0236
name: Rough endoplasmic reticulum lumen
namespace: uniprot:locations:cellular_component
def: "The rough endoplasmic reticulum lumen is the area enclosed by the rough endoplasmic reticulum membrane." []
xref: GO:0048237 "rough endoplasmic reticulum lumen"
is_a: SL-0096
relationship: part_of SL-0235

[Term]
id: SL-0237
name: Rough endoplasmic reticulum membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the rough endoplasmic reticulum." []
xref: GO:0030867 "rough endoplasmic reticulum membrane"
is_a: SL-0097
relationship: part_of SL-0235

[Term]
id: SL-0238
name: Sarcolemma
namespace: uniprot:locations:cellular_component
def: "The sarcolemma is a specialized membrane which surrounds striated muscle fiber cells. It consists of a lipid bilayer typical of a plasma membrane and a thin outer coat of polysaccharide material, called glycocalyx, that contacts the basement membrane and allows the cell to anchor into the tissues that build and support muscle fibers." []
synonym: "Myolemma" [UniProt]
xref: GO:0042383 "sarcolemma"
is_a: SL-0039

[Term]
id: SL-0239
name: Sarcoplasmic reticulum
namespace: uniprot:locations:cellular_component
def: "The sarcoplasmic reticulum (SR) is a highly specialized form of the smooth endoplasmic reticulum which is dedicated to the regulation of intracellular calcium homeostasis. The SR can be subdivided in at least two well-characterized regions: the terminal cisternae, where the calcium ions are released, and the longitudinal tubules specialized in the uptake of the calcium ions." []
xref: GO:0016529 "sarcoplasmic reticulum"

[Term]
id: SL-0240
name: Sarcoplasmic reticulum lumen
namespace: uniprot:locations:cellular_component
def: "The lumen of the sarcoplasmic reticulum is the area enclosed by the sarcoplasmic reticulum membrane." []
xref: GO:0033018 "sarcoplasmic reticulum lumen"
relationship: part_of SL-0239

[Term]
id: SL-0241
name: Sarcoplasmic reticulum membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the sarcoplasmic reticulum (SR)." []
xref: GO:0033017 "sarcoplasmic reticulum membrane"
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0239

[Term]
id: SL-0242
name: Secondary cell wall
namespace: uniprot:locations:cellular_component
def: "In some plants, and cell types after a maximum size or point in development has been reached, a secondary wall, often layered, is constructed below the primary wall. Unlike the primary wall, it losts plasticity and is made usually of cellulose, hemicellulose and lignin." []
xref: GO:0009531 "secondary cell wall"
is_a: SL-0041

[Term]
id: SL-0243
name: Secreted
namespace: uniprot:locations:cellular_component
def: "Protein located outside the cell membrane(s)." []
xref: GO:0005576 "extracellular region"

[Term]
id: SL-0244
name: Secretory vesicle
namespace: uniprot:locations:cellular_component
def: "The secretory vesicle is a vesicle that mediates the vesicular transport of cargo - e.g. hormones or neurotransmitters - from an organelle to specific sites at the cell membrane, where it docks and fuses to release its content. It has been demonstrated that membrane- bound secretory vesicles dock and fuse at porosomes, which are specialized supramolecular structures at the cell membrane." []
synonym: "Secretory granule" [UniProt]
xref: GO:0030133 "transport vesicle"
is_a: SL-0088

[Term]
id: SL-0245
name: Secretory vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding secretory vesicles." []
synonym: "Secretory granule membrane" [UniProt]
xref: GO:0030658 "transport vesicle membrane"
is_a: SL-0089
relationship: part_of SL-0244

[Term]
id: SL-0246
name: Septate junction
namespace: uniprot:locations:cellular_component
def: "The septate junction (SJ) in invertebrates is an occluding complex located basolateral to the adherens junction which have regularly spaced septa bridging a circa 15-nm intercellular space. SJs form the paracellular barrier that regulates passage of solutes through the spaces between adjacent cells in an epithelium for proper nutrient absorption or secretion." []
synonym: "Paired septate junction" [UniProt]
synonym: "Pleated septate junction" [UniProt]
synonym: "SJ" [UniProt]
xref: GO:0005918 "septate junction"
is_a: SL-0038

[Term]
id: SL-0247
name: Slime layer
namespace: uniprot:locations:cellular_component
def: "The slime layer is an easily removed, diffuse, unorganized layer of extracellular material which surrounds the bacterial cell. It is usually composed of polysaccharides and it may serve to trap nutrients, to aid in cell motility, to bind cells together or to adhere to smooth surfaces. Slime layers are a more-diffuse glycocalyx than capsules." []
xref: GO:0030114 "slime layer"
relationship: part_of SL-0243

[Term]
id: SL-0248
name: Smooth endoplasmic reticulum
namespace: uniprot:locations:cellular_component
def: "The smooth endoplasmic reticulum (SER) is the portion of the ER which is free of ribosomes." []
synonym: "SER" [UniProt]
synonym: "Smooth ER" [UniProt]
xref: GO:0005790 "smooth endoplasmic reticulum"
relationship: part_of SL-0095

[Term]
id: SL-0249
name: Smooth endoplasmic reticulum lumen
namespace: uniprot:locations:cellular_component
def: "The smooth endoplasmic reticulum lumen is the area enclosed by the smooth endoplasmic reticulum membrane." []
xref: GO:0048238 "smooth endoplasmic reticulum lumen"
is_a: SL-0096
relationship: part_of SL-0248

[Term]
id: SL-0250
name: Smooth endoplasmic reticulum membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the smooth endoplasmic reticulum." []
xref: GO:0030868 "smooth endoplasmic reticulum membrane"
is_a: SL-0097
relationship: part_of SL-0248

[Term]
id: SL-0251
name: Spindle
namespace: uniprot:locations:cellular_component
def: "The spindle is a specialized microtubule structure designed to attach and capture chromosomes in order to partition them evenly to each daughter cells." []
synonym: "Meiotic spindle" [UniProt]
synonym: "Mitotic apparatus" [UniProt]
synonym: "Mitotic spindle" [UniProt]
xref: GO:0005819 "spindle"
relationship: part_of SL-0090

[Term]
id: SL-0252
name: Spindle pole body
namespace: uniprot:locations:cellular_component
def: "The spindle pole body is the microtubule organizing center (MTOC) in fungi, functionally equivalent to the animal cell centrosome. The SPB is responsible for the nucleation and organisation of microtubules. This may include the spindle microtubules required for chromosome segregation in mitosis and meiosis as well as the cytoplasmic interphase microtubules." []
synonym: "SPB" [UniProt]
synonym: "Spindle polar body" [UniProt]
xref: GO:0005816 "spindle pole body"
relationship: part_of SL-0484

[Term]
id: SL-0253
name: Spore core
namespace: uniprot:locations:cellular_component
def: "Protein found in the spore core. The core also called spore matrix is the central part of the spore and contains normal cell structures, such as DNA, proteins and ribosomes, but is metabolically inactive." []
relationship: part_of SL-0539

[Term]
id: SL-0254
name: Spore wall
namespace: uniprot:locations:cellular_component
def: "Protein found in the spore wall. The spore wall is the main element of the spore's resistance to environmental stress. It is usually composed of several layers of different sugar polymers like mannans and glucans which are associated to glycoproteins. The composition, structure and number of layers are very different between bacteria, plants, protozoans or fungi." []
xref: GO:0031160 "spore wall"
relationship: part_of SL-0539

[Term]
id: SL-0255
name: Surface film
namespace: uniprot:locations:cellular_component
def: "The film of pulmonary surfactants which cover the alveolar surface of the mammalian lung. These surfactants are composed of 90% phospholipids and 10% proteins." []
relationship: part_of SL-0112

[Term]
id: SL-0256
name: Symbiosome
namespace: uniprot:locations:cellular_component
def: "Symbiosis lead to the formation of a new compartment in the plant cell when bacteria enter the plant cell by endocytosis, the symbiosome. This compartment harbours the bacteroids surrounded by a peribacteroid membrane (PMB) originating from the plant plasma membrane. The space between this membrane and the bacteroid membrane is called the peribacteroid space." []
xref: GO:0043659 "symbiosome"

[Term]
id: SL-0257
name: Symplast
namespace: uniprot:locations:cellular_component
def: "The symplast is a highly ordered and connected space within plants formed by the cytoplasms of individual cells connected by plasmodesmata. The symplast is held in place by a rigid framework, the apoplast." []
xref: GO:0055044 "symplast"

[Term]
id: SL-0258
name: Synapse
namespace: uniprot:locations:cellular_component
def: "Synapses are the communicating cell-cell junctions that allow signals to pass from a nerve cell to a target cell. In a chemical synapse, the signal is carried by a neurotransmitter which diffuses across a narrow synaptic cleft and activates a receptor on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, neuronal axon, a specialized region of a muscle or a secretory cell. In an electrical synapse, a direct connection is made between the cytoplasms of two cells via gap junctions." []
xref: GO:0045202 "synapse"

[Term]
id: SL-0259
name: Synaptic vesicle
namespace: uniprot:locations:cellular_component
def: "The synaptic vesicles mediate the exocytosis of neurotransmitters and subsequent re-uptake by endocytosis of vesicular components. Re-uptake is a crucial element in the maintenance of synaptic transmission in the nervous system." []
xref: GO:0008021 "synaptic vesicle"
is_a: SL-0244
relationship: part_of SL-0258

[Term]
id: SL-0260
name: Synaptic vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a synaptic vesicle." []
synonym: "Synaptic vesicular membrane" [UniProt]
xref: GO:0030672 "synaptic vesicle membrane"
is_a: SL-0245
relationship: part_of SL-0259

[Term]
id: SL-0261
name: Synaptosome
namespace: uniprot:locations:cellular_component
def: "Synaptosomes are the pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the postsynaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates." []
relationship: part_of SL-0258

[Term]
id: SL-0262
name: S-layer
namespace: uniprot:locations:cellular_component
def: "The S-layer is a paracrystalline protein thin layer attached to the outermost portion of the cell wall. Found in some bacteria and common in archaea where it can constitute the only cell wall structure outside the plasma membrane. In Gram-negative bacteria, the S-layer is directly attached to the outer membrane. In Gram-positive bacteria, the S-layer is attached to the peptidoglycan layer. The S-layer may protect the cell from aggressions such as phagocytosis, harmful enzymes, etc. It also allows bacteria to adhere to host cells or other environmental surfaces and to maintain shape and envelope rigidity." []
xref: GO:0030115 "S-layer"
relationship: part_of SL-0041

[Term]
id: SL-0263
name: Tegument
namespace: uniprot:locations:cellular_component
def: "The tegument of schistosomes is an outer-surface covering blood- dwelling flatworms. This unique structure consists of a double phospholipid bilayer (also known as the heptalaminar outer-surface structure) that ovelay a syncytium of fused cells surrounding the entire worm. These outer-tegumental membranes form many surface pits that substantially increase the surface area of the schistosome. The underlying syncytial-matrix contains some mitochondria, many vesicular structures and an extensive cytoskeleton. A basal lamina separates the syncytium from a layer of muscle cells. Nuclei and ribosomes are located in cytons, which are located underneath the muscle layer and connected by microtubule-lined cytoplasmic connections." []

[Term]
id: SL-0264
name: Tegument membrane
namespace: uniprot:locations:cellular_component
def: "The membrane suroounding the tegument of schistosomes." []
synonym: "Tegumental membrane" [UniProt]
is_a: SL-0162
relationship: part_of SL-0263

[Term]
id: SL-0265
name: Tight junction
namespace: uniprot:locations:cellular_component
def: "The tight junction (TJ) is a dynamic, multifunctional complex which, together with adherens junctions and desmosomes, maintains the integrity of the epithelial cell layer(s) that protects multicellular organisms. TJ is located at the apical-most portion of the intercellular junction. It separates the apical and basolateral compartments of epithelia (preventing the lateral diffusion of lipids and proteins between the apical and basolateral domains of plasma membrane) and plays a key role in limiting paracellular permeability to ions and solutes in a charge and size selective manner. TJs appear as multiple strands of fibrils forming a continuous circumferential seal around cells." []
synonym: "TJ" [UniProt]
synonym: "Zonula occludens" [UniProt]
xref: GO:0005923 "bicellular tight junction"
xref: http://celljunctions.med.nyu.edu/desmosomes/desframe.html
is_a: SL-0038

[Term]
id: SL-0266
name: trans-Golgi network
namespace: uniprot:locations:cellular_component
def: "The trans-Golgi network is a highly dynamic series of interconnected tubules and vesicles at the trans face of the Golgi stack. The trans- Golgi network functions in the processing and sorting of glycoproteins and glycolipids at the interface of the biosynthetic and endosomal pathways. The generation and maintenance of apical and basolateral membranes rely on sorting events that occur in the TGN." []
synonym: "Golgi trans-face" [UniProt]
synonym: "TGN" [UniProt]
synonym: "trans-Golgi" [UniProt]
synonym: "trans-Golgi complex" [UniProt]
xref: GO:0005802 "trans-Golgi network"
relationship: part_of SL-0132

[Term]
id: SL-0267
name: trans-Golgi network membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the trans-Golgi network." []
synonym: "Golgi trans-face membrane" [UniProt]
synonym: "TGN membrane" [UniProt]
synonym: "trans-Golgi complex membrane" [UniProt]
synonym: "trans-Golgi membrane" [UniProt]
xref: GO:0032588 "trans-Golgi network membrane"
is_a: SL-0134
relationship: part_of SL-0266

[Term]
id: SL-0268
name: Trichocyst
namespace: uniprot:locations:cellular_component
def: "The trichocyst is an architecturally complex secretory granule having a highly constrained shape docked at specialized cortical sites in Paramecium and other ciliates. Each cell bears about 1'000 trichocysts, which are supposed to be defensive organelles against predators. Trichocyst consists of a spindle-shaped body bearing at its wide end a tip often compared to an inverted golf tee. An external stimulus can trigger massive and synchronous exocytosis. After exocytotic membrane fusion, contact with the H2O and calcium ions in the external medium leads to an extremely rapid (< 50 ms) and irreversible expansion of the trichocyst contents, to yield a second, needle-shaped form which remains insoluble." []
xref: GO:0055039 "trichocyst"

[Term]
id: SL-0269
name: Mitochondrion nucleoid
namespace: uniprot:locations:cellular_component
def: "The mitochondrial nucleoid is the mitochondrial pseudocompartment formed by the chromatin-dense area. This region, which is functionally equivalent to the eukaryotic nucleus, is not surrounded by a membrane." []
synonym: "Mitochondrial nucleoid" [UniProt]
synonym: "Mitochromosome" [UniProt]
xref: GO:0042645 "mitochondrial nucleoid"
relationship: part_of SL-0170

[Term]
id: SL-0270
name: Vacuole lumen
namespace: uniprot:locations:cellular_component
def: "The lumen of a vacuole is the area enclosed by the vacuolar membrane." []
synonym: "Vacuolar lumen" [UniProt]
xref: GO:0005775 "vacuolar lumen"
relationship: part_of SL-0272

[Term]
id: SL-0271
name: Vacuole membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a vacuole." []
synonym: "Vacuolar membrane" [UniProt]
xref: GO:0005774 "vacuolar membrane"
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0272

[Term]
id: SL-0272
name: Vacuole
namespace: uniprot:locations:cellular_component
def: "The vacuole is a generally large fluid-filled membrane-bound compartment in the cytoplasm. The precise form and function of vacuoles may vary between phyla. Plant vacuoles are among the best characterized. They differ in terms of their lumenal contents and processing enzymes, as well as on the basis of the type of integral proteins in their membranes (tonoplast intrinsic proteins, TIPs). Examples include the lytic vacuole, the storage vacuole and the lutoid. One important function of plant vacuoles is the maintenance of hydrostatic pressure. Other eukaryotes employ vacuoles for a variety of purposes, including storage (as in the yeast lysosome/vacuole), secretion and phagocytosis. In Protozoa, contractile vacuoles can be used to discharge water from the cytoplasm to the external environment." []
xref: GO:0005773 "vacuole"

[Term]
id: SL-0273
name: Virion tegument
namespace: uniprot:locations:cellular_component
def: "The viral tegument is a protein structure that resides between the capsid and envelope of herpesviruses and which appears amorphous in electron micrographs." []
synonym: "Viral tegument" [UniProt]
xref: GO:0019033 "viral tegument"
relationship: part_of SL-0274

[Term]
id: SL-0274
name: Virion
namespace: uniprot:locations:cellular_component
def: "The virion is the complete fully infectious extracellular virus particle." []

[Term]
id: SL-0275
name: Virion membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the virion." []
xref: GO:0055036 "virion membrane"
is_a: SL-0162
relationship: part_of SL-0274

[Term]
id: SL-0276
name: Telomere
namespace: uniprot:locations:cellular_component
def: "The telomere is a nucleoprotein structure comprising the terminal section of a eukaryotic chromosome. It has a specialized structure which is replicated by a special process, thereby counteracting the tendency of a chromosome to be shortened during each round of replication." []
synonym: "Chromosome, telomeric region" [UniProt]
xref: GO:0000781 "chromosome, telomeric region"
relationship: part_of SL-0468

[Term]
id: SL-0277
name: Cyanelle thylakoid
namespace: uniprot:locations:cellular_component
def: "The cyanelle thylakoid is an internal system of interconnected photosynthetic membranes resembling that of cyanobacteria found in the cyanelles of certain algae." []
xref: GO:0009843 "cyanelle thylakoid"
is_a: SL-0278
relationship: part_of SL-0082

[Term]
id: SL-0278
name: Plastid thylakoid
namespace: uniprot:locations:cellular_component
def: "The thylakoid of a plastid is an internal system of interconnected membranes found within a plastid." []
synonym: "Plastidic thylakoid" [UniProt]
xref: GO:0031976 "plastid thylakoid"
is_a: SL-0450
relationship: part_of SL-0209

[Term]
id: SL-0279
name: Axon
namespace: uniprot:locations:cellular_component
def: "The axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." []
synonym: "Axon shaft" [UniProt]
xref: GO:0030424 "axon"
is_a: SL-0518

[Term]
id: SL-0280
name: Cell projection
namespace: uniprot:locations:cellular_component
def: "A cell projection is a cell protrusion such as pseudopodium, filopodium, lamellipodium, growth cone, flagellum, acrosome, axon, or bacterial comet tail. These membrane-cytoskeleton-coupled processes are involved in many biological functions, such as cell motility, cancer-cell invasion, endocytosis, phagocytosis, exocytosis, pathogen infection, neurite extension and cytokinesis." []
synonym: "Cell protrusion" [UniProt]
xref: GO:0042995 "cell projection"

[Term]
id: SL-0281
name: Cytoplasmic granule
namespace: uniprot:locations:cellular_component
def: "Protein found in or associated with cytoplasmic granules." []

[Term]
id: SL-0282
name: Cytoplasmic granule membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a cytoplasmic granule." []
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0281

[Term]
id: SL-0283
name: Dendrite
namespace: uniprot:locations:cellular_component
def: "The dendrite is a short and typically branched process extending from the cell body of a neuron that receives and integrates signals coming from axons of other neurons, and conveys the resulting signal to the body of the cell." []
xref: GO:0030425 "dendrite"
is_a: SL-0518

[Term]
id: SL-0284
name: Dendritic spine
namespace: uniprot:locations:cellular_component
def: "A dendritic spine is a small, club-like cell protrusion from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. Spines are complex, dynamic structures that contain a dense array of cytoskeletal, transmembrane, and scaffolding molecules. Despite their modest size, most spines contain at least some form of smooth endoplasmic reticulum, which in the largest spines takes the form of a specialized organelle called the \"spine apparatus\". These cell protrusions play a critical role in synaptic transmission and plasticity." []
synonym: "Postsynaptic dendritic spine" [UniProt]
synonym: "Spine" [UniProt]
xref: GO:0043197 "dendritic spine"
is_a: SL-0515
relationship: part_of SL-0518

[Term]
id: SL-0285
name: Dendritic spine membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding the dendritic spine, a small, club-like cell protrusion from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain." []
xref: GO:0032591 "dendritic spine membrane"
is_a: SL-0219
relationship: part_of SL-0284

[Term]
id: SL-0286
name: Filopodium
namespace: uniprot:locations:cellular_component
def: "The filopodium is a thin, tubular, finger-like cell protrusion filled with straight bundled, crosslinked actin filaments having their barbed ends directed towards the cell membrane. Filopodium are observed at the advancing front of the migrating cell and are implicated in cell motility as well as in cell-substrate adhesion. Filopodia explore the environment and form nascent adhesive structures in response to external signaling cues. These long and highly dynamic protrusions, which can extend and retract, are involved in mesenchymal migration. They are observed in many cell types, such as amoebae, keratinocytes, fibroblasts and in neurite growth cones." []
synonym: "Filopodia" [UniProt]
synonym: "Microspike" [UniProt]
xref: GO:0030175 "filopodium"
is_a: SL-0280

[Term]
id: SL-0287
name: Filopodium membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding the filopodium. The filopodium is a thin, tubular, finger-like cell protrusion filled with straight bundled, crosslinked actin filaments having their barbed ends directed towards the cell membrane." []
synonym: "Filopodia membrane" [UniProt]
synonym: "Microspike membrane" [UniProt]
xref: GO:0031527 "filopodium membrane"
relationship: part_of SL-0039
relationship: part_of SL-0286

[Term]
id: SL-0288
name: Growth cone
namespace: uniprot:locations:cellular_component
def: "The growth cone is a dynamic cell protrusion at the tip of the extending axon or dendrite. Neuron extends a specialized structure, the growth cone, to find targets in the wiring of the nervous system. The growth cone explores its environment by extending dynamic filopodia. Growth cone is composed of an ensemble of protruding and retracting veils (lamellipodia), net growth cone advance may be considered the vector sum of all veil's motility behavior in response to their local environments. Filopodia play a key role in delimiting veils and serving to nucleate the formation of new veils." []
xref: GO:0030426 "growth cone"
is_a: SL-0518

[Term]
id: SL-0289
name: Growth cone membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding a growth cone." []
xref: GO:0032584 "growth cone membrane"
relationship: part_of SL-0039
relationship: part_of SL-0288

[Term]
id: SL-0290
name: Invadopodium membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding an invadopodium." []
relationship: part_of SL-0039
relationship: part_of SL-0148

[Term]
id: SL-0291
name: Lamellipodium
namespace: uniprot:locations:cellular_component
def: "The lamellipodium is a broad, flat, veil-shaped cell protrusion formed at the leading edge of migrating cells. Lamellipodium contain a branched dendritic network of actin filaments having their barbed ends directed towards the cell membrane. It is associated with ameboid motility (or crawling motility)." []
synonym: "Lamellipodia" [UniProt]
synonym: "Veil" [UniProt]
xref: GO:0030027 "lamellipodium"
is_a: SL-0280

[Term]
id: SL-0292
name: Lamellipodium membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding a lamellipodium." []
xref: GO:0031258 "lamellipodium membrane"
relationship: part_of SL-0039
relationship: part_of SL-0291

[Term]
id: SL-0293
name: Microvillus
namespace: uniprot:locations:cellular_component
def: "Microvilli are thin cylindrical dynamic cell projections containing a core bundle of actin filaments. They serve a diverse set of functions, such as increasing absorptive surface area in the epithelial brush border, tethering leukocytes to the surface of endothelial cells or participate in sperm-oocyte fusion." []
synonym: "Microvilli" [UniProt]
xref: GO:0005902 "microvillus"
is_a: SL-0280

[Term]
id: SL-0294
name: Microvillus membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding a microvillus." []
synonym: "Microvillar membrane" [UniProt]
xref: GO:0031528 "microvillus membrane"
relationship: part_of SL-0039
relationship: part_of SL-0293

[Term]
id: SL-0295
name: Podosome
namespace: uniprot:locations:cellular_component
def: "The podosome is a ring-like cell protrusion which mediates cell- extracellular matrix interactions. Podosomes are composed of an actin- bundle core, flanked by a ring containing adhesion proteins connected to the core via dome-like radial actin fibers. Podosomes are rich in actin filaments, matrix-degrading enzymes, focal adhesion molecules and molecules involved in vesicle trafficking. These structures protrudes into the extracellular matrix and are essential for invasion and metastasis. Classical podosomes are highly dynamic structures formed by cell types of monocytic origin, such as macrophages, dendritic cells, and osteoclasts." []
xref: GO:0002102 "podosome"
is_a: SL-0038
is_a: SL-0280

[Term]
id: SL-0296
name: Podosome membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding a podosome." []
synonym: "Podosomal membrane" [UniProt]
relationship: part_of SL-0039
relationship: part_of SL-0295

[Term]
id: SL-0297
name: Postsynaptic density
namespace: uniprot:locations:cellular_component
def: "The postsynaptic density is a network of proteins within and adjacent to the postsynaptic membrane, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. In asymmetric synapses, the postsynaptic density is a thick electron dense network but in symmetric synapses this structure is thinner and not electron dense." []
synonym: "Postsynaptic specialization" [UniProt]
synonym: "PSD" [UniProt]
xref: GO:0014069 "postsynaptic density"
relationship: part_of SL-0515

[Term]
id: SL-0298
name: Pseudopodium
namespace: uniprot:locations:cellular_component
def: "The pseudopodium is a thick knobby cell protrusion. Pseudopodia are produced by polymerization of extensive dendritic meshwork of actin filaments along broad sectors of the cell surface. These temporary irregular and dynamic protrusion or retractile processes of a cell, are associated with ameboid movement (crawling). Pseudopodium, or \"false foot\", mostly used for motile protozoans is comparable to the 'lamellipodium' in vertebrate cells." []
synonym: "Pseudopod" [UniProt]
synonym: "Pseudopodia" [UniProt]
xref: GO:0031143 "pseudopodium"
is_a: SL-0280

[Term]
id: SL-0299
name: Pseudopodium membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding a pseudopodium." []
xref: GO:0031260 "pseudopodium membrane"
relationship: part_of SL-0039
relationship: part_of SL-0298

[Term]
id: SL-0300
name: Ruffle
namespace: uniprot:locations:cellular_component
def: "A ruffle is a cell protrusion at the leading edge of a crawling cell. Ruffles are supported by a microfilament meshwork." []
xref: GO:0001726 "ruffle"
is_a: SL-0280

[Term]
id: SL-0301
name: Ruffle membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding a ruffle." []
xref: GO:0032587 "ruffle membrane"
relationship: part_of SL-0039
relationship: part_of SL-0300

[Term]
id: SL-0302
name: Stereocilium
namespace: uniprot:locations:cellular_component
def: "The stereocilium is a finger-like projection forming the hair bundle on the apical surface of sensory hair cells in the cochlea. Stereocilia stiffness and function depend on the several hundreds of uniformly polarized and tightly cross-linked actin filaments. Stereocilia cytoskeleton shows continuous turnover with actin filament assembly occuring at the stereocilium tip and its disassembly at the base so that stereocilium length is maintained in a dynamic steady- state. This staircase-like bundle of stereocilia is responsible for mechanosensation and ultimately the perception of sound." []
synonym: "Stereocilia" [UniProt]
xref: GO:0032420 "stereocilium"
is_a: SL-0280

[Term]
id: SL-0303
name: Stereocilium membrane
namespace: uniprot:locations:cellular_component
def: "The stereocilium membrane is the portion of the cell membrane surrounding a stereocilium." []
synonym: "Stereocilia membrane" [UniProt]
xref: GO:0060171 "stereocilium membrane"
relationship: part_of SL-0039
relationship: part_of SL-0302

[Term]
id: SL-0304
name: Cilium axoneme
namespace: uniprot:locations:cellular_component
def: "The cilium axoneme is the most prominent structural component of the cilium. It consists of nine doublet microtubules, with all motile cilia - except those at the embryonic node - containing an additional central pair of microtubules. The axonemal microtubules of all cilia nucleate and extend from a basal body, a centriolar structure most often composed of a radial array of nine triplet microtubules. In most cells, basal bodies associate with cell membranes and cilia are assembled as 'extracellular' membrane-enclosed compartments." []
synonym: "Ciliary axoneme" [UniProt]
relationship: part_of SL-0066
relationship: part_of SL-0090

[Term]
id: SL-0305
name: Cilium membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the cell membrane surrounding the cilium." []
synonym: "Ciliary membrane" [UniProt]
xref: GO:0060170 "ciliary membrane"
relationship: part_of SL-0039
relationship: part_of SL-0066

[Term]
id: SL-0306
name: Archaeal flagellum
namespace: uniprot:locations:cellular_component
def: "The archaellum (archaeal flagellum) is the motility apparatus of archaea which propels the cell through liquid medium. The archaellum is the functional equivalent of the bacterial flagellum but its architecture, composition and mode of assembly is completely unrelated. The archaellum is thinner (10-15 nm) compared to the bacterial flagellum (18-24 nm). Its filament is assembled from archaellin subunits, which are N-glycosylated proteins. The archaellum is considered to be a type IV pilus-like structure." []
synonym: "Archaeal flagella" [UniProt]
synonym: "Archaeal flagellar apparatus" [UniProt]
synonym: "Archaellum" [UniProt]
xref: GO:0097589 "archaeal-type flagellum"

[Term]
id: SL-0307
name: Bacterial flagellum
namespace: uniprot:locations:cellular_component
def: "The flagellum of Bacteria is a long hair-like cell surface appendage. The flagellar apparatus consists of the flagellar filament made of polymerized flagellin (the propeller), the hook-like structure near the cell surface (the universal joint) and the basal body (the engine) which is a rod and a system of rings embedded in the cell envelope. The basal body and the hook anchor the whip-like filament to the cell surface. The flagellum is a rotating structure whose switches propels the cell through a liquid medium." []
synonym: "Bacterial flagella" [UniProt]
synonym: "Bacterial flagellar apparatus" [UniProt]
xref: GO:0009288 "bacterial-type flagellum"

[Term]
id: SL-0308
name: Flagellum basal body
namespace: uniprot:locations:cellular_component
def: "The basal body is a barrel-shaped microtubule-based structure required for the formation of flagella. Basal bodies, structuraly related to and often interconvertible with centrioles, serves as a nucleation site for axoneme growth." []
synonym: "Flagellar basal body" [UniProt]
synonym: "Flagellar kinetosome" [UniProt]
synonym: "Flagellum kinetosome" [UniProt]
is_a: SL-0087
relationship: part_of SL-0117

[Term]
id: SL-0309
name: Plastid thylakoid lumen
namespace: uniprot:locations:cellular_component
def: "The plastid thylakoid lumen is the plastid compartment bounded by the thylakoid membranes." []
synonym: "Plastid thylakoidal lumen" [UniProt]
xref: GO:0031978 "plastid thylakoid lumen"
relationship: part_of SL-0278

[Term]
id: SL-0310
name: Cell surface
namespace: uniprot:locations:cellular_component
def: "The outermost side of the cell." []
xref: GO:0009986 "cell surface"

[Term]
id: SL-0311
name: Sarcoplasm
namespace: uniprot:locations:cellular_component
def: "The sarcoplasm is the cytoplasm of a muscle fiber or muscle cell or myofiber." []
xref: GO:0016528 "sarcoplasm"
is_a: SL-0086

[Term]
id: SL-0312
name: Myofibril
namespace: uniprot:locations:cellular_component
def: "A myofibril is a long cylindrical organelle found in muscle cells formed by two transverse filament systems: the thick and thin filaments. The thin filament is composed primarily of actin; it is tethered at one end to the Z-disk, and it interdigitates with the thick filaments. The main constituent of the thick filament is myosin; the direction of the myosin heads changes polarity at the M-line, allowing interaction with the thin filaments anchored from the next adjacent Z-disk. A third and a fourth filament complex exist, comprising the giant proteins titin and nebulin." []
xref: GO:0030016 "myofibril"
is_a: SL-0311

[Term]
id: SL-0313
name: Sarcomere
namespace: uniprot:locations:cellular_component
def: "The sarcomere represents the basal contractile unit of striated muscles. A single myofibril is composed of these short structural units arranged end to end, which contract due to the relative sliding of thick (myosin) over thin (actin) filaments. The mammalian sarcomere is ~ 2 mm in length, and can shorten to ~ 70% of its original length during contraction. Structural features of the sarcomere include bundles of parallel thick and thin filaments assembled by two transverse structures, the Z lines and M lines. The Z lines and the M lines are connected by transverse filaments to the sarcolemma or to the neighboring myofibrils. Sarcomeres give to skeletal and cardiac muscles their striated appearance with I bands surrounding the Z lines, followed by A bands. The A bands contain a paler region called the H zone and in the middle the M line." []
xref: GO:0030017 "sarcomere"
xref: http://www.sarcomere.org/
relationship: part_of SL-0312

[Term]
id: SL-0314
name: Z line
namespace: uniprot:locations:cellular_component
def: "Z-disks are the lateral boundaries of a single sarcomere. In electron micrographs of cross striated muscle the Z line appears as a series of dark lines. They represent a key interface between the contractile apparatus and the cytoskeleton. The Z line (from the German \"Zwischen\") largely consists of alpha-actinin homodimers organized in an antiparallel fashion, thereby providing a backbone for the insertions of actin-based thin filaments, as well as titin and nebulin/nebulette. Z line of neighbouring sarcomeres are aligned in parallel and connected via the intermediate filament protein desmin. They maintain the actin filaments in a tetragonal lattice." []
synonym: "Z bodies" [UniProt]
synonym: "Z body" [UniProt]
synonym: "Z disc" [UniProt]
synonym: "Z disk" [UniProt]
synonym: "Z-band" [UniProt]
synonym: "Z-disc" [UniProt]
synonym: "Z-disk" [UniProt]
synonym: "Z-line" [UniProt]
xref: GO:0030018 "Z disc"
relationship: part_of SL-0478

[Term]
id: SL-0315
name: M line
namespace: uniprot:locations:cellular_component
def: "In electron micrographs of the sarcomere, the M line appears as a series of parallel electron-dense lines in the central zone of the A band impliing that the M line is needed for the regular packing of the thick filaments. The M line maintains the myosin filaments in a hexagonal lattice." []
synonym: "M band" [UniProt]
synonym: "M-band" [UniProt]
synonym: "M-line" [UniProt]
xref: GO:0031430 "M band"
xref: http://www.sarcomere.org/
relationship: part_of SL-0477

[Term]
id: SL-0316
name: Acidocalcisome lumen
namespace: uniprot:locations:cellular_component
def: "The acidocalcisome compartment bounded by the acidocalcisomal membrane." []
synonym: "Acidocalcisomal lumen" [UniProt]
xref: GO:0033985 "acidocalcisome lumen"
relationship: part_of SL-0002

[Term]
id: SL-0317
name: Aleurone grain lumen
namespace: uniprot:locations:cellular_component
def: "The aleurone grain compartment bounded by the aleurone grain membrane." []
synonym: "Protein body lumen" [UniProt]
xref: GO:0034422 "aleurone grain lumen"
is_a: SL-0270
relationship: part_of SL-0010

[Term]
id: SL-0318
name: Autophagosome lumen
namespace: uniprot:locations:cellular_component
def: "The autophagosomal compartment bounded by the autophagosomal membrane." []
synonym: "Autophagic vacuolar lumen" [UniProt]
synonym: "Autophagic vacuole lumen" [UniProt]
synonym: "Autophagosomal lumen" [UniProt]
xref: GO:0034423 "autophagosome lumen"
is_a: SL-0325
relationship: part_of SL-0023

[Term]
id: SL-0319
name: Clathrin-coated vesicle lumen
namespace: uniprot:locations:cellular_component
def: "The clathrin-coated vesicle compartment bounded by the clathrin-coated vesicle membrane." []
synonym: "Clathrin-coated vesicular lumen" [UniProt]
is_a: SL-0325
relationship: part_of SL-0070

[Term]
id: SL-0320
name: Contractile vacuole lumen
namespace: uniprot:locations:cellular_component
def: "The contractile vacuole compartment bounded by the contractile vacuole membrane." []
synonym: "Contractile vacuolar lumen" [UniProt]
is_a: SL-0270
relationship: part_of SL-0073

[Term]
id: SL-0321
name: COPI-coated vesicle lumen
namespace: uniprot:locations:cellular_component
def: "The COPI-coated vesicle compartment bounded by the COPI-coated vesicle membrane." []
is_a: SL-0325
relationship: part_of SL-0075

[Term]
id: SL-0322
name: COPII-coated vesicle lumen
namespace: uniprot:locations:cellular_component
def: "The COPII-coated vesicle compartment bounded by the COPII-coated vesicle membrane." []
synonym: "Coat protein complexes II lumen" [UniProt]
synonym: "ER to Golgi transport vesicle lumen" [UniProt]
is_a: SL-0325
relationship: part_of SL-0077

[Term]
id: SL-0323
name: Cvt vesicle lumen
namespace: uniprot:locations:cellular_component
def: "The cvt vesicle compartment bounded by the cvt vesicle membrane." []
is_a: SL-0325
relationship: part_of SL-0080

[Term]
id: SL-0324
name: Cytoplasmic granule lumen
namespace: uniprot:locations:cellular_component
def: "The cytoplasmic granule compartment bounded by the cytoplasmic granule membrane." []
relationship: part_of SL-0281

[Term]
id: SL-0325
name: Cytoplasmic vesicle lumen
namespace: uniprot:locations:cellular_component
def: "The cytoplasmic vesicle compartment bounded by the cytoplasmic vesicle membrane." []
xref: GO:0060205 "cytoplasmic vesicle lumen"
relationship: part_of SL-0088

[Term]
id: SL-0326
name: Endoplasmic reticulum-Golgi intermediate compartment lumen
namespace: uniprot:locations:cellular_component
def: "The ERGIC compartment bounded by the ERGIC membrane." []
synonym: "ER-Golgi intermediate compartment lumen" [UniProt]
synonym: "ERGIC lumen" [UniProt]
synonym: "IC lumen" [UniProt]
synonym: "Intermediate compartment lumen" [UniProt]
synonym: "Vesiculo-tubular cluster lumen" [UniProt]
synonym: "VTC lumen" [UniProt]
relationship: part_of SL-0098

[Term]
id: SL-0327
name: Endosome lumen
namespace: uniprot:locations:cellular_component
def: "The endosomal compartment bounded by the endosomal membrane." []
synonym: "Endosomal lumen" [UniProt]
xref: GO:0031904 "endosome lumen"
relationship: part_of SL-0101

[Term]
id: SL-0328
name: Esterosome lumen
namespace: uniprot:locations:cellular_component
def: "The esterosomal compartment bounded by the esterosomal membrane." []
synonym: "Esterosomal lumen" [UniProt]
xref: GO:0034467 "esterosome lumen"
is_a: SL-0325
relationship: part_of SL-0109

[Term]
id: SL-0329
name: Etioplast membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the etioplast, a plastid found in plants grown in the dark. Also used when it is not clear in which etioplast membrane a protein is found." []
xref: GO:0034426 "etioplast membrane"
is_a: SL-0213
relationship: part_of SL-0110

[Term]
id: SL-0330
name: Etioplast stroma
namespace: uniprot:locations:cellular_component
def: "The etioplast stroma is the space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." []
xref: GO:0009578 "etioplast stroma"
is_a: SL-0215
relationship: part_of SL-0110

[Term]
id: SL-0331
name: Gas vesicle lumen
namespace: uniprot:locations:cellular_component
def: "The gas vesicle compartment bounded by the protein shell of the gas vesicle." []
relationship: part_of SL-0125

[Term]
id: SL-0332
name: Glycosome matrix
namespace: uniprot:locations:cellular_component
def: "The glycosomal compartment bounded by the membrane of the glycosome, a specialized peroxisome found in all members of the protist order Kinetoplastida examined." []
synonym: "Glycosomal lumen" [UniProt]
synonym: "Glycosomal matrix" [UniProt]
synonym: "Glycosome lumen" [UniProt]
xref: GO:0034468 "glycosome lumen"
is_a: SL-0202
relationship: part_of SL-0129

[Term]
id: SL-0333
name: Glyoxysome matrix
namespace: uniprot:locations:cellular_component
def: "The glyoxysomal compartment bounded by the membrane of the glyoxysome, a plant peroxisome, especially found in germinating seeds, involved in the breakdown and conversion of fatty acids to acetyl-CoA for the glyoxylate bypass." []
synonym: "Glyoxysomal lumen" [UniProt]
synonym: "Glyoxysomal matrix" [UniProt]
synonym: "Glyoxysome lumen" [UniProt]
xref: GO:0031908 "glyoxysomal lumen"
is_a: SL-0202
relationship: part_of SL-0131

[Term]
id: SL-0334
name: Golgi stack lumen
namespace: uniprot:locations:cellular_component
def: "The Golgi stack compartment bounded by the membrane of the Golgi stack." []
synonym: "Dictyosome lumen" [UniProt]
synonym: "Golgi bodies lumen" [UniProt]
synonym: "Golgi body lumen" [UniProt]
xref: GO:0034469 "Golgi stack lumen"
is_a: SL-0133
relationship: part_of SL-0135

[Term]
id: SL-0335
name: Hydrogenosome lumen
namespace: uniprot:locations:cellular_component
def: "The hydrogenosomal compartment bounded by the membrane of the hydrogenosome, a redox organelle found in anaerobic unicellular eukaryotes." []
synonym: "Hydrogenosomal lumen" [UniProt]
xref: GO:0034492 "hydrogenosome lumen"
relationship: part_of SL-0145

[Term]
id: SL-0336
name: Late endosome lumen
namespace: uniprot:locations:cellular_component
def: "The late endosomal comaprtment bounded by the membrane of the late endosome." []
synonym: "Late endosomal lumen" [UniProt]
xref: GO:0031906 "late endosome lumen"
is_a: SL-0327
relationship: part_of SL-0152

[Term]
id: SL-0337
name: Early endosome lumen
namespace: uniprot:locations:cellular_component
def: "The early endosomal compartment bounded by the membrane of early endosomes, which form a tubulovesicular network spread throughout the cortical cytoplasm of the cell." []
synonym: "Early endosomal lumen" [UniProt]
xref: GO:0031905 "early endosome lumen"
is_a: SL-0327
relationship: part_of SL-0094

[Term]
id: SL-0338
name: Melanosome lumen
namespace: uniprot:locations:cellular_component
def: "The melanosomal compartment bounded by the membrane surrounding a melanosome." []
synonym: "Melanosomal lumen" [UniProt]
xref: GO:0034493 "melanosome lumen"
relationship: part_of SL-0161

[Term]
id: SL-0339
name: Microneme lumen
namespace: uniprot:locations:cellular_component
def: "The micronemal compartment bounded by the membrane of a microneme." []
synonym: "Micronemal lumen" [UniProt]
xref: GO:0034494 "microneme lumen"
is_a: SL-0347
relationship: part_of SL-0163

[Term]
id: SL-0340
name: Multivesicular body lumen
namespace: uniprot:locations:cellular_component
def: "The multivesicular body compartment bounded by the membrane of the multivesicular bodies." []
synonym: "Corpuscula multivesicularis lumen" [UniProt]
synonym: "ECV lumen" [UniProt]
synonym: "Endosomal carrier vesicle lumen" [UniProt]
synonym: "Multivesicular bodies lumen" [UniProt]
synonym: "MVB lumen" [UniProt]
is_a: SL-0327
relationship: part_of SL-0174

[Term]
id: SL-0341
name: Parasitophorous vacuole lumen
namespace: uniprot:locations:cellular_component
def: "The parasitophorous vacuole compartment bounded by the membrane of the parasitophorous vacuole." []
synonym: "Parasitophorous vacuolar lumen" [UniProt]
relationship: part_of SL-0194

[Term]
id: SL-0342
name: Phagosome lumen
namespace: uniprot:locations:cellular_component
def: "The phagosomal compartment bounded by the membrane a phagosome." []
synonym: "Phagocytic vesicle lumen" [UniProt]
synonym: "Phagosomal lumen" [UniProt]
is_a: SL-0325
relationship: part_of SL-0206

[Term]
id: SL-0343
name: Prevacuolar compartment lumen
namespace: uniprot:locations:cellular_component
def: "The PVC compartment bounded by the membrane of the PVC." []
synonym: "PVC lumen" [UniProt]
relationship: part_of SL-0223

[Term]
id: SL-0344
name: Protein storage vacuole lumen
namespace: uniprot:locations:cellular_component
def: "The protein storage vacuolar compartment bounded by the membrane of the protein storage vacuole." []
synonym: "Protein storage vacuolar lumen" [UniProt]
xref: GO:0034495 "protein storage vacuole lumen"
is_a: SL-0270
relationship: part_of SL-0228

[Term]
id: SL-0345
name: Recycling endosome lumen
namespace: uniprot:locations:cellular_component
def: "The recycling endosomal compartment bounded by the membrane of the recycling endosome." []
synonym: "Recycling endosomal lumen" [UniProt]
xref: GO:0034777 "recycling endosome lumen"
is_a: SL-0327
relationship: part_of SL-0232

[Term]
id: SL-0346
name: Rhoptry lumen
namespace: uniprot:locations:cellular_component
def: "The rhoptry compartment bounded by the membrane of a rhoptry." []
xref: GO:0034591 "rhoptry lumen"
is_a: SL-0347
relationship: part_of SL-0233

[Term]
id: SL-0347
name: Secretory vesicle lumen
namespace: uniprot:locations:cellular_component
def: "The secretory vesicle compartment bounded by the membrane of the secretory vesicle." []
synonym: "Secretory granule lumen" [UniProt]
is_a: SL-0325
relationship: part_of SL-0244

[Term]
id: SL-0348
name: Synaptic vesicle lumen
namespace: uniprot:locations:cellular_component
def: "The synaptic vesicle compartment bounded by the membrane of a synaptic vesicle." []
synonym: "Synaptic vesicular lumen" [UniProt]
xref: GO:0034592 "synaptic vesicle lumen"
is_a: SL-0347
relationship: part_of SL-0259

[Term]
id: SL-0349
name: Chromaffin granule lumen
namespace: uniprot:locations:cellular_component
def: "The chromaffin granule comparment bounded by the chromaffin granule membrane." []
synonym: "Chromaffin granular lumen" [UniProt]
xref: GO:0034466 "chromaffin granule lumen"
is_a: SL-0347
relationship: part_of SL-0061

[Term]
id: SL-0350
name: Cyanelle stroma
namespace: uniprot:locations:cellular_component
def: "The internal space enclosed by the cyanelle double membrane but excluding the thylakoid space. This space, filled with a colorless hydrophilic matrix, contains DNA, ribosomes and some temporary products of photosynthesis." []
xref: GO:0034060 "cyanelle stroma"
is_a: SL-0215
relationship: part_of SL-0082

[Term]
id: SL-0351
name: Organellar chromatophore
namespace: uniprot:locations:cellular_component
def: "The organellar chromatophore is the photosynthetic inclusion found in Paulinella species, which are photosynthetic thecate amoeba. It probably derives from a different endosymbiotic event than that which led to all other plastids. Houses the machinery necessary for photosynthesis and CO(2) fixation and may also be able to make a few amino acids, some fatty acids and a few cofactors. They are surrounded by 2 membranes, between which is found a residual peptidoglycan wall, and contain thylakoids." []
xref: GO:0070111 "organellar chromatophore"
is_a: SL-0209

[Term]
id: SL-0352
name: Organellar chromatophore membrane
namespace: uniprot:locations:cellular_component
def: "One of the membranes of an organellar chromatophore. This term is used when it is not known with which membrane (outer membrane, inner membrane or thylakoid) a protein is associated. Found exclusively in Paulinella species, which are photosynthetic thecate amoeba." []
xref: GO:0070112 "organellar chromatophore membrane"
is_a: SL-0213
relationship: part_of SL-0351

[Term]
id: SL-0353
name: Organellar chromatophore stroma
namespace: uniprot:locations:cellular_component
def: "The internal space enclosed by the organellar chromatophore double membrane but excluding the thylakoid space. This space, filled with a colorless hydrophilic matrix, contains DNA, ribosomes and some temporary products of photosynthesis; other biosynthetic functions that could also occur there include amino acid, fatty acid and some cofactor biosynthesis. Found exclusively in Paulinella species, which are photosynthetic thecate amoeba." []
synonym: "Organellar chromatophore plasma" [UniProt]
is_a: SL-0215
relationship: part_of SL-0351

[Term]
id: SL-0354
name: Organellar chromatophore thylakoid
namespace: uniprot:locations:cellular_component
def: "The thylakoid of an organellar chromatophore is an internal system of interconnected membranes that carry the complexes for the light reactions of photosynthesis. Found exclusively in Paulinella species, which are photosynthetic thecate amoeba." []
xref: GO:0070116 "organellar chromatophore thylakoid"
is_a: SL-0278
relationship: part_of SL-0351

[Term]
id: SL-0355
name: Organellar chromatophore thylakoid lumen
namespace: uniprot:locations:cellular_component
def: "The organellar chromatophore thylakoid lumen is the compartment bounded by the thylakoid membrane. Found exclusively in Paulinella species, which are photosynthetic thecate amoeba." []
xref: GO:0070117 "organellar chromatophore thylakoid lumen"
is_a: SL-0309
relationship: part_of SL-0354

[Term]
id: SL-0356
name: Organellar chromatophore thylakoid membrane
namespace: uniprot:locations:cellular_component
def: "The organellar chromatophore thylakoid membrane is an internal system of interconnected membranes that house the complexes which carry out the light reactions of photosynthesis. Found exclusively in Paulinella species, which are photosynthetic thecate amoeba." []
xref: GO:0070118 "organellar chromatophore thylakoid membrane"
is_a: SL-0216
relationship: part_of SL-0354

[Term]
id: SL-0357
name: Bacterial flagellum hook
namespace: uniprot:locations:cellular_component
def: "The hook of a bacterial flagellum connects the basal body and the filament and acts as a universal joint. This flexible hinge relays the energy generated by the motor into torque formation that is transferred onto the rigid filament." []
synonym: "Bacterial flagella hook" [UniProt]
synonym: "Bacterial flagellar hook" [UniProt]
xref: GO:0009424 "bacterial-type flagellum hook"
relationship: part_of SL-0307

[Term]
id: SL-0358
name: Bacterial flagellum filament
namespace: uniprot:locations:cellular_component
def: "The bacterial flagellar filament is made of polymerized flagellin." []
synonym: "Bacterial flagella filament" [UniProt]
synonym: "Bacterial flagellar filament" [UniProt]
xref: GO:0009420 "bacterial-type flagellum filament"
relationship: part_of SL-0307

[Term]
id: SL-0359
name: Organellar chromatophore inner membrane
namespace: uniprot:locations:cellular_component
def: "The organellar chromatophore inner membrane is the membrane which separates the chromatophore stroma from the intermembrane space. Found exclusively in Paulinella species, which are photosynthetic thecate amoeba." []
xref: GO:0070113 "organellar chromatophore inner membrane"
is_a: SL-0211
is_a: SL-0352
relationship: part_of SL-0351

[Term]
id: SL-0360
name: Organellar chromatophore intermembrane space
namespace: uniprot:locations:cellular_component
def: "The intermembrane space between the inner and the outer organellar chromatophore membranes. Found exclusively in Paulinella species, which are photosynthetic thecate amoeba." []
xref: GO:0070115 "organellar chromatophore intermembrane space"
is_a: SL-0212
relationship: part_of SL-0351

[Term]
id: SL-0361
name: Organellar chromatophore outer membrane
namespace: uniprot:locations:cellular_component
def: "The organellar chromatophore outer membrane is the organellar chromatophore membrane facing the cytoplasm. Found exclusively in Paulinella species, which are photosynthetic thecate amoeba." []
xref: GO:0070114 "organellar chromatophore outer membrane"
is_a: SL-0214
is_a: SL-0352
relationship: part_of SL-0351

[Term]
id: SL-0362
name: Inner membrane complex
namespace: uniprot:locations:cellular_component
def: "The inner membrane complex, found in apicocomplexan parasites, is composed of flattened membrane cisternae closely associated to the cell membrane. Together, the cell membrane and the IMC form a triple lipid bilayer called the pellicle (or cell wall)." []
synonym: "IMC" [UniProt]
xref: GO:0070258 "inner membrane pellicle complex"
relationship: part_of SL-0162

[Term]
id: SL-0363
name: Spore membrane
namespace: uniprot:locations:cellular_component
def: "Protein associated with the membrane that surrounds the center or core of a spore, often called spore inner membrane in bacterial spores." []
synonym: "Spore inner membrane" [UniProt]
is_a: SL-0162
relationship: part_of SL-0539

[Term]
id: SL-0364
name: Spore cortex
namespace: uniprot:locations:cellular_component
def: "Protein found in the spore cortex. The spore cortex is a loosely cross-linked peptidoglycan layer localized between the spore core and the outer membrane or cortex membrane of bacterial mature spores. The cortex maintains heat resistance and dormancy." []
xref: GO:0043595 "endospore cortex"
relationship: part_of SL-0539

[Term]
id: SL-0365
name: Spore outer membrane
namespace: uniprot:locations:cellular_component
def: "Protein associated with the spore outer membrane. The outer membrane, also called the cortex membrane, is a membrane localized between the cortex and the inner layer of the coat of bacterial mature spores." []
xref: GO:0043594 "outer endospore membrane"
is_a: SL-0162
relationship: part_of SL-0539

[Term]
id: SL-0366
name: Spore coat
namespace: uniprot:locations:cellular_component
def: "Protein found in the spore coat. The spore coat is the thick layer found beneath the perispore of some eukaryotic spores and bacterial mature spores. It is made up of highly cross-linked keratin and layers of specific proteins. The coat is composed of several electron-dense and lamella-like layers, differing between species." []
relationship: part_of SL-0539

[Term]
id: SL-0367
name: Perispore
namespace: uniprot:locations:cellular_component
def: "Protein found in the perispore. The perispore corresponds to the outer surface layer of mature bacterial spores and eukaryotic spores. The perispore, also called perine or exosporium, represents the primary contact surface between the spore and environment/host and is a site of spore antigens." []
synonym: "Exosporium" [UniProt]
synonym: "Perine" [UniProt]
relationship: part_of SL-0539

[Term]
id: SL-0368
name: Prospore membrane
namespace: uniprot:locations:cellular_component
def: "The prospore membrane is a double membrane which forms at the spindle pole body outer plaque during the second meiotic division of the sporulation process. The prospore membrane grows larger and finally engulfs the post-meiotic nuclei to form immature spores called prospores. The de novo synthesis of the spore wall occurs in the prospore intermembrane space and leads to mature spores." []
synonym: "Prespore membrane" [UniProt]
xref: GO:0005628 "prospore membrane"
is_a: SL-0162
relationship: part_of SL-0369

[Term]
id: SL-0369
name: Prospore
namespace: uniprot:locations:cellular_component
def: "The prospore or immature spore is formed during sporulation by the engulfment of the post-meiotic nuclei by the prospore double membrane. These prospores are then maturated into spores with the synthesis of the spore wall." []
synonym: "Prespore" [UniProt]
xref: GO:0042764 "ascospore-type prospore"

[Term]
id: SL-0370
name: Membrane raft
namespace: uniprot:locations:cellular_component
def: "Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. Multiple types of rafts are likely to exist, based both on their lipid and protein composition." []
synonym: "Lipid microdomain" [UniProt]
synonym: "Lipid raft" [UniProt]
synonym: "Membrane microdomain" [UniProt]
xref: GO:0045121 "membrane raft"
relationship: part_of SL-0147

[Term]
id: SL-0371
name: Pollen coat
namespace: uniprot:locations:cellular_component
def: "The relatively impermeable, lipidic layer which surrounds the outer exine layer of a pollen grain." []
synonym: "Pollenkitt" [UniProt]
xref: GO:0070505 "pollen coat"
is_a: SL-0111

[Term]
id: SL-0372
name: Host apical cell membrane
namespace: uniprot:locations:cellular_component
def: "The fraction of the host cell membrane at the apical end of the host cell, which faces the outside world or the lumen of the host cavity." []
synonym: "Host apical plasma membrane" [UniProt]
xref: GO:0020002 "host cell plasma membrane"
relationship: part_of SL-0375

[Term]
id: SL-0373
name: Host cell inner membrane
namespace: uniprot:locations:cellular_component
def: "The prokaryotic host cell inner membrane is the selectively permeable membrane which separates the host cytoplasm from the host periplasm in prokaryotes with 2 membranes." []
synonym: "Host inner membrane" [UniProt]
xref: GO:0020002 "host cell plasma membrane"
is_a: SL-0375

[Term]
id: SL-0374
name: Host cell junction
namespace: uniprot:locations:cellular_component
def: "The host cell junction is a host cell-host cell or host cell-host extracellular matrix contact within a tissue of a host multicellular organism, especially abundant in host epithelia. In vertebrates, there are three major types of cell junctions: anchoring junctions (e.g. adherens junctions), communicating junctions (e.g. gap junctions) and occluding junctions (e.g. tight junctions)." []
xref: GO:0044156 "host cell junction"
relationship: part_of SL-0431

[Term]
id: SL-0375
name: Host cell membrane
namespace: uniprot:locations:cellular_component
def: "The host cell membrane is the selectively permeable membrane which separates the host cytoplasm from its surroundings. Known as the host cell inner membrane in prokaryotes with 2 membranes." []
synonym: "Host cytoplasmic membrane" [UniProt]
synonym: "Host plasma membrane" [UniProt]
synonym: "Host plasmalemma" [UniProt]
xref: GO:0020002 "host cell plasma membrane"
is_a: SL-0380
relationship: part_of SL-0398
relationship: part_of SL-0421

[Term]
id: SL-0376
name: Host cell outer membrane
namespace: uniprot:locations:cellular_component
def: "The prokaryotic host cell outer membrane is the selectively permeable membrane which separates the prokaryotic periplasm from its surroundings in prokaryotes with 2 membranes. Traditionally only Gram- negative bacteria were thought of as having an outer membrane, but recent work has shown some Actinobacteria, including Mycobacterium tuberculosis, as well as at least 1 archaea (Ignicoccus hospitalis) have a cell outer membrane." []
synonym: "Host outer membrane" [UniProt]
xref: GO:0020002 "host cell plasma membrane"
is_a: SL-0380

[Term]
id: SL-0377
name: Host cell projection
namespace: uniprot:locations:cellular_component
def: "A host cell projection is a host cell protrusion such as pseudopodium, filopodium, lamellipodium, growth cone, flagellum, acrosome, axon, pili or bacterial comet tail. These membrane-cytoskeleton-coupled processes are involved in many biological functions, such as host cell motility, cancer-cell invasion, endocytosis, phagocytosis, exocytosis, pathogen infection, neurite extension and cytokinesis." []
synonym: "Host cell protrusion" [UniProt]
xref: GO:0044157 "host cell projection"
relationship: part_of SL-0427

[Term]
id: SL-0378
name: Host cell surface
namespace: uniprot:locations:cellular_component
def: "The outermost side of the host cell." []
xref: GO:0044228 "host cell surface"
relationship: part_of SL-0427

[Term]
id: SL-0379
name: Host filopodium
namespace: uniprot:locations:cellular_component
def: "The host filopodium is a thin, tubular, finger-like host cell protrusion filled with straight bundled, crosslinked actin filaments having their barbed ends directed towards the host cell membrane." []
synonym: "Host filopodia" [UniProt]
synonym: "Host microspike" [UniProt]
xref: GO:0044176 "host cell filopodium"
is_a: SL-0377

[Term]
id: SL-0380
name: Host membrane
namespace: uniprot:locations:cellular_component
def: "A host membrane is a lipid bilayer which surrounds host enclosed spaces and compartments. This selectively permeable structure is essential for effective separation of a host cell or organelle from its surroundings." []
xref: GO:0033644 "host cell membrane"
is_a: SL-0162

[Term]
id: SL-0381
name: Host cytoplasm
namespace: uniprot:locations:cellular_component
def: "The host cytoplasm is the content of a host cell within the plasma membrane and, in eukaryotics cells, surrounds the host nucleus." []
xref: GO:0030430 "host cell cytoplasm"
relationship: part_of SL-0427

[Term]
id: SL-0382
name: Host perinuclear region
namespace: uniprot:locations:cellular_component
def: "The host perinuclear region is the host cytoplasmic region just around the host nucleus." []
synonym: "Host nuclear periphery" [UniProt]
synonym: "Host perinuclear region of cytoplasm" [UniProt]
xref: GO:0044220 "host cell perinuclear region of cytoplasm"
relationship: part_of SL-0381

[Term]
id: SL-0383
name: Host cytoskeleton
namespace: uniprot:locations:cellular_component
def: "The host cytoskeleton is a dynamic three-dimensional structure that fills the host cytoplasm of eukaryotic cells. It is responsible for cell movement, cytokinesis, and the organization of the organelles or organelle-like structures within the host cell." []
xref: GO:0044163 "host cytoskeleton"
relationship: part_of SL-0381

[Term]
id: SL-0384
name: Host cytosol
namespace: uniprot:locations:cellular_component
def: "The host cytosol is the unstructured aqueous phase of the host cytoplasm excluding organelles, membranes, and insoluble cytoskeletal components." []
xref: GO:0044164 "host cell cytosol"
relationship: part_of SL-0381

[Term]
id: SL-0385
name: Host plasmodesma
namespace: uniprot:locations:cellular_component
def: "The host plasmodesma (plural host plasmodesmata) is a plasma membrane- lined channel that crosses the cell wall between two adjacent host plant cells and which allows a cytoplasmic exchange between the cells. It provides passage of ions and small molecules, but also of macromolecules such as RNA or proteins. Host plasmodesmata are sheathed by a host plasma membrane that is simply an extension of the cell membrane of the adjoining cells." []
synonym: "Host PD" [UniProt]
synonym: "Host plasmodesmata" [UniProt]
xref: GO:0044219 "host cell plasmodesma"
is_a: SL-0374

[Term]
id: SL-0386
name: Host cytoplasmic vesicle
namespace: uniprot:locations:cellular_component
def: "The host cytoplasmic vesicles mediate vesicular transport among the organelles of host secretory and endocytic systems." []
xref: GO:0044161 "host cell cytoplasmic vesicle"
relationship: part_of SL-0427

[Term]
id: SL-0387
name: Host cytoplasmic vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a host cytoplasmic vesicle. These vesicles mediate vesicular transport among the organelles of secretory and endocytic systems." []
xref: GO:0044162 "host cell cytoplasmic vesicle membrane"
is_a: SL-0380
relationship: part_of SL-0386
relationship: part_of SL-0398

[Term]
id: SL-0388
name: Host endoplasmic reticulum
namespace: uniprot:locations:cellular_component
def: "The host endoplasmic reticulum (ER) is an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic host cell, especially those responsible for the production of hormones and other secretory products." []
xref: GO:0044165 "host cell endoplasmic reticulum"
relationship: part_of SL-0427

[Term]
id: SL-0389
name: Host endoplasmic reticulum lumen
namespace: uniprot:locations:cellular_component
def: "The lumen of the host endoplasmic reticulum (ER) is the area enclosed by the host endoplasmic reticulum membrane, an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products." []
xref: GO:0044166 "host cell endoplasmic reticulum lumen"
relationship: part_of SL-0388

[Term]
id: SL-0390
name: Host endoplasmic reticulum membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the host endoplasmic reticulum (ER). The host endoplasmic reticulum is an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic host cell, especially those responsible for the production of hormones and other secretory products." []
xref: GO:0044167 "host cell endoplasmic reticulum membrane"
is_a: SL-0380
relationship: part_of SL-0388
relationship: part_of SL-0398

[Term]
id: SL-0391
name: Host endoplasmic reticulum-Golgi intermediate compartment
namespace: uniprot:locations:cellular_component
def: "The host ER-Golgi intermediate compartment is a collection of tubulovesicular membrane clusters in the vicinity of host ER exit sites. The host ERGIC mediates transport between the endoplasmic reticulum and the Golgi and is the first anterograde/retrograde sorting station in the host secretory pathway." []
synonym: "Host ER-Golgi intermediate compartment" [UniProt]
synonym: "Host ERGIC" [UniProt]
synonym: "Host IC" [UniProt]
synonym: "Host intermediate compartment" [UniProt]
synonym: "Host vesiculo-tubular cluster" [UniProt]
synonym: "Host VTC" [UniProt]
xref: GO:0044172 "host cell endoplasmic reticulum-Golgi intermediate compartment"
relationship: part_of SL-0427

[Term]
id: SL-0392
name: Host endoplasmic reticulum-Golgi intermediate compartment membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the host ER-Golgi intermediate compartment, which is a collection of tubulovesicular membrane clusters in the vicinity of host ER exit sites." []
synonym: "Host ER-Golgi intermediate compartment membrane" [UniProt]
synonym: "Host ERGIC membrane" [UniProt]
synonym: "Host IC membrane" [UniProt]
synonym: "Host intermediate compartment membrane" [UniProt]
synonym: "Host vesiculo-tubular cluster membrane" [UniProt]
synonym: "Host VTC membrane" [UniProt]
xref: GO:0044173 "host cell endoplasmic reticulum-Golgi intermediate compartment membrane"
is_a: SL-0380
relationship: part_of SL-0391
relationship: part_of SL-0398

[Term]
id: SL-0393
name: Host endosome
namespace: uniprot:locations:cellular_component
def: "Host endosomes are highly dynamic membrane systems involved in transport within the host cell, they receive endocytosed host cell membrane molecules and sort them for either degradation or recycling back to the host cell surface. They also receive newly synthesised proteins destined for host vacuolar/lysosomal compartments." []
xref: GO:0044174 "host cell endosome"
relationship: part_of SL-0427

[Term]
id: SL-0394
name: Host endosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the host endosome. Host endosomes are highly dynamic membrane systems involved in transport within the cell, they receive endocytosed host cell membrane molecules and sort them for either degradation or recycling back to the host cell surface." []
synonym: "Host endosomal membrane" [UniProt]
xref: GO:0044175 "host cell endosome membrane"
is_a: SL-0380
relationship: part_of SL-0393
relationship: part_of SL-0398

[Term]
id: SL-0395
name: Host Golgi apparatus
namespace: uniprot:locations:cellular_component
def: "The host Golgi apparatus is a series of flattened, cisternal membranes and similar vesicles usually arranged in close apposition to each other to form stacks. In mammalian cells, the host Golgi apparatus is juxtanuclear, often pericentriolar. The stacks are connected laterally by tubules to create a perinuclear ribbon structure, the 'Golgi ribbon'. In plants and lower animal cells, the host Golgi exists as many copies of discrete stacks dispersed throughout the host cytoplasm. It is a polarized structure with, in most higher eukaryotic cells, a cis-face associated with a tubular reticular network of membranes facing the endoplasmic reticulum, the cis-Golgi network (CGN), a medial area of disk-shaped flattened cisternae, and a trans- face associated with another tubular reticular membrane network, the trans-Golgi network (TGN) directed toward the host plasma membrane and compartments of the host endocytic pathway." []
synonym: "Host apparatus golgiensis" [UniProt]
synonym: "Host complexus golgiensis" [UniProt]
synonym: "Host Golgi" [UniProt]
synonym: "Host Golgi complex" [UniProt]
xref: GO:0044177 "host cell Golgi apparatus"
relationship: part_of SL-0427

[Term]
id: SL-0396
name: Host cis-Golgi network
namespace: uniprot:locations:cellular_component
def: "The host cis-Golgi network is an extensive tubulovesicular network bound to the cis face of the Golgi stack and whose function is to receive process the biosynthetic output from the ER." []
synonym: "Host CGN" [UniProt]
synonym: "Host cis-Golgi" [UniProt]
synonym: "Host cis-Golgi complex" [UniProt]
synonym: "Host Golgi cis-face" [UniProt]
relationship: part_of SL-0395

[Term]
id: SL-0397
name: Host cis-Golgi network membrane
namespace: uniprot:locations:cellular_component
def: "The lipid bilayer surrounding any of the compartments that make up the host cis-Golgi network." []
synonym: "Host CGN membrane" [UniProt]
synonym: "Host cis-Golgi complex membrane" [UniProt]
synonym: "Host cis-Golgi membrane" [UniProt]
synonym: "Host Golgi cis-face membrane" [UniProt]
is_a: SL-0426
relationship: part_of SL-0396

[Term]
id: SL-0398
name: Host endomembrane system
namespace: uniprot:locations:cellular_component
def: "A collection of membranous structures involved in transport within the host cell. The main components of the host endomembrane system are endoplasmic reticulum, Golgi apparatus, vesicles, and cell membrane and nuclear envelope. The endomembrane system does not include the membranes of mitochondria or plastids." []
synonym: "Host endomembrane" [UniProt]
xref: GO:0033645 "host cell endomembrane system"
is_a: SL-0380

[Term]
id: SL-0399
name: Host late endosome
namespace: uniprot:locations:cellular_component
def: "Host late endosomes are pleiomorphic with cisternal, tubular and multivesicular regions. They are found in juxtanuclear regions and concentrated at the host microtubule organizing center. They are an important sorting station in the endocytic pathway. Recycling to the plasma membrane and to the Golgi occurs in late endosomes." []
xref: GO:0044184 "host cell late endosome"
relationship: part_of SL-0393

[Term]
id: SL-0400
name: Host late endosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the host late endosomes." []
synonym: "Host late endosomal membrane" [UniProt]
xref: GO:0044185 "host cell late endosome membrane"
is_a: SL-0394
relationship: part_of SL-0399

[Term]
id: SL-0401
name: Host lipid droplet
namespace: uniprot:locations:cellular_component
def: "The host lipid droplet is a dynamic cytoplasmic host organelle which consists of an heterogeneous macromolecular assembly of lipids and proteins covered by a unique phospholipid monolayer. They may play a role in host lipid metabolism and storage, and they may be involved in the regulation of intracellular trafficking and signal transduction." []
synonym: "Host adiposome" [UniProt]
synonym: "Host lipid bodies" [UniProt]
synonym: "Host lipid body" [UniProt]
synonym: "Host lipid particle" [UniProt]
synonym: "Host monolayer-surrounded lipid storage body" [UniProt]
synonym: "Host oil bodies" [UniProt]
synonym: "Host oil body" [UniProt]
synonym: "Host oleosome" [UniProt]
synonym: "Host spherosome" [UniProt]
xref: GO:0044186 "host cell lipid droplet"
relationship: part_of SL-0427

[Term]
id: SL-0403
name: Host lysosome
namespace: uniprot:locations:cellular_component
def: "The host lysosome is a membrane-limited organelle present in all eukaryotic cells, which contains a large number of hydrolytic enzymes that are used for degrading almost any kind of cellular constituent, including entire organelles. The mechanisms responsible for delivering cytoplasmic cargo to the host lysosome/vacuole are known collectively as autophagy and play an important role in the maintenance of homeostasis." []
xref: GO:0044187 "host cell lysosome"
relationship: part_of SL-0427

[Term]
id: SL-0404
name: Host lysosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a host lysosome." []
synonym: "Host lysosomal membrane" [UniProt]
xref: GO:0044188 "host cell lysosomal membrane"
is_a: SL-0380
relationship: part_of SL-0398
relationship: part_of SL-0403

[Term]
id: SL-0405
name: Host microsome
namespace: uniprot:locations:cellular_component
def: "The host microsomes are a heterogenous set of vesicles 20-200nm in diameter and formed from the host endoplasmic reticulum when host cells are disrupted." []
xref: GO:0033648 "host intracellular membrane-bounded organelle"
relationship: part_of SL-0427

[Term]
id: SL-0406
name: Host microsome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the host microsome." []
synonym: "Host microsomal membrane" [UniProt]
xref: GO:0033648 "host intracellular membrane-bounded organelle"
is_a: SL-0380
relationship: part_of SL-0398
relationship: part_of SL-0405

[Term]
id: SL-0407
name: Host mitochondrion
namespace: uniprot:locations:cellular_component
def: "The host mitochondrion is a semiautonomous, self-reproducing organelle that occurs in the cytoplasm of all cells of most, but not all, host eukaryotes. Each host mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. They are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP." []
xref: GO:0033650 "host cell mitochondrion"
relationship: part_of SL-0427

[Term]
id: SL-0408
name: Host mitochondrion envelope
namespace: uniprot:locations:cellular_component
def: "The host mitochondrial envelope comprises the inner and outer host mitochondrial membrane including the mitochondrial intermembrane space." []
synonym: "Host mitochondrial envelope" [UniProt]
xref: GO:0044190 "host cell mitochondrial envelope"
relationship: part_of SL-0407

[Term]
id: SL-0409
name: Host mitochondrion inner membrane
namespace: uniprot:locations:cellular_component
def: "The host mitochondrion inner membrane is the membrane which separates the host mitochondrial matrix from the host mitochondrial intermembrane space." []
synonym: "Host inner mitochondrial membrane" [UniProt]
synonym: "Host mitochondrial inner membrane" [UniProt]
xref: GO:0044192 "host cell mitochondrial inner membrane"
is_a: SL-0410

[Term]
id: SL-0410
name: Host mitochondrion membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a host mitochondrion. This term is used when it is not known if the protein is found in or associated with the inner or outer host mitochondrial membrane." []
synonym: "Host mitochondrial membrane" [UniProt]
xref: GO:0044191 "host cell mitochondrial membrane"
is_a: SL-0380
relationship: part_of SL-0408

[Term]
id: SL-0411
name: Host mitochondrion outer membrane
namespace: uniprot:locations:cellular_component
def: "The host mitochondrion outer membrane is the host mitochondrial membrane facing the host cytoplasm." []
synonym: "Host mitochondrial outer membrane" [UniProt]
synonym: "Host outer mitochondrial membrane" [UniProt]
xref: GO:0044193 "host cell mitochondrial outer membrane"
is_a: SL-0410

[Term]
id: SL-0412
name: Host nucleolus
namespace: uniprot:locations:cellular_component
def: "The host nucleolus is a dark, dense, roughly spherical area of fibers and granules in the host nucleus. Only plant and animal nuclei contain one or more nucleoli, although some do not. No membrane separates the host nucleolus from the host nucleoplasm. It mediates ribosomal RNA biogenesis." []
synonym: "Host nucleoli" [UniProt]
xref: GO:0044196 "host cell nucleolus"
relationship: part_of SL-0414

[Term]
id: SL-0413
name: Host nucleoplasm
namespace: uniprot:locations:cellular_component
def: "The host nucleoplasm is a highly viscous liquid contained within the host nucleus that surrounds the chromosomes and other subnuclear organelles. A network of fibers known as the host nuclear matrix can also be found in there." []
synonym: "Host karyolymph" [UniProt]
synonym: "Host karyoplasm" [UniProt]
xref: GO:0044095 "host cell nucleoplasm"
relationship: part_of SL-0414

[Term]
id: SL-0414
name: Host nucleus
namespace: uniprot:locations:cellular_component
def: "The host nucleus is the most obvious organelle in any host eukaryotic cell. It is a membrane-bound organelle and is surrounded by double membranes. It communicates with the surrounding cytosol via numerous nuclear pores." []
xref: GO:0042025 "host cell nucleus"
relationship: part_of SL-0427

[Term]
id: SL-0415
name: Host nucleus envelope
namespace: uniprot:locations:cellular_component
def: "The host nuclear envelope is a membrane system which surrounds the host nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the host nuclear intermembrane space." []
synonym: "Host karyotheca" [UniProt]
synonym: "Host nuclear envelope" [UniProt]
synonym: "Host nucleolemma" [UniProt]
synonym: "Host perinuclear envelope" [UniProt]
xref: GO:0044199 "host cell nuclear envelope"
relationship: part_of SL-0414

[Term]
id: SL-0416
name: Host nucleus lamina
namespace: uniprot:locations:cellular_component
def: "The host nuclear lamina is a meshwork of intermediate filament proteins called lamins and lamin-binding proteins that are embedded in the host inner nuclear membrane." []
synonym: "Host nuclear lamina" [UniProt]
xref: GO:0044203 "host cell nuclear lamina"
relationship: part_of SL-0415

[Term]
id: SL-0417
name: Host nucleus matrix
namespace: uniprot:locations:cellular_component
def: "The host nuclear matrix is a three-dimensional filamentous protein network, found in the host nucleoplasm, which provides a structural framework for organising host chromatin, while facilitating transcription and replication." []
synonym: "Host nuclear matrix" [UniProt]
synonym: "Host nuclear scaffold" [UniProt]
synonym: "Host nuclear skeleton" [UniProt]
xref: GO:0044204 "host cell nuclear matrix"
relationship: part_of SL-0414

[Term]
id: SL-0418
name: Host nucleus membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the host nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer host nuclear membrane." []
synonym: "Host nuclear membrane" [UniProt]
xref: GO:0044200 "host cell nuclear membrane"
is_a: SL-0380
relationship: part_of SL-0398
relationship: part_of SL-0415

[Term]
id: SL-0419
name: Host nucleus inner membrane
namespace: uniprot:locations:cellular_component
def: "The inner membrane surrounding the host nucleus is the membrane which separates the host nuclear matrix from the host intermembrane space." []
synonym: "Host inner nuclear membrane" [UniProt]
synonym: "Host nuclear inner membrane" [UniProt]
xref: GO:0044201 "host cell nuclear inner membrane"
is_a: SL-0418

[Term]
id: SL-0420
name: Host periplasm
namespace: uniprot:locations:cellular_component
def: "The host periplasm is the space between the inner and outer membrane in host Gram-negative bacteria. In Gram-positive bacteria a smaller periplasmic space is found between the inner membrane and the peptidoglycan layer. Also used for the host intermembrane spaces of host fungi and host organelles." []
synonym: "Host periplasmic space" [UniProt]
xref: GO:0044229 "host cell periplasmic space"
relationship: part_of SL-0421

[Term]
id: SL-0421
name: Host cell envelope
namespace: uniprot:locations:cellular_component
def: "The host cell envelope comprises the cell membrane, the cell wall and an outer membrane if present. The Gram-positive bacteria host cell envelope consists of the cytoplasmic membrane, cell wall and capsule. The Gram-negative host envelope consists of the cytoplasmic membrane, cell wall, periplasmic space, outer membrane and capsule. The archaeal cell host envelope consists generally of single typical bilayer membrane covered by a surface layer (S-layer). Ignicoccus host species exceptionally have an outer membrane which encloses a large periplasmic space. Extreme host thermophiles and acidophiles have tetraether type glycerophospholipids with C40 isoprenoid chains. The yeast host cell envelope is a protecting capsule which consists of the cytoplasmic membrane, the periplasmic space, and the cell wall." []
synonym: "Host envelope" [UniProt]
xref: GO:0044230 "host cell envelope"
relationship: part_of SL-0427

[Term]
id: SL-0422
name: Host rough endoplasmic reticulum
namespace: uniprot:locations:cellular_component
def: "The host rough endoplasmic reticulum (host RER) is the portion of the host ER which is covered with ribosomes." []
synonym: "Host RER" [UniProt]
synonym: "Host rough ER" [UniProt]
xref: GO:0044168 "host cell rough endoplasmic reticulum"
relationship: part_of SL-0388

[Term]
id: SL-0423
name: Host rough endoplasmic reticulum membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the host rough endoplasmic reticulum." []
xref: GO:0044169 "host cell rough endoplasmic reticulum membrane"
is_a: SL-0390
relationship: part_of SL-0422

[Term]
id: SL-0424
name: Host cell wall
namespace: uniprot:locations:cellular_component
def: "The complex and rigid layer surrounding the host cell. Host cell walls are found in bacteria, archaea, fungi, plants, and algae. The host cell wall is surrounded by an outer membrane in Gram-negative host bacteria, and envelopes the inner or plasma host membrane all host bacteria. It plays a role in host cell shape, cell stability and development, and protection against environmental dangers." []
xref: GO:0044158 "host cell wall"
relationship: part_of SL-0421

[Term]
id: SL-0425
name: Host extracellular space
namespace: uniprot:locations:cellular_component
def: "The host extracellular space is the space outside of the host cell membrane but part of a multicellular host organism." []
synonym: "Host intercellular space" [UniProt]
xref: GO:0043655 "host extracellular space"
relationship: part_of SL-0431

[Term]
id: SL-0426
name: Host Golgi apparatus membrane
namespace: uniprot:locations:cellular_component
def: "The host membrane surrounding the host Golgi apparatus." []
synonym: "Host apparatus golgiensis membrane" [UniProt]
synonym: "Host complexus golgiensis membrane" [UniProt]
synonym: "Host Golgi complex membrane" [UniProt]
synonym: "Host Golgi membrane" [UniProt]
xref: GO:0044178 "host cell Golgi membrane"
is_a: SL-0380
relationship: part_of SL-0395
relationship: part_of SL-0398

[Term]
id: SL-0427
name: Host cell
namespace: uniprot:locations:cellular_component
def: "A cell within a host organism including the host cell membrane and any external encapsulating structures such as the host cell wall and cell envelope." []
xref: GO:0043657 "host cell"

[Term]
id: SL-0428
name: Host caveola
namespace: uniprot:locations:cellular_component
def: "The host caveola is a small (apparently) uncoated pit found mostly in the host cell membrane of many highly differentiated mammalian cells, such as adipocytes, endothelial cells and muscle cells. These flask- shaped invaginations are defined by the presence of caveolins and contains a subset of lipid-raft components, including cholesterol and sphingolipids." []
synonym: "Host caveolae" [UniProt]
synonym: "Host membrane microdomain" [UniProt]
synonym: "Host plasmalemmal vesicle" [UniProt]
xref: GO:0044155 "host caveola"
relationship: part_of SL-0398

[Term]
id: SL-0429
name: Host cellular thylakoid
namespace: uniprot:locations:cellular_component
def: "The host cellular thylakoids are formed usually by extensive invaginations of the host cyanobacterial cell membrane. In Synechocystis sp. strain PCC 6803, the thylakoid membranes are physically discontinuous from the plasma membrane, and thus represent bona fide intracellular organelles." []
xref: GO:0044159 "host thylakoid"
is_a: SL-0449
relationship: part_of SL-0427

[Term]
id: SL-0430
name: Host cellular thylakoid membrane
namespace: uniprot:locations:cellular_component
def: "The membrane of the host cyanobacterial cellular thylakoid." []
xref: GO:0044160 "host thylakoid membrane"
is_a: SL-0380
relationship: part_of SL-0398
relationship: part_of SL-0429

[Term]
id: SL-0431
name: Host
namespace: uniprot:locations:cellular_component
def: "The host is any organism in which another organism, or symbiont, spends part or all of its life cycle. Most animals and plants live symbiotically with microorganisms. The larger organism is called the host and smaller organism the symbiont. When the interactions between the symbiont and the host benefits both partners, the symbiotic interaction is called mutualism. When there is a negative effect on one of the partners, it is called a parasitic symbiosis and if there is no beneficial or negative effect it is a commensal symbiosis. These clear-cut definitions are not always easy to apply in nature. Take the bacterium Pseudomonas aeruginosa for example. This bacterium can be found on the skin of humans and not cause disease, perhaps we would call it a commensial, but if the person has a severe burn P. aeruginosa can cause an infection and becomes a pathogen (a medicinal term for parasitism). This type of organism is called an opportunistic pathogen. Whether an association is a mutualist, commensal or parasitic depends on the relative \"strengths\" of the partners and the balance of power can change over time." []
xref: GO:0018995 "host cellular component"
xref: http://web.uconn.edu/mcbstaff/graf/GenSym/GenSym.htm

[Term]
id: SL-0432
name: Host phagosome
namespace: uniprot:locations:cellular_component
def: "The host phagosome is a phagocytic host cell-specific compartment. These large endocytic membrane-bound vesicles form upon ingestion by the host cell of extracellular materials." []
synonym: "Host phagocytic vesicle" [UniProt]
is_a: SL-0386

[Term]
id: SL-0433
name: Host phagosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a host phagosome." []
synonym: "Host phagocytic vesicle membrane" [UniProt]
synonym: "Host phagosomal membrane" [UniProt]
is_a: SL-0387
relationship: part_of SL-0432

[Term]
id: SL-0434
name: Host presynaptic cell membrane
namespace: uniprot:locations:cellular_component
def: "In a host chemical synapse, the host presynaptic membrane is the cell membrane of an axon terminal that faces the receiving cell. The postsynaptic membrane is separated from the presynaptic membrane by the synaptic cleft." []
synonym: "Host presynaptic membrane" [UniProt]
xref: GO:0044231 "host cell presynaptic membrane"
relationship: part_of SL-0375
relationship: part_of SL-0435

[Term]
id: SL-0435
name: Host synapse
namespace: uniprot:locations:cellular_component
def: "Host synapses are the communicating cell-cell junctions that allow signals to pass from a host nerve cell to a target cell. In a chemical synapse, the signal is carried by a neurotransmitter which diffuses across a narrow synaptic cleft and activates a receptor on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, neuronal axon, a specialized region of a muscle or a secretory cell. In an electrical synapse, a direct connection is made between the cytoplasms of two cells via gap junctions." []
xref: GO:0044221 "host cell synapse"

[Term]
id: SL-0436
name: Spore polar tube
namespace: uniprot:locations:cellular_component
def: "The polar tube is a highly specialised structure unique to Microsporidia and required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell." []
xref: GO:0044099 "polar tube"
relationship: part_of SL-0539

[Term]
id: SL-0437
name: Mitosome
namespace: uniprot:locations:cellular_component
def: "The mitosome is an organelle found in \"amitochondrial\" unicellular organisms which do not have the capability of gaining energy from oxidative phosphorylation. Mitosomes are almost certainly derived from mitochondria, they have a double membrane and most proteins are delivered to them by a targeting sequence. Unlike mitochondria, mitosomes do not contain any DNA. The mitosome functions in iron- sulphur cluster assembly." []
xref: GO:0032047 "mitosome"

[Term]
id: SL-0438
name: Mitosome envelope
namespace: uniprot:locations:cellular_component
def: "The mitosomal envelope comprises the inner and outer mitosomal membrane including the intermembrane space." []
synonym: "Mitosomal envelope" [UniProt]
relationship: part_of SL-0437

[Term]
id: SL-0439
name: Mitosome inner membrane
namespace: uniprot:locations:cellular_component
def: "The inner membrane of a mitosome is the membrane which separates the mitosomal matrix from the intermembrane space." []
synonym: "Inner mitosomal membrane" [UniProt]
synonym: "Mitosomal inner membrane" [UniProt]
is_a: SL-0442

[Term]
id: SL-0440
name: Mitosome intermembrane space
namespace: uniprot:locations:cellular_component
def: "The mitosomal intermembrane space is the space between inner and outer mitosomal membranes." []
synonym: "Mitosomal intermembrane space" [UniProt]
synonym: "Mitosomal periplasm" [UniProt]
synonym: "Mitosomal periplasmic space" [UniProt]
relationship: part_of SL-0438

[Term]
id: SL-0441
name: Mitosome matrix
namespace: uniprot:locations:cellular_component
def: "The matrix of a mitosome is the mitosomal internal spaces enclosed by the inner membrane." []
synonym: "Mitosomal matrix" [UniProt]
relationship: part_of SL-0437

[Term]
id: SL-0442
name: Mitosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a mitosome. This term is used when it is not known if the protein is found in or associated with the inner or outer mitosomal membrane." []
synonym: "Mitosomal membrane" [UniProt]
is_a: SL-0162
relationship: part_of SL-0438

[Term]
id: SL-0443
name: Mitosome outer membrane
namespace: uniprot:locations:cellular_component
def: "The outer membrane of a mitosome is the mitosomal membrane facing the cytoplasm." []
synonym: "Mitosomal outer membrane" [UniProt]
synonym: "Outer mitosomal membrane" [UniProt]
is_a: SL-0442

[Term]
id: SL-0444
name: Host smooth endoplasmic reticulum
namespace: uniprot:locations:cellular_component
def: "The host smooth endoplasmic reticulum (host SER) is the portion of the host ER which is free of ribosomes." []
synonym: "Host SER" [UniProt]
synonym: "Host smooth ER" [UniProt]
xref: GO:0044170 "host cell smooth endoplasmic reticulum"
relationship: part_of SL-0388

[Term]
id: SL-0445
name: Host smooth endoplasmic reticulum membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the host smooth endoplasmic reticulum." []
xref: GO:0044171 "host cell smooth endoplasmic reticulum membrane"
is_a: SL-0390
relationship: part_of SL-0422

[Term]
id: SL-0446
name: Host nucleus outer membrane
namespace: uniprot:locations:cellular_component
def: "The outer membrane of the host nucleus is the membrane facing the host cytoplasm. In host mammals, the host outer nuclear membrane is continuous in many places with the host rough endoplasmic reticulum and is dotted with ribosomes." []
synonym: "Host nuclear outer membrane" [UniProt]
synonym: "Host outer nuclear membrane" [UniProt]
xref: GO:0044202 "host cell nuclear outer membrane"
is_a: SL-0418

[Term]
id: SL-0447
name: Acrosome outer membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the acrosomal membrane just beneath the sperm cell membrane." []
synonym: "Acrosomal outer membrane" [UniProt]
synonym: "Outer acrosomal membrane" [UniProt]
xref: GO:0002081 "outer acrosomal membrane"
relationship: part_of SL-0006

[Term]
id: SL-0448
name: Spindle pole
namespace: uniprot:locations:cellular_component
def: "Either of the ends of a spindle, a specialized microtubule structure designed to attach and capture chromosomes in order to partition them evenly to each daughter cells." []
xref: GO:0000922 "spindle pole"
relationship: part_of SL-0251

[Term]
id: SL-0449
name: Host thylakoid
namespace: uniprot:locations:cellular_component
def: "The host thylakoid is a membranous cellular structure containing the photosynthetic pigments, reaction centers and electron-transport chain. In host chloroplast, thylakoids stack up to form the grana or stay as single cisternae and interconnect the grana. Thylakoid, where photosynthesis occurs, are found in chloroplasts, cyanelles and in photosynthetic bacteria where they are the extensive invaginations of the plasma membrane." []
xref: GO:0044159 "host thylakoid"
relationship: part_of SL-0427

[Term]
id: SL-0450
name: Thylakoid
namespace: uniprot:locations:cellular_component
def: "The thylakoid is a membranous cellular structure containing the photosynthetic pigments, reaction centers and electron-transport chain. In chloroplast, thylakoids stack up to form the grana or stay as single cisternae and interconnect the grana. Thylakoid, where photosynthesis occurs, are found in chloroplasts, cyanelles and in photosynthetic bacteria where they are the extensive invaginations of the plasma membrane." []
xref: GO:0009579 "thylakoid"

[Term]
id: SL-0451
name: Target cell membrane
namespace: uniprot:locations:cellular_component
def: "The target cell membrane is the selectively permeable membrane which separates the target cell cytoplasm from its surroundings. This term is used to describe a toxin located to the cell membrane of a target cell." []
synonym: "Target cytoplasmic membrane" [UniProt]
synonym: "Target plasma membrane" [UniProt]
synonym: "Target plasmalemma" [UniProt]
is_a: SL-0452

[Term]
id: SL-0452
name: Target membrane
namespace: uniprot:locations:cellular_component
def: "A target membrane is a lipid bilayer which surrounds target cell enclosed spaces and compartments. This selectively permeable structure is essential for effective separation of a target cell or target cell organelle from its surroundings. This term is used to describe a toxin located to a membrane of a target cell." []
is_a: SL-0162
is_a: SL-0487

[Term]
id: SL-0453
name: Host multivesicular body
namespace: uniprot:locations:cellular_component
def: "The host multivesicular bodies are a type of late endosome containing internal vesicles formed following the inward budding of the host outer endosomal membrane. The contents of the MVBs are then released into the lysosome lumen. The proteins found in the limiting membrane of MVBs are recycled to other compartments." []
synonym: "Host corpuscula multivesicularis" [UniProt]
synonym: "Host ECV" [UniProt]
synonym: "Host endosomal carrier vesicle" [UniProt]
synonym: "Host multivesicular bodies" [UniProt]
synonym: "Host MVB" [UniProt]
xref: GO:0072494 "host multivesicular body"
relationship: part_of SL-0393

[Term]
id: SL-0454
name: Barrier septum
namespace: uniprot:locations:cellular_component
def: "The barrier septum, is a septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." []
xref: GO:0000935 "division septum"
is_a: SL-0455

[Term]
id: SL-0455
name: Cell septum
namespace: uniprot:locations:cellular_component
def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." []
xref: GO:0030428 "cell septum"

[Term]
id: SL-0456
name: Cell tip
namespace: uniprot:locations:cellular_component
def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth may occur." []
xref: GO:0051286 "cell tip"

[Term]
id: SL-0457
name: Photoreceptor inner segment
namespace: uniprot:locations:cellular_component
def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." []
xref: GO:0001917 "photoreceptor inner segment"

[Term]
id: SL-0458
name: Photoreceptor outer segment
namespace: uniprot:locations:cellular_component
def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." []
xref: GO:0001750 "photoreceptor outer segment"
is_a: SL-0066

[Term]
id: SL-0459
name: Host basolateral cell membrane
namespace: uniprot:locations:cellular_component
def: "The fraction of the host cell membrane at the basolateral side of the cell, which faces adjacent host cells and the underlying host connective tissue." []
synonym: "Host basolateral plasma membrane" [UniProt]
relationship: part_of SL-0375

[Term]
id: SL-0460
name: Kinocilium
namespace: uniprot:locations:cellular_component
def: "The kinocilium is an immotile primary cilium that is found at the apical surface of auditory receptor cells. Hair bundles, the mechanosensory device of the sensory hair cells, are composed of height-ranked rows of stereocilia and a single kinocilium that are interconnected by extracellular proteinaceous links." []
synonym: "Kinocilia" [UniProt]
xref: GO:0060091 "kinocilium"
is_a: SL-0066

[Term]
id: SL-0461
name: Host early endosome
namespace: uniprot:locations:cellular_component
def: "The host early endosomes form a tubulovesicular network spread throughout the cortical cytoplasm of the host cell. Host early endosomes are the primary sorting station in the endocytic pathway from which endocytosed molecules can be recycled back to the host cell membrane or targeted to degradation in the host lysosomes." []
relationship: part_of SL-0393

[Term]
id: SL-0462
name: Host early endosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the host early endosomes, which form a tubulovesicular network spread throughout the cortical cytoplasm of the host cell." []
synonym: "Host early endosomal membrane" [UniProt]
is_a: SL-0394
relationship: part_of SL-0461

[Term]
id: SL-0463
name: Host trans-Golgi network
namespace: uniprot:locations:cellular_component
def: "The host trans-Golgi network is a highly dynamic series of interconnected tubules and vesicles at the trans face of the host Golgi stack. The host trans-Golgi network functions in the processing and sorting of glycoproteins and glycolipids at the interface of the biosynthetic and endosomal pathways. The generation and maintenance of host apical and basolateral membranes rely on sorting events that occur in the host TGN." []
synonym: "Host Golgi trans-face" [UniProt]
synonym: "Host TGN" [UniProt]
synonym: "Host trans-Golgi" [UniProt]
synonym: "Host trans-Golgi complex" [UniProt]
relationship: part_of SL-0395

[Term]
id: SL-0464
name: Host trans-Golgi network membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the host trans-Golgi network." []
synonym: "Host Golgi trans-face membrane" [UniProt]
synonym: "Host TGN membrane" [UniProt]
synonym: "Host trans-Golgi complex membrane" [UniProt]
synonym: "Host trans-Golgi membrane" [UniProt]
is_a: SL-0426
relationship: part_of SL-0463

[Term]
id: SL-0465
name: PML body
namespace: uniprot:locations:cellular_component
def: "The PML bodies are dynamic nuclear protein aggregates interspersed between chromatin. These punctate nuclear structures are call PML bodies because the PML gene is essential for their formation. These discrete nuclear foci, 0.2-1.0 micrometer wide, are present in most mammalian cell nuclei and typically number 1 to 30 bodies per nucleus, depending on the cell type, cell-cycle phase and differentiation stage. Recent evidence implies that, although they appear to be uniform, PML-NBs are structurally and functionally heterogeneous and are dynamic structures." []
synonym: "Kremer body" [UniProt]
synonym: "ND10" [UniProt]
synonym: "Nuclear domains-10" [UniProt]
synonym: "PML oncogenic domain" [UniProt]
synonym: "PML-NB" [UniProt]
synonym: "PML-nuclear body" [UniProt]
synonym: "Promyelocytic leukaemia nuclear body" [UniProt]
synonym: "Promyelocytic leukemia nuclear body" [UniProt]
xref: GO:0016605 "PML body"
is_a: SL-0494
relationship: part_of SL-0191

[Term]
id: SL-0466
name: Extracellular exosome
namespace: uniprot:locations:cellular_component
def: "Exosomes are 30-120 nm microvesicles of endocytic origin secreted by most cell types and found in abundance in body fluids, including blood, saliva, urine, and breast milk. They contain various molecular constituents of their cell of origin, including proteins and nucleic acids, and carry this cargo between diverse locations in the body. These microvesicles form by budding into the lumen of the multivesicular bodies (MVBs) and are released to extracellular fluids by fusion of MVBs with the plasma membrane." []
synonym: "Extracellular vesicular exosome" [UniProt]
xref: http://exocarta.ludwig.edu.au/
relationship: part_of SL-0243

[Term]
id: SL-0467
name: Cleavage furrow
namespace: uniprot:locations:cellular_component
def: "In fungal, amoeboid and animal cells, during the cytokinesis at the end of cell division, a cleavage furrow forms in the plasma membrane. A contractile ring containing actin and myosin is assembled at the selected site of the future cleavage furrow. Ring contraction produces the force to constrict the cleavage furrow and the daughter cells separate by membrane fusion." []
xref: GO:0032154 "cleavage furrow"

[Term]
id: SL-0468
name: Chromosome
namespace: uniprot:locations:cellular_component
def: "An organized structure composed of a single very long molecule of coiled DNA and associated proteins (e.g. histones) that carries hereditary information." []
synonym: "Chromoplastic stroma" [UniProt]
xref: GO:0005694 "chromosome"

[Term]
id: SL-0469
name: Midbody
namespace: uniprot:locations:cellular_component
def: "The midbody is the central region of the thin intercellular cytoplasmic bridge formed between daughter cells during cytokinesis. It consists of tightly bundled antiparallel microtubules, which embrace a phase-dense circular structure, called midbody ring. At the final stage of cytokinesis, the intercellular bridge is cleaved, in a process termed abscission, and two daughter cells are formed. Following abscission, the residual midbody structure, known as the midbody remnant or midbody derivative, can have different fates depending on the cell type. It can be either released to the extracellular medium, degraded by autophagy or persists in the cytoplasm, showing asymmetric accumulation in the daughter cells." []
synonym: "Midbody derivative" [UniProt]
synonym: "Midbody remnant" [UniProt]
xref: GO:0030496 "midbody"

[Term]
id: SL-0470
name: Filopodium tip
namespace: uniprot:locations:cellular_component
def: "The end of the filopodium distal to the body of the cell. The filopodium is a thin, tubular, finger-like cell protrusion filled with straight bundled, crosslinked actin filaments having their barbed ends directed towards the cell membrane." []
synonym: "Filopodia tip" [UniProt]
synonym: "Microspike tip" [UniProt]
xref: GO:0032433 "filopodium tip"
relationship: part_of SL-0286

[Term]
id: SL-0471
name: Pseudopodium tip
namespace: uniprot:locations:cellular_component
def: "The end of the pseudopodium distal to the body of the cell." []
relationship: part_of SL-0298

[Term]
id: SL-0472
name: Bleb
namespace: uniprot:locations:cellular_component
def: "These cellular membrane protrusions are the result of actomyosin contractions of the cortex, which cause either transient detachment of the cell membrane from the actin cortex or a rupture in the actin cortex. Then, cytosol streams out of the cell body and inflates the newly formed bleb. Once expansion slows, an actin cortex is reconstituted. Retraction is powered by myosin motor proteins. Blebbing is a common feature of cell physiology during cell movement, cytokinesis, cell spreading and apoptosis." []
xref: GO:0032059 "bleb"
is_a: SL-0280

[Term]
id: SL-0473
name: Phagocytic cup
namespace: uniprot:locations:cellular_component
def: "Cup-shaped invaginations of the cell membrane that subsequently close at their distal margins to form phagosomes during phagocytosis. By progression of its rim along the particle surface, this phagocytic cup envelops and eventually encloses the particle by separation of the phagosome membrane from the cell membrane. Filamentous actin accumulates between the outer and inner leaflet of the cup membrane and is most strongly enriched at the rim of the cup, the site of its protrusion." []
xref: GO:0001891 "phagocytic cup"
is_a: SL-0280

[Term]
id: SL-0474
name: Host glyoxysome
namespace: uniprot:locations:cellular_component
def: "The host glyoxysome is a plant peroxisome, especially found in germinating seeds, involved in the breakdown and conversion of fatty acids to acetyl-CoA for the glyoxylate bypass. Since it is also rich in catalase, the glyoxysome may be related to the microbodies or peroxisomes or derived from them." []
is_a: SL-0475

[Term]
id: SL-0475
name: Host peroxisome
namespace: uniprot:locations:cellular_component
def: "The host peroxisome is a small eukaryotic organelle limited by a single membrane, specialized for carrying out oxidative reactions. Contains mainly peroxidases, several other oxidases and catalase. The catalase regulates the contents of the produced toxic hydrogen peroxide thus protecting the cell. Beta-oxidation of fatty acids is another major function of peroxisomes. In plants and fungi this degradation occurs only in this cellular compartment." []
xref: GO:0120149 "host cell peroxisome"

[Term]
id: SL-0476
name: A band
namespace: uniprot:locations:cellular_component
def: "The appearance of the striated muscle is created by a pattern of alternating dark A bands and light I bands. A bands comprise thick filaments of myosin and proteins that bind myosin. They are bisected by the H zone, a paler region where the thick and the thin filaments do not overlap. The exact center of the A band is termed the M line." []
synonym: "A line" [UniProt]
synonym: "A-band" [UniProt]
xref: GO:0031672 "A band"
relationship: part_of SL-0313

[Term]
id: SL-0477
name: H zone
namespace: uniprot:locations:cellular_component
def: "The A band of a sarcomer is bisected by a paler zone, the H zone, where the thick and the thin filaments do not overlap. At the center of the H zone is the M line." []
synonym: "H band" [UniProt]
synonym: "H disc" [UniProt]
synonym: "H disk" [UniProt]
synonym: "H-band" [UniProt]
xref: GO:0031673 "H zone"
relationship: part_of SL-0476

[Term]
id: SL-0478
name: I band
namespace: uniprot:locations:cellular_component
def: "The appearance of the striated muscle is created by a pattern of alternating dark A bands and light I bands. I bands are composed of thin actin filaments and proteins that bind actin and they are bisected by the Z line. The thin filaments extend in each direction from the Z-disk, where they do not overlap the thick filaments, they create the light I band." []
synonym: "I disc" [UniProt]
synonym: "I disk" [UniProt]
synonym: "I-band" [UniProt]
xref: GO:0031674 "I band"
xref: http://www.sarcomere.org/
relationship: part_of SL-0313

[Term]
id: SL-0479
name: Cyanelle envelope
namespace: uniprot:locations:cellular_component
def: "The envelope of a cyanelle comprises the inner and outer cyanelle membrane including the intermembrane space and the vestigal peptidoglycan layer." []
xref: GO:0033112 "cyanelle envelope"
is_a: SL-0210
relationship: part_of SL-0082

[Term]
id: SL-0480
name: Cyanelle inner membrane
namespace: uniprot:locations:cellular_component
def: "The inner membrane of a cyanelle is the membrane which separates the cyanelle stroma from the intermembrane space." []
xref: GO:0036012 "cyanelle inner membrane"
is_a: SL-0083
is_a: SL-0211
relationship: part_of SL-0479

[Term]
id: SL-0481
name: Cyanelle intermembrane space
namespace: uniprot:locations:cellular_component
def: "The intermembrane space between the inner and the outer cyanelle membranes, it includes the vestigial peptidoglycan layer." []
synonym: "Cyanelle periplasm" [UniProt]
xref: GO:0036014 "cyanelle intermembrane space"
is_a: SL-0212
relationship: part_of SL-0479

[Term]
id: SL-0482
name: Cyanelle outer membrane
namespace: uniprot:locations:cellular_component
def: "The outer membrane of a cyanelle is the cyanelle membrane facing the cytoplasm." []
xref: GO:0036013 "cyanelle outer membrane"
is_a: SL-0083
is_a: SL-0214
relationship: part_of SL-0479

[Term]
id: SL-0483
name: Host chloroplast envelope
namespace: uniprot:locations:cellular_component
def: "The envelope of a host chloroplast comprises the inner and outer chloroplast membrane including the intermembrane space." []
synonym: "Host chloroplastic envelope" [UniProt]

[Term]
id: SL-0484
name: Microtubule organizing center
namespace: uniprot:locations:cellular_component
def: "The microtubule organizing center (MTOC) is an intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules." []
synonym: "MTOC" [UniProt]
xref: GO:0005815 "microtubule organizing center"
relationship: part_of SL-0090

[Term]
id: SL-0485
name: Centriolar satellite
namespace: uniprot:locations:cellular_component
def: "Centriolar satellites are nonmembranous, electron-dense and spherical cytoplasmic granules of about 70-100 nm in diameter, occurring around centrosomes in most vertebrate cell types. They contain a number of centrosomal proteins. Centriolar satellites have the ability to move along microtubules, toward their minus ends, i.e. toward centrosomes. Their number increase during interphase and decrease during mitosis." []
synonym: "Massule" [UniProt]
synonym: "satellites" [UniProt]
xref: GO:0034451 "centriolar satellite"
relationship: part_of SL-0048

[Term]
id: SL-0486
name: Target cell cytoplasm
namespace: uniprot:locations:cellular_component
def: "The contents of a target cell within the plasma membrane and which, in eukaryotic cells, surrounds the host nucleus. This term is used to describe a toxin located in the cytoplasm of a target cell." []
synonym: "Target cytoplasm" [UniProt]
is_a: SL-0487

[Term]
id: SL-0487
name: Target cell
namespace: uniprot:locations:cellular_component
def: "A cell including the cell membrane and any external encapsulating of another cell. This term is used to describe a toxin located in the structures such as the cell wall and cell envelope that is the target." []
xref: GO:0044216 "obsolete other organism cell"

[Term]
id: SL-0488
name: Inflammasome
namespace: uniprot:locations:cellular_component
def: "Inflammasomes are supramolecular micron-sized complexes that assemble in the cytosol adjacent to the nucleus in response to pathogens and other damage-associated signals. The inflammasome assembly leads to the activation of proinflammatory procaspases, hence is usually involved in innate immunity and inflammation. The core of inflammasomes consists of at least 2 components: a signal sensor and an effector inflammatory caspase (mostly CASP1). However, most inflammasomes contain a third element, an adaptor (often ASC/PYCARD). The interaction between the sensor component and the adaptor initiates speck formation (nucleation) which greatly enhances further addition of soluble adaptor molecules to the speck in a prion-like polymerization process. The kinetic properties of the adaptor aggregation have been shown to generate a rapid 'all-or-none' response, this is why only one speck by cell is observed." []
synonym: "ASC focus" [UniProt]
synonym: "ASC speck" [UniProt]
xref: GO:0061702 "canonical inflammasome complex"
relationship: part_of SL-0091

[Term]
id: SL-0489
name: Bacterial extracellular vesicle
namespace: uniprot:locations:cellular_component
def: "Small membrane vesicle (< 1 um) that buds off a prokaryotic cell's plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, etc. Bacterial extracellular vesicles are important in intercellular communication and pathogenesis, and can exist within host cells." []
synonym: "Bacterial membrane vesicle" [UniProt]
synonym: "Membrane vesicle" [UniProt]
synonym: "Microvesicle" [UniProt]
xref: GO:0097691 "bacterial extracellular vesicle"
is_a: SL-0499

[Term]
id: SL-0490
name: Midbody ring
namespace: uniprot:locations:cellular_component
def: "The midbody ring is the central region of the midbody characterized by a gap in alpha-tubulin staining, although interdigitating microtubules persist through the gap. It is thought that high local protein density masks tubulin epitopes known to be present. The midbody ring serves as a scaffold for a wide variety of structural and regulatory proteins required for completion of cytokinesis." []
synonym: "Flemming body" [UniProt]
synonym: "Stembody" [UniProt]
xref: GO:0090543 "Flemming body"
is_a: SL-0469

[Term]
id: SL-0491
name: Anammoxosome
namespace: uniprot:locations:cellular_component
def: "The anammoxosome is a large intracytoplasmic compartment bounded by a single bilayer, ladderane-lipid-containing membrane present in bacteria that perform anaerobic ammonium oxidation (anammox). This organelle is the site of the anammox process, in which nitrite is used as the electron acceptor in the conversion of ammonium to dinitrogen (N2) gas and water. Anammox bacteria belong to the phylum Planctomycetes and are recognized as major players in the global nitrogen cycle." []
xref: GO:0044222 "anammoxosome"

[Term]
id: SL-0492
name: Anammoxosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane of the anammoxosome, a single bilayer membrane that contains unusual lipids, i.e. the so-called ladderane lipids, which appear to be unique for anammox bacteria." []
is_a: SL-0162
relationship: part_of SL-0491

[Term]
id: SL-0494
name: Nuclear body
namespace: uniprot:locations:cellular_component
def: "Nuclear body is a collective term for several nuclear, extra- nucleolar, non-membrane-bound sub-compartments, including, but not limited to Cajal bodies, Gemini of Cajal bodies (gems), nuclear speckles and PML bodies. Nuclear bodies are visible as distinct spots in the nucleoplasm. They can vary in number and size depending on the cell line and the type of nuclear body." []
xref: GO:0016604 "nuclear body"
relationship: part_of SL-0191

[Term]
id: SL-0495
name: Cytoplasmic ribonucleoprotein granule
namespace: uniprot:locations:cellular_component
def: "Cytoplasmic ribonucleoprotein granule is a collective term for distinct protein and RNA foci inside the cytoplasm, including processing bodies (P-bodies), U snRNP bodies (U-bodies), stress granules, neuronal ribonucleoprotein granule (neuronal transport granule) and germ granules (germline granules)." []
synonym: "Cytoplasmic mRNP granule" [UniProt]
synonym: "Cytoplasmic mRNP granules" [UniProt]
synonym: "mRNP granule" [UniProt]
synonym: "mRNP granules" [UniProt]
xref: GO:0036464 "cytoplasmic ribonucleoprotein granule"
relationship: part_of SL-0086

[Term]
id: SL-0496
name: Stress granule
namespace: uniprot:locations:cellular_component
def: "Stress granules are dense non-membrane bound aggregations in the cytosol composed of proteins and RNAs that appear when the cell is under stress. The aggregates are mostly composed of stalled translation initiation complexes. They are 100-200 nm in size. Stress granules can also precipitate the formation of toxic protein aggregates such as those seen during the progression of certain types of neurological disease." []
xref: GO:0010494 "cytoplasmic stress granule"
is_a: SL-0495

[Term]
id: SL-0497
name: Nucleolus fibrillar center
namespace: uniprot:locations:cellular_component
def: "The nucleolus fibrillar center (FC) is a sub-compartment of most metazoan nucleoli. The transcription of ribosomal RNA (rRNA) genes generates 2 structures that are found in all nucleoli: the dense fibrillar component (DFC) and the granular component (GC). The DFC contains newly synthesized preribosomal RNA and a collection of proteins; the GC is made up of nearly completed preribosomal particles destined for the cytoplasm. In most metazoans, but generally not in lower eukaryotes, a third component, the FC, can be seen. The FC is surrounded by the DFC. The zone of transcription from multiple copy rRNA genes is in the border region between these 2 structures." []
synonym: "Nucleoli fibrillar center" [UniProt]
xref: GO:0001650 "fibrillar center"
relationship: part_of SL-0188

[Term]
id: SL-0498
name: Vesicle
namespace: uniprot:locations:cellular_component
def: "A vesicle is a small structure consisting of fluid enclosed by a lipid bilayer. Vesicles form naturally during the processes of secretion (exocytosis), uptake (endocytosis) and transport of materials within the cytoplasm or between cells, and exist both within the cell and in the extracellular space." []
xref: GO:0031982 "vesicle"

[Term]
id: SL-0499
name: Extracellular vesicle
namespace: uniprot:locations:cellular_component
def: "Extracellular vesicles are vesicles that have been released by cells." []
synonym: "Microparticle" [UniProt]
is_a: SL-0498

[Term]
id: SL-0500
name: Extracellular vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding an extracellular vesicle." []
is_a: SL-0162
relationship: part_of SL-0499

[Term]
id: SL-0501
name: Stress fiber
namespace: uniprot:locations:cellular_component
def: "Stress fibers are contractile actomyosin bundles found in non-muscle cells, in eukaryotes, mostly in animals. They are composed of bundles of 10 to 30 actin filaments (microfilaments), crosslinked by alpha- actinin, and non-muscle myosin. They are often anchored to focal adhesions, that connect the extracellular matrix to the actin cytoskeleton. Stress fibers play an essential role in cell contractility, governing cell morphology, adhesion, and migration. In non-motile cells, stress fibers are usually thick and relatively stable. By contrast, highly motile cells typically contain fewer, thinner and more dynamic stress fibers. Stress fibers can be divided into at least 4 different categories : dorsal and ventral stress fibers, transverse arcs and the perinuclear actin cap." []
xref: GO:0001725 "stress fiber"
relationship: part_of SL-0090

[Term]
id: SL-0502
name: Host synaptic vesicle
namespace: uniprot:locations:cellular_component
def: "In a host synapse, host synaptic vesicles mediate the exocytosis of neurotransmitters and subsequent re-uptake by endocytosis of vesicular components. Re-uptake is a crucial element in the maintenance of host synaptic transmission in the nervous system." []
is_a: SL-0504
relationship: part_of SL-0435

[Term]
id: SL-0503
name: Host synaptic vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The host membrane surrounding a host synaptic vesicle" []
synonym: "Host synaptic vesicular membrane" [UniProt]
relationship: part_of SL-0502

[Term]
id: SL-0504
name: Host secretory vesicle
namespace: uniprot:locations:cellular_component
def: "The host secretory vesicle is a host vesicle that mediates the vesicular transport of cargo - e.g. hormones or neurotransmitters - from an organelle to specific sites at the host cell membrane, where it docks and fuses to release its content." []
is_a: SL-0386

[Term]
id: SL-0505
name: T-tubule
namespace: uniprot:locations:cellular_component
def: "T-tubules are invaginations of the sarcolemma penetrating into the myocyte interior, forming a highly branched and interconnected network that makes junctions with the sarcoplasmic reticulum. T-tubules are selectively enriched with specific ion channels and proteins crucial in the development of calcium transients necessary in excitation- contraction coupling, thereby facilitating a fast and synchronous contraction across the entire cell volume. T-tubules are unique to striated muscle cells, i.e. skeletal and cardiac muscle cells." []
synonym: "Transverse tubule" [UniProt]
synonym: "Transverse-axial tubular system" [UniProt]
xref: GO:0030315 "T-tubule"
relationship: part_of SL-0238

[Term]
id: SL-0506
name: Host vacuole
namespace: uniprot:locations:cellular_component
def: "The host vacuole is a fluid-filled, membrane-bound compartment in the cytoplasm. The precise form and function of vacuoles may vary between phyla. They are employed for a variety of purposes, including storage, as a degradative compartment, cell size control, secretion and following phagocytosis." []
relationship: part_of SL-0427

[Term]
id: SL-0507
name: Host pathogen-containing vacuole
namespace: uniprot:locations:cellular_component
def: "A host-derived vacuole formed upon pathogen internalization by a host cell, within which the pathogen resides. The pathogen extensively modifies the vacuole membrane and contents, as well as its fate, in the process protecting the pathogen from destruction." []
synonym: "Pathogen inclusion" [UniProt]
xref: GO:0140220 "pathogen-containing vacuole"
relationship: part_of SL-0506

[Term]
id: SL-0508
name: Host pathogen-containing vacuole lumen
namespace: uniprot:locations:cellular_component
def: "The volume enclosed in a host-derived vacuole formed upon pathogen internalization by a host cell." []
synonym: "Pathogen inclusion lumen" [UniProt]
xref: GO:0140222 "pathogen-containing vacuole lumen"
is_a: SL-0507

[Term]
id: SL-0509
name: Host pathogen-containing vacuole membrane
namespace: uniprot:locations:cellular_component
def: "The host-derived membrane which encloses a vacuole formed upon pathogen internalization by a host cell." []
synonym: "Pathogen inclusion membrane" [UniProt]
xref: GO:0140221 "pathogen-containing vacuole membrane"
is_a: SL-0380
relationship: part_of SL-0507

[Term]
id: SL-0510
name: Magnetosome
namespace: uniprot:locations:cellular_component
def: "A specialized, membrane-bound bacterial organelle that envelops nanometer-sized crystals of magnetic iron minerals. They form linear chains at midcell along the cellular motility axis." []
xref: GO:0110143 "magnetosome"

[Term]
id: SL-0511
name: Magnetosome lumen
namespace: uniprot:locations:cellular_component
def: "The magnetosome lumen." []
xref: GO:0110145 "magnetosome lumen"
relationship: part_of SL-0510

[Term]
id: SL-0512
name: Magnetosome membrane
namespace: uniprot:locations:cellular_component
def: "The magnetosome membrane." []
xref: GO:0110146 "magnetosome membrane"
is_a: SL-0162
relationship: part_of SL-0510

[Term]
id: SL-0513
name: Photoreceptor outer segment membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the outer segment of a vertebrate photoreceptor." []
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0458

[Term]
id: SL-0514
name: Photoreceptor inner segment membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the inner segment of a vertebrate photoreceptor. SL Photoreceptor inner segment membrane. HI Membrane. HP Endomembrane system. HP ." []
is_a: SL-0162
relationship: part_of SL-0147
relationship: part_of SL-0457

[Term]
id: SL-0515
name: Postsynapse
namespace: uniprot:locations:cellular_component
def: "The receiving part of a synapse which contains the neurotransmitter- receptor scaffold and signaling machinery to respond to signals from the presynaptic cell." []
synonym: "Post-synapse" [UniProt]
synonym: "Postsynaptic region" [UniProt]
synonym: "Postsynaptic terminal" [UniProt]
xref: GO:0098794 "postsynapse"
relationship: part_of SL-0258

[Term]
id: SL-0516
name: Presynapse
namespace: uniprot:locations:cellular_component
def: "In the synapse, the specialized axon's terminal end of the presynaptic cell that contains the specialized apparatus necessary to release neurotransmitters to the synaptic cleft." []
synonym: "Axon terminal" [UniProt]
synonym: "Pre-synapse" [UniProt]
synonym: "Presynaptic bouton" [UniProt]
synonym: "Presynaptic region" [UniProt]
synonym: "Presynaptic terminal" [UniProt]
xref: GO:0098793 "presynapse"
relationship: part_of SL-0258
relationship: part_of SL-0279

[Term]
id: SL-0517
name: Synaptic cleft
namespace: uniprot:locations:cellular_component
def: "The narrow space between the presynaptic and postsynaptic membranes into which neurotransmitters are released by synaptic vesicles through exocytosis and diffuse to activate receptors on post-synaptic membrane." []
xref: GO:0043083 "synaptic cleft"
relationship: part_of SL-0112
relationship: part_of SL-0258

[Term]
id: SL-0518
name: Neuron projection
namespace: uniprot:locations:cellular_component
def: "Prolongation or process extending from a nerve cell, such as an axon or a dendrite. Used when speaking of immature or developing neurons, especially of cells in culture, because it can be difficult to tell axons from dendrites before differentiation is complete." []
synonym: "Neurite" [UniProt]
synonym: "Neuronal process" [UniProt]
xref: GO:0043005 "neuron projection"
is_a: SL-0280

[Term]
id: SL-0519
name: Presynaptic active zone
namespace: uniprot:locations:cellular_component
def: "The active zone is the region that lies at the interface between the presynaptic terminal and the synaptic cleft and mediates neurotransmitter release. Consists of an electron dense protein network called the cytomatrix at the active zone (CAZ) that is tightly anchored to the presynaptic membrane, and precisely aligned with post- synaptic receptors. CAZ docks and fuses synaptic vesicles, recruits voltage-gated Ca(2+) channels to the presynaptic membrane to allow fast synchronous excitation/release coupling and mediates short- and long-term presynaptic plasticity." []
xref: GO:0048786 "presynaptic active zone"
relationship: part_of SL-0516

[Term]
id: SL-0520
name: Postsynaptic density membrane
namespace: uniprot:locations:cellular_component
def: "The membrane component of the postsynaptic specialization. Part of the postsynaptic membrane attached to the postsynaptic density in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated and organized." []
xref: GO:0098839 "postsynaptic density membrane"
relationship: part_of SL-0219
relationship: part_of SL-0297

[Term]
id: SL-0521
name: Golgi outpost
namespace: uniprot:locations:cellular_component
def: "Golgi outpost is an organelle that shares common markers with the perinuclear Golgi body, but is typically much smaller in size and located far from the nucleus or cell body. Golgi outposts can function as acentrosomal microtubule-organizing centers (MTOCs) and play specialized roles in building the cytoarchitecture of neuronal dendrites, muscle cells, and oligodendrocytes." []
synonym: "Golgi elements" [UniProt]
synonym: "Golgi vesicles" [UniProt]
synonym: "Mini Golgi" [UniProt]
synonym: "Postsynaptic Golgi apparatus" [UniProt]
synonym: "Satellite Golgi" [UniProt]
is_a: SL-0132

[Term]
id: SL-0522
name: Postsynaptic endosome
namespace: uniprot:locations:cellular_component
def: "An endosomal compartment that is part of the postsynapse. The endosomal pathway in postsynapses and dendrites is essential for membrane receptor trafficking and proper synaptic function and plasticity. Only early and recycling endosomes are typically present in the postsynapse." []
synonym: "postsynaptic endosome" [UniProt]
xref: GO:0098845 "postsynaptic endosome"
is_a: SL-0101
relationship: part_of SL-0515

[Term]
id: SL-0523
name: Postsynaptic early endosome
namespace: uniprot:locations:cellular_component
def: "An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degredation or recycling." []
xref: GO:0098842 "postsynaptic early endosome"
is_a: SL-0094
relationship: part_of SL-0522

[Term]
id: SL-0524
name: Postsynaptic recycling endosome
namespace: uniprot:locations:cellular_component
def: "A recycling endosome of the postsynapse. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane and serves as intracellular reserve pools of neurotransmitter receptors. In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation." []
xref: GO:0098837 "postsynaptic recycling endosome"
is_a: SL-0232
is_a: SL-0522
relationship: part_of SL-0515

[Term]
id: SL-0525
name: Presynaptic endosome
namespace: uniprot:locations:cellular_component
def: "An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. Presynaptic endosomes are involved on synaptic vesicle regeneration in GABAergic synapses at least, even if different modes of synaptic vesicles recycling exist depending on the type of synapse." []
xref: GO:0098830 "presynaptic endosome"
is_a: SL-0101
relationship: part_of SL-0516

[Term]
id: SL-0526
name: Neuronal dense core vesicle
namespace: uniprot:locations:cellular_component
def: "Dense core vesicle that is part of a neuron. Stores and releases neuropeptides (peptide neurotransmitters) and neurotrophins by exocytosis. Filled with cargo at the Golgi network, they are transported through axons and dendrites to the synapses where the release takes place. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." []
synonym: "Large dense-core vesicles" [UniProt]
synonym: "Neuronal dense core granule" [UniProt]
synonym: "Neuronal large dense-core vesicles" [UniProt]
xref: GO:0098992 "neuronal dense core vesicle"
is_a: SL-0244

[Term]
id: SL-0527
name: Presynaptic active zone membrane
namespace: uniprot:locations:cellular_component
def: "The membrane portion of the presynaptic active zone that allows presynaptic vesicles to dock, fuse, and, ultimately, release neurotransmitter into the synaptic cleft." []
xref: GO:0048787 "presynaptic active zone membrane"
relationship: part_of SL-0222
relationship: part_of SL-0519

[Term]
id: SL-0528
name: Postsynaptic endocytic zone
namespace: uniprot:locations:cellular_component
def: "Stably positioned sites of clathrin adjacent to the postsynaptic density (PSD). The physical link with the PSD ensures localized endocytosis and recycling by recapturing and maintaining a proximate pool of cycling postsynaptic receptors." []
xref: GO:0098843 "postsynaptic endocytic zone"
relationship: part_of SL-0515

[Term]
id: SL-0529
name: Presynaptic endocytic zone
namespace: uniprot:locations:cellular_component
def: "Region of the presynaptic membrane and underlying cytoplasm that surrounds the active zone and where synaptic vesicles are endocytosed and recycled following release." []
synonym: "Peri-active zone" [UniProt]
synonym: "Periactive zone" [UniProt]
xref: GO:0098833 "presynaptic endocytic zone"
relationship: part_of SL-0516

[Term]
id: SL-0530
name: Spine apparatus
namespace: uniprot:locations:cellular_component
def: "Specialized form of endoplasmic reticulum found in a subpopulation of dendritic spines in central neurons consisting of two or more closely apposed lamellae with interspersed electron dense material." []
xref: GO:0097444 "spine apparatus"
is_a: SL-0095
relationship: part_of SL-0284
relationship: part_of SL-0515

[Term]
id: SL-0531
name: Synaptic cell membrane
namespace: uniprot:locations:cellular_component
def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." []
xref: GO:0097060 "synaptic membrane"
is_a: SL-0039
relationship: part_of SL-0258

[Term]
id: SL-0532
name: Neuronal dense core vesicle membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a neuronal dense core vesicle." []
xref: GO:0099012 "neuronal dense core vesicle membrane"
is_a: SL-0245
relationship: part_of SL-0526

[Term]
id: SL-0533
name: Postsynaptic recycling endosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a postsynaptic recycling endosome" []
xref: GO:0098944 "postsynaptic recycling endosome membrane"
is_a: SL-0162
relationship: part_of SL-0524

[Term]
id: SL-0534
name: Postsynaptic early endosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding a postsynaptic early endosome" []
xref: GO:0098896 "postsynaptic early endosome membrane"
is_a: SL-0162
relationship: part_of SL-0523

[Term]
id: SL-0535
name: Autolysosome
namespace: uniprot:locations:cellular_component
def: "The autolysosome is a single-membrane organelle resulting from the fusion of a double-membrane autophagosome with a lysosome during macroautophagy. The outer membrane of the autophagosome fuses with the lysosome membrane whereas the inner membrane and the autophagic cargo are released into the lumen and degraded. Alternatively, the convergence of macroautophagy and endocytosis produces a single- membrane amphisome that also results in an autolysosome upon fusion with a lysosome." []
synonym: "Degrading autophagic vacuole" [UniProt]
xref: GO:0044754 "autolysosome"
is_a: SL-0023
is_a: SL-0158

[Term]
id: SL-0536
name: Autolysosome membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding the autolysosome." []
xref: GO:0120281 "autolysosome membrane"
is_a: SL-0162
relationship: part_of SL-0535

[Term]
id: SL-0537
name: Autolysosome lumen
namespace: uniprot:locations:cellular_component
def: "The autolysosome lumen is the area enclosed by the autolysosomal membrane." []
synonym: "Degrading autophagic vacuole lumen" [UniProt]
xref: GO:0120282 "autolysosome lumen"
relationship: part_of SL-0535

[Term]
id: SL-0538
name: Ascus epiplasm
namespace: uniprot:locations:cellular_component
def: "Ascus cytoplasm that is not packaged into ascospores." []
xref: GO:0072324 "ascus epiplasm"

[Term]
id: SL-0539
name: Spore
namespace: uniprot:locations:cellular_component
def: "Spores are hardy unicellular units used by various bacteria, fungi, plants and protozoa to allow them to remain dormant during long periods of time and under often unfavorable conditions." []
synonym: "Ascospore" [UniProt]
synonym: "Basidiospore" [UniProt]
synonym: "Chlamydospore" [UniProt]
synonym: "Megaspore" [UniProt]
synonym: "Microspore" [UniProt]
synonym: "Teliospore" [UniProt]
synonym: "Tetraspore" [UniProt]
synonym: "Zoospore" [UniProt]

[Term]
id: SL-0540
name: Zona pellucida
namespace: uniprot:locations:cellular_component
def: "Zona pellucida is a specialized extracellular matrix that surrounds the plasma membrane of mammalian oocytes. It is required for successful fertilization. Zona pellucida allows species-specific fertilization, prevents polyspermy, and enables acrosomal reaction for the successful adhesion and penetration of the sperm cell." []
synonym: "Egg coat" [UniProt]
synonym: "Pellucid zone" [UniProt]
synonym: "Vitelline membrane" [UniProt]
xref: GO:0035805 "egg coat"
relationship: part_of SL-0111

[Term]
id: SL-0541
name: Cortical granule
namespace: uniprot:locations:cellular_component
def: "Cortical granules are secretory organelles located under the cell membrane of unfertilized oocytes. Following fertilization, cortical granules fuse with the oocyte's cell membrane and release their contents into the extracellular matrix. This exocytosis, known as the cortical reaction, is involved in the prevention of polyspermy. Cortical granules are found in all mammals and many other vertebrates, as well as some invertebrates." []
synonym: "Cortical vesicle" [UniProt]
xref: GO:0060473 "cortical granule"
is_a: SL-0244

[Term]
id: SL-0542
name: Dynein axonemal particle
namespace: uniprot:locations:cellular_component
def: "Dynein axonemal particles are ciliated cell-specific cytoplasmic membrane-less organelles, where dynein axonemal assembly factors (DNAAFs) and chaperones flux through rapidly while dynein subunits are stably retained. May act in storage or assembly of axonemal dyneins for rapid deployment to cilia." []
synonym: "DynAP" [UniProt]
xref: GO:0120293 "dynein axonemal particle"
relationship: part_of SL-0086

[Term]
id: SL-0543
name: Cytolytic granule
namespace: uniprot:locations:cellular_component
def: "A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells." []
synonym: "Lytic granule, cytotoxic granule" [UniProt]
xref: GO:0044194 "cytolytic granule"
relationship: part_of SL-0158

[Term]
id: SL-0544
name: Bacterial microcompartment
namespace: uniprot:locations:cellular_component
def: "Bacterial microcompartments (BMC) are proteinaceous polyhedral shells that encapsulate enzymes. The selectively permeable organelles protect their contents from the cytoplasm and/or the cytoplasm from reactants in their interior. The best characterized BMC is the carboxysome, which encapsulates RuBisCO and carbonic anhydrase, and enhances autotrophic CO(2) fixation. Other characterized BMCs encapsulate enzymes involved in ethanolamine or propanediol degradation; both pathways make toxic intermediates. Artifical BMCs can be expressed and filled with cargo proteins for biotechnological uses. BMCs are found in many bacterial phyla; in most cases their cargo is unknown." []
synonym: "Metabolosome" [UniProt]
synonym: "Polyhedral organelle" [UniProt]
xref: GO:0031469 "bacterial microcompartment"

[Term]
id: SL-0545
name: Zymogen granule
namespace: uniprot:locations:cellular_component
def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme- secreting cells that allows the sorting, packaging and regulated apical secretion of digestive enzymes. Enzymes are packaged in these granules as zymogen or proenzyme, their inactive precursor form." []
xref: GO:0042588 "zymogen granule"
is_a: SL-0244

[Term]
id: SL-0546
name: Cytolytic granule lumen
namespace: uniprot:locations:cellular_component
def: "The cytolytic granule comparment bounded by the cytolytic granule membrane." []
is_a: SL-0156
relationship: part_of SL-0543

[Term]
id: SL-0547
name: Cytolytic granule membrane
namespace: uniprot:locations:cellular_component
def: "The cytolytic granule membrane is the membrane surrounding a cytolytic granule." []
xref: GO:0101004 "cytolytic granule membrane"
is_a: SL-0157
relationship: part_of SL-0543

[Term]
id: SL-0548
name: Zymogen granule lumen
namespace: uniprot:locations:cellular_component
def: "The zymogen granule compartment bounded by the membrane of the secretory vesicle." []
is_a: SL-0347
relationship: part_of SL-0545

[Term]
id: SL-0549
name: Zymogen granule membrane
namespace: uniprot:locations:cellular_component
def: "The membrane surrounding zymogen granules." []
xref: GO:0042589 "zymogen granule membrane"
is_a: SL-0245
relationship: part_of SL-0545

[Term]
id: SL-0550
name: Encapsulin nanocompartment
namespace: uniprot:locations:cellular_component
def: "Proteinaceous polyhedral shells that encapsulate enzymes. The selectively permeable organelles protect their contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only 1 protein, and has only a few proteins inside. Shells 25 nm in diameter are made of 60 monomers, shells 32 nm are made of 180 monomers, while shells 42 nm in diameter are made of 240 monomers with T=1, T=3 or T=4 icosahedral symmetry respectively. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla. In anammox bacteria they may be located inside the anammoxosome." []
xref: GO:0140737 "encapsulin nanocompartment"

[Term]
id: SL-0551
name: Rhabdomere
namespace: uniprot:locations:cellular_component
def: "A specialized organelle found in the photoreceptor cells of an ommatidium (the individual component of the arthropod compound eye) and the photoreceptor cells in the eye of cephalopods. Composed of thousands of tightly packed microvilli that expand the membrane surface area to accommodate millions of molecules of rhodopsin. Orthologous to the tightly packed membrane discs of the ciliary outer segment in vertebrate photoreceptor cells." []
xref: GO:0016028 "rhabdomere"
is_a: SL-0280

[Term]
id: SL-0552
name: Rhabdomere membrane
namespace: uniprot:locations:cellular_component
def: "The portion of the plasma membrane surrounding the rhabdomere." []
xref: GO:0033583 "rhabdomere membrane"
is_a: SL-0551
relationship: part_of SL-0039

[Term]
id: SL-0553
name: U-body
namespace: uniprot:locations:cellular_component
def: "Non-membranous cytoplasmic structures containing Uridine-rich small nuclear ribonucleoproteins (U snRNPs) and snRNP assembly factors. U- bodies probably function as assembly or storage sites for snRNPs prior to their import into the nucleus. U-bodies associate with P-bodies and may cooperate in snRNP metabolism." []
synonym: "Cytoplasmic U snRNP body" [UniProt]
synonym: "U bodies" [UniProt]
synonym: "U body" [UniProt]
synonym: "U-bodies" [UniProt]
is_a: SL-0495

[Term]
id: SL-9900
name: Peptidoglycan-anchor
namespace: uniprot:locations:topology
def: "Surface protein of a Gram-positive bacteria anchored to the cell wall envelope by a transpeptidation mechanism which requires a C-terminal sorting signal with a conserved LPXTG motif. An amide bond is created between the carboxyl-group of the conserved threonine and the amino- group of peptidoglycan cross-bridges." []

[Term]
id: SL-9901
name: Lipid-anchor
namespace: uniprot:locations:topology
def: "Protein bound to the lipid bilayer of a membrane through a posttranslationally modification by the attachment of at least one lipid or fatty acid, e.g. farnesyl, palmitate and myristate." []

[Term]
id: SL-9902
name: GPI-anchor
namespace: uniprot:locations:topology
def: "Protein bound to the lipid bilayer of a membrane through a GPI-anchor (glycosylphosphatidylinositol anchor), a complex oligoglycan linked to a phosphatidylinositol group, resulting in the attachment of the C- terminus of the protein to the membrane." []
synonym: "Glycosylphosphatidylinositol anchor" [UniProt]
synonym: "Glycosylphospholipidinositol anchor" [UniProt]
is_a: SL-9901

[Term]
id: SL-9903
name: Peripheral membrane protein
namespace: uniprot:locations:topology
def: "Protein that is physically associated with a membrane, via interactions with lipid headgroups at the membrane surface or with another membrane protein. Peripheral membrane proteins are typically bound to the membrane surface, but may dip slightly into the lipid bilayer. Peripheral membrane protein." []
is_a: SL-0162

[Term]
id: SL-9904
name: Single-pass membrane protein
namespace: uniprot:locations:topology
def: "Protein spanning the membrane once." []
synonym: "Single pass" [UniProt]
synonym: "Single span" [UniProt]
synonym: "Single-pass" [UniProt]
synonym: "Singlepass" [UniProt]
synonym: "Singlespan" [UniProt]
is_a: SL-0162

[Term]
id: SL-9905
name: Single-pass type I membrane protein
namespace: uniprot:locations:topology
def: "Protein spanning the membrane once, with its N-terminus on the extracellular side of the membrane and removal of its signal sequence." []
synonym: "Single pass" [UniProt]
synonym: "Single span" [UniProt]
synonym: "Single-pass" [UniProt]
synonym: "Singlepass" [UniProt]
synonym: "Singlespan" [UniProt]
is_a: SL-9904

[Term]
id: SL-9906
name: Single-pass type II membrane protein
namespace: uniprot:locations:topology
def: "Protein spanning the membrane once, with its N-terminus on the cytoplasmic side of the membrane. The transmembrane domain is located close to the N-terminus and it functions as an anchor." []
synonym: "Single pass" [UniProt]
synonym: "Single span" [UniProt]
synonym: "Single-pass" [UniProt]
synonym: "Singlepass" [UniProt]
synonym: "Singlespan" [UniProt]
is_a: SL-9904

[Term]
id: SL-9907
name: Single-pass type III membrane protein
namespace: uniprot:locations:topology
def: "Protein spanning the membrane once, with its N-terminus on the extracellular side of the membrane and no signal sequence." []
synonym: "Single pass" [UniProt]
synonym: "Single span" [UniProt]
synonym: "Single-pass" [UniProt]
synonym: "Singlepass" [UniProt]
synonym: "Singlespan" [UniProt]
is_a: SL-9904

[Term]
id: SL-9908
name: Single-pass type IV membrane protein
namespace: uniprot:locations:topology
def: "Protein spanning the membrane once, with its N-terminus on the cytoplasmic side of the membrane. The transmembrane domain is located close to the C-terminus and it functions as an anchor." []
synonym: "Single pass" [UniProt]
synonym: "Single span" [UniProt]
synonym: "Single-pass" [UniProt]
synonym: "Singlepass" [UniProt]
synonym: "Singlespan" [UniProt]
is_a: SL-9904

[Term]
id: SL-9909
name: Multi-pass membrane protein
namespace: uniprot:locations:topology
def: "Protein spanning the membrane more than once." []
synonym: "Multi pass" [UniProt]
synonym: "Multi span" [UniProt]
synonym: "Multi-pass" [UniProt]
synonym: "Multipass" [UniProt]
synonym: "Multispan" [UniProt]
synonym: "Polytopic membrane protein" [UniProt]
is_a: SL-0162

[Term]
id: SL-9910
name: Cytoplasmic side
namespace: uniprot:locations:orientation
def: "Protein found mostly on the cytoplasmic side of the membrane." []

[Term]
id: SL-9911
name: Extracellular side
namespace: uniprot:locations:orientation
def: "Protein found mostly on the extracellular side of the membrane." []

[Term]
id: SL-9912
name: Intermembrane side
namespace: uniprot:locations:orientation
def: "Protein found mostly on the intermembrane side of the membrane." []

[Term]
id: SL-9913
name: Matrix side
namespace: uniprot:locations:orientation
def: "Protein found mostly on the matrix side of the membrane." []

[Term]
id: SL-9914
name: Lumenal side
namespace: uniprot:locations:orientation
def: "Protein found mostly on the lumenal side of the membrane." []

[Term]
id: SL-9915
name: Nucleoplasmic side
namespace: uniprot:locations:orientation
def: "Protein found mostly on the nucleoplasmic side of the membrane." []

[Term]
id: SL-9916
name: Periplasmic side
namespace: uniprot:locations:orientation
def: "Protein found mostly on the periplasmic side of the membrane." []

[Term]
id: SL-9917
name: Stromal side
namespace: uniprot:locations:orientation
def: "Protein found mostly on the stromal side of the membrane." []

[Term]
id: SL-9918
name: Extravirionic side
namespace: uniprot:locations:orientation
def: "Protein found mostly on the extracellular side of the virion membrane." []

[Term]
id: SL-9919
name: Intravirionic side
namespace: uniprot:locations:orientation
def: "Protein found mostly on the intravirionic side of the virion membrane." []

[Term]
id: SL-9920
name: GPI-like-anchor
namespace: uniprot:locations:topology
def: "Protein bound to the lipid bilayer of a membrane through a GPI-like- anchor, a complex oligoglycan linked to a sphingolipidinositol group, resulting in the attachment of the C-terminus of the protein to the membrane." []
synonym: "Glycosylphospholipidinositol anchor" [UniProt]
synonym: "Glycosylsphingolipidinositol anchor" [UniProt]
is_a: SL-9901